scholarly journals IgE hypersensitivity mediated to lysine clonixinate

2020 ◽  
Vol 30 (4) ◽  
Author(s):  
AL Villalón García ◽  
A Pérez Pimiento ◽  
MG López San Martín ◽  
A Iglesias Cadarso
Keyword(s):  
Lysine Clonixinate

scholarly journals Lysine clonixinate versus dipyrone (metamizole) for the acute treatment of severe migraine attacks: a single-blind, randomized study

2008 ◽  
Vol 66 (2a) ◽  
pp. 216-220 ◽  
Author(s):  
Abouch Valenty Krymchantowski ◽  
Henrique Carneiro ◽  
Jackeline Barbosa ◽  
Carla Jevoux
Keyword(s):  
Acute Treatment ◽  
Rescue Medication ◽  
International Headache Society ◽  
Randomized Study ◽  
Group 13 ◽  
Lysine Clonixinate ◽  
Inflammatory Drugs ◽  
Rectal Indomethacin ◽  
Single Blind ◽  
Severe Migraine

BACKGROUND AND OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAID) are effective to treat migraine attacks. Lysine clonixinate (LC) and dipyrone (metamizol) have been proven effective to treat acute migraine. The aim of this study was to evaluate the efficacy and tolerability of the intravenous formulations of LC and dipyrone in the treatment of severe migraine attacks. METHOD: Thirty patients (28 women, 2 men), aged 18 to 48 years with migraine according the International Headache Society (IHS) (2004) were studied. The patients were randomized into 2 groups when presenting to an emergency department with a severe migraine attack. The study was single-blind. Headache intensity, nausea, photophobia and side effects were evaluated at 0, 30, 60 and 90 minutes after the drug administration. Rectal indomethacin as rescue medication (RM) was available after 2 hours and its use compared between groups. RESULTS: All patients completed the study. At 30 minutes, 0% of the dipyrone group 13% of the LC group were pain free (p=0.46). At 60 and 90 minutes, 2 (13%) and 5 (33%) patients from the dipyrone group and 11 (73%) and 13 (86.7%) patients from the LC group were pain free (p<0.001). At 60 minutes, significantly more patients from the LC group were nausea-free (p<0.001). Regarding photophobia, there were no differences between groups at 60 minutes (p=0.11). The use of RM at 2 hours did not differ among groups (p=0.50). Pain in the site of the injection was reported by more patients of the LC group compared to the dipyrone group (p<0.0001). CONCLUSION: LC is significantly superior to dipyrone in treating severe migraine attacks. LC promotes significantly more burning at the site of the injection.

scholarly journals Oral lysine clonixinate in the acute treatment of migraine: a double-blind placebo-controlled study

2001 ◽  
Vol 59 (1) ◽  
pp. 46-49 ◽  
Author(s):  
Abouch V. Krymchantowski ◽  
Jackeline S. Barbosa ◽  
Celia Cheim ◽  
Luiz A. Alves
Keyword(s):  
Placebo Group ◽  
Acute Treatment ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Pain Syndromes ◽  
Severe Intensity ◽  
Ihs Criteria ◽  
Lysine Clonixinate ◽  
Severe Migraine

Several oral nonsteroidal anti-inflammatory drugs (NSAIDs) are effective to treat migraine attacks. Lysine clonixinate (LC) is a NSAID derived from nicotinic acid that has proven to be effective in various pain syndromes such as renal colic and muscular pain. The aim of this double-blind, placebo-controlled study was to evaluate the efficacy of oral LC compared to placebo in the acute treatment of migraine. Sixty four patients with the diagnosis of migraine, according to the IHS criteria, were studied prospectively. Patients received LC or placebo once the headache reached moderate or severe intensity for 6 consecutive attacks. With regard to the moderate attacks, LC was superior than placebo after 1, 2 and 4 hours. The consumption of other rescue medications after 4 hours was significantly higher in the placebo group. With regard to the severe attacks, there was no difference between the active drug group and the placebo group concerning headache intensity and consumption of other rescue medications. We conclude that the NSAID lysine clonixinate is effective in treating moderately severe migraine attacks. It is not superior than placebo in treating severe migraine attacks.

Naloxone Reverses the Antinociceptive Synergistic Interaction Between Acetaminophen and Lysine Clonixinate in the Formalin Test

2013 ◽  
Vol 74 (5) ◽  
pp. 316-321 ◽  
Author(s):  
Mario A. Isiordia-Espinoza ◽  
Gaby E. Tiznado-Orozco ◽  
Amaury de J. Pozos-Guillén
Keyword(s):  
Formalin Test ◽  
Synergistic Interaction ◽  
Lysine Clonixinate

Effects of single oral doses of lysine clonixinate and acetylsalicylic acid on platelet functions in man

1996 ◽  
Vol 49 (5) ◽  
pp. 351-354
Author(s):  
D. Pallapies ◽  
A. Muhs ◽  
L. Bertram ◽  
G. Rohleder ◽  
P. Nagyiv�nyi ◽  
...  
Keyword(s):  
Acetylsalicylic Acid ◽  
Lysine Clonixinate ◽  
Oral Doses ◽  
Platelet Functions

Effects of lysine clonixinate and ketorolac tromethamine on prostanoid release from various rat organs incubated ex vivo

Life Sciences ◽  
1995 ◽  
Vol 57 (2) ◽  
pp. 83-89 ◽  
Author(s):  
D. Pallapies ◽  
A. Salinger ◽  
A.Meyer zum Gottesberge ◽  
D.-J. Atkins ◽  
G. Rohleder ◽  
...  
Keyword(s):  
Ex Vivo ◽  
Ketorolac Tromethamine ◽  
Rat Organs ◽  
Lysine Clonixinate

Lysine clonixinate

1993 ◽  
Vol &NA; (478) ◽  
pp. 9
Author(s):  
&NA;
Keyword(s):  
Lysine Clonixinate

In Vivo and in Vitro Effects of Lysine Clonixinate on Nitric Oxide Synthase in LPS-Treated and Untreated Rat Lung Preparations

Nitric Oxide ◽  
2001 ◽  
Vol 5 (2) ◽  
pp. 150-157 ◽  
Author(s):  
A.M. Franchi ◽  
G. Di Girolamo ◽  
M. Farina ◽  
A.R. de los Santos ◽  
M.L. Martı́ ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Rat Lung ◽  
Lysine Clonixinate ◽  
In Vitro Effects ◽  
Oxide Synthase
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