Reduced anti-inflammatory activity of acetylsalicylic acid maltol ester, aspalatone

1994 ◽  
Vol 17 (3) ◽  
pp. 166-169 ◽  
Author(s):  
Byung Hoon Han ◽  
Dae-Yeon Suh ◽  
Hyun Ok Yang ◽  
Song Jin Lee ◽  
Hyun Pyo Kim
Keyword(s):  
Acetylsalicylic Acid ◽  
Inflammatory Activity ◽  
Anti Inflammatory

Analgesic and anti-inflammatory activity of new oleanolic and acetylsalicylic acid hybride in rodents

2013 ◽  
Vol 65 ◽  
pp. 137
Author(s):  
Natalia Wachowiak ◽  
Przemysław Ł. Mikołajczak ◽  
Ewa Kamińska ◽  
Barbara Bednarczyk-Cwynar ◽  
Lucjusz Zaprutko ◽  
...  
Keyword(s):  
Acetylsalicylic Acid ◽  
Inflammatory Activity ◽  
Anti Inflammatory

scholarly journals Aminoacids Derivatives with a Potential Anti-inflammatory Activity

2016 ◽  
Vol 5 (4) ◽  
pp. 323 ◽  
Author(s):  
Valeriu Sunel ◽  
Marcel Popa ◽  
Liliana Verestiuc ◽  
Claudia Ivanov ◽  
Aura Angelica Popa
Keyword(s):  
Biological Activity ◽  
Acute Toxicity ◽  
Acetylsalicylic Acid ◽  
Hplc Method ◽  
Point Of View ◽  
Inflammatory Activity ◽  
Benzimidazole Derivatives ◽  
Reaction Products ◽  
Anti Inflammatory ◽  
Physical And Chemical

The paper presents the synthesis of benzimidazole derivatives starting from asparagic acid. The reaction products were analysed from physical and chemical point of view and their biological activity (acute toxicity, anti-inflammatory activity and gastric tolerance) was evaluated. The product association with acetylsalicylic acid (Aspirin) improves its anti-inflammatory activity (higher with 38%). For acetylsalicylic acid dosing, in mixtures with benzimidazole derivatives, a new HPLC method has been proposed. The method is reproducible, selective and easy to manipulate. The derivatives based on benzimidazole and asparagic acid and their associates with acetylsalicylic acid present good anti-inflammatory properties.

Evaluation of the Anti-inflammatory and Analgesic Activity of the Ethanolic Extract Arial Parts of Calendula suffruticosa subsp. Suffruticosa Vahl

2021 ◽  
Author(s):  
I. Sofiane ◽  
K. Azin ◽  
R. Seridi
Keyword(s):  
Acetylsalicylic Acid ◽  
Analgesic Activity ◽  
Skin Diseases ◽  
Ethanolic Extract ◽  
Inflammatory Activity ◽  
Duodenal Ulcers ◽  
North East ◽  
The North ◽  
Inflammatory Edema ◽  
Anti Inflammatory

The current study aims to evaluate the toxicity and the pharmacological activities of a spontaneous, medicinal and aromatic plant of the North-east of Algeria. Calendula suffruticosa subsp. suffruticosa Vahl. (Asteraceae) is widely used in traditional medicine to treat various diseases including inflammation, duodenal ulcers, burns and skin diseases. The anti-inflammatory activity of the ethanolic extract was evaluated by the inflammatory edema test induced by carrageenan in mice. And the analgesic activity has been determined in a model of pain induced by acetic acid. The diclofenac and acetylsalicylic acid are used as reference drugs. The toxicological study of the ethanolic extract revealed that the LD50 of this extract is greater than 1,000 mg/kg of body weight. The ethanolic extract at the dose 200 and 400 mg/kg administered orally and possesses a significant anti-inflammatory activity (test of Anova). The results of the analgesic activity also show the strong effect of the extract tested against chemical pain. This extract at a dose of 400 mg/kg, has analgesic activity greater to that of acetylsalicylic acid in the dose of 100 mg/kg, with a percentage inhibition of 81.13 ± 1.09%. These results confirm the anti-inflammatory and analgesic properties of Calendula suffruticosa subsp. suffruticosa Vahl., which are mainly due to the phytochemical composition of the extract studied.

scholarly journals AB0059 STUDY OF THE ANTI-INFLAMMATORY EFFECT OF CINNAMOMUM VERUM IN RATS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1061.2-1061
Author(s):  
R. Dhouibi ◽  
A. Hanène ◽  
S. Ben Youssef ◽  
M. Ben Salem ◽  
R. Marrakchi ◽  
...  
Keyword(s):  
Acetylsalicylic Acid ◽  
Glucose Transporter ◽  
Saline Solution ◽  
Dose Effect ◽  
Inflammatory Activity ◽  
Mouse Macrophages ◽  
Term Administration ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Background:Inflammatory response is a common physiological response that protects the host of many harmful stimuli such as toxins, local injuries and pathogens. Today, non-steroidal anti-inflammatory drugs are the most commonly prescribed for the treatment of many inflammatory treatments. However, long term administration of these NSAIDs causes many adverse effects, including gastrointestinal ulcers and bleeding and kidney damage. Therefore, the need for new anti-inflammatory drugs with fewer side effects is required.Objectives:The aim of our study was to evaluate the anti-inflammatory activity of Cinnamomum verum (C. Verum) on rats while testing the dose effect and the typical effect of the solvent.Methods:The edema was induced by injection of carrageenan solution (CARR) in paw of rats according to the method of Winter et al, 1963. The measurements of volumes of right hind paw of each rat were taken before induction of edema and each 1 h, 2 h, 3 h, 4 h and 5 h after the injection of carrageenan. 7 groups of 6 rats received, one hour before the injection of the carrageenan, different treatment: G1= witness, G2=CARR + saline solution, G3= CARR+ Acetylsalicylic acid, G4= CARR + C. verum- MeOH 100, G5= CARR + C. verum- MeOH 300, G6= CARR + CARR + C. verum- EtOH 100 and G7= CARR + C.verum- EtOH 300.Results:For this test, the volume of edema increases with time, this increase is greater in the group treated with saline solution than with the extracts of C.Verum and with Acetylsalicylic acid. The extracts of C. Verum administered intraperitoneally one hour before the injection of the carrageenan, reduced the edema in the third hour after.Conclusion:The interesting anti-inflammatory activity of Cinnamomum verum recorded in this work may at least in part support its popular use in traditional medicine [1, 2].References:[1]Mirza Muhammad Fahd Qadir, Attya Bhatti, Muhammad Usman Ashraf, Mansur Abdullah Sandhu, Sidrah Anjum, Peter John. Immunomodulatory and therapeutic role of Cinnamomum verum extracts in collagen-induced arthritic BALB/c mice. Inflammopharmacology 2018 Feb;26(1):157-170.[2]Heping Cao, Joseph F Urban Jr, Richard A Anderson. Cinnamon polyphenol extract affects immune responses by regulating anti- and proinflammatory and glucose transporter gene expression in mouse macrophages. J Nutr 2008 May;138(5):833-40.Disclosure of Interests:None declared

scholarly journals Influence of antihypoxants on the development of acute phormalin-induced edema

2015 ◽  
Vol 13 (1) ◽  
pp. 41-44
Author(s):  
Vasiliy Egorovich Novikov ◽  
Elena Vasil'yevna Pozhilova ◽  
Sergey Alekseevich Ilyukhin
Keyword(s):  
Acetylsalicylic Acid ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Enteral Administration ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Inflammatory Effect

In the experiment in a model of acute formalin-induced inflammation of rat paw, the changes of size of the affected limbs (paw edema) and parameters of leukogram were registered. The anti-inflammatory effect of antihypoxants (amtizol, hesperidin, hypoxen, metaprot) was investigated. It has been shown that hypoxen 50 mg/kg have weak anti-inflammatory activity, but potentiate the effect of nonsteroid anti-inflammatory drugs. At simultaneous enteral administration of hypoxen with acetylsalicylic acid or diclofenac, evident anti-inflammatory effect was marked, that was manifested by significant reduction in registered inflammation symptoms.

Anti-platelet and anti-inflammatory activity of Plumbago zeylanicus (Pz), Phyllanthus emblica (Pe) and their combination

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
DA Uchil ◽  
SK Kamat ◽  
SS Menon ◽  
AM Scindia ◽  
GK Dang ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Phyllanthus Emblica ◽  
Anti Inflammatory

A new flavonol with anti-inflammatory activity from Boldoa purpurascens Cav.

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
DM González Mosquera ◽  
A Kilonda ◽  
S Toppet ◽  
F Compernolle ◽  
W Dehaen ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Anti Inflammatory

Isolation characterization and anti-inflammatory activity of Rhaphiostylis beninensis Planch. Ex Benth (Icacinaceae)

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
J Ofeimun ◽  
B Ayinde ◽  
I Igbe ◽  
MI Choudhary ◽  
I Husain ◽  
...  
Keyword(s):  
Inflammatory Activity ◽  
Anti Inflammatory
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