sodium ipodate
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1997 ◽  
Vol 107 (8) ◽  
pp. 1066-1070 ◽  
Author(s):  
Sharon M. Tomaski ◽  
Eileen M. Mahoney ◽  
Lawrence P.A. Burgess ◽  
Kristen B. Raines ◽  
Michael Bornemann

1995 ◽  
Vol 80 (7) ◽  
pp. 2178-2180 ◽  
Author(s):  
I J Chopra ◽  
A J van Herle ◽  
S G Korenman ◽  
S Viosca ◽  
S Younai

1993 ◽  
Vol 264 (6) ◽  
pp. E966-E972 ◽  
Author(s):  
J. J. DiStefano ◽  
A. de Luze ◽  
T. T. Nguyen

Intestinal bacteria hydrolyze conjugates of thyroxine (T4) and 3,5,3'-triiodothyronine (T3) secreted in bile, but it is not clear whether they have any other role in metabolism, storage, transport, or action of thyroid hormone in the intestines. We have examined aspects of T3 and T4 binding and degradation processes in fresh feces and cecum contents, obtained from normal control rats and from rats partially decontaminated by treatment with oral antibiotics for 2-3 wk. Samples were homogenized in phosphate buffer, fractionated, and subjected to various test conditions and incubated at 37 degrees C with 125I-labeled T3 (T3*) or T4 (T4*) for 2 or 24 h. Supernatants of high-speed centrifuged incubates were chromatographed to test for degradation products, and percentage binding was measured in the pellets. Substantial binding of T3* and T4* was found in all control rat feces and cecum content samples by 2 h, but binding was absent or significantly reduced in partially decontaminated rat samples. Bacterial binding of T3* and T4* were further shown to be competitive with graded doses of bovine serum albumin. Considerable degradation of T3* and T4* to labeled iodide (I*) only was also observed in feces and cecum content samples and was much greater in control rat than in corresponding partially decontaminated rat samples. Light had no effects in our system and heat reduced I* production. Propylthiouracil and sodium ipodate had little effect or equivocal effects, but dithiothreitol substantially inhibited I* production.(ABSTRACT TRUNCATED AT 250 WORDS)


Metabolism ◽  
1993 ◽  
Vol 42 (4) ◽  
pp. 403-408 ◽  
Author(s):  
Elio Roti ◽  
Eliana Gardini ◽  
Roberta Minelli ◽  
Lina Bianconi ◽  
Lewis E. Braverman

1993 ◽  
Vol 32 (3) ◽  
pp. 181-184 ◽  
Author(s):  
Renu Joshi ◽  
Howard E. Kulin

1992 ◽  
Vol 15 (7) ◽  
pp. 507-512
Author(s):  
J. H. Hays ◽  
C. Eil ◽  
R. C. Smallridge
Keyword(s):  

1991 ◽  
Vol 14 (10) ◽  
pp. 847-851 ◽  
Author(s):  
Enio Martino ◽  
S. Balzano ◽  
L. Bartalena ◽  
A. Loviselli ◽  
V. Sica ◽  
...  

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