The adhesion G protein-coupled receptor BAI1 regulates the innate immune response to Gram-negative bacteria in macrophages

2016 ◽  
Author(s):  
Emily Billings
Keyword(s):  
Immune Response ◽  
G Protein ◽  
Innate Immune Response ◽  
Innate Immune ◽  
Gram Negative Bacteria ◽  
G Protein Coupled Receptor ◽  
Gram Negative ◽  
G Protein Coupled

scholarly journals Activation of a G protein–coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans

2014 ◽  
Vol 15 (9) ◽  
pp. 833-838 ◽  
Author(s):  
Olivier Zugasti ◽  
Neelanjan Bose ◽  
Barbara Squiban ◽  
Jérôme Belougne ◽  
C Léopold Kurz ◽  
...  
Keyword(s):  
Immune Response ◽  
Caenorhabditis Elegans ◽  
G Protein ◽  
Innate Immune Response ◽  
Innate Immune ◽  
G Protein Coupled Receptor ◽  
Endogenous Ligand ◽  
G Protein Coupled

scholarly journals Absorption of PCB126 by upper airways impairs G protein-coupled receptor-mediated immune response

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Ana Lúcia B. Shimada ◽  
Wesley S. Cruz ◽  
Rodrigo A. Loiola ◽  
Carine C. Drewes ◽  
Fabiane Dörr ◽  
...  
Keyword(s):  
Immune Response ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Upper Airways ◽  
G Protein Coupled

Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity

Immunobiology ◽  
2008 ◽  
Vol 213 (3-4) ◽  
pp. 193-203 ◽  
Author(s):  
Marina A. Freudenberg ◽  
Sandrine Tchaptchet ◽  
Simone Keck ◽  
György Fejer ◽  
Michael Huber ◽  
...  
Keyword(s):  
Immune Response ◽  
Innate Immune Response ◽  
Bacterial Infections ◽  
Innate Immune ◽  
Gram Negative

scholarly journals Immune Responses to Gram-Negative Bacteria in Hemolymph of the Chinese Horseshoe Crab, Tachypleus tridentatus

2021 ◽  
Vol 11 ◽  
Author(s):  
Wei-Feng Wang ◽  
Xiao-Yong Xie ◽  
Kang Chen ◽  
Xiu-Li Chen ◽  
Wei-Lin Zhu ◽  
...  
Keyword(s):  
Immune Response ◽  
Horseshoe Crab ◽  
Mapk Signaling ◽  
Innate Immune ◽  
Coagulation Cascade ◽  
Gram Negative Bacteria ◽  
Fossil Species ◽  
Living Fossil ◽  
Gram Negative ◽  
Tachypleus Tridentatus

Chinese horseshoe crab, Tachypleus tridentatus, is an ancient marine arthropod with a long evolutionary history. As a kind of living fossil species, the pathogen defenses of horseshoe crabs entirely depend on the innate immune system. Although, there are abundant immune molecules found in the horseshoe crab hemolymph, the biological mechanisms underlying their abilities of distinguishing and defending against invading microbes are still unclear. In this study, we used high-throughput sequencing at mRNA and protein levels and bioinformatics analysis methods to systematically analyze the innate immune response to Gram-negative bacteria in hemolymph of Chinese horseshoe crab. These results showed that many genes in the complement and coagulation cascades, Toll, NF-κB, C-type lectin receptor, JAK-STAT, and MAPK signaling pathways, and antimicrobial substances were activated at 12 and 24 h post-infection, suggesting that Gram-negative bacteria could activate the hemolymph coagulation cascade and antibacterial substances release via the above pathways. In addition, we conjectured that Toll and NF-κB signaling pathway were most likely to participate in the immune response to Gram-negative bacteria in hemolymph of horseshoe crab through an integral signal cascade. These findings will provide a useful reference for exploring the ancient original innate immune mechanism.

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