1-desamino-8-D-arginin-vasopressin, DDAVP, increases the content of brain-derived neurotrophic factor (BDNF) in blood plasma of rats in model of post-traumatic stress disorder

2021 ◽  
Vol 20 (4) ◽  
pp. 27-34
Author(s):  
Svetlana G. Belokoskova ◽  
Darya V. Krytskaya ◽  
Gleb V. Beznin ◽  
Marina N. Karpenko ◽  
Sergey G. Tsikunov
Keyword(s):  
Blood Plasma ◽  
Neurotrophic Factor ◽  
Immunohistochemical Method ◽  
Post Traumatic Stress ◽  
Female Wistar Rats ◽  
Psychogenic Stress ◽  
Post Traumatic ◽  
Threat To Life ◽  
In Blood Plasma

Objective. We aimed to analyze the effect of an agonist of vasopressin type 2 receptors, 1-desamino-8-D-arginine-vasopressin, DDAVP, on the content of the brain neurotrophic factor, BDNF, in the hippocampus and blood plasma of rats exposed to vital stress. Material and methods. The study carried out on female Wistar rats divided into 4 groups: first group included control animals, 2 those who received DDAVP intranasally in small doses (once 2 ∙ 109 g, course 20 ∙ 109 g), 3 those who exposed to the stress of a threat to life caused by the experience of the death of a partner from the actions of a tiger python, 4 those who exposed to stress and received DDAVP. BDNF concentration in samples was measured by immunohistochemical method. Results. An increase in the content of BDNF in blood plasma in rats exposed to acute psychogenic stress and received DDAVP therapy was revealed on the tenth day after stress. There was no effect of stress, DDAVP, or their combined effect on the BDNF content in the homogenate of hippocampal tissues. Conclusion. The results of this pilot study indicate that DDAVP has a modulatory effect on BDNF metabolism in rats exposed to vital stress. It is assumed that an increase in the level of neurotrophin in the blood of rats reflects the activation of compensatory processes.

scholarly journals Unique relations between post-traumatic stress disorder symptoms and patient functioning in type 2 diabetes

2017 ◽  
Vol 25 (5) ◽  
pp. 652-664
Author(s):  
Danielle Arigo ◽  
Vanessa Juth ◽  
Paula Trief ◽  
Kenneth Wallston ◽  
Jan Ulbrecht ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Diabetes Distress ◽  
Post Traumatic Stress ◽  
Glucose Testing ◽  
Blood Glucose Testing ◽  
Post Traumatic

This study examined reported post-traumatic stress disorder symptoms in adults with poorly controlled type 2 diabetes who had no history of psychiatric diagnosis or treatment ( n = 184, MHbA1c = 9.13%, standard deviation = 1.68). Participants reported moderate to severe intensity of post-traumatic stress disorder symptoms ( M = 19.17, SD = 17.58). Together, depressive and post-traumatic stress disorder symptoms accounted for 10–40 percent of the variance in type 2 diabetes outcomes; post-traumatic stress disorder symptoms were associated with elevated diabetes distress and more frequent exercise and self-blood glucose testing (unique R2 ~ 3%). Post-traumatic stress disorder symptoms may be overlooked in type 2 diabetes among patients without formal psychiatric diagnoses, and warrant increased attention.

The roles of apo E genotype, gender and adipokines in blood plasma lipids in Caucasians with well-controlled type 2 diabetes

2010 ◽  
Vol 18 (2) ◽  
pp. 49-54
Author(s):  
Douglas E. Barre D.E. ◽  
Kazimiera A. Mizier-Barre K.A. ◽  
Odette Griscti O. ◽  
Kevin Hafez K.
Keyword(s):  
Type 2 Diabetes ◽  
Blood Plasma ◽  
Plasma Lipids ◽  
Apo E ◽  
Apo E Genotype ◽  
In Blood Plasma

Plasma brain-derived neurotrophic factor in earthquake survivors with full and partial post-traumatic stress disorder

2013 ◽  
Vol 67 (5) ◽  
pp. 363-364 ◽  
Author(s):  
Paolo Stratta ◽  
Roberto L. Bonanni ◽  
Patrizia Sanità ◽  
Stefano de Cataldo ◽  
Adriano Angelucci ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Neurotrophic Factor ◽  
Stress Disorder ◽  
Brain Derived Neurotrophic Factor ◽  
Post Traumatic Stress ◽  
Post Traumatic ◽  
Earthquake Survivors

scholarly journals Failure to Protect?: Applying the DRRI-2 Scales to Rwanda and Srebrenica

2020 ◽  
Vol 14 (3) ◽  
pp. 27-47
Author(s):  
Elizabeth Mason
Keyword(s):  
Assessment Tool ◽  
The United States ◽  
Post Traumatic Stress ◽  
Related Factors ◽  
Conflict Zones ◽  
Diagnostic Categories ◽  
Close Analysis ◽  
Post Traumatic ◽  
Failure To Protect ◽  
Threat To Life

This article critically reanalyses the action, or lack of action, taken by UN peacekeepers in Rwanda and Srebrenica in the 1990's. The lack of action of UN peacekeepers in Rwanda and Bosnia has long been criticised as a conscious decision made by peacekeepers to not act in defence of those being targeted but instead to act as bystanders of genocide when they had the ability to prevent acts of genocide taking place. This article re-examines the actions of the UN command under Romeo Dallaire in Rwanda and Thom Karremans in Srebrenica, Bosnia in terms of the stress-related factors which influenced their decisions and actions. A modern risk assessment tool for Post- Traumatic Stress Disorder, the DRRI-2 Scales, developed by psychologists at the National Centre for PTSD in the United States, evaluates which stress-related factors make modern-day soldiers deployed to conflict zones susceptible or more resilient to developing PTSD. This article reveals that in four out of the six diagnostic categories analysed by the DRRI-2 Scales, that UN peacekeepers in Rwanda and Srebrenica would have answered affirmatively to being exposed to a significant number of stressors outlined in the DRRI-2 Scales. This article challenges the reader to critically rethink the judgements that have been placed on peacekeeper's actions in Rwanda and Srebrenica based on this close analysis of their deployment environment, operational limitations and perceived threat to life. Given the multi-layered and persistent stress which these circumstances placed on peacekeepers, I ask what behaviour could have been reasonably expected of UN peacekeepers in Rwanda and Bosnia?

scholarly journals Introduction to the Theme “New Therapeutic Targets”

2019 ◽  
Vol 59 (1) ◽  
pp. 15-20
Author(s):  
Paul A. Insel ◽  
Susan G. Amara ◽  
Terrence F. Blaschke ◽  
Urs A. Meyer
Keyword(s):  
Chronic Renal Disease ◽  
Therapeutic Targets ◽  
Annual Review ◽  
Post Traumatic Stress ◽  
Thyroid Associated Ophthalmopathy ◽  
Post Traumatic ◽  
Pharmacology And Toxicology ◽  
New Therapeutic Targets ◽  
Novel Therapeutic

“New Therapeutic Targets” is the theme of articles in the Annual Review of Pharmacology and Toxicology, Volume 59. Reviews in this volume discuss targets for a variety of conditions in need of new therapies, including type 2 diabetes, heart failure with preserved ejection fraction, obesity, thyroid-associated ophthalmopathy, tinnitus, multiple sclerosis, Parkinson's disease and other neurodegenerative diseases, pain, depression, post-traumatic stress disorder, muscle wasting diseases, cancer, and anemia associated with chronic renal disease. Numerous articles in this volume focus on the identification, validation, and utility of novel therapeutic targets, in particular, ones that involve new or unexpected molecular entities. This theme complements several previous themes, including “New Approaches for Studying Drug and Toxicant Action: Applications to Drug Discovery and Development,” “Precision Medicine and Prediction in Pharmacology,” and “New Methods and Novel Therapeutic Approaches in Pharmacology and Toxicology.”

scholarly journals Peripheral blood levels of brain-derived neurotrophic factor in patients with post-traumatic stress disorder (PTSD): A systematic review and meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241928
Author(s):  
Helia Mojtabavi ◽  
Amene Saghazadeh ◽  
Leigh van den Heuvel ◽  
Joana Bucker ◽  
Nima Rezaei
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Neurotrophic Factor ◽  
Stress Disorder ◽  
Meta Analysis ◽  
Sandwich Elisa ◽  
Brain Derived Neurotrophic Factor ◽  
Blood Levels ◽  
Post Traumatic Stress ◽  
Post Traumatic

Background Brain-derived neurotrophic factor (BDNF) plays a crucial role in the survival, differentiation, growth, and plasticity of the central nervous system (CNS). Post-traumatic stress disorder (PTSD) is a complex syndrome that affects CNS function. Evidence indicates that changes in peripheral levels of BDNF may interfere with stress. However, the results are mixed. This study investigates whether blood levels of BDNF in patients with post-traumatic stress disorder (PTSD) are different. Methods We conducted a systematic search in the major electronic medical databases from inception through September 2019 and identified Observational studies that measured serum levels of BDNF in patients with PTSD compared to controls without PTSD. Results 20 studies were eligible to be included in the present meta-analysis. Subjects with PTSD (n = 909) showed lower BDNF levels compared to Non-PTSD controls (n = 1679) (SMD = 0.52; 95% confidence interval: 0.18 to 0.85). Subgroup meta-analyses confirmed higher levels of BDNF in patients with PTSD compared to non-PTSD controls in plasma, not serum, and in studies that used sandwich ELISA, not ELISA, for BDNF measurement. Meta-regressions showed no significant effect of age, gender, NOS, and sample size. Conclusions PTSD patients had increased serum BDNF levels compared to healthy controls. Our finding of higher BDNF levels in patients with PTSD supports the notion that PTSD is a neuroplastic disorder.

Sign in / Sign up

Export Citation Format

Share Document