Safety study of fentanyl and dexmedetomidine combination in an experimental model of respiratory failure

2016 ◽  
Vol 14 (3) ◽  
pp. 53-57
Author(s):  
Nikolay G. Vengerovich ◽  
Mikhail A. Judin ◽  
Yury O. Kon’shakov ◽  
Konstantin A. Sherbasov ◽  
Stanislav V. Gadzikovskiy ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Experimental Model ◽  
Respiratory Function ◽  
Therapeutic Action ◽  
Safety Study ◽  
Single Drug ◽  
Single Intraperitoneal Injection ◽  
Pulmonary Pathology ◽  
Average Effective Dose ◽  
Lethal Doses

In an experimental model of respiratory failure induced by a single intraperitoneal injection of 1 LD50 of paraquat (24 mg/kg) the changes of physical activity tolerance, respiratory function parameters were studied and histomorphologic validation of experimental results was confirmed. In a model of respiratory failure the assessment of analgesic activity and toxicity of fentanyl, dexmedetomidine and their combination was made and compared with intact animals. The integral tolerance rates (therapeutic action width) were also estimated. It was shown that on the background of pulmonary pathology for each of the drugs 13-28% decrease of average lethal doses was observed. At the same time when administered in combination an average effective dose of the drugs wasn’t changed in contrast with single-drug analgesia.

SAFETY STUDY OF FENTANYL AND DEXMEDETOMIDINE COMBINATION ON AN EXPERIMENTAL MODEL OF IMPAIRED CARDIAC FUNCTION

2017 ◽  
pp. 8-12
Author(s):  
N. G. Vengerovich ◽  
M. А. Yudin ◽  
M. S. Vakhviyajnen ◽  
O. O. Vladimirova ◽  
I. I. Аlekseeva ◽  
...  
Keyword(s):  
Physical Activity ◽  
Comparative Analysis ◽  
Experimental Model ◽  
Suggested Model ◽  
Safety Study ◽  
Subcutaneous Injections ◽  
Cardiac Pathology ◽  
Single Drug ◽  
Lethal Doses ◽  
Impaired Cardiac Function

A comparative analysis of influence of fentanyl, dexmedetomidine and their combination on physical activity tolerance, electrocardiogram indexes and integral tolerance rates (therapeutic indices range) was conducted on an experimental model of cardiac failure induced by daily subcutaneous injections of 0.4 mg/kg adrenaline hydrochloride over 7 days. The findings were also confirmed by histomorphologic validation. In a suggested model of impaired cardial function, the analgesic activity and toxicity of fentanyl, dexmedetomidine and their combination were assessed in comparison with intact animals. It was shown that on the background of cardiac pathology, 13 to 25% decrease of average lethal doses was observed for each of the drugs under consideration. At the same time when drugs were administered in combination, an average aanalgetic dose did not change unlike single-drug analgesia.

scholarly journals Effect of organophosphorus compounds on the external respiratory function in rats during intratracheal and intraperitoneal administration

2021 ◽  
Author(s):  
Anastasiya A. Kryazhevskikh ◽  
Aleksey A. Kryazhevskikh ◽  
Svetlana N. Subbotina ◽  
Nataliia A. Sklyarova
Keyword(s):  
Respiratory Failure ◽  
Respiratory Function ◽  
Organophosphorus Compounds ◽  
Intraperitoneal Administration ◽  
Toxic Chemicals ◽  
Organophosphate Poisoning ◽  
Toxic Chemical ◽  
Intratracheal Administration ◽  
Chemical Factors ◽  
Lethal Doses

Due to the increasing influence of chemical factors on the human body, the experiment has been conducted using organophosphorus compounds (OPC) to stimulate poisoning cases in the production facilities. Given that the development of respiratory failure is a specific organophosphate poisoning symptom, a comparative analysis of external respiratory function (ERF) in rats with intratracheal and intraperitoneal administration of diisopropyl fluorophosphates (DFP) has been carried out. During the research, the average lethal doses of the toxic chemicals have been established, the conditions of DFP intoxication have been modeled. Thus, LD16 was 0.284 mg/kg by intratracheal administration, 1.6 mg/kg by intraperitoneal administration. Experimental data have shown that the intratracheal intake of OPC causes the development of respiratory failure in the first minutes after poisoning. The return of the ERF indicators to the background values was noted a day after poisoning. With the intraperitoneal administration of the toxic chemical, the rate of development of ERF disorders was lower, toxic effects persisted for two days. The data obtained can be used to make appropriate recommendations for the prevention of accidents and non-emergency cases in a production facility.

scholarly journals Pulmonary comorbidity in chronic lymphoproliferative diseases: realities of the problem in the Dnipro region

2021 ◽  
Vol 26 (4) ◽  
pp. 62-67
Author(s):  
K.Yu. Gashynova  ◽  
G.V. Usenko
Keyword(s):  
Respiratory Function ◽  
Chronic Respiratory Disease ◽  
Community Acquired Pneumonia ◽  
Chronic Obstructive ◽  
Shortness Of Breath ◽  
Lymphoproliferative Diseases ◽  
Obstructive Pulmonary Disease ◽  
Pulmonary Pathology ◽  
Chronic Lymphoproliferative Diseases ◽  
Possible Cause

The prevalence of the chronic lymphoproliferative diseases is increasing worldwide with increase of the population age. It is known that the presence of comorbidities in such patients plays an important role in predicting treatment outcomes. The aim of the work was to study the prevalence and determine the structure of respiratory symptoms and comorbid pulmonary pathology in patients with chronic lymphoproliferative diseases (CLPD) in the Dnipro region of Ukraine. After analyzing 986 cards of inpatients of the hematology department, whose average age was 65 (56; 69) years, it was determined that 9.0% of patients had at least one chronic respiratory disease, the most common among which were chronic bronchitis, chronic obstructive pulmonary disease, as well as community-acquired pneumonia. Dyspnea and tachypnea are also common among patients with CLPD without established respiratory comorbidity, cardiovascular disease, or anemia. Based on the data obtained, we can recommend a study of the respiratory function and pulse oximetry, as well as a thorough collection of anamnesis of smoking and analysis of the results of chest computed tomography in all patients with CLPD in order to identify the possible cause of shortness of breath and establish the presence of respiratory comorbidity.

Percorso assistenziale e scelte terapeutiche nella Sclerosi Laterale Amiotrofica (SLA) / Care pathway and therapeutics choices for Amyiotrophic Lateral Sclerosis (ALS)

2018 ◽  
Vol 67 (2) ◽  
pp. 157-174
Author(s):  
Mario Sabatelli
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Respiratory Function ◽  
Care Pathway ◽  
Muscular Weakness ◽  
Sulla Base ◽  
Novel Technology ◽  
Sclerosi Laterale Amiotrofica ◽  
Lateral Sclerosis ◽  
Critical Aspects

La Sclerosi laterale amiotrofica (SLA) è una malattia devastante caratterizzata da una paralisi progressiva dei muscoli scheletrici compresi quelli degli arti, della deglutizione, della fonazione e della respirazione. La morte si verifica entro 3-5 anni nella gran parte dei casi e in un contesto di grande sofferenza a causa dei sintomi della insufficienza respiratoria. La introduzione di tecnologie innovative per supportare la funzione respiratoria con la ventilazione meccanica ha cambiato notevolmente l’approccio assistenziale alle persone con SLA. Il presente contributo intende approfondire, sulla base dell’esperienza maturata presso il Centro Clinico NeMOFondazione Policlinico Universitario A. Gemelli - IRCCS, alcuni aspetti problematici nel percorso assistenziale e delle relative scelte terapeutiche per i pazienti affetti da SLA. ---------- Amyiotrophic Lateral Sclerosis (ALS) is a devastating disease characterized by progressive muscular weakness, leading to limb palsy, difficulties in swallowing, speaking and breathing. Death occurs within 3-5 years in most patients in the context of significant suffering due to symptoms of respiratory failure. The availability of novel technology to support respiratory function by mechanical ventilation has profoundly changed the management of people with ALS. The present article addresses some critical aspects of both care pathway and the related therapeutics choices for patients with ALS on the basis of the experience of the Centro Clinico NeMO-Fondazione Policlinico Universitario A. Gemelli - IRCCS.

scholarly journals Assessing Pulmonary Pathology by Detailed Examination of Respiratory Function

2010 ◽  
Vol 177 (4) ◽  
pp. 1861-1869 ◽  
Author(s):  
Louis J. Vaickus ◽  
Jacqueline Bouchard ◽  
Jiyoun Kim ◽  
Sudha Natarajan ◽  
Daniel G. Remick
Keyword(s):  
Respiratory Function ◽  
Detailed Examination ◽  
Pulmonary Pathology

scholarly journals A Neonate with an Unusual Midline Defect and Cardiovascular Anomaly

2018 ◽  
Vol 06 (01) ◽  
pp. e15-e17
Author(s):  
Martin Poryo ◽  
Paul Hoffmann ◽  
Hans-Joachim Schäfers ◽  
Clemens-Magnus Meier ◽  
Katrin Altmeyer ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Aortic Aneurysm ◽  
Respiratory Function ◽  
Surgical Correction ◽  
Autologous Graft ◽  
Midline Defect ◽  
Sternal Cleft ◽  
Cardiovascular Anomaly

AbstractWe present a female neonate with a sternal cleft (SC) and additional aortic aneurysm who presented with respiratory failure. Stabilization of the SC was achieved by using the xyphoid process as an autologous graft bridging the upper part of the SC. We conclude that a step-wise correction of the SC with the use of an autologous graft may improve respiratory function, and should be considered when complete surgical correction is not feasible.

scholarly journals A METHOD FOR RESTORING VOICE FUNCTION OF THE LARYNX AFTER OPERATIONS FOR THYROID CANCER

2020 ◽  
Vol 75 (3) ◽  
pp. 120-122
Author(s):  
N.V. Kovalenko ◽  
◽  
D.V. Fainshtein ◽  
V.V. Ponomaryev ◽  
A.Yu. Nenarokomov ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Respiratory Failure ◽  
Recurrent Laryngeal Nerve ◽  
Respiratory Function ◽  
Clinical Case ◽  
Vocal Folds ◽  
Laryngeal Nerve ◽  
Main Trunk ◽  
The Russian Federation ◽  
The Voice

The incidence of thyroid cancer in the period from 2008 to 2018 in the Russian Federation increased from 74,8 to 114,1 cases per 100,000 population. The risk of damage to the recurrent laryngeal nerve during primary operations ranges from 0,5 to 23 %, with repeated operations increases to 62 %. The Volgograd regional clinical oncological dispensary uses the technique of intraoperative restoration of the function of the recurrent laryngeal nerve by means of a micro-neural anastomosis with the main trunk of the vagus nerve. We have experience in performing 6 similar operations. The description of this technique is given on the example of a clinical case. The described technique allows you to completely restore the voice and mobility of the vocal folds of the larynx. Respiratory function is fully restored, which makes it possible to avoid the formation of a tracheostomy in case of bilateral nerve damage, and if even unilateral paresis led to decompensated respiratory failure.

scholarly journals Efektivitas Ventilator dalam Proses End of Life dan Tinjauannya Menurut Pandangan Islam

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Yulya Mauliddina ◽  
Ferryal Basbeth ◽  
Muhammad Arsyad
Keyword(s):  
Intensive Care Unit ◽  
Mechanical Ventilation ◽  
Intensive Care ◽  
Respiratory Failure ◽  
Medical Record ◽  
Medical Records ◽  
Respiratory Function ◽  
Sampling Techniques ◽  
Mechanical Ventilator ◽  
Probability Sampling

Background: A mechanical ventilator is a device used to help with respiratory function. Its use is indicated for patients with hypoxemia, severe hypercapnia and respiratory failure. Mechanical ventilator is one of the important and widely used aspects for critical patient care in the Intensive Care Unit (ICU). Methods: This research was conducted with non-probability sampling techniques. Non-probability sampling techniques was determined by purposive method, which is to determine the criteria first, then the samples are taken according to predetermined criteria. Results: As much as 98 medical records taken from the Juwita Bekasi Hospital ICU from  2013-2017  showed  that 3 patients showed effective results for ventilator installation and 95 patients showed ineffective results. Conclusion: Based on medical record in Juwita Bekasi Hospital from 2013 to 2017, The mechanical ventilation installation was not effective and only has 1% effectivity.

scholarly journals The Management of Respiratory Failure in Infancy

1973 ◽  
Vol 1 (6) ◽  
pp. 486-506 ◽  
Author(s):  
J. G. Stocks
Keyword(s):  
Respiratory Failure ◽  
Respiratory Function ◽  
New Techniques ◽  
Pathophysiological Mechanisms ◽  
The Past ◽  
Neonates And Infants

The management of respiratory failure in infancy has altered considerably over the past two decades, due both to an increasing understanding of the underlying pathophysiological mechanisms involved and the development of new techniques of treatment. This paper outlines the rationale, indications, and details of the therapy which may be required in neonates and infants suffering from illnesses affecting respiratory function.

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