scholarly journals Acoustic Rhinometry in Nasal Provocation Tests in Children and Adolescents

2016 ◽  
Vol 26 (3) ◽  
pp. 156-160 ◽  
Author(s):  
GF Wandalsen ◽  
AI Mende ◽  
F Matsumoto ◽  
D Solé
2007 ◽  
Vol 18 (5) ◽  
pp. 372-377 ◽  
Author(s):  
Holger Mittenzwey ◽  
Eike Gunther Wüstenberg ◽  
Wolfgang Leupold

2017 ◽  
Vol 31 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Fausto Yoshio Matsumoto ◽  
Tessa Rachel Tranquillini Gonçalves ◽  
Dirceu Solé ◽  
Gustavo Falbo Wandalsen

Background Currently, the diagnosis of allergic rhinitis (AR) is arrived at predominantly by a clinical history and by systemic sensitization tests, but specific nasal provocation tests (NPT) may establish a better direct correlation between etiologic surveyed allergens and nasal symptoms. Objectives To standardize the specific NPT with one of the most important house-dust mites, Dermatophagoides pteronyssinus, monitored by acoustic rhinometry, in children and adolescents, and propose a simplified specific NPT to improve its clinical applicability as a diagnostic tool. Methods Sixteen controls (group 1) and 17 patients with an AR diagnosis sensitized to D. pteronyssinus (group 2) underwent a specific NPT with D. pteronyssinus. The acoustic rhinometry was performed after instillation of 0.15 mL of increasing concentrations of D. pteronyssinus (5000 BU/mL). The test was finalized after (1) instillation of the final concentration of D. pteronyssinus, or (2) after a 20% or more reduction in the volume of the first 5 cm of the nasal cavity (V5), or (3) a score of >3 in the symptoms questionnaire (a score from 0 to 7). A simplified specific NPT with two concentrations was proposed and implemented in a group of 10 patients with AR (group 3). Results At the end of the specific NPT, the median (range) variation in V5 was -5.7% (-9 to 4%) in the control group and -22.8% (-24 to -20%) in group 2. None of the patients in the control group and 88% of group 2 (15/17) showed positive specific NPT results. The simplified specific NPT triggered a positive response in 80% of patients in group 3, with median (range) V5 variation of -30.4% (-36 to -20%). Conclusion This protocol has been proven safe and useful to differentiate between children and adolescents with AR and controls. Concentrations of 1:1000 and 1:100 D. pteronyssinus were the best for use in simplified specific NPT, which made it simpler and faster, and expanded its clinical applicability.


2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Andres Sánchez ◽  
Ricardo Cardona ◽  
Marlon Munera ◽  
Victor Calvo ◽  
Manuela Tejada-Giraldo ◽  
...  

Background. IgE sensitization (atopy) to pets is commonly evaluated using pet dander extracts. However, the diagnosis by components seems to be more adequate to evaluate the clinical relevance (allergy) of sIgE sensitization. Objective. To study the association between IgE sensitization to pet allergen components and clinical symptoms. Methodology. Dander extracts and sIgE levels to pet components (Can f 1, Can f 2, Can f 3, Can f 5, Fel d 1, Fel 2, and Fel 4) were measured in a rhinitis group (n=101) and a control group (n=68). Nasal provocation tests with pet extract were done in patients with atopy to pets. Results. Dog (34.6% vs. 23.5%) and cat dander (26.7% vs. 8.8%, p=0.05) IgE sensitization was frequent among rhinitis and no-rhinitis subjects, and it was similar to dog (29.7% vs. 20.5%) and cat (18.8% vs. 8.8%) components. Polysensitization for dog (3.1, 95% CI: 1.5 to 6.1, p<0.001) or cat (2.5, 95% CI: 0.8 to 8.0, p=0.01) components was the principal risk factor for a positive nasal provocation test. Additionally, positive nasal provocation test with one animal increased the risk of atopy and positive nasal provocation test to others animals. Pet ownership or asthma was not associated with increased risk of atopy or positive nasal provocation test. Conclusions. Sensitization to pet dander extract identifies atopic patients, but its utility to predict clinical relevance is poor. Allergenic components could help to define the clinical relevance of sensitization to furry animals and could reduce the need for provocation test.


2019 ◽  
Vol 30 (3) ◽  
pp. 296-304 ◽  
Author(s):  
Olympia Tsilochristou ◽  
Marialena Kyriakakou ◽  
Ioanna Manolaraki ◽  
John Lakoumentas ◽  
Ekaterini Tiligada ◽  
...  

2002 ◽  
Vol 32 (4) ◽  
pp. 543-550 ◽  
Author(s):  
J. N. Baraniuk ◽  
M. Ali ◽  
K. Naranch

2017 ◽  
Vol 4 (1) ◽  
pp. 98-109 ◽  
Author(s):  
Paloma Campo ◽  
Esther Barrionuevo ◽  
Ibon Eguiluz ◽  
María Salas ◽  
M. José Torres ◽  
...  

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