scholarly journals Absorption of PCB126 by upper airways impairs G protein-coupled receptor-mediated immune response

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Ana Lúcia B. Shimada ◽  
Wesley S. Cruz ◽  
Rodrigo A. Loiola ◽  
Carine C. Drewes ◽  
Fabiane Dörr ◽  
...  
Keyword(s):  
Immune Response ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Upper Airways ◽  
G Protein Coupled

scholarly journals Altered Immune Response in Mice Deficient for the G Protein-coupled Receptor GPR34

2010 ◽  
Vol 286 (3) ◽  
pp. 2101-2110 ◽  
Author(s):  
Ines Liebscher ◽  
Uwe Müller ◽  
Daniel Teupser ◽  
Eva Engemaier ◽  
Kathrin M. Y. Engel ◽  
...  
Keyword(s):  
Immune Response ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Altered Immune Response ◽  
G Protein Coupled

scholarly journals Development of Inflammatory Immune Response-Related Drugs Based on G Protein-Coupled Receptor Kinase 2

2018 ◽  
Vol 51 (2) ◽  
pp. 729-745 ◽  
Author(s):  
Chenchen Han ◽  
Yifan Li ◽  
Yang Wang ◽  
Dongqian Cui ◽  
Tingting Luo ◽  
...  
Keyword(s):  
Immune Response ◽  
G Protein ◽  
Immune Cells ◽  
Regulatory Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Molecular Abnormalities ◽  
Inflammatory Immune Response ◽  
Cancer Multiple ◽  
G Protein Coupled

G protein-coupled receptor kinase 2 (GRK2), as a vital Ser/Thr kinase, is an important regulatory protein in the inflammatory immune response (IIR) by maintaining the balance between the function of inflammatory immune cells and non-conventional inflammatory immune cells and regulating inflammatory immune cell infiltration, inflammatory cytokine secretion, and the signaling associated with endothelial function. However, the imbalance of GRK2 expression and activity plays an important role in the development of IIR-related diseases, such as hypertension, heart failure, Alzheimer’s disease, type 2 diabetes mellitus, insulin resistance, rheumatoid arthritis, thyroid cancer, multiple sclerosis, and liver cancer. Small molecule GRK2 inhibitors, including balanol, Takeda inhibitors, paroxetine and derivatives, M119 and gallein, peptides, RNA aptamers, Raf kinase inhibitory protein, and microRNAs, that can directly inhibit GRK2 kinase activity have been identified by different strategies. This review discusses recent progress in one of the hallmark molecular abnormalities of GRK2 in IIR-related diseases and explores the soft regulation of IIR by innovative drugs reducing the excessive activity of GRK2 to basal levels, without damaging normal physiological function, to ameliorate inflammatory disorders.

scholarly journals Activation of a G protein–coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans

2014 ◽  
Vol 15 (9) ◽  
pp. 833-838 ◽  
Author(s):  
Olivier Zugasti ◽  
Neelanjan Bose ◽  
Barbara Squiban ◽  
Jérôme Belougne ◽  
C Léopold Kurz ◽  
...  
Keyword(s):  
Immune Response ◽  
Caenorhabditis Elegans ◽  
G Protein ◽  
Innate Immune Response ◽  
Innate Immune ◽  
G Protein Coupled Receptor ◽  
Endogenous Ligand ◽  
G Protein Coupled

Vanadium compounds cause activation of G protein-coupled receptor signaling

2020 ◽  
Author(s):  
Debbie C. Crans ◽  
Duaa Althumairy ◽  
Heide Murakami ◽  
B. George Barisas ◽  
Deborah Roess
Keyword(s):  
G Protein ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
Vanadium Compounds ◽  
G Protein Coupled
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