scholarly journals Immunogenicity against Far Eastern and Siberian subtypes of tick-borne encephalitis (TBE) virus elicited by the currently available vaccines based on the European subtype: Systematic review and meta-analysis

2014 ◽  
Vol 10 (10) ◽  
pp. 2819-2833 ◽  
Author(s):  
Alexander Domnich ◽  
Donatella Panatto ◽  
Eva Klementievna Arbuzova ◽  
Alessio Signori ◽  
Ulderico Avio ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Far Eastern ◽  
European Subtype

TBE in Croatia

2020 ◽  
Keyword(s):  
Tick Species ◽  
Limited Data ◽  
Notifiable Disease ◽  
Genetic Characteristics ◽  
Central European ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Endemic Areas ◽  
European Subtype

Even though tick-borne encephalitis (TBE) has been a notifiable disease in Croatia since 2007, there are no or only limited data available on the occurring tick species in the endemic areas, on the prevalence of TBE virus (TBEV) in ticks, its distribution in Croatia, and its genetic characteristics. Reporting of human cases also is very scarce. The Central European subtype of virus (TBEV-EU) appears to be present in Croatia

TBE in Croatia

2019 ◽  
Author(s):  
Wilhelm Erber ◽  
Tamara Vuković Janković
Keyword(s):  
Tick Species ◽  
Limited Data ◽  
Notifiable Disease ◽  
Genetic Characteristics ◽  
Central European ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Endemic Areas ◽  
European Subtype

Even though tick-borne encephalitis (TBE) has been a notifiable disease in Croatia since 2007, there are no or only limited data available on the occurring tick species in the endemic areas, on the prevalence of TBE virus (TBEV) in ticks, its distribution in Croatia, and its genetic characteristics. Reporting of human cases also is very scarce. The Central European subtype of virus (TBEV-EU) appears to be present in Croatia.

TBE in Croatia

2021 ◽  
Author(s):  
Wilhelm Erber ◽  
Tamara Vuković-Janković
Keyword(s):  
Tick Species ◽  
Limited Data ◽  
Notifiable Disease ◽  
Genetic Characteristics ◽  
Central European ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Endemic Areas ◽  
European Subtype

Even though tick-borne encephalitis (TBE) has been a notifiable disease in Croatia since 2007, there are no or only limited data available on the occurring tick species in the endemic areas, on the prevalence of TBE virus (TBEV) in ticks, its distribution in Croatia, and its genetic characteristics. Reporting of human cases also is very scarce. The Central European subtype of virus (TBEV-EU) appears to be present in Croatia.

scholarly journals Phylogenetic analysis and distribution of far eastern tick-borne encephalitis virus subtype (Flaviridae, Flavirus, TBEV-FE) from Asia

2019 ◽  
Vol 64 (5) ◽  
pp. 250-256 ◽  
Author(s):  
G. N. Leonova ◽  
S. I. Belikov
Keyword(s):  
Molecular Genetic ◽  
Primorsky Krai ◽  
Khabarovsk Krai ◽  
Genetic Characteristics ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern ◽  
Virus Strains ◽  
Virus Subtype

To date, a lot of data on molecular genetic characteristics of different tick-borne encephalitis virus strains has appeared. Only on the basis of the E protein genome, sequences of about 1,500 TBEV strains were registered in GenBank.The purpose of the work – revision and comparative analysis of data on complete genomes sequences of the Far Eastern subtype of TBE virus strains distributed in the Asian part of Eurasian continent.Material and methods. The data on the complete genomes of 84 strains of TBEV isolated in Asia were used; phylogenetic analysis was performed.Results and discussion: it was shown that variants of the TBEV of the Far Eastern subtype are circulating here and form three separate clusters (Sofjin, Senzhang- и Shkotovo-like strains). Sofjin strain (Sofjin-1953, Sofjin-Chumakov, Sofjin-KSY) was considered to be the reference for Far Eastern TBE virus subtype strains and a cluster of Sofjin-like strains. Sofjin-like strains were not found in China and Japan, but widely distributed throughout the area of Primorsky and Khabarovsk krai. The group of Senzhang-like strains was distributed in China, Eastern Siberia, Khabarovsk krai and northern Primorsky krai, but was not found in Japan (Hokkaido). According to molecular genetic characteristics the youngest and more genetically homogeneous group was the Shkotovo-like strains, isolated in the southern part of Primorsky krai, however not found on Hokkaido Island (Japan).Conclusion: revision of the complete genome characteristics of TBEV strains revealed the features of micro-evolutionary process of viral populations in the Asian part of Eurasia, show the individual affection of strains to certain territories, as well as detect random finds of such strains in the territories of other natural foci.

scholarly journals The present vaccinoprophilaxis of tick-borne encephalitis and vaccines for its provision

2006 ◽  
Vol 5 ◽  
pp. 63-71
Author(s):  
M. S. Vorob’Eva ◽  
M. N. Rashchepkina ◽  
L. I. Pavlova ◽  
L. D. Bystritsky ◽  
N. H. Stavitskaya ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Russian Federation ◽  
Vaccination Campaign ◽  
High Rate ◽  
Postmarketing Surveillance ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Mass Vaccination Campaign ◽  
High Level ◽  
Far Eastern

The high rate of tick-borne encephalitis (TBE) morbidity is lasting for recent years in many areas of Russian Federation. Vac- cination with TBE vaccine is considered to be most effective mean of TBE prophylaxis in endemic areas. VIRION branch (in Tomsk) of MICROGEN State Company have been producing inactivated TBE vaccines for more than 40 years. Since 2001 VIRION have been producing and selling novel purified concentrated TBE vaccine EnceVir. Vaccine EnceVir contains inactivated TBE virus of Far Eastern subtype as active substance with high level of its purity. The vaccine substantiated high level of immuno- genicy and safety in adult and children clinical trials. Postmarketing surveillance during 2001—2005 has verified these conclusions. Hence EnceVir is effective, safe and most available regarding value vaccine for mass vaccination campaign in Russian Federation.

scholarly journals DEFINITION AND COMPARATIVE ANALYSIS OF THE GENOMIC STRUCTURE OF SIBERIAN STRAINS OF TICK-BORNE ENCEPHALITIS VIRUS OF THE EUROPEAN SUBTYPE

2018 ◽  
Vol 63 (1) ◽  
pp. 29-36 ◽  
Author(s):  
T. V. Demina ◽  
I. V. Kozlova ◽  
S. E. Tkachev ◽  
E. K. Doroshchenko ◽  
O. V. Lisak ◽  
...  
Keyword(s):  
Genomic Structure ◽  
Encephalitis Virus ◽  
Coding Region ◽  
Forest Zone ◽  
Tick Borne Encephalitis ◽  
European Part Of Russia ◽  
Degree Of Stability ◽  
Tick Borne Encephalitis Virus ◽  
Far Eastern ◽  
European Subtype

Tick-borne encephalitis virus (TBEV) is classified into three subtypes: Far Eastern (TBEV-FE), European (TBEV-EU) and Siberian (TBEV-SIB). In Russia, these are also called genotypes 1, 2 and 3, respectively. Geographically, TBEV-EU dominates in Central and Northern Europe, but its representatives are also found to the east - along the southern part of the forest zone of extratropical Eurasia - up to Eastern Siberia and South Korea. However, the strains isolated outside Europe remain poorly investigated. In the proposed study, eight full genomes of the Siberian isolates of TBEV-EU were determined and 13 complete genomes were compared. The analysis of 152 full-genome TBEV sequences showed that the TBEV-EU has a higher degree of stability of the genome-coding region in the entire Eurasian area (3.1% of differences) compared to TBEV-FE (6.6%) and TBEV-SIB (7.8%). At the same time, the maximum differences are observed not between European and Siberian strains, as one could expect, but between the representatives from Europe - TBEV strains Mandl-2009 from Norway and Hypr from the Czech Republic. The studied strains from Siberia form the compact genetic cluster of 42 TBEV-EU strains and are divided into two subclusters - West Siberian and East Siberian variants. These variants differ in the combinations of amino acid substitutions in all proteins except NS2B. The West Siberian variant mostly circulates in the territory of Altai, and the closest relative of its representatives is Absettarov strain from the European part of Russia. The strains similar to the East Siberian variant of the European subtype were recorded in the Altai (strain 84.2, 2007) and in Belarus (N256, about 1940).

scholarly journals Phylogenetic and virulence analysis of tick-borne encephalitis viruses from Japan and far-eastern Russia

1999 ◽  
Vol 80 (12) ◽  
pp. 3127-3135 ◽  
Author(s):  
Daisuke Hayasaka ◽  
Yoshiyuki Suzuki ◽  
Hiroaki Kariwa ◽  
Leonid Ivanov ◽  
Vladimir Volkov ◽  
...  
Keyword(s):  
Divergence Time ◽  
Specific Area ◽  
Viral Envelope ◽  
Viral Envelope Protein ◽  
Tick Borne Encephalitis ◽  
Far Eastern Russia ◽  
Tbe Virus ◽  
Far Eastern ◽  
Virus Strains ◽  
Eastern Russia

We have previously reported that tick-borne encephalitis (TBE) is endemic in a specific area of Hokkaido, Japan. In Oshima, the southern part of Hokkaido, TBE virus was isolated from sentinel dogs, ticks and rodents in 1995 and 1996. To identify when these TBE viruses emerged in Hokkaido, the times of divergence of TBE virus strains isolated in Oshima and far-eastern Russia were estimated. TBE virus was isolated in Khabarovsk in 1998 and the nucleotide sequences of viral envelope protein genes of isolates from Oshima and Khabarovsk were compared. From the synonymous substitution rate of these virus strains, the lineage divergence time of these TBE virus strains was predicted phylogenetically to be about 260–430 years ago. Furthermore, the virulence of TBE virus isolates from Oshima and Khabarovsk were compared in a mouse model. The results showed that the isolates possessed very similar virulence in mice. This report provides evidence that the Oshima strains of TBE virus in Hokkaido emerged from far-eastern Russia a few hundred years ago and this explains why these strains possess virulence similar to the TBE viruses isolated in Russia.

Tick Borne Encephalitis

2021 ◽  
Author(s):  
Gerhard Dobler
Keyword(s):  
Clinical Course ◽  
Specific Treatment ◽  
Viral Disease ◽  
Ixodes Persulcatus ◽  
Effective Prevention ◽  
Taiga Tick ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
The Family ◽  
European Subtype

Tick-borne encephalitis (TBE) is the medically most common tick-borne viral disease in Europe and Asia. The TBE virus (TBEV) is a member of the family Flaviviridae. Transmission mainly to humans occurs by ticks of the Family Ixodidae, mainly the castor bean tick (Ixodes ricinus) in Europe and the taiga tick (Ixodes persulcatus) in Asia. Rarely TBEV is also transmitted by contaminated milk of infected ungulates (goat, sheep, cow). The clinical course of TBE is variable and may range from subclinical to fatal encephalomyelitis. Probably host and viral factors are involved in the pathogenesis of disease. So far, no specific treatment of the disease is available. The only effective prevention of TBE is vaccination. A number of different vaccines are available worldwide. In Europe two vaccines are licensed which contain inactivated European subtype TBEV. Probably the European vaccines protect also against infections with other subtypes of TBEV.

Are all vaccines safe for the pregnant traveller? A systematic review and meta-analysis

2019 ◽  
Vol 27 (2) ◽  
Author(s):  
Roni Nasser ◽  
Stav Rakedzon ◽  
Yaakov Dickstein ◽  
Amjad Mousa ◽  
Ido Solt ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Pregnant Women ◽  
Yellow Fever ◽  
Japanese Encephalitis ◽  
Observational Studies ◽  
Hepatitis A ◽  
Meta Analysis ◽  
Meningococcal Vaccines ◽  
Tick Borne Encephalitis

Abstract Pregnant travellers and their offspring are vulnerable to severe outcomes following a wide range of infections. Vaccine-preventable diseases can have a particularly severe course in pregnant women, but little is known about the safety of travel vaccines in pregnant women. We performed a systematic review of all published literature concerning the safety of vaccines frequently given to travellers such as yellow fever, MMR (mumps, measles and rubella), influenza, Tdap (tetanus, diphtheria and pertussis), meningococcus, hepatitis A and B, rabies, polio, typhoid fever, tick-borne encephalitis and Japanese encephalitis vaccines. We included case series, cohort studies and randomized controlled trials (RCTs). For the meta-analysis, we included only RCTs that compared the administration of a vaccine to placebo or to no vaccine. Outcome measures included severe systemic adverse events, maternal outcomes related to the course of pregnancy, neonatal outcomes and local adverse events. We calculated the risk ratio and its 95% confidence interval as the summary measure. The safety of influenza vaccine is supported by high-quality evidence. For Tdap vaccine, no evidence of any harm was found in the meta-analysis of RCTs. A slight increase in chorioamnionitis rate was reported in 3 out of 12 observational studies. However, this small possible risk is far outweighed by a much larger benefit in terms of infant morbidity and mortality. Meningococcal vaccines are probably safe during pregnancy, as supported by RCTs comparing meningococcal vaccines to other vaccines. Data from observational studies support the safety of hepatitis A, hepatitis B and rabies vaccines, as well as that of the live attenuated yellow fever vaccine. We found little or no data about the safety of polio, typhoid, Japanese encephalitis, tick-borne encephalitis and MMR vaccines during pregnancy.

scholarly journals Unusual case of lethal tick-borne encephalitis in patient vaccinated with vaccines produced from different viruses strains (the Chelyabinsk Region)

2015 ◽  
Vol 20 (1) ◽  
pp. 56-64 ◽  
Author(s):  
V. V Pogodina ◽  
S. V Luchinina ◽  
O. N Stepanova ◽  
E. A Stenko ◽  
A. N Gorfinkel ◽  
...  
Keyword(s):  
Genetic Difference ◽  
Virus Antigen ◽  
First Case ◽  
Tick Borne Encephalitis ◽  
Tbe Virus ◽  
Inactivated Vaccines ◽  
Chelyabinsk Region ◽  
Immunofluorescent Test ◽  
Far Eastern ◽  
Siberian Subtype

Lethal cases of tick-borne encephalitis in previously vaccinated patients have not been described. Modern inactivated vaccines against Tick-borne encephalitis (TBE) are high effective. The TBE cases, preference unfocal forms, are developed in persons with incomplete irregular vaccination. First case of lethal TBE after plural vaccination was described in the Kurgan region, the second case - in the Chelyabinsk region. These very rare unusual cases were studied. Being dominant the Siberian subtype of TBE virus is related with lethal TBE cases in the Chelyabinsk region. Unusual TBE case was developed in patient who had been vaccinated 8 limes with vaccines produced from strains of Far-Eastern TBE subtype («Virion», Tomsk, Chumakov institute, Moscow) and European TBE subtype (Encepur; FSME-Immun). Two years after the last vaccination a focal form of TBE was developed with lethal outcome at 9 th day. Specific antibodies IgM and IgG seroconversion were detected. The TBE virus antigen was detected in brain neurons by immunofluorescent test. Destructed neurons and gliocyles were shown by hystological study in cerebral hemispheres and cerebellum. The Purkinje cells were destructed. Possible reasons of surmounting vaccinal immunity including a genetic difference of vaccine and infection virus strains are discussed.

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