Naloxone Reverses the Antinociceptive Synergistic Interaction Between Acetaminophen and Lysine Clonixinate in the Formalin Test

2013 ◽  
Vol 74 (5) ◽  
pp. 316-321 ◽  
Author(s):  
Mario A. Isiordia-Espinoza ◽  
Gaby E. Tiznado-Orozco ◽  
Amaury de J. Pozos-Guillén
Keyword(s):  
Formalin Test ◽  
Synergistic Interaction ◽  
Lysine Clonixinate

Synergistic interaction between tapentadol and flupirtine in the rat orafacial formalin test

2015 ◽  
Vol 762 ◽  
pp. 350-356 ◽  
Author(s):  
Hongki Lee ◽  
Virginia De Vito ◽  
Mario Giorgi ◽  
Hyoin Yun
Keyword(s):  
Formalin Test ◽  
Synergistic Interaction

scholarly journals Synergistic Interaction between Metformin and Sulfonylureas on Diclofenac-Induced Antinociception Measured Using the Formalin Test in Rats

2013 ◽  
Vol 18 (5) ◽  
pp. 253-258 ◽  
Author(s):  
Mario I Ortiz
Keyword(s):  
Formalin Test ◽  
Synergistic Interaction ◽  
Second Phase ◽  
Dependent Manner ◽  
Additive Effects ◽  
Multiple Sources ◽  
Systemic Injection ◽  
Patients With Diabetes ◽  
Effective Doses ◽  
Dose Dependent

BACKGROUND: There is evidence that biguanides and sulfonylureas block diclofenac-induced antinociception (DIA) in rat models. However, little is known about the interaction between these hypoglycemics with respect to DIA.OBJECTIVE: To determine whether metformin-sulfonylurea combinations affect DIA during the formalin test.METHODS: Rats received the appropriate vehicle or diclofenac before 1% formaldehyde was injected into the paw. Rats were also pretreated with vehicle, glibenclamide, glipizide, metformin or glibenclamide/metformin and glipizide/metformin combinations before the diclofenac and formaldehyde injections, and the effect on antinociception was assessed. Isobolograms of the combinations were constructed to test for a synergistic interaction.RESULTS: Systemic injection of diclofenac resulted in antinociception during the second phase of the test. Systemic pretreatment with the combinations of glibenclamide (0.56 mg/kg to 10 mg/kg)/metformin (10 mg/kg to 180 mg/kg) and glipizide (0.56 mg/kg to10 mg/kg)/metformin (10 mg/kg to 180 mg/kg) blocked DIA. The derived theoretical effective doses for 50% of subjects (ED50) for the glibenclamide/metformin and glipizide/metformin combinations were 32.52 mg/kg and 32.42 mg/kg, respectively, and were significantly higher than the actual observed experimental ED50values (7.57 mg/kg and 8.43 mg/kg, respectively).CONCLUSION: Pretreatment with glibenclamide, glipizide or metformin blocked DIA in a dose-dependent manner, and combining either sulfonylurea with metformin produced even greater effects. The observed ED50s for the combinations were approximately fourfold lower than the calculated additive effects. These data indicate that sulfonylureas interact to produce antagonism of DIA. Combination therapy is a common second-line treatment for patients with diabetes and metabolic syndrome, a group that experiences pain from multiple sources. The results suggest that at least some anti-inflammatory agents may not be effective in this group.

Synergistic interaction of gabapentin with tiagabine in the formalin test in mice: An isobolographic analysis

2009 ◽  
Vol 13 (7) ◽  
pp. 665-672 ◽  
Author(s):  
Jarogniew J. Luszczki ◽  
Agnieszka Kolacz ◽  
Miroslaw Czuczwar ◽  
Krzysztof Przesmycki ◽  
Stanislaw J. Czuczwar
Keyword(s):  
Formalin Test ◽  
Synergistic Interaction ◽  
Isobolographic Analysis

Loneliness, social isolation, their synergistic interaction, and mortality.

2018 ◽  
Vol 37 (9) ◽  
pp. 808-813 ◽  
Author(s):  
Johannes Beller ◽  
Adina Wagner
Keyword(s):  
Social Isolation ◽  
Synergistic Interaction

Synergistic interaction of triterpenoid saponins and plant protein toxins

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
A Weng ◽  
M Thakur ◽  
F Beceren-Braun ◽  
R Gilabert-Oriol ◽  
S Boettger ◽  
...  
Keyword(s):  
Synergistic Interaction ◽  
Plant Protein ◽  
Triterpenoid Saponins ◽  
Protein Toxins

Antinociceptive Effect of the Intrathecal Phosphodiesterase Inhibitor, Zaprinast, in a Rat Formalin Test

2005 ◽  
Vol 18 (2) ◽  
pp. 99 ◽  
Author(s):  
Burn Young Heo ◽  
Chang Mo Kim ◽  
Sung Tae Jeong ◽  
Seok Jai Kim ◽  
Jeong Il Choi ◽  
...  
Keyword(s):  
Formalin Test ◽  
Antinociceptive Effect ◽  
Phosphodiesterase Inhibitor
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