Surgical treatment of diffuse toxic goiter in children. A review of the literature

2013 ◽  
Vol 4 (4) ◽  
pp. 69-76
Author(s):  
Alexander Vadimovich Gostimsky ◽  
Sergey Sergeevich Peredereev
Keyword(s):  
Surgical Treatment ◽  
Radioactive Iodine ◽  
Term Treatment ◽  
Graves Disease ◽  
Radioactive Iodine Therapy ◽  
Review Of The Literature ◽  
Large Size ◽  
Long Term Treatment ◽  
Toxic Goiter

Diffuse toxic goiter (DTG) is an autoimmune disease, to which there is a genetic predisposition. In children DTG is less common than in adults. Manifestation of graves‘ disease in childhood has a number of peculiarities. During the DTG in children is usually manifested thyrotoxicosis, requiring long-term treatment to achieve euthyroid, tendency to relapse and more frequently than adults, accompanied by ophthalmopathy and the large size of goiter. Diagnosis of graves‘ disease is based on the clinical picture of thyrotoxicosis, the existence of which is confirmed by the level of thyroid hormones and TSH in the blood. There are three types of treatment of patients DTG: medical, radioactive iodine therapy and surgery. There is no а single glance at the choice of the volume of operations in children.

Sodium ipodate and methimazole in the long-term treatment of hyperthyroid Graves' disease

Metabolism ◽  
1993 ◽  
Vol 42 (4) ◽  
pp. 403-408 ◽  
Author(s):  
Elio Roti ◽  
Eliana Gardini ◽  
Roberta Minelli ◽  
Lina Bianconi ◽  
Lewis E. Braverman
Keyword(s):  
Term Treatment ◽  
Graves Disease ◽  
Long Term Treatment ◽  
Sodium Ipodate

scholarly journals Preserved activation of thyrotropin receptor antibody to stimulate thyroid function despite long-term treatment in euthyroid patients with Graves' disease

1998 ◽  
pp. 281-285 ◽  
Author(s):  
M Akuzawa ◽  
M Murakami ◽  
M Yamada ◽  
T Satoh ◽  
H Shimizu ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Normal Subjects ◽  
Term Treatment ◽  
Graves Disease ◽  
Thyrotropin Receptor ◽  
Receptor Antibody ◽  
Thyrotropin Receptor Antibody ◽  
Long Term Treatment ◽  
Tsh Levels

Clinical evaluation was conducted to ascertain whether thyrotropin receptor antibody (TRAb) in the normal range may still be involved in the regulation of thyroid function after prolonged treatment for Graves' disease. All patients (n = 33) were treated with antithyroid drugs for an average of 10.6 years and were under euthyroid conditions in which normal blood levels of tri-iodothyronine (T3) were significantly correlated with blood thyrotropin (TSH) levels, but not with titers of TRAb. A significant correlation was observed between TRAb titer and thyroid-stimulating antibody (TSAb) activity. In contrast, this correlation was not found in normal subjects. After administration of T3 (75 microg daily for 8 days), the patients showed increased levels of T3 with concomitant suppression of TSH levels. Under these conditions, linear regression analysis showed significant correlations of TRAb titer and TSAb activity with 24-h thyroid radioiodine uptake (r = 0.641 and 0.621 respectively, P < 0.01), in contrast to declining blood thyroxine levels. Moreover, the immunoglobulin G (IgG) of the patients precipitated to a greater extent than IgG from normal subjects a peptide consisting of the amino acid sequence near the terminus of the human TSH receptor. These findings indicated that TRAb at normal levels possessed significant unremitting activities on thyroid function despite long-term treatment in euthyroid patients with Graves' disease.

Long-term treatment with interferon-β therapy for multiple sclerosis and occurrence of Graves’ disease

2000 ◽  
Vol 23 (5) ◽  
pp. 321-324 ◽  
Author(s):  
M. Rotondi ◽  
G. Mazziotti ◽  
B. Biondi ◽  
G. Manganella ◽  
A. Del Buono ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Term Treatment ◽  
Graves Disease ◽  
Interferon Β ◽  
Long Term Treatment

Graves' disease in children and adolescents: Response to long-term treatment

2005 ◽  
Vol 94 (11) ◽  
pp. 1583-1589 ◽  
Author(s):  
Raquel Barrio ◽  
Marta López-Capapé ◽  
Itziar Martinez-Badás ◽  
Angel Carrillo ◽  
Jose Moreno ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Term Treatment ◽  
Graves Disease ◽  
Long Term Treatment

scholarly journals Effective long-term treatment with bevacizumab for relapsed glioblastoma: case report and review of the literature

2014 ◽  
Vol 3 (1) ◽  
Author(s):  
Katrin Schweneker ◽  
Christoph Clemm ◽  
Melanie Brügel ◽  
Michael Souvatzoglou ◽  
Mirjam Hermisson ◽  
...  
Keyword(s):  
Case Report ◽  
Term Treatment ◽  
Review Of The Literature ◽  
Long Term Treatment

Long Term Treatment of Graves' Disease with Iopanoic Acid (Telepaque)

1987 ◽  
Vol 65 (4) ◽  
pp. 679-682 ◽  
Author(s):  
YUH-SHYUN WANG ◽  
CHUNG-TIDE TSOU ◽  
WEN-HAN LIN ◽  
JEROME M. HERSHMAN
Keyword(s):  
Term Treatment ◽  
Graves Disease ◽  
Iopanoic Acid ◽  
Long Term Treatment
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