Activation of a G protein–coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans

Olivier Zugasti; Neelanjan Bose; Barbara Squiban; Jérôme Belougne; C Léopold Kurz; Frank C Schroeder; Nathalie Pujol; Jonathan J Ewbank

doi:10.1038/ni.2957

Activation of a G protein–coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans

Nature Immunology ◽

10.1038/ni.2957 ◽

2014 ◽

Vol 15 (9) ◽

pp. 833-838 ◽

Cited By ~ 69

Author(s):

Olivier Zugasti ◽

Neelanjan Bose ◽

Barbara Squiban ◽

Jérôme Belougne ◽

C Léopold Kurz ◽

...

Keyword(s):

Immune Response ◽

Caenorhabditis Elegans ◽

G Protein ◽

Innate Immune Response ◽

Innate Immune ◽

G Protein Coupled Receptor ◽

Endogenous Ligand ◽

G Protein Coupled

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The adhesion G protein-coupled receptor BAI1 regulates the innate immune response to Gram-negative bacteria in macrophages

10.18130/v3958v ◽

2016 ◽

Author(s):

Emily Billings

Keyword(s):

Immune Response ◽

G Protein ◽

Innate Immune Response ◽

Innate Immune ◽

Gram Negative Bacteria ◽

G Protein Coupled Receptor ◽

Gram Negative ◽

G Protein Coupled

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404 Deficiency for the G protein-coupled receptor Mas leads to cardiomyopathy and illustrates the importance of its endogenous ligand angiotensin-(1?7) for cardiac function

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(04)90306-2 ◽

2004 ◽

Vol 3 (1) ◽

pp. 105

Author(s):

T WALTHER

Keyword(s):

Cardiac Function ◽

G Protein ◽

G Protein Coupled Receptor ◽

Endogenous Ligand ◽

G Protein Coupled

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Absorption of PCB126 by upper airways impairs G protein-coupled receptor-mediated immune response

Scientific Reports ◽

10.1038/srep14917 ◽

2015 ◽

Vol 5 (1) ◽

Cited By ~ 7

Author(s):

Ana Lúcia B. Shimada ◽

Wesley S. Cruz ◽

Rodrigo A. Loiola ◽

Carine C. Drewes ◽

Fabiane Dörr ◽

...

Keyword(s):

Immune Response ◽

G Protein ◽

G Protein Coupled Receptor ◽

Upper Airways ◽

G Protein Coupled

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Translational Fusion of a G‐protein Coupled‐Receptor from the Hookworm Ancylostoma ceylanicum Expressed in Caenorhabditis elegans

The FASEB Journal ◽

10.1096/fasebj.2019.33.1_supplement.649.8 ◽

2019 ◽

Vol 33 (S1) ◽

Author(s):

Brandon Norman ◽

Lauren DeLong ◽

Myra Dickey ◽

Mollie Jewell ◽

Patti T. Erickson ◽

...

Keyword(s):

Caenorhabditis Elegans ◽

G Protein ◽

G Protein Coupled Receptor ◽

Ancylostoma Ceylanicum ◽

Translational Fusion ◽

G Protein Coupled

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Neuronal control of lipid metabolism by STR‐2 G protein‐coupled receptor promotes longevity in Caenorhabditis elegans

Aging Cell ◽

10.1111/acel.13160 ◽

2020 ◽

Vol 19 (6) ◽

Cited By ~ 2

Author(s):

Anubhuti Dixit ◽

Anjali Sandhu ◽

Souvik Modi ◽

Meghana Shashikanth ◽

Sandhya P. Koushika ◽

...

Keyword(s):

Lipid Metabolism ◽

Caenorhabditis Elegans ◽

G Protein ◽

G Protein Coupled Receptor ◽

Neuronal Control ◽

G Protein Coupled

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The G protein-coupled receptor FSHR-1 is required for theCaenorhabditis elegansinnate immune response

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.0813048106 ◽

2009 ◽

Vol 106 (8) ◽

pp. 2782-2787 ◽

Cited By ~ 75

Author(s):

Jennifer R. Powell ◽

Dennis H. Kim ◽

Frederick M. Ausubel

Keyword(s):

Immune Response ◽

G Protein ◽

G Protein Coupled Receptor ◽

G Protein Coupled

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Histoplasma capsulatum and Caenorhabditis elegans: a simple nematode model for an innate immune response to fungal infection

Medical Mycology ◽

10.1080/13693780802660532 ◽

2009 ◽

pp. 1-6

Author(s):

Clayton Johnson ◽

Srinivas Ayyadevara ◽

Joan Mcewen ◽

Robert Shmookler Reis

Keyword(s):

Immune Response ◽

Caenorhabditis Elegans ◽

Fungal Infection ◽

Innate Immune Response ◽

Histoplasma Capsulatum ◽

Innate Immune

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A putative G protein-coupled receptor involved in innate immune defense of Procambarus clarkii against bacterial infection

Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology ◽

10.1016/j.cbpa.2011.09.006 ◽

2012 ◽

Vol 161 (2) ◽

pp. 95-101 ◽

Cited By ~ 17

Author(s):

Chaohua Dong ◽

Peng Zhang

Keyword(s):

Bacterial Infection ◽

G Protein ◽

Procambarus Clarkii ◽

Immune Defense ◽

Innate Immune ◽

G Protein Coupled Receptor ◽

Innate Immune Defense ◽

G Protein Coupled

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Caenorhabditis elegans Innate Immune Response Triggered by Salmonella enterica Requires Intact LPS and Is Mediated by a MAPK Signaling Pathway

Current Biology ◽

10.1016/s0960-9822(02)01396-9 ◽

2003 ◽

Vol 13 (1) ◽

pp. 47-52 ◽

Cited By ~ 112

Author(s):

Alejandro Aballay ◽

Eliana Drenkard ◽

Layla R Hilbun ◽

Frederick M Ausubel

Keyword(s):

Immune Response ◽

Caenorhabditis Elegans ◽

Signaling Pathway ◽

Innate Immune Response ◽

Salmonella Enterica ◽

Mapk Signaling ◽

Innate Immune ◽

Mapk Signaling Pathway

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Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans

Biochemical Journal ◽

10.1042/bj20150563 ◽

2015 ◽

Vol 470 (1) ◽

pp. 145-154 ◽

Cited By ~ 8

Author(s):

Hsiang Yu ◽

Huey-Jen Lai ◽

Tai-Wei Lin ◽

Chang-Shi Chen ◽

Szecheng J. Lo

Keyword(s):

Immune Response ◽

Innate Immunity ◽

Caenorhabditis Elegans ◽

Innate Immune Response ◽

Innate Immune ◽

Dnase Ii ◽

C Elegans ◽

Elevated Expression

This study uncovered NUC-1 and CRN-7 function in germline apoptosis. Mutations of nuc-1 and crn-7 led to elevated expression of five innate-immunity-related genes and demonstrated that DNase II activity is associated with an innate immune response in C. elegans.

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