Plasma brain-derived neurotrophic factor in earthquake survivors with full and partial post-traumatic stress disorder

2013 ◽  
Vol 67 (5) ◽  
pp. 363-364 ◽  
Author(s):  
Paolo Stratta ◽  
Roberto L. Bonanni ◽  
Patrizia Sanità ◽  
Stefano de Cataldo ◽  
Adriano Angelucci ◽  
...  
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Neurotrophic Factor ◽  
Stress Disorder ◽  
Brain Derived Neurotrophic Factor ◽  
Post Traumatic Stress ◽  
Post Traumatic ◽  
Earthquake Survivors

scholarly journals Peripheral blood levels of brain-derived neurotrophic factor in patients with post-traumatic stress disorder (PTSD): A systematic review and meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241928
Author(s):  
Helia Mojtabavi ◽  
Amene Saghazadeh ◽  
Leigh van den Heuvel ◽  
Joana Bucker ◽  
Nima Rezaei
Keyword(s):  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Neurotrophic Factor ◽  
Stress Disorder ◽  
Meta Analysis ◽  
Sandwich Elisa ◽  
Brain Derived Neurotrophic Factor ◽  
Blood Levels ◽  
Post Traumatic Stress ◽  
Post Traumatic

Background Brain-derived neurotrophic factor (BDNF) plays a crucial role in the survival, differentiation, growth, and plasticity of the central nervous system (CNS). Post-traumatic stress disorder (PTSD) is a complex syndrome that affects CNS function. Evidence indicates that changes in peripheral levels of BDNF may interfere with stress. However, the results are mixed. This study investigates whether blood levels of BDNF in patients with post-traumatic stress disorder (PTSD) are different. Methods We conducted a systematic search in the major electronic medical databases from inception through September 2019 and identified Observational studies that measured serum levels of BDNF in patients with PTSD compared to controls without PTSD. Results 20 studies were eligible to be included in the present meta-analysis. Subjects with PTSD (n = 909) showed lower BDNF levels compared to Non-PTSD controls (n = 1679) (SMD = 0.52; 95% confidence interval: 0.18 to 0.85). Subgroup meta-analyses confirmed higher levels of BDNF in patients with PTSD compared to non-PTSD controls in plasma, not serum, and in studies that used sandwich ELISA, not ELISA, for BDNF measurement. Meta-regressions showed no significant effect of age, gender, NOS, and sample size. Conclusions PTSD patients had increased serum BDNF levels compared to healthy controls. Our finding of higher BDNF levels in patients with PTSD supports the notion that PTSD is a neuroplastic disorder.

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