scholarly journals Big Picture, Rational, Engineering Design Methodology

2020 ◽  
Author(s):  
Andrew Foley
Keyword(s):  
Engineering Design ◽  
Design Methodology ◽  
Rational Engineering ◽  
Big Picture

Principles of Protein Stability and Their Application in Computational Design

2018 ◽  
Vol 87 (1) ◽  
pp. 105-129 ◽  
Author(s):  
Adi Goldenzweig ◽  
Sarel J. Fleishman
Keyword(s):  
Thermal Stability ◽  
Phylogenetic Analysis ◽  
Protein Design ◽  
Biomedical Research ◽  
Design Methodology ◽  
Computational Design ◽  
Marginal Stability ◽  
Computational Stability ◽  
Rational Engineering ◽  
The Past

Proteins are increasingly used in basic and applied biomedical research. Many proteins, however, are only marginally stable and can be expressed in limited amounts, thus hampering research and applications. Research has revealed the thermodynamic, cellular, and evolutionary principles and mechanisms that underlie marginal stability. With this growing understanding, computational stability design methods have advanced over the past two decades starting from methods that selectively addressed only some aspects of marginal stability. Current methods are more general and, by combining phylogenetic analysis with atomistic design, have shown drastic improvements in solubility, thermal stability, and aggregation resistance while maintaining the protein's primary molecular activity. Stability design is opening the way to rational engineering of improved enzymes, therapeutics, and vaccines and to the application of protein design methodology to large proteins and molecular activities that have proven challenging in the past.

The two best ways to derive the Black–Scholes PDE

2019 ◽  
Vol 10 (2) ◽  
pp. 168-174
Author(s):  
Paul Wilmott
Keyword(s):  
Differential Equation ◽  
Partial Differential Equation ◽  
Design Methodology ◽  
Content Type ◽  
Technical Requirements ◽  
Black Scholes Model ◽  
Black Scholes ◽  
Business Perspective ◽  
Big Picture ◽  
Complex Methods

Purpose The purpose of this paper is to explain the Black–Scholes model with minimal technical requirements and to illustrate its impact from a business perspective. Design/methodology/approach The paper employs simple accounting concepts and an argument part based on business need. Findings The Black–Scholes partial differential equation can be derived in many ways, some easy to understand, some hard, some useful and others not. The two methods in this paper are extremely insightful. Originality/value The paper takes a big-picture view of derivatives valuation. As such, it is a simple accompaniment to more complex methods and aims to keep modelling grounded in reality.

scholarly journals Experiential Learning vs Systematic Prescriptions in Engineering Design: A Crossroads for Education

2018 ◽  
Author(s):  
G. R. Gressfc ◽  
S. Li ◽  
R. W. Brennan
Keyword(s):  
Engineering Design ◽  
Design Methodology ◽  
Design Research ◽  
Great Difficulty ◽  
Research Literature ◽  
Classical Design ◽  
Classical Methodology ◽  
Successful Design ◽  
Research And Education ◽  
Visual Domain

The systematic, non-experiential prescriptions of classical design methodology continue to have a strong presence in large segments of design research and education while another segment sees domain experience and consequent intuition and creativity as being key to successful design. In this paper the two approaches are outlined and the empirical research literature in human behaviour is employed to discern discrepancies and potential weaknesses. Results show that gaining experience in a domain intrinsically changes how one designs, which the classical methodology does not account for. For example, only designers with tactile and visual domain experience can abstract functions per the dictates of the classical (non-experiential) methodology, which means that they cannot have used the methodology to learn basic design in the first place – or did so only with great difficulty. This and other conflicts pose problems for the education of engineering design students, and to fathom their extent this paper surveys engineering design textbooks offered in Canada and the U. S.; all of the books are found to embrace the classical methodology. If they are to remain involved in preparing students for entry into industry then some aspects of their contained classical methodology must be supplanted by experiential approaches to design educatio

Customer perceptions of CSR authenticity

2018 ◽  
Vol 26 (4) ◽  
pp. 614-629 ◽  
Author(s):  
Saju Jose ◽  
Nilesh Khare ◽  
F. Robert Buchanan
Keyword(s):  
Corporate Social Responsibility ◽  
Social Responsibility ◽  
Design Methodology ◽  
Cross Sectional ◽  
Content Type ◽  
Customer Perceptions ◽  
Novel Approach ◽  
Big Picture ◽  
Corporate Social ◽  
Practical Implications

Purpose The purpose of this paper is to look at corporate social responsibility (CSR)-related actions to see whether they relate to clients’ perception of CSR. Design/methodology/approach Ninety-nine bank customers in Brisbane, Australia were surveyed by mail in a cross-sectional field study. Findings Not all CSR-related behaviors of the organizations were influential to perceptions of social responsibility. Big picture actions for the betterment of humanity were found to be influential to the perception of the firm’s CSR. However, respondents did not relate the firms’ profit and revenue initiatives to social responsibility, other than negativity toward false and misleading practices. Research limitations/implications Results are limited to one industry in Australia. Practical implications Actions for human betterment were found to be influential to the perception of the firm’s CSR. Also the uses of dishonest marketing schemes were seen as detrimental to CSR perceptions of the firm. However, respondents did not connect the firm’s business actions affecting profitability with customers, to their perceptions of its CSR. Thus, the authors conclude that altruism from a “big picture” standpoint has value in shaping CSR perception, but the organization may not always find it necessary to deprioritize profit, or to attempt to weave CSR actions into every aspect of their business. Originality/value The inquiry takes a novel approach to CSR, capturing an unexplored aspect of how CSR is perceived and valued by stakeholders.

scholarly journals CONCEPTUALIZE–DESIGN ENHANCEMENT OF SYSTEMATIC DESIGN ENGINEERING METHOD

2013 ◽  
Author(s):  
W. Ernst Eder
Keyword(s):  
Life Cycle ◽  
Engineering Design ◽  
Design Methodology ◽  
Engineering Method ◽  
Design Engineering ◽  
Systematic Design ◽  
Transformation System ◽  
Levels Of Abstraction ◽  
Case Examples ◽  
Decomposition Of Functions

The engineering design methodology of Pahl and Beitz is good in the detailed stages, but needs enhancement in the early stages of conceptualizing and embodiment-in-principle. The concept of ‘functions’ has been enhanced by Hubka and colleagues. A ‘functional basis’ (Hirtz et al) has improved the definitions of ‘flows’ and ‘functions’, their work does not go far enough to provide a basis for conceptualizing. ‘Affordances’ (Maier and Fadel) are covered by full use of systematic conceptualizing of design engineering solutions. The Pahl-Beitz model and method of ‘decomposition of functions’, ‘physics’, and components is contrasted with the Hubka models of a transformation system, TrfS, its constituents, structures, properties life cycle, etc., and their use as method for design engineering by searching for alternative embodiments at each of these levels of abstraction. These steps are illustrated in (to date) 21 case examples published between 1976 and 2012, several of them in the CEEA conferences and their predecessors.

scholarly journals REFLECTING ON THE USE OF DESIGN METHODOLOGY IN ENGINEERING DESIGN EDUCATION

2019 ◽  
Author(s):  
S. Li ◽  
G. Gress ◽  
P. Ziadé
Keyword(s):  
Engineering Design ◽  
Design Education ◽  
Design Methodology ◽  
Course Delivery ◽  
Engineering Design Education ◽  
Need Support ◽  
Design Activities ◽  
Design Ideas ◽  
Context Free ◽  
Capstone Design

In the teaching of engineering design, it may be common to use design methodology (DM), as documented in several textbooks, in the course delivery.  However, considerable drawbacks could be observed in our case when DM is taken as the major guidance for a capstone design course. We argue that DM tends to prescribe some context-free methods and procedures, which cannot be easily applied by students to their capstone design projects. At the same time, we observe that students need support to characterize a design problem, integrate technical knowledge in design activities and verify design ideas. These aspects require analytical and critical thinking, where DM may not be particularly helpful for students. In the five-year journey of deemphasizing DM in a capstone design course, we have explored and examined various pedagogical approaches such as online modules, design labs and peer evaluations.  Without the teaching of DM, the pedagogical strategy needs to be carefully planned to deliver specific learning in engineering design.  

“Through the looking glass: envisioning new library technologies” educational trends that will impact library technology

2017 ◽  
Vol 34 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Peter Fernandez
Keyword(s):  
Digital Literacy ◽  
Design Methodology ◽  
Personalized Learning ◽  
Formal Learning ◽  
Content Type ◽  
It Impacts ◽  
Big Picture ◽  
Competing Models ◽  
Library Technology ◽  
Looking Glass

Purpose This column takes a big picture look at some of the technology-related trends in education to identify potential opportunities for libraries. Design/methodology/approach In particular, it is inspired by the 2016 NMC Horizon Report, which attempts to identify and describe emerging technologies likely to have an impact on learning, teaching and creative inquiry in education. Findings Although this report was created in the context of higher education, it impacts all libraries that support lifelong learning. In fact, some of the concepts considered in the report, such as digital literacy and makerspaces, are already well integrated into the operations of many libraries. Originality/value This column’s focus will be on the concepts of personalized learning, competing models of education and the blending of informal and formal learning, and it will examine how libraries can use related technologies to position themselves to best assist their patrons in the future.

Thermal-hydraulic test facility for nuclear reactor containment: Engineering design methodology and benchmarking

2021 ◽  
pp. 103837
Author(s):  
Maneesh Punetha ◽  
Mahesh Kumar Yadav ◽  
Samyak Jain ◽  
Sameer Khandekar ◽  
Pavan K. Sharma
Keyword(s):  
Engineering Design ◽  
Design Methodology ◽  
Nuclear Reactor ◽  
Test Facility ◽  
Hydraulic Test
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