scholarly journals Micronuclei in blood lumphocytes of existing and former coal miners: evaluation of the effect of anthracosilicosis

2019 ◽  
Vol 17 (4) ◽  
pp. 57-64
Author(s):  
Vladimir G. Druzhinin ◽  
Svetlana V. Apalko ◽  
Elizaveta D. Baranova ◽  
Valentin P. Volobaev ◽  
Tatiana Yu. Drobchik ◽  
...  
Keyword(s):  
Coal Dust ◽  
Additional Contribution ◽  
Coal Miners ◽  
Genotoxic Effects ◽  
The Status ◽  
Long Time ◽  
Inflammatory Processes ◽  
Simultaneous Decrease ◽  
Genotoxic Risk ◽  
Cytogenetic Parameters

Background. The purpose of this study was to investigate the genotoxic risk in anthracosilicosis patients and in those with occupational exposure to coal dust. Materials and methods. We studied micronuclei (MN) and other cytogenetic lesions in blood lymphocytes in three groups of men comparable in age: 74 coal miners suffering from anthracosilicosis (AS), 41 healthy miners, and 70 control donors. Results. A significant increase in the frequency of MN was revealed with a simultaneous decrease in proliferative activity in samples of healthy and sick miners compared with the control. The level of MN in the lymphocytes of patients with AS significantly exceeded the corresponding indicator in the sample of healthy miners (1.22 0.05% versus 1.03 0.07%; p 0.01). The age of the subjects and the status of smoking did not have a significant effect on the frequency of cytogenetic parameters. Conclusion. AS in miners makes an additional contribution to the formation of DNA damage in lymphocytes. This contribution is probably due to oxidative stress accompanying inflammatory processes in pulmonary fibrosis. The results of the study also indicate the absence of differences in the frequency of MN when comparing subgroups of current and former miners. This means that the genotoxic effects in the lymphocytes of miners are able to persist for a long time after the termination of exposure by adverse factors in coal mining.

Euratom and Brexit: Could the United Kingdom Maintain One Foot in the European Union? Current Scenarios and Future Prospects of British withdrawal from the EAEC

2018 ◽  
Vol 18 (2) ◽  
pp. 134-151
Author(s):  
Andrea Circolo ◽  
Ondrej Hamuľák
Keyword(s):  
European Union ◽  
United Kingdom ◽  
Independent Solution ◽  
Legal Regulation ◽  
The European Union ◽  
The United Kingdom ◽  
The Status ◽  
Long Time ◽  
Energy Community ◽  
The Impact

Abstract The paper focuses on the very topical issue of conclusion of the membership of the State, namely the United Kingdom, in European integration structures. The ques­tion of termination of membership in European Communities and European Union has not been tackled for a long time in the sources of European law. With the adop­tion of the Treaty of Lisbon (2009), the institute of 'unilateral' withdrawal was intro­duced. It´s worth to say that exit clause was intended as symbolic in its nature, in fact underlining the status of Member States as sovereign entities. That is why this institute is very general and the legal regulation of the exercise of withdrawal contains many gaps. One of them is a question of absolute or relative nature of exiting from integration structures. Today’s “exit clause” (Art. 50 of Treaty on European Union) regulates only the termination of membership in the European Union and is silent on the impact of such a step on membership in the European Atomic Energy Community. The presented paper offers an analysis of different variations of the interpretation and solution of the problem. It´s based on the independent solution thesis and therefore rejects an automa­tism approach. The paper and topic is important and original especially because in the multitude of scholarly writings devoted to Brexit questions, vast majority of them deals with institutional questions, the interpretation of Art. 50 of Treaty on European Union; the constitutional matters at national UK level; future relation between EU and UK and political bargaining behind such as all that. The question of impact on withdrawal on Euratom membership is somehow underrepresented. Present paper attempts to fill this gap and accelerate the scholarly debate on this matter globally, because all consequences of Brexit already have and will definitely give rise to more world-wide effects.

scholarly journals Sustainable exploitation of temperate fish stocks

2009 ◽  
Vol 6 (1) ◽  
pp. 124-127 ◽  
Author(s):  
Henrik Sparholt ◽  
Robin M. Cook
Keyword(s):  
Species Interactions ◽  
Fishery Management ◽  
Regional Scale ◽  
Single Species ◽  
Fishing Effort ◽  
Theoretical Concept ◽  
Maximum Sustainable Yield ◽  
Production Model ◽  
The Status ◽  
Long Time

The theory of maximum sustainable yield (MSY) underpins many fishery management regimes and is applied principally as a single species concept. Using a simple dynamic biomass production model we show that MSY can be identified from a long time series of multi-stock data at a regional scale in the presence of species interactions and environmental change. It suggests that MSY is robust and calculable in a multispecies environment, offering a realistic reference point for fishery management. Furthermore, the demonstration of the existence of MSY shows that it is more than a purely theoretical concept. There has been an improvement in the status of stocks in the Northeast Atlantic, but our analysis suggests further reductions in fishing effort would improve long-term yields.

scholarly journals The generality of post-antimicrobial treatment persistence of replicatively-attenuatedBorrelia burgdorferiin a mouse model

2019 ◽  
Author(s):  
Emir Hodzic ◽  
Denise M. Imai ◽  
Edlin Escobar
Keyword(s):  
Mouse Model ◽  
Antimicrobial Agents ◽  
Basic Feature ◽  
Antimicrobial Treatment ◽  
Therapy Failure ◽  
Treatment Persistence ◽  
Disease Resistant ◽  
C3h Mice ◽  
The Status ◽  
Long Time

ABSTRACTA basic feature of infection caused byBorrelia burgdorferi, the etiological agent of Lyme borreliosis, is that persistent infection is the rule, not the norm, in its many hosts. The ability to persist and evade host immune clearance poses a challenge to effective antimicrobial treatment. A link between therapy failure and the presence of persister cells has started to emerge. There is growing experimental evidence that viable, but non-cultivable spirochetes persist following treatment with several different antimicrobial agents, then resurge after 12 months. The current study utilized the mouse model to evaluate if persistence and resurgence occur following antimicrobial treatment in a disease-susceptible (C3H/HeN) and disease-resistant (C57BL/6) mouse strain infected withB. burgdorferistrains N40 and B31, to confirm the generality of these phenomena. The status of infection was evaluated at 12 and 18-months after treatment. The results demonstrated that persistent spirochetes remain viable for up to 18 months following treatment, but divide slowly, thereby being tolerant to the effects of antimicrobial agents, as well as being non-cultivable. The phenomenon of persistence and resurgence in disease-susceptible C3H mice is equally evident in disease-resistant B6 mice, and not unique to any particularB. burgdorferistrain. The results also demonstrate that following antimicrobial treatment, both strains ofB. burgdorferi, N40 and B31, lose one or more small plasmids, resulting in attenuation. The biological relevance of attenuatedB. burgdorferispirochetes is probably inconsequential. The study demonstrated that non-cultivable spirochetes can persist in a host following antimicrobial treatment for a long time but did not demonstrate their clinical relevance in a mouse model of chronic infection.

scholarly journals Morphology and distribution of the freshwater mussel Diplodon granosus, a rare and poorly understood species

2020 ◽  
Vol 50 (1) ◽  
pp. 44-53 ◽  
Author(s):  
Igor Christo MIYAHIRA ◽  
Maria Cristina Dreher MANSUR ◽  
Daniel Mansur PIMPÃO ◽  
Sheyla Regina Marques COUCEIRO ◽  
Sonia Barbosa dos SANTOS
Keyword(s):  
South America ◽  
Freshwater Mussels ◽  
Freshwater Mussel ◽  
Wide Distribution ◽  
Large Area ◽  
The North ◽  
Coastal Rivers ◽  
The Status ◽  
Long Time

ABSTRACT Diplodon granosus was one of the first freshwater mussels to be described for South America. However, the status of the species was confusing for a long time, receiving different taxonomic treatments. In this paper, we redescribe the shell, with new data on the soft parts and information on the distribution and conservation of D. granosus, a rarely recorded species. The shell is thin, not inflated; the macrosculpture is composed only by granules that cover the whole shell, not forming bars; the microsculpture comprises short spikes. In the soft parts we highlight the few, weak and irregularly distributed lamellar connections of the outer demibranch and some features of the stomach, such as the distally enlarged minor typhlosole. There are records of D. granosus over a large area of South America, from Guiana to Argentina. However, most of these records are related to other species and the distribution of D. granosus is restricted to the north of South America in the basins of the Amazonas and Orinoco rivers, and coastal rivers in between. Despite this wide distribution, the species occurs in specific habitats, mainly streams (igarapés), resulting in an extremely fragmented occurrence. Thus, any disturbance to these habitats can threat this freshwater mussel.

scholarly journals BEST PRACTICE PENGEMBANGAN MUTU SMK TERPADU LAMPANG SUBANG

2019 ◽  
Vol 26 (1) ◽  
pp. 1-16
Author(s):  
Asep Priatna
Keyword(s):  
Best Practice ◽  
Program Planning ◽  
Vocational School ◽  
National Standard ◽  
Content Standards ◽  
Vocational Schools ◽  
Education Standards ◽  
National Education ◽  
The Status ◽  
Long Time

This study aims to reveal the efforts and results that have been achieved by Lampang Subang Integrated Private Vocational Schools in improving the quality of learning to meet national education standards (SNP), so that they become private schools with the status of national standard schools (SSN). This research is a survey research with a quantitative approach. The study was conducted at the Integrated Vocational School of Lampang Subang, West Java. The results showed that the level of achievement of the program that had been compiled in the RPS of Lampang Integrated Vocational School had reached 90% with the main target being the achievement of the UAN level and graduation that had been carried out by teachers both in the preparation of RPPs and teaching materials had reached 85%, Management developed by Integrated Vocational Schools Long-time contributed significant value, especially in program planning and implementation, while the supervision and leadership of the Principal has been running well, so the value obtained is quite significant, while other components that are quite prominent are PBM and content standards that get good enough grades , so that it can be developed further

scholarly journals Cytotoxic, Genotoxic, and Polymorphism Effects on Vanilla planifolia Jacks ex Andrews after Long-Term Exposure to Argovit® Silver Nanoparticles

Nanomaterials ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. 754 ◽  
Author(s):  
Jericó Bello-Bello ◽  
José Spinoso-Castillo ◽  
Samantha Arano-Avalos ◽  
Eduardo Martínez-Estrada ◽  
María Arellano-García ◽  
...  
Keyword(s):  
Genetic Variability ◽  
Large Scale ◽  
Inter Simple Sequence Repeat ◽  
Metallic Silver ◽  
Vanilla Planifolia ◽  
Genotoxic Effects ◽  
Total Percentage ◽  
Long Time ◽  
Mexican Government

Worldwide demands of Vanilla planifolia lead to finding new options to produce large-scale and contaminant-free crops. Particularly, the Mexican Government has classified Vanilla planifolia at risk and it subject to protection programs since wild species are in danger of extinction and no more than 30 clones have been found. Nanotechnology could help to solve both demands and genetic variability, but toxicological concerns must be solved. In this work, we present the first study of the cytotoxic and genotoxic effects promoted by AgNPs in Vanilla planifolia plantlets after a very long exposure time of six weeks. Our results show that Vanilla planifolia plantlets growth with doses of 25 and 50 mg/L is favored with a small decrease in the mitotic index. A dose-dependency in the frequency of cells with chromosomal aberrations and micronuclei was found. However, genotoxic effects could be considered as minimum due to with the highest concentration employed (200 mg/L), the total percentage of chromatic aberrations is lower than 5% with only three micronuclei in 3000 cells, despite the long-time exposure to AgNP. Therefore, 25 and 50 mg/L (1.5 and 3 mg/L of metallic silver) were identified as safe concentrations for Vanilla planifolia growth on in vitro conditions. Exposure of plantlets to AgNPs increase the polymorphism registered by inter-simple sequence repeat method (ISSR), which could be useful to promote the genetic variability of this species.

On the question of amygdala sepsis

1930 ◽  
Vol 26 (10) ◽  
pp. 1055-1056
Author(s):  
B. Goland
Keyword(s):  
Mucous Membrane ◽  
High Fever ◽  
Recurrent Tonsillitis ◽  
Lower Jaw ◽  
Long Time ◽  
Inflammatory Processes

Abstracts. Laryngology. On the question of amygdala sepsis. Prof. Uffenоrdе. (Deutsche med. Woch., 1929, No. 19, S. 775) gives 4 cases of sepsis after inflammatory processes in the pharynx. 1st case. An 18-year-old girl who had suffered from frequent recurrent tonsillitis for a long time, 2 days after a new exacerbation, a swelling formed on the left side of the neck, with difficulty in the mobility of the lower jaw, chills and high fever. Objective examination revealed a thickening of the left tonsilla without plaque (the peritonsillar area was unchanged), swelling and redness of the left side of the epiglottis, the left scooped-epiglottis fold and the mucous membrane covering the left scoop.

Status of Indian Wetlands With Special Reference to Pesticides and Their Impact

2019 ◽  
pp. 64-83
Author(s):  
Javid Manzoor ◽  
Manoj Sharma ◽  
Irfan Rashid Sofi ◽  
Mufida Fayaz ◽  
Musadiq Hussain Bhat
Keyword(s):  
Special Reference ◽  
Water Bodies ◽  
Pivotal Role ◽  
Small Fish ◽  
Chemical Fertilizers ◽  
Numerous Species ◽  
The Status ◽  
Long Time ◽  
Mangrove Trees ◽  
Harmful Effects

Wetlands are home to numerous species of fish, birds, and reptiles. The enormous roots of the mangrove trees act as shelter to small fish, reptiles, and amphibians. Pesticides and agro-chemical fertilizers have been playing a very pivotal role in the degradation of the land and the water bodies. The different herbicides that are present in wetlands are Dicamba, Endothall, MCPA, Triallate, Trifluralin, 2, 4-D, and insecticides Carbaryl, Carbofuran, Fenvalerate, Malathion, Parathion, and Terbufos. These pesticides have been provided with the aim of catering to the security of the crops which are highly vulnerable to the pests. However, harmful effects of pesticides on wetland species have been a concern for long time. Wetlands constitute one such habitat threatened by the pesticides. But there has been a lack of comprehensive research in this direction. The chapter will identify the gaps in the current research and will review the status of Indian wetlands with special reference to pesticides and their impact.

The Process of Acute and Chronic Inflammation

2020 ◽  
pp. 1-23
Author(s):  
Sedat Demir
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Aging Process ◽  
Inflammatory Process ◽  
Ischemic Heart ◽  
Clinical Markers ◽  
Rheumatologic Diseases ◽  
Long Time ◽  
Inflammatory Processes ◽  
Acute And Chronic Inflammation

Inflammation is a physiopathological process that has been known for a long time but its relation with acute and chronic diseases and its role in the development of disease is becoming better understood. Diabetes, hypertension, ischemic heart disease, various organ cancers, rheumatologic diseases, the most common diseases of the liver, lungs and kidneys are either closely related to inflammatory processes or are caused by direct inflammatory processes. In one aspect, the aging process is a progressive inflammatory process. The understanding of what inflammation is and the mechanisms by which the inflammation occurs in the organism and by accurately identifying and following the clinical markers that show the course of inflammation. In this section, basic issues related to inflammation is examined.

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