scholarly journals Unusual case of lethal tick-borne encephalitis in patient vaccinated with vaccines produced from different viruses strains (the Chelyabinsk Region)

2015 ◽  
Vol 20 (1) ◽  
pp. 56-64 ◽  
Author(s):  
V. V Pogodina ◽  
S. V Luchinina ◽  
O. N Stepanova ◽  
E. A Stenko ◽  
A. N Gorfinkel ◽  
...  
Keyword(s):  
Genetic Difference ◽  
Virus Antigen ◽  
First Case ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Inactivated Vaccines ◽  
Chelyabinsk Region ◽  
Immunofluorescent Test ◽  
Far Eastern ◽  
Siberian Subtype

Lethal cases of tick-borne encephalitis in previously vaccinated patients have not been described. Modern inactivated vaccines against Tick-borne encephalitis (TBE) are high effective. The TBE cases, preference unfocal forms, are developed in persons with incomplete irregular vaccination. First case of lethal TBE after plural vaccination was described in the Kurgan region, the second case - in the Chelyabinsk region. These very rare unusual cases were studied. Being dominant the Siberian subtype of TBE virus is related with lethal TBE cases in the Chelyabinsk region. Unusual TBE case was developed in patient who had been vaccinated 8 limes with vaccines produced from strains of Far-Eastern TBE subtype («Virion», Tomsk, Chumakov institute, Moscow) and European TBE subtype (Encepur; FSME-Immun). Two years after the last vaccination a focal form of TBE was developed with lethal outcome at 9 th day. Specific antibodies IgM and IgG seroconversion were detected. The TBE virus antigen was detected in brain neurons by immunofluorescent test. Destructed neurons and gliocyles were shown by hystological study in cerebral hemispheres and cerebellum. The Purkinje cells were destructed. Possible reasons of surmounting vaccinal immunity including a genetic difference of vaccine and infection virus strains are discussed.

scholarly journals Modern Problems of Tick-Borne Encephalitis Specific Prevention Communication I: Vaccinal Prevention in Area with Siberian Virus Subtype Domination

2015 ◽  
Vol 14 (5) ◽  
pp. 77-84 ◽  
Author(s):  
V. V. Pogodina ◽  
M. S. Shcherbinina ◽  
S. G. Gerasimov ◽  
N. M. Kolyasnikova
Keyword(s):  
Far East ◽  
Eastern European ◽  
Review Of The Literature ◽  
The Far East ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
The Central Nervous System ◽  
Far Eastern ◽  
Siberian Subtype ◽  
Virus Subtype

Tick-borne encephalitis (TBE) is a disease mainly affecting the central nervous system, serious medical and social problem in Russia and many European countries. TBE virus (TBEV) genetically divided into three major subtypes: the Far Eastern, European and Siberian. Siberian subtype of TBEV dominates in most part of Russia outside of the Far East. Modern cultural inactivated vaccine of domestic and foreign production prepared from the strains of the Far Eastern and European subtypes. In a review of the literature and our own researches are shown: the dominance of Siberian subtype (TBE) and data of vaccine-prevention. The importance of genetic differences between the Siberian subtype strains and vaccines strains are analyzed as well new approaches of the test strain selection.

scholarly journals Modern Problems of Tick-Borne Encephalitis Specific Prevention. Communication II: Peculiarity of Immunity in Area with Siberian Subtype Domination

2015 ◽  
Vol 14 (6) ◽  
pp. 65-73 ◽  
Author(s):  
V. V. Pogodina ◽  
M. S. Shcherbinina ◽  
L. S. Levina ◽  
S. G. Gerasimov ◽  
N. M. Kolyasnikova
Keyword(s):  
Far East ◽  
Inapparent Infection ◽  
The Far East ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Siberian Subtype

Siberian subtype of TBE virus dominates in the most part of Russia outside of the Far East. Peculiarity of immunity induced by Siberian subtype during disease or inapparent infection and change of immunity after vaccination are described in this article. Protective titre of antibodies and persistence of TBE virus (TBEV) in vaccinated organism are discussed.

scholarly journals Phylogenetic analysis and distribution of far eastern tick-borne encephalitis virus subtype (Flaviridae, Flavirus, TBEV-FE) from Asia

2019 ◽  
Vol 64 (5) ◽  
pp. 250-256 ◽  
Author(s):  
G. N. Leonova ◽  
S. I. Belikov
Keyword(s):  
Molecular Genetic ◽  
Primorsky Krai ◽  
Khabarovsk Krai ◽  
Genetic Characteristics ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern ◽  
Virus Strains ◽  
Virus Subtype

To date, a lot of data on molecular genetic characteristics of different tick-borne encephalitis virus strains has appeared. Only on the basis of the E protein genome, sequences of about 1,500 TBEV strains were registered in GenBank.The purpose of the work – revision and comparative analysis of data on complete genomes sequences of the Far Eastern subtype of TBE virus strains distributed in the Asian part of Eurasian continent.Material and methods. The data on the complete genomes of 84 strains of TBEV isolated in Asia were used; phylogenetic analysis was performed.Results and discussion: it was shown that variants of the TBEV of the Far Eastern subtype are circulating here and form three separate clusters (Sofjin, Senzhang- и Shkotovo-like strains). Sofjin strain (Sofjin-1953, Sofjin-Chumakov, Sofjin-KSY) was considered to be the reference for Far Eastern TBE virus subtype strains and a cluster of Sofjin-like strains. Sofjin-like strains were not found in China and Japan, but widely distributed throughout the area of Primorsky and Khabarovsk krai. The group of Senzhang-like strains was distributed in China, Eastern Siberia, Khabarovsk krai and northern Primorsky krai, but was not found in Japan (Hokkaido). According to molecular genetic characteristics the youngest and more genetically homogeneous group was the Shkotovo-like strains, isolated in the southern part of Primorsky krai, however not found on Hokkaido Island (Japan).Conclusion: revision of the complete genome characteristics of TBEV strains revealed the features of micro-evolutionary process of viral populations in the Asian part of Eurasia, show the individual affection of strains to certain territories, as well as detect random finds of such strains in the territories of other natural foci.

scholarly journals The present vaccinoprophilaxis of tick-borne encephalitis and vaccines for its provision

2006 ◽  
Vol 5 ◽  
pp. 63-71
Author(s):  
M. S. Vorob’Eva ◽  
M. N. Rashchepkina ◽  
L. I. Pavlova ◽  
L. D. Bystritsky ◽  
N. H. Stavitskaya ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Russian Federation ◽  
Vaccination Campaign ◽  
High Rate ◽  
Postmarketing Surveillance ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Mass Vaccination Campaign ◽  
High Level ◽  
Far Eastern

The high rate of tick-borne encephalitis (TBE) morbidity is lasting for recent years in many areas of Russian Federation. Vac- cination with TBE vaccine is considered to be most effective mean of TBE prophylaxis in endemic areas. VIRION branch (in Tomsk) of MICROGEN State Company have been producing inactivated TBE vaccines for more than 40 years. Since 2001 VIRION have been producing and selling novel purified concentrated TBE vaccine EnceVir. Vaccine EnceVir contains inactivated TBE virus of Far Eastern subtype as active substance with high level of its purity. The vaccine substantiated high level of immuno- genicy and safety in adult and children clinical trials. Postmarketing surveillance during 2001—2005 has verified these conclusions. Hence EnceVir is effective, safe and most available regarding value vaccine for mass vaccination campaign in Russian Federation.

scholarly journals Epidemiologic Characteristics of Combined Natural Focus of Lyme Bоrreliosis and Tick-Borne Encephalitis

2017 ◽  
Vol 16 (2) ◽  
pp. 70-73 ◽  
Author(s):  
A. R. Efimova ◽  
O. M. Drozdova
Keyword(s):  
Lyme Borreliosis ◽  
Risk Groups ◽  
Virus Antigen ◽  
Natural Focus ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Increased Risk ◽  
Sickness Rate ◽  
Risk Areas ◽  
Epidemiologic Characteristics

Epidemiologic patterns of spread of TBE and Lyme Borreliosis in the Kemerovo region within 23 years (1993 - 2015) have been studied. It has been established that sickness rate of TBE has reduced while sickness rate of Lyme Borreliosis has increased. Risk groups and risk areas of distribution of tick-borne infections have been detected. Borrelia DNA has been detected in 35,46 ± 6,26% of ticks, TBE virus antigen has been detected in 2,2 ± 0,28% of ticks. Sickness rate of tick-borne infections and rate of detection of infected ticks differentiate in different areas of the region which therefore should involve differential approach to organization preventive measures.

scholarly journals Phylogenetic and virulence analysis of tick-borne encephalitis viruses from Japan and far-eastern Russia

1999 ◽  
Vol 80 (12) ◽  
pp. 3127-3135 ◽  
Author(s):  
Daisuke Hayasaka ◽  
Yoshiyuki Suzuki ◽  
Hiroaki Kariwa ◽  
Leonid Ivanov ◽  
Vladimir Volkov ◽  
...  
Keyword(s):  
Divergence Time ◽  
Specific Area ◽  
Viral Envelope ◽  
Viral Envelope Protein ◽  
Tick Borne Encephalitis ◽  
Far Eastern Russia ◽  
Tbe Virus ◽  
Far Eastern ◽  
Virus Strains ◽  
Eastern Russia

We have previously reported that tick-borne encephalitis (TBE) is endemic in a specific area of Hokkaido, Japan. In Oshima, the southern part of Hokkaido, TBE virus was isolated from sentinel dogs, ticks and rodents in 1995 and 1996. To identify when these TBE viruses emerged in Hokkaido, the times of divergence of TBE virus strains isolated in Oshima and far-eastern Russia were estimated. TBE virus was isolated in Khabarovsk in 1998 and the nucleotide sequences of viral envelope protein genes of isolates from Oshima and Khabarovsk were compared. From the synonymous substitution rate of these virus strains, the lineage divergence time of these TBE virus strains was predicted phylogenetically to be about 260–430 years ago. Furthermore, the virulence of TBE virus isolates from Oshima and Khabarovsk were compared in a mouse model. The results showed that the isolates possessed very similar virulence in mice. This report provides evidence that the Oshima strains of TBE virus in Hokkaido emerged from far-eastern Russia a few hundred years ago and this explains why these strains possess virulence similar to the TBE viruses isolated in Russia.

Tick-borne encephalitis and its global importance

2018 ◽  
Vol 39 (4) ◽  
pp. 191 ◽  
Author(s):  
Gerhard Dobler
Keyword(s):  
Viral Disease ◽  
Oral Route ◽  
Ixodes Persulcatus ◽  
Tick Borne Encephalitis ◽  
Etiologic Agents ◽  
The Family ◽  
Viremic Phase ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern ◽  
Siberian Subtype

Tick-borne encephalitis (TBE) is the most important tick-transmitted human viral disease in Europe and Asia with up to 10000 human cases annually. The etiologic agents of TBE are the three subtypes of tick-borne encephalitis virus (TBEV), a member of the genus Flavivirus in the family Flaviviridae. The Far-Eastern subtype and the Siberian subtype are both mainly transmitted by Ixodes persulcatus; the European subtype is mainly transmitted by Ixodes ricinus. Besides tick bite, TBEV can be transmitted by unpasteurised milk from goat, sheep and cattle during the viremic phase of infection by the oral route of infection (alimentary form of TBE). There is no treatment for TBE available, but there are effective and well tolerated vaccines against TBE, which are recommended for people living or travelling to endemic countries with a risk of infection.

scholarly journals The features of tick-borne encephalitis in the Yaroslavl region at the present stage. The problem of evolution of the infection

2014 ◽  
Vol 19 (4) ◽  
pp. 37-44
Author(s):  
S. G Gerasimov ◽  
T. A Druzhinina ◽  
L. S Karan ◽  
N. M Kolyasnikova ◽  
N. S Baranova ◽  
...  
Keyword(s):  
High Frequency ◽  
Federal District ◽  
Total Percentage ◽  
Cyclical Fluctuations ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Average Annual Incidence ◽  
Natural Foci ◽  
Siberian Subtype ◽  
Epidemiological Significance

In the Yaroslavl region (Central Federal District of Russia), endemic of tick-borne encephalitis (TBE), the features of epidemiology of this infection were studied during 1992-2012. Cyclical fluctuations in the incidence of TBE, the lack of the trend to decrease of the incidence were observed, the average annual incidence was 1,6 ± 0,32 per 100 thousand ofpopulation. The prevalence offebrile forms of disease was 62,2%, meningeal forms - 16,3%, the total percentage offocal forms was 13,9%. Manifestations of evolution of TBE were: the increase of the epidemiological significance of anthropogenically transformed natural foci, anthropurgical foci of TBE, until 81% of TBE cases were unvaccinated citizens, the high lethality of 4% and the high frequency of cases of alimentary infection of TBE of 7,8% with lethality of 10,8%. The aethiological agent of 10 lethal cases was Siberian subtype of TBE virus.

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