scholarly journals Detection of local allergic rhinitis in children with chronic, difficult‐to‐treat, non‐allergic rhinitis using multiple nasal provocation tests

2019 ◽  
Vol 30 (3) ◽  
pp. 296-304 ◽  
Author(s):  
Olympia Tsilochristou ◽  
Marialena Kyriakakou ◽  
Ioanna Manolaraki ◽  
John Lakoumentas ◽  
Ekaterini Tiligada ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Local Allergic Rhinitis ◽  
Provocation Tests ◽  
Nasal Provocation ◽  
Non Allergic Rhinitis

scholarly journals Peculiarities of non-allergic rhinitis with eosinophilia syndrome

2015 ◽  
Vol 12 (4) ◽  
pp. 3-7
Author(s):  
V A Utesheva ◽  
G P Bondareva ◽  
A I Kryukov ◽  
T G Barkhina
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Specific Ige ◽  
Skin Tests ◽  
Eosinophilic Infiltration ◽  
Eosinophilic Inflammation ◽  
Nonallergic Rhinitis ◽  
Provocation Tests ◽  
Nasal Provocation ◽  
Non Allergic Rhinitis

Nonallergic rhinitis with eosinophilia syndrome (NARES) is a syndrome containing the symptoms similar to allergic rhinitis, with absence of atopy and the presence of eosinophila more than 20% in smears from nasal mucosa. Pathophysiology of NARES has not been studied completely, but permanent eosinophilic inflammation is the keystone of NARES pathogenesis. This disease is marked by local eosinophilic infiltration without atopy, confirmed by negative skin tests, normal levels of total and specific IgE in serum, negative nasal provocation tests with allergens. Nowadays this nosology is considered to be poorly understood.

scholarly journals Local allergic rhinitis

2014 ◽  
Vol 67 (suppl. 1) ◽  
pp. 49-56
Author(s):  
Maja Buljcik-Cupic ◽  
Dragana Lemez ◽  
Slobodan Savovic ◽  
Ljiljana Jovancevic ◽  
Danijela Dragicevic
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Immunoglobulin E ◽  
Provocation Test ◽  
Allergic Response ◽  
Prick Test ◽  
Local Allergic Rhinitis ◽  
Provocation Tests ◽  
Number Of Patients ◽  
The Impact

Local allergic rhinitis is a localized allergic response of the nasal mucosa to aeroallergens in the absence of atopy with characteristic production of specific local immunoglobulin E antibodies in the nasal mucosa, T helper type 2 cellular infiltration response during the exposure to aeroallergens and positive results via the nasal allergic provocation test with the release of inflammatory mediators (triptase and eosinophil cationic proteins). Even though the prevalence of local allergic rhinitis has been and is still being investigated, a large number of patients with diagnosed non-allergic rhinitis or idiopathic rhinitis are currently classified as having local allergic rhinitis. The causes of local allergic rhinitis are most commonly house dust, dust mites, pollens and many others. Diagnosis of local allergic rhinitis is made using nasal allergen provocation tests when the prick test for standard inhalation allergens and the serum specific immunoglobulin analysis for aeroallergens are negative. The increasing amount of data on localized allergic response in non-atopic patients asks for many answers regarding local allergic rhinitis. These answers can be obtained by a study on the prevalence and incidence in children and adults, the impact of positive family atopy in the development of disease, the impact of associated diseases of the lower respiratory tract and conjunctiva, the effectiveness of drug treatment and the issue of administration of specific immunotherapy.

Review of Symptoms Assessment During Nasal Allergen Provocation in Patients with Allergic Rhinitis

2010 ◽  
Vol 3 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Akli Zetchi ◽  
Marie-Claire Rousseau ◽  
Annie LeBlanc ◽  
Marie-Eve Boulay ◽  
Louis-Philippe Boulet
Keyword(s):  
Allergic Rhinitis ◽  
Animal Models ◽  
Therapy Monitoring ◽  
Literature Searching ◽  
Validation Process ◽  
Provocation Tests ◽  
Nasal Provocation ◽  
Nasal Symptoms ◽  
Allergen Provocation ◽  
Allergen Extracts

Background: Allergic rhinitis is the most prevalent allergic disease. Nasal provocation tests (NPTs) may be useful for its clinical diagnostic and therapy monitoring although they are mostly used in clinical research. However, the lack of standardisation in the symptoms assessed and the variety of instruments used make effective comparison between studies difficult. Objective: To review the published literature searching for instruments assessing nasal symptoms during NPTs for allergic rhinitis. Methods: Pubmed and Embase electronic databases were reviewed, looking for all methods including an instrument assessing symptoms during or following NPTs. Studies on animal models, pediatric subjects, and patients without allergic rhinitis were excluded. Studies were also excluded if they did not assess nasal symptoms during or following the NPT. Only NPT studies performed with allergen extracts or histamine were included. Results: A total of 520 studies were retrieved, from which 81 different instruments from 81 studies were included in the present analysis. There was no instrument reporting a validation process for the assessment of symptoms during NPTs. From the remaining instruments, the most common symptoms assessed were rhinorrhea (67), sneezing (70), congestion (67), and nasal pruritus (50). The most frequently used type of scales among those instruments was the four-point Likert scale (39), although different methods were used. Conclusions: This review illustrates the large variety of symptoms and methods used to assess the aforementioned NPTs. The lack of validation studies suggests the need to develop and validate a standardized instrument assessing symptoms following NPTs.

scholarly journals Current Update of Local Allergic Rhinitis

2021 ◽  
Vol 64 (8) ◽  
pp. 533-539
Author(s):  
Su-Jong Kim ◽  
Jee Won Moon ◽  
Heung-Man Lee
Keyword(s):  
Allergic Rhinitis ◽  
Provocation Test ◽  
High Sensitivity ◽  
Specific Ige ◽  
Nasal Provocation Test ◽  
Local Allergic Rhinitis ◽  
Nasal Provocation ◽  
Nasal Secretions ◽  
Positive Results ◽  
A Current

Local allergic rhinitis (LAR) is a localized nasal allergic response in the absence of systemic atopy. The symptoms, duration, severity, and comorbidities of LAR are similar to those of allergic rhinitis. Although pathophysiology of LAR is not fully understood, in some patients specific IgE can be demonstrated in the nasal secretions. The diagnosis currently relies on the positive results of nasal provocation test. Nasal provocation test has shown high sensitivity and specificity with safety, and is considered as the gold standard. LAR patients benefit from the same therapeutic strategies as allergic rhinitis patients, including the avoidance of allergen exposure and the pharmacotherapy. Effectiveness and safety of allergen immunotherapy open a window of treatment opportunity in LAR. This review provides a current update on LAR.

scholarly journals Nasal allergen provocation tests in inner-city patients with perennial local allergic rhinitis

2018 ◽  
Vol 141 (2) ◽  
pp. AB273
Author(s):  
Denisa E. Ferastraoaru ◽  
Nadeem Akbar ◽  
Waleed M. Abuzeid ◽  
Elina Jerschow ◽  
David L. Rosenstreich
Keyword(s):  
Allergic Rhinitis ◽  
Inner City ◽  
Local Allergic Rhinitis ◽  
Provocation Tests ◽  
Allergen Provocation

scholarly journals Nasal Provocation Tests Used to Assess Different Phenotypes in the Diagnosis of Allergic Rhinitis

2020 ◽  
Vol 145 (2) ◽  
pp. AB150
Author(s):  
Iryna Shchurok ◽  
D. Novicau ◽  
A. Ishchanka ◽  
I. Semenova ◽  
Lawrence Dubuske
Keyword(s):  
Allergic Rhinitis ◽  
Provocation Tests ◽  
Nasal Provocation
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