Influence of the condition of antenatal development on the content of immunoglobulins in the blood of newborns

1982 ◽  
Vol 63 (5) ◽  
pp. 38-41
Author(s):  
L. K. Fazleeva ◽  
N. A. Romanova
Keyword(s):  
Pregnant Women ◽  
Antigenic Stimulation ◽  
Antenatal Development ◽  
Immunological Changes ◽  
Stimulation Of

Studied IgG, IgA and IgM in 103 newborns up to the 12th day of life. In children whose mothers have suffered from pregnancy toxicosis, IgG and Dovppen IgA and IgM are reduced. Immunological changes in late toxicosis in pregnant women for the presence of additional antigenic stimulation of the fetus.

scholarly journals THE MECHANISM OF ANTIGENIC STIMULATION OF PRIMARY AND SECONDARY CLONAL PRECURSOR CELLS

1972 ◽  
Vol 136 (2) ◽  
pp. 241-260 ◽  
Author(s):  
Norman R. Klinman
Keyword(s):  
Serum Antibody ◽  
Precursor Cells ◽  
Antigenic Stimulation ◽  
Soluble Antigen ◽  
Antigen Receptors ◽  
Antigen Concentration ◽  
High Affinity ◽  
Specific Enhancement ◽  
Stimulation Of

Cell transfers to carrier-immunized irradiated mice have permitted an analysis of the in vitro stimulation of clonal precursors of anti-2,4-dinitrophenyl (DNP) antibody-producing cells derived from both immune and nonimmune mice. The results indicate that: (a) carrier-specific enhancement is obligatory for stimulation of primary precursor cells and increases both the size and number of detectable foci derived from secondary precursors. (b) This carrier-specific enhancement is most apparent in the stimulation of precursors of high-affinity antibody producer cells. (c) The antibody produced by primary foci, like that of secondary foci, appears homogeneous. (d) The frequency of clonal precursors in normal spleens is 38% that in spleens from mice 4–8 months after immunization, and the number of such precursors in normal spleens can be reduced fivefold by specific suppression of donor mice with soluble antigen. (e) The average of association constants of primary monofocal antibodies, like that of primary serum antibody produced in carrier-primed mice, is less than 10-fold lower than that of secondary clonal or serum antibody. (f) The affinity of primary monofocal antibodies shows a slight dependence on stimulating antigen concentration; however, a minimum threshold affinity consonant with stimulation is apparent. (g) Free hapten inhibits antigenic stimulation of primary precursor cells at a much lower concentration than is required for the inhibition of secondary precursors. These results are interpreted as indicating that (a) primary stimulation, like secondary stimulation, results from the selective stimulation by antigen of a population of cells differing from one another in their potential antibody product but each having only a single such product; (b) the antigen receptors of primary cells interact with antigen as if they are monovalent while receptors of secondary cells evidence multivalence; (c) antigenic stimulation appears to require both a relatively high affinity of receptors for bound antigen and an interlinking of receptors through such antigen; stimulation is thus seen as resulting from a stabilization of receptors within antigen-receptor aggregates to the cell surface; (d) T-cells appear to serve both in cross-linking antigens and in amplifying the size of stimulated clones.

Features hormonal status in pregnant women with benign cervical pathology in anamnesis

2017 ◽  
pp. 71-73
Author(s):  
N.Yu. Bysaha ◽  
Keyword(s):  
Statistical Analysis ◽  
Pregnant Women ◽  
Placental Lactogen ◽  
Control Group ◽  
Hormonal Status ◽  
Hormonal Changes ◽  
Fetoplacental Complex ◽  
History Of ◽  
Objective Study ◽  
Stimulation Of

The objective: study of hormonal status in pregnant women with benign cervical pathology (CP) in anamnesis. Patients and methods. Clinical and statistical analysis of the hormonal status of 100 women with a history of benign CP pathology has been performed. According to the revealed symptoms of CP during colposcopic examination, women were divided into two groups: 100 pregnant women, in whom colposcopic and cytologically signs of CP pathology were not detected, were included in the control group; and 100 women who had a pathology of CP, entered the main group. Results. The study examined hormonal relationships in the system mother–placenta–fetus, namely the level of hormones such as estriol, progesterone, human chorionic gonadotropin, placental lactogen. Hormonal changes in pregnant women and contribute to reducing the immunoreactivity unwanted stimulation of existing benign hyperplastic background processes in the cervix. Conclusion. Determining functional state placenta is an important factor in the timely diagnosis of disorders in the functioning of the system mother–placenta–fetus. Key words: hormonal status, placenta, uterine cervix, fetoplacental complex.

scholarly journals Hematological Changes, Serum Interferon Gamma and Interleukin-4 Alterations in Normal Pregnancy and Preeclampsia

2020 ◽  
Vol 9 (1) ◽  
pp. 44-51
Author(s):  
Shilan Anwar Mawlood ◽  
Bakhtiar Mohamed Mahmoud
Keyword(s):  
Pregnant Women ◽  
Antiphospholipid Antibodies ◽  
Study Groups ◽  
Normal Pregnancy ◽  
Anticardiolipin Antibodies ◽  
Interleukin 4 ◽  
Control Group ◽  
Immunological Parameters ◽  
Immunological Changes ◽  
Hematological Changes

Background: Various hematological and immunological changes can occur in pregnancy which could be beneficial for the growth of the fetus and the maintenance of the pregnancy although some of these changes could be hazardous to the fetus and can cause complications during pregnancy. Thus, this study was conducted to investigate the hematological and immunological changes in normal pregnancy and preeclampsia (PE). Materials and Methods: To this end, hematological and immunological changes were evaluated in 62 normal pregnant women and 56 pregnant women with PE. Moreover, 58 healthy non-pregnant women were studied as the control group. The study was done between December 1, 2018 to May 1, 2019 in Chwarbakh Private Clinic and Shorsh Teaching Hospital. The venous peripheral blood from the antecubital vein was used in this study. Results: The results revealed a significant increase in the number of granulocytes, monocytes, and mean platelet (PLT) volume in both normal pregnant women and PE patients in comparison to normal (non-pregnant) controls (P<0.01). In addition, there was a significant correlation between a reduction in their hematocrit (HCT), PLT, and lymphocytes (P<0.01). With regard to immunological changes, a significant increase was also observed in the serum interleukin-4 (IL-4) levels in both normal pregnancy and preeclamptic patients when compared to non-pregnant controls (P<0.01), but gamma interferon was not significantly different. Conversely, there were no significant associations between the serum level of antiphospholipid antibodies and anticardiolipin antibodies in the study groups except for antiphospholipid antibodies which were significantly lower in the third trimester of pregnancy in the preeclamptic patients (P<0.05). Conclusion: In general, significant changes in hematological and immunological parameters were observed in both normal pregnant and PE patients although further studies are required to include more immunological parameters.

Immunological regulation of colonic ion transport

1989 ◽  
Vol 256 (2) ◽  
pp. G396-G403 ◽  
Author(s):  
D. A. Russell ◽  
G. A. Castro
Keyword(s):  
Guinea Pigs ◽  
Trichinella Spiralis ◽  
Short Circuit ◽  
Short Circuit Current ◽  
Antigenic Stimulation ◽  
Synthesis Inhibitor ◽  
Combined Use ◽  
Maximum Elevation ◽  
Prostaglandin Synthesis Inhibitor ◽  
Stimulation Of

Challenge of distal colonic epithelium from Trichinella spiralis-infected guinea pigs with parasite-derived antigen elevated short-circuit current (Isc) for approximately 60 min. The maximum elevation (delta Isc) was approximately 250 microA/cm2 at 5 min after the addition of trichinella antigen. The antigen-induced alterations in Isc were of greater magnitude and duration than those evoked in jejunum. Colonic electrical resistance was transiently reduced after exposure to antigen. There was no significant effect of antigen on electrical parameters of colon from nonimmunized (uninfected) guinea pigs. The antihistamine pyrilamine (10(-5) M) and the prostaglandin synthesis inhibitor indomethacin (10(-6) M) reduced the colonic Isc response to antigen by 40% when used in combination but had insignificant effects when used singly. In contrast, the jejunal Isc response to antigen was totally eliminated by the combined use of those inhibitors. Antigenic stimulation of sensitized colon released histamine and prostaglandin E2 (PGE2). However, the histamine released was only about one-tenth that stimulated by antigen in the jejunum, and PGE2 released was only one-tenth of that stimulated by bradykinin in the colon. PGE2 was not released after antigenic stimulation of jejunum. The antigen-induced colonic delta Isc was reduced approximately 50% by either furosemide or tetrodotoxin. Although histamine- and indomethacin-sensitive factors contribute greatly to the mediation of the antigen-induced delta Isc in jejunum, these autacoids contribute to a lesser extent to the antigen-induced delta Isc in guinea pig colon.

Kinetics of CXCR4 and CCR5 up-regulation and human immunodeficiency virus expansion after antigenic stimulation of primary CD4+ T lymphocytes

Blood ◽  
2000 ◽  
Vol 96 (5) ◽  
pp. 1853-1856
Author(s):  
Reinhard Maier ◽  
Marı́a Matilde Bartolomé-Rodrı́guez ◽  
Corinne Moulon ◽  
Hans Ulrich Weltzien ◽  
Andreas Meyerhans
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cells ◽  
T Lymphocytes ◽  
Chemokine Receptors ◽  
Surface Expression ◽  
Antigenic Stimulation ◽  
Productive Infection ◽  
Immunodeficiency Virus ◽  
Kinetics Of ◽  
Stimulation Of

The chemokine receptors CCR5 and CXCR4 are coreceptors for the human immunodeficiency virus (HIV) and determine the cell tropism of different HIV strains. Previous studies on their regulation were performed under conditions of unspecific T-lymphocyte stimulation and provided conflicting results. To mimick physiologic conditions, highly purified primary Staphylococcus enterotoxin B (SEB)-reactive CD4 T lymphocytes were stimulated in the presence of autologous antigen-presenting cells and the kinetics of CCR5 and CXCR4 surface expression and HIV replication were studied. Both chemokine receptors were transiently up-regulated with maximal expression at day 3 after stimulation. The stimulated T cells were equally susceptible to productive infection with R5-and X4-tropic virus strains. Thus, antigenic stimulation of T cells promotes efficient replication of both, T cell-tropic and macrophage-tropic HIV.

scholarly journals CD40 Co-stimulation Inhibits Sustained BCR-induced Ca2+Signaling in Response to Long-term Antigenic Stimulation of Immature B Cells

2011 ◽  
Vol 15 (3) ◽  
pp. 179 ◽  
Author(s):  
Yen Hoang Nguyen ◽  
Ki-Young Lee ◽  
Tae Jin Kim ◽  
Sung Joon Kim ◽  
Tong Mook Kang
Keyword(s):  
B Cells ◽  
Antigenic Stimulation ◽  
Immature B Cells ◽  
Stimulation Of
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