scholarly journals Role of Apolipoprotein E gene polymorphism in the risk of familial hypercholesterolemia: a case-control study

2018 ◽  
Vol 65 (3) ◽  
Author(s):  
Turky H Almigbal ◽  
Mohammed Ali Batais ◽  
Rana M Hasanato ◽  
Fawaziah Khalaf Alharbi ◽  
Imran Ali Khan ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Familial Hypercholesterolemia ◽  
Case Control Study ◽  
Case Control ◽  
Lipid Profiles ◽  
Apoe Gene ◽  
Taqman Assay ◽  
Saudi Population ◽  
Elevated Cholesterol ◽  
Control Study

Familial Hypercholesterolemia (FH) is characterized by elevated cholesterol; this is based on biochemical, clinical, and genetic studies and FH disease, which was documented even with limited mutations. Earlier studies were associated with Apolipoprotein E (ApoE) in variable diseases. The current study aims to investigate the genetic association between FH disease and ApoE gene (rs429358 and rs7412) in the Saudi population. This study has been carried out as a case-control and is a hospital-based study in Saudi Arabia. Two hundred and four subjects were recruited as FH participants (n=104) and the others as controls (n=100). Common polymorphisms (rs429358 and rs7412) were selected from the ApoE gene and we then performed the genotyping as the TaqMan assay. Moreover, the ApoE risk allele E4 is significantly associated in FH cases and controls (OR-2.24 (95%CI: 1.06-4.70); p=0.02). Lipid profile parameters were significantly associated (p<0.05); however, a combination of ApoE alleles and lipid profiles could not find a correlation (p>0.05). The FH case-control study was associated with the E4 allele in the Saudi population. The risk of allele E4 which is a reliable marker for lipid profiles, but did not correlate with ApoE alleles. 

A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy

2002 ◽  
Vol 23 (4) ◽  
pp. 209-223 ◽  
Author(s):  
Silke Schmidt ◽  
Caroline C. W. Klaver ◽  
Ann M. Saunders ◽  
Eric A. Postel ◽  
Monica A. De La Paz ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Case Control Study ◽  
Case Control ◽  
Apoe Gene ◽  
Age Related ◽  
Control Study

scholarly journals Correlation between Levels of Vitamins D3 and E in Type 2 Diabetes Mellitus: A Case-Control Study in Serdang, Selangor, Malaysia

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2288
Author(s):  
Nurliyana Najwa Md Razip ◽  
Banulata Gopalsamy ◽  
Mohd Sokhini Abdul Mutalib ◽  
Sui Kiat Chang ◽  
Muhammad Mikhail Joseph Anthony Abdullah ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D3 ◽  
Case Control Study ◽  
Density Lipoprotein ◽  
Case Control ◽  
Lipid Profiles ◽  
C Peptide ◽  
Spearman’S Correlation ◽  
Control Study

An overview of vitamins D3 and E suggests micronutrient deficiency contributes to type 2 diabetes mellitus (T2DM). A case-control study was conducted to determine the status of plasma vitamins D3 and E isomers amongst diabetic Malaysians. Two groups were recruited for participation, one comprising fifty diabetic subjects (DM) and one comprising fifty non-diabetic (non-DM) subjects, in order to assess their plasma vitamin D3, calcium and vitamin E status. Glycaemic status (haemoglobin A1c, HbA1c; fasting blood glucose, FBG; C-Peptide) and lipid profiles (total cholesterol, TC; triglycerides, TG; low-density lipoprotein-cholesterol, LDL-C; high-density lipoprotein-cholesterol, HDL-C) were assessed, followed by anthropometric measurements. The Mann–Whitney U-test, Kruskal–Wallis and Spearman’s correlation coefficient were used to elucidate the association between levels of plasma vitamins D3 and E and T2DM. The vitamin D3 deficiency group (<20 ng/mL) showed a significant correlation (p < 0.05) with glycaemic status (HbA1c and FBG) and lipid profiles (HDL-C, LDL and TC). Spearman’s correlation demonstrated that vitamin D3 status is strongly correlated with HDL levels (p < 0.05). Similarly, plasma total vitamin E levels >4.9 μg/mL revealed significantly different FBG, HbA1c, C-Peptide, LDL, HDL and TC levels across both groups. Moreover, family history, smoking, waist circumference and HbA1c levels demonstrated a significant association (p < 0.05) with levels of vitamins D and E but not FBG and lipid profiles. This could be because the pre-diabetic status among the non-DM group influenced the outcomes of this study.

scholarly journals Association Between Blood Lipid Profiles and Atrial Fibrillation: A Case-Control Study

2018 ◽  
Vol 24 ◽  
pp. 3903-3908 ◽  
Author(s):  
Zhi-Zhao Li ◽  
Xin Du ◽  
Xue-yuan Guo ◽  
Ri-bo Tang ◽  
Chao Jiang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Case Control Study ◽  
Blood Lipid ◽  
Case Control ◽  
Lipid Profiles ◽  
Control Study

scholarly journals Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker–based case–control study

PLoS Medicine ◽  
2020 ◽  
Vol 17 (8) ◽  
pp. e1003289 ◽  
Author(s):  
Hana Saddiki ◽  
Aurore Fayosse ◽  
Emmanuel Cognat ◽  
Séverine Sabia ◽  
Sebastiaan Engelborghs ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Case Control Study ◽  
Case Control ◽  
Fluid Biomarker ◽  
Control Study ◽  
Apolipoprotein E Genotype

Frequencies of apolipoprotein E alleles in depressed patients undergoing hemodialysis – a case-control study

Renal Failure ◽  
2015 ◽  
Vol 37 (5) ◽  
pp. 804-809 ◽  
Author(s):  
Yan-yan Su ◽  
Yun-fang Zhang ◽  
Shen Yang ◽  
Jie-lin Wang ◽  
Bao-jun Hua ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Case Control Study ◽  
Case Control ◽  
Depressed Patients ◽  
Control Study

scholarly journals Case-control study of apoE gene polymorphism in young CHD patients and controls in the Serbian population

2011 ◽  
Vol 63 (1) ◽  
pp. 89-98 ◽  
Author(s):  
I. Djan ◽  
Edita Stokic ◽  
D. Sakac ◽  
Mihajla Djan ◽  
Dragana Obreht ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Gene Polymorphism ◽  
Biochemical Parameters ◽  
Case Control Study ◽  
Apoe Genotype ◽  
Case Control ◽  
Apoe Gene ◽  
E4 Allele ◽  
Apoe Gene Polymorphism ◽  
Control Study

Apolipoprotein E displays polymorphism with three common alleles, e2, e3, and e4. The aim of this research was to determine apoE gene polymorphism in a group of healthy patients and a group of patients with CHD, and to reveal the relation between anthropometric and biochemical parameters and the apoE genotype. In CHD group significantly higher values of blood pressure, waist circumference, BMI and fat %, triglycerides, insulin (HOMA IR) and CRP were found. A statistically significant higher presence of the e3e4 genotype and e4 allele was detected in the CHD group. Statistically significant differences between waist circumference, BMI, insulin and HOMA IR were found between subjects with e3e3 and e3e4 genotypes.

scholarly journals Consanguinity and Diabetes in Saudi Population: A Case-Control Study

Cureus ◽  
2021 ◽  
Author(s):  
Saad H Alzahrani ◽  
Nawaf M Alzahrani ◽  
Fahad S Al jabir ◽  
Mohammed K Alsharef ◽  
Shawana Zaheer ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Saudi Population ◽  
Control Study

scholarly journals Risk factors of colorectal cancer among Saudi Population: Case-control study

2020 ◽  
Vol 9 (9) ◽  
pp. 5035
Author(s):  
RishiK Bharti ◽  
MansourZ Alqahtani ◽  
AshryG Mohammed ◽  
AwadS Alsamghan ◽  
AbdullahA Alsharm ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Case Control Study ◽  
Case Control ◽  
Saudi Population ◽  
Control Study
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