Evaluation of Analgetic Effect of Dexalginum 25 (Dexketoprofen) in Traumatology and Orthopaedics

2004 ◽  
Vol 11 (1) ◽  
pp. 61-65
Author(s):  
G M Kavalerskiy ◽  
L L Silin ◽  
A V Garkavi ◽  
A A Sorokin ◽  
Kader Ali ◽  
...  
Keyword(s):  
Motor System ◽  
Pain Syndrome ◽  
Control Group ◽  
System Control ◽  
Clinical Testing ◽  
Moderate Severity ◽  
Inflammatory Drug ◽  
Anti Inflammatory ◽  
Therapeutic Doses ◽  
Better Than

Clinical testing of analgetic effect and safety of nonsteroid anti-inflammatory drug dexalginum 25 was conducted in 45 patients with injuries and pathology of loco-motor system. Control group (49 patients with similar pathology and manifestation of pain syndrome) was treated by opium analgetic tramadol retard. It was shown that dexalgin 25 in therapeutic doses possessed analgetic effect in acute and chronic pains of various severity. The highest efficacy of the drug was noted in acute pains of medium and moderate severity. In patients with very severe pains dexalgin 25 allowed to decrease narcotic analgetics dose by 2 times. Dexalgimun 25 provided chronic pain relief only within the period of its use. Side effect were noted 2.7 times rarely in comparison to tramadol retard and such effect were less marked. Rate «favor-risk* of unsteroid anti-inflammatory drug dexalginum 25 was better than in opium analgetic tramadol retard.

scholarly journals Analge­tic and Anti-Inflammatory Therapy in Early Postoperative Period in Patients with Injuries and Diseases of Loco-Motor System

2005 ◽  
Vol 12 (1) ◽  
pp. 46
Author(s):  
L. L Silin ◽  
A. V Garkavi ◽  
A. E Pikhlak ◽  
S. M Mezhidov
Keyword(s):  
Drug Therapy ◽  
Motor System ◽  
Pain Syndrome ◽  
Early Postoperative Period ◽  
Control Group ◽  
Complex Treatment ◽  
Local Inflammatory Reaction ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Action

A protocol for gradual use of nonsteroid anti-inflammatory drugs with mainly analgetic action (Ketorol) and mainly anti-inflammatory action (Nise) are suggested for complex treatment after operations on loco-motor system. It is shown that the protocol (applied in 38 patients) allows to cup off both pain syndrome and local inflammatory reaction in the operation zone more effective as compared with the routine drug therapy (40 patients — control group).

Reducing pain in certain forms of obstetric pathology: nonsteroidal anti-inflammatory drugs (Сlinical lecture)

2017 ◽  
pp. 9-14
Author(s):  
L. Nazarenko ◽  
Keyword(s):  
Preterm Birth ◽  
Side Effects ◽  
Key Words ◽  
Clinical Efficacy ◽  
Premature Birth ◽  
Pain Syndrome ◽  
Inflammatory Drug ◽  
Threatened Abortion ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

The article discusses the pathogenetic basis for the use of non-steroidal anti-inflammatory drugs (NSPVP) in obstetric practice for the treatment of pain syndrome in women with threatened abortion and pathological preliminary period. Provided with modern views on the mechanisms of analgesic clinical efficacy, side effects NSPVP. Provides information about the place of NSPVP during pregnancy, the risks to the fetus, the positive aspects in the conduct of women at risk of preterm birth, the pathological preliminary period. Key words: nonsteroidal anti-inflammatory drug, pain, premature birth, preliminary period.

scholarly journals NUTRITION FOR CORRECTING METABOLISM DISORDERS OF THE JOINT-LIGAMENT SYSTEM IN PHYSICALLY ACTIVE PEOPLE

2019 ◽  
Vol 19 (1) ◽  
pp. 108-116
Author(s):  
O Tolmachyov ◽  
A Vekovtsev ◽  
V Vovchenko ◽  
A Bykov ◽  
V Poznyakovsky
Keyword(s):  
Nutritional Support ◽  
Pain Syndrome ◽  
Disease Recurrence ◽  
Biologically Active ◽  
Control Group ◽  
Movement Activity ◽  
Physically Active ◽  
Daily Movement ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Aim. The article deals with developing and assessing the efficiency of a complex nutritional support program for the joint-ligament system in athletes and physically active people. Materials and methods. The clinical evidence of biologically active substance (BAS) efficiency and functional orientation was obtained from the representative group of people with knee-joint osteoarthrosis. The main group of participants received a BAS complex with synergistic properties in terms of metabolism correction during osteoarthrosis: BAS 1 – 2 pills, BAS 2 – 1 capsule (2 times per day, 12 weeks), and BAS 3 – 1 capsule (2 times per day, 8 weeks). Nonsteroidal anti-inflammatory drugs were also prescribed to participants from the main and control groups. We used the general and special methods for assessing the quality and functional properties of specialized products. Knee joints were studied by using the Lequesne index (scores) characterizing pain syndrome, maximal distance, and daily movement activity. The intensity of pain syndrome was assessed with the visual analog scale (VAS, in mm). Results. We provided a scientific justification for the qualitative and quantitative content of BAS recipes for complex nutritional support of the joint-ligament system: BAS 1 – chondroprotective orientation; BAS 2 – an optimal source of minerals and vitamins; BAS 3 – polyunsaturated fatty acids. The results obtained revealed that specialized products improve the movement activity of participants with osteoarthrosis and significantly decrease pain syndrome (36 %). Apart from a chondroprotective effect such nutrition provides an anti-inflammatory effect and allows decreasing the intake of Nonsteroidal anti-inflammatory drugs in the absence of side effects. We revealed an insignificant number of disease recurrence – 6.7% (in the control group – 36.5 %) and established the mechanisms of such an influence. Conclusion. The application of biologically active complexes could serve as a reliable means of preventing and treating the diseases of the joint-ligament system, providing physical performance, and preserving health in athletes and physically active people.

The anti-inflammatory effects of erythromycin, clarithromycin, azithromycin and roxithromycin on histamine-induced otitis media with effusion in guinea pigs

2018 ◽  
Vol 132 (7) ◽  
pp. 579-583 ◽  
Author(s):  
B Ersoy ◽  
B Aktan ◽  
K Kilic ◽  
M S Sakat ◽  
S Sipal
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Guinea Pigs ◽  
Otitis Media With Effusion ◽  
Study Groups ◽  
Control Group ◽  
Middle Ear Mucosa ◽  
Anti Inflammatory ◽  
The Right ◽  
Better Than

AbstractBackgroundOtitis media with effusion is a clinical manifestation characterised by inflammation of middle-ear mucosa. This study investigated the therapeutic effect of erythromycin, clarithromycin, azithromycin and roxithromycin on a histamine-induced animal model of otitis media with effusion.MethodsThe animals were divided into five groups, receiving erythromycin, clarithromycin, azithromycin, roxithromycin or saline solution. The guinea pigs in the study groups received erythromycin (40 mg/kg/day), clarithromycin (15 mg/kg/day), azithromycin (10 mg/kg/day) or roxithromycin (10 mg/kg/day) for 3 days by gastric tube. Four hours after the end of the administration, histamine solution was injected into the right middle ear.ResultsThe lowest neutrophil density value obtained using stereological techniques was in the azithromycin group (0.86 ± 0.25 × 10−5/μm3), while the highest value was observed in the control group (6.68 ± 3.12 × 10−5/μm3). The anti-inflammatory properties of clarithromycin, azithromycin and roxithromycin were similar to one another, but better than that of erythromycin.ConclusionThe use of macrolide antibiotics is recommended, as they show antibacterial and anti-inflammatory efficacy in otitis media with effusion.

scholarly journals Collagen-Polyvinyl Alcohol-Indomethacin Biohybrid Matrices as Wound Dressings

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 224 ◽  
Author(s):  
Ștefania Marin ◽  
Mădălina Albu Kaya ◽  
Mihaela Ghica ◽  
Cristina Dinu-Pîrvu ◽  
Lăcrămioara Popa ◽  
...  
Keyword(s):  
Wound Healing ◽  
Polyvinyl Alcohol ◽  
Enzymatic Degradation ◽  
Healing Process ◽  
Control Group ◽  
Type I ◽  
Inflammatory Drug ◽  
Composite Gels ◽  
Ft Ir ◽  
Anti Inflammatory

The aim of this study is to design, develop and evaluate new biohybrid sponges based on polymers (collagen and polyvinyl alcohol) with and without indomethacin as anti-inflammatory drug model to be used for tissue regeneration in wound healing. Type I fibrillar collagen in the form of a gel and different concentrations of polyvinyl alcohol were mixed together to prepare composite gels. Both control samples, without indomethacin and with indomethacin, were obtained. All samples were crosslinked with glutaraldehyde. By freeze-drying of hydrogels, the spongious forms (matrices) were obtained. The matrices were characterized by FT-IR spectroscopy, scanning electron microscopy (SEM), water absorption, enzymatic degradation and in vitro indomethacin release. The pharmacological effect of the spongious biohybrid matrices was determined on an experimental model of burns induced to Wistar rats. The SEM images showed a porous structure with interconnected pores. Collagen sponges present a structure with pore sizes between 20 and 200 µm, which became more and more compact with polyvinyl alcohol addition. The FT-IR showed interactions between collagen and polyvinyl alcohol. The enzymatic degradation indicated that the most stable matrix is the one with the ratio 75:25 of collagen:polyvinyl alcohol (ACI75), the other ones being degradable in time. The kinetic data of indomethacin release from matrices were fitted with different kinetic models and highlighted a biphasic release of the drug. Such kinetic profiles are targeted in skin wound healing for which important aspects are impaired inflammation and local pain. The treatment with sponges associated with anti-inflammatory drug had beneficial effects on the healing process in experimentally induced burns compared to the corresponding matrices without indomethacin and the classical treated control group.

scholarly journals PATHOGENIC ROLE OF CYTOKINES IN PSORIASIS

2018 ◽  
Vol 21 (2) ◽  
pp. 90-93
Author(s):  
Sh. V Karapetyan ◽  
Khachik M. Khachikyan
Keyword(s):  
Inflammatory Cytokines ◽  
Proinflammatory Cytokines ◽  
Control Group ◽  
Moderate Severity ◽  
Duration Of Disease ◽  
Anti Inflammatory ◽  
Group 2 ◽  
Commercial Kits ◽  
Group 1

Aim. The aim of this study is determination of the role of certain pro-inflammatory and anti-inflammatory cytokines in the pathogenesis of psoriasis. Material and methods. The 110 patients with plaque form of psoriasis of moderate severity were examined, who were divided into 2 groups. Group 1 includes 65 patients (43 men and 22 women) from 18 to 64 years old with a duration of disease from 1 year to 39 years. The traditional treatment (detoxification, antioxidant, antihistamine, multivitamin, membrane stabilizing, local anti-inflammatory) was prescribed to the patients of group 1. Group 2 includes 45 patients from 18 to 65 years old (31 men and 14 women) with a duration of disease from 6 months to 32 years. The alternative treatment (with traditional therapy, the hepatoprotectors was also used) was prescribed to the patients of group 2. The control group makes 18 practically healthy periodic donors (9 men and 9 women) from 19 to 57 years old. The level of IFNγ, TNFα, IL-1α, IL-2, IL-10 and TGFβ was investigated in the serum of psoriatic patients by ELISA (commercial kits of Demeditec Diagnostics GmbH were used). Results. Before the treatment, the significant increase of level of circulating pro-inflammatory cytokines and significant decrease of level of anti-inflammatory cytokines were seen in both groups of patients with psoriasis compared with the control group. After the treatment, the level of proinflammatory cytokines is significantly reduced and the level of anti-inflammatory cytokines is significantly increased in group 1, approaching to the normal values. In group 2, the level of proinflammatory cytokines decreases more than in group 1 after the treatment. The level of anti-inflammatory cytokines also increases more than in group 1 (high treatment efficiency). The intensity of the rate of decrease of PASI after treatment in patients of group 2 is at least 1.2 times higher than in I group, of DLQI after treatment in patients of group 2 is at least 1.44 times higher than in group 1. Conclusions. The registered changes in the serum of patients with moderate severity of papular-plaque form of psoriasis indicate their essential role in the pathogenesis of psoriasis.

scholarly journals Therapeutic niche of hyaluronic acid derivatives in osteoarthritis

2021 ◽  
pp. 123-132
Author(s):  
I. G. Krasivina ◽  
L. N. Dolgova ◽  
N. V. Dolgov
Keyword(s):  
Hyaluronic Acid ◽  
Pain Syndrome ◽  
Reduction Of Pain ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Viscoelastic Substances ◽  
Local Use ◽  
Point Of Intersection ◽  
Therapeutic Doses

Osteoarthritis (OA) is a widespread disease of synovial joints, the treatment of which determines a significant number of tactical and strategic directions. Currently, there is experience in the local use of so-called synovial fluid (SF) prostheses, which are viscoelastic substances that improve the cushioning properties of the native intra-articular environment. The overwhelming majority of viscoelastic additives are represented by hyaluronic acid (HA) derivatives, a natural component of SF, whose biological role consists in maintaining the rheological properties of fluid and the presence of anti-inflammatory, anti-nociceptive and chondro-protective properties. In the development of HA drugs, the main goals are the sustained and controlled release of therapeutic doses of the drug, taking into account the choice of carrier, drug molecule and target articular tissue. Assessing the quality and physiological feasibility of introducing a particular viscoelastic drug into the joint involves determining the so-called crossover frequency - the point of intersection of the viscosity modulus G’ and the elastic modulus G” (G’/G”), which reflects changes in the viscoelastic properties of the SF with increasing load frequency when transitioning from walking to running. Physiological range of frequencies out of the majority of investigated medical products corresponds to a single one, among which there are also variants of domestic production. Numerous studies of local application of some HA drugs in patients with OA confirm their effectiveness and safety, in particular, reduction of pain syndrome, reduction of the need for nonsteroidal anti-inflammatory drugs, improvement of the quality of life. However, unfortunately, most HA drugs available on the market have not undergone full-fledged clinical trials, so there is a need to study the comparative effectiveness of drugs of this group approved for use and determine their place in the treatment of OA with different variants of the course.

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