scholarly journals Сorneal endothelium after laser activation of trabecula in patients with primary open-angle glaucoma

2019 ◽  
Author(s):  
Valeria Yashina ◽  
Tatiana Sokolovskaya ◽  
Pavel Volodin
Keyword(s):  
Endothelial Cells ◽  
Laser Radiation ◽  
Confocal Microscopy ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
The State ◽  
Corneal Tissue ◽  
Open Angle ◽  
Corneal Endothelial Cells ◽  
Yag Laser

Laser interventions as microinvasive methods of treatment of patients with primary open-angle glaucoma are widely used in clinical practice because they are effective, safe, the period of rehabilitation after this type of treatment is short, the risk of postoperative complications is minimal. In the scientific literature there are data on the effect of laser radiation on the corneal endothelial cells, that is why this aspect should be investigated in the development and use of new laser technologies in the treatment of patients with primary open-angle glaucoma. One of the most modern methods of corneal examination is known to be lifetime confocal microscopy, which allows to visualize corneal tissue at the cellular level. Purpose: to study the effect of laser radiation on the state of corneal endothelial cells in YAG-laser activation of trabecula in patients with primary open-angle glaucoma. Materials and methods. Sixteen eyes of 15 patients were included in the analysis: 7 men and 8 women aged 53 to 74 years. The mean age of patients was 65.8±5.35 years. All patients underwent YAG-laser activation of trabecula: Nd-YAG laser, 1064nm, 0.8-1.2MJ, 30NS pulse duration, 10-15µm a spot diameter, 55-70 pulses in the circle. In different periods of observation (before laser treatment, 1 hour, 1 week, 1 month, 6 months after laser intervention) the level of IOP was monitored, the state of endothelial corneal cells was studied by confocal microscopy. Results. According to the results of confocal microscopy statistically significant difference between the average density of endothelial cells, polymegathism, and pleomorphism have not been identified. Conclusion. The study did not reveal a negative impact of YAG-laser activation of trabecula on the endothelium of the cornea, which indicates the safety of this technology.

scholarly journals Use of 5-Fluorouracil-Soaked Bioamniotic Membranes in Trabeculectomy for Primary Open-Angle Glaucoma: A Retrospective Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Chenming Zhang ◽  
Min Wu ◽  
Jianrong Wang ◽  
Miaomiao Zhang ◽  
Xu Wang ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Visual Acuity ◽  
Retrospective Analysis ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Corneal Endothelial Cells ◽  
Amniotic Membranes ◽  
Surgical Option

The study is a retrospective analysis of 51 patients (76 eyes) with primary open-angle glaucoma (POAG) who admitted to our hospital from 2008 to 2010 to analyze the efficacy of trabeculectomy in combination with 5-fluorouracil- (5-FU-) soaked amniotic membranes for the treatment of POAG patients. Among them, 30 patients (41 eyes) were treated with trabeculectomy in combination with 5-FU-soaked amniotic membrane and 21 patients (35 eyes) were treated with trabeculectomy in combination with MMC. Preoperative and postoperative intraocular pressures (IOP), cup/disc ratio, visual acuity and postoperative macular OCT, complications, treatment, and number of corneal endothelial cells were measured, recorded, and analyzed. At the end of 2 years of follow-up, IOP of 36 (87.8%) eyes of patients in the 5-FU group and IOP of 28 (80%) eyes of patients in the MMC group were ≤21 mmHg and patients in the 5-FU group had more stable IOP than patients in the MMC group. During the two years of follow-up, the visual acuity of 22 (53.7%) eyes in the 5-FU group remained unchanged or even improved. Trabeculectomy in combination with 5-FU-soaked biological amniotic membranes can be a surgical option for POAG patients.

scholarly journals The state of the oxidation-reduction system in patients with primary open angle glaucoma

2012 ◽  
Vol 93 (3) ◽  
pp. 488-490
Author(s):  
I R Gazizova
Keyword(s):  
Lipid Peroxidation ◽  
Blood Serum ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Thiobarbituric Acid ◽  
The State ◽  
Open Angle ◽  
Reduction System ◽  
Oxidation Reduction ◽  
Peroxidation Processes

Aim. To study the state of the oxidation-reduction system in patients with primary open-angle glaucoma. Methods. Conducted were biochemical studies of the state of the oxidation-reduction system in 30 patients with primary open-angle glaucoma. The level of lipid peroxidation of cell membranes was determined in blood serum by the method of accumulation of malondialdehyde based on its interaction with thiobarbituric acid. The state of the antioxidant system was assessed according to the activity of superoxide dismutase, catalase, glutathione reductase and the content of thiol disulfide groups in the blood. The concentration of lactate in the blood serum was determined using an automated analyzer. Results. In patients with a chronic course of glaucoma elevated levels of oxidized thiol groups of proteins, increased activity of antioxidant enzymes, activation of lipid peroxidation processes, increased lactate content have been identified. Conclusion. Changes in the oxidation-reduction system in patients with primary open-angle glaucoma may be a sign of mitochondrial dysfunction.

Question on clinical efficiency and principles of diode laser radiation activity at a primary open-angle glaucoma

1999 ◽  
Author(s):  
A. V. Bolshunov ◽  
G. G. Litvinova ◽  
O. S. Ilyina ◽  
A. L. Easakiva ◽  
A. A. Fyodorov ◽  
...  
Keyword(s):  
Laser Radiation ◽  
Diode Laser ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Clinical Efficiency
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