scholarly journals The efficacy of platelet-rich plasma therapy in the treatment of androgenetic alopecia: a literature review

2020 ◽  
Vol 23 (4) ◽  
pp. 252-257
Author(s):  
A. A. Lepehova ◽  
Maria B. Potapova
Keyword(s):  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
High Tolerance ◽  
Plasma Therapy ◽  
Preparation Methods ◽  
Double Spin ◽  
Current Review ◽  
New Treatment ◽  
Genetically Determined

Androgenetic alopecia is a genetically determined disease characterized by gradual thinning of hair, which subsequently leads to hair loss, and thereby significantly affects a patients quality of life. The existing methods of disease management have a number of side effects and drawbacks. Thus, new treatment methods combining both high tolerance and efficacy are continuously determined. This current review presents an analysis of the effectiveness of single- and double-spin preparation methods of platelet-rich plasma for the management of patients with androgenetic alopecia.

Comparison of efficacy of topical 5% minoxidil alone versus topical 5% minoxidil with autologous Platelet Rich Plasma (PRP) therapy in treatment of androgenetic alopecia: A randomised open label study

2021 ◽  
Vol 7 (2) ◽  
pp. 107-114
Author(s):  
Bela Padhiar ◽  
Sruthy Raveendran
Keyword(s):  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Androgenic Alopecia ◽  
Open Label ◽  
Hair Density ◽  
Convenience Sample ◽  
Double Spin ◽  
Autologous Platelet Rich Plasma ◽  
Group B ◽  
Autologous Platelet

Androgenic alopecia (AGA) is a type of progressive hairloss, where there is androgen mediated conversion of susceptible terminal hairs into vellus hairs, in genetically predisposed individuals. To compare efficacy of Topical 5% Minoxidil alone versus Topical 5% Minoxidil with Autologous Platelet Rich Plasma (PRP) therapy in patients with Androgenetic Alopecia.This is aProspective study conducted in Department of Dermatology GMERS Medical College, Gandhinagar, Gujarat. A convenience sample of 62 men in the age group of 20-40 with Grade 2-5 AGA according to Hamilton- Norwood Grading were selected and was divided into 2 groups of 31 each. Presitting digital photographs and dermoscopic photos were taken. Autologous PRP was prepared using 18 ml of patients blood after double spin centrifugation and injected by Nappage technique. Results were assessed at the baseline and at the end of each sitting on the basis of change in hair density, photographic evaluation and patient’s self satisfaction. Highly significant increase in hair density was achieved after 4 months of treatment. At T4 (Fourth Session of treatment) Group B showed higher hair density (42.97± 8.96) as compared to Group A (36.94 ± 11.57) which was statistically significant at P = 0.03Group B showed better improvement as compared to Group A.PRP treatment has a positive therapeutic effect on male Androgenetic alopecia without major side effects.

scholarly journals Impact of the Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma (A-PRP) and Activated Platelet-Rich Plasma (AA-PRP) in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

2020 ◽  
Vol 21 (2) ◽  
pp. 431 ◽  
Author(s):  
Pietro Gentile ◽  
Claudio Calabrese ◽  
Barbara De Angelis ◽  
Laura Dionisi ◽  
Jacopo Pizzicannella ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Quality Criteria ◽  
Preparation Technique ◽  
Quality And Safety ◽  
Preparation Methods ◽  
Closed Technique ◽  
Sterile Processing

Autologous therapies using platelet-rich plasma (PRP) need meticulous preparation—currently, no standardised preparation technique exists. Processing Quantitative Standards (PQSs) define manufacturing quantitative variables (such as time, volume and pressure). Processing Qualitative Standards (PQLSs) define the quality of the materials and methods of manufacturing. The aim of this review is to use existing PQSs and PQLs to report the in vivo/in vitro results obtained by using different Kits, that utilise different procedures (classified as Closed-Technique and Opened-Technique) to isolate autologous human activated (AA-PRP) or non-activated PRP (A-PRP). PQSs included the volumes of blood collected as well as the reagents used, the time/gravity of centrifugation, and the duration, temperature and tilt level/speed of centrifugation. PQLSs included the use of Calcium Chloride CaCl2, Kit weight, transparency of Kit components, the maintenance of a closed sterile processing environment and the use of a small centrifuge. Eight CE marked devices for PRP extraction were evaluated: Angel®, Biomed®, Cascade® and Selphyl®, Mag-18®, i-Stem®, MyCells® and Regenlab®. Using a Kit with the PQSs and PQLSs described in this study enables the isolation of A-PRP, thereby meeting consensus quality criteria. As our understanding of Critical Quality Attributes (CQAs) of A-PRP continues to evolve, especially with respect to purity and potency, adjustments to these benchmark PQSs and PQLs will hopefully help isolate A-PRP of desired CQAs with greater reproducibility, quality, and safety. Confirmatory studies will no doubt need to be completed.

Stromal vascular fraction‐enriched platelet‐rich plasma therapy reverses the effects of androgenetic alopecia

2019 ◽  
Vol 19 (5) ◽  
pp. 1078-1085
Author(s):  
Ghazala Butt ◽  
Ijaz Hussain ◽  
Fridoon Jawad Ahmad ◽  
Mahmood S. Choudhery
Keyword(s):  
Platelet Rich Plasma ◽  
Stromal Vascular Fraction ◽  
Androgenetic Alopecia ◽  
Plasma Therapy

scholarly journals Investigating the Safety and Efficacy of Platelet-Rich Plasma (PRP) Treatment for Female Androgenetic Alopecia: Review of the Literature

Medicina ◽  
2021 ◽  
Vol 57 (4) ◽  
pp. 311
Author(s):  
Santo Raffaele Mercuri ◽  
Giovanni Paolino ◽  
Matteo Riccardo Di Nicola ◽  
Laura Vollono
Keyword(s):  
Hair Loss ◽  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Cochrane Central Register ◽  
Review Of The Literature ◽  
Psychosocial Burden ◽  
Female Pattern Hair Loss ◽  
Central Register ◽  
Topical Minoxidil

Background: female androgenetic alopecia (FAGA) is a common cause of non-scarring alopecia in women, affecting approximately 40% of women by age 50, bearing a significant psychosocial burden on affected patients. Platelet-rich plasma (PRP) has been widely investigated as a potential effective treatment for several dermatological conditions, including male androgenetic alopecia (MAGA). However, few studies have been conducted focusing on the use of PRP in FAGA. The aim of this review was to identify reports that investigated the use of PRP for the treatment of FAGA. Methods: Electronic databases of MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to September 2020 have been searched using different combinations of the following terms: “androgenetic alopecia,” “FAGA,” “female pattern hair loss,” “platelet-rich fibrin,” “platelet-rich plasma,” and “PRP”. Results and conclusions: Eight (n = 8) clinical studies consistent with our research were identified. A total of 197 subjects has been enrolled in the included studies. All of them were adult female patients (mean age: 38.9) affected by female pattern hair loss. PRP is a well-tolerated procedure which showed promising results in males-only and mixed populations of AGA patients. PRP showed to produce high levels of satisfaction and improvement in the quality of life in patients affected by FAGA. In the light of this evidence, PRP may be proposed in patients who did not respond or did not tolerate topical minoxidil, as well as in combination with topical and oral treatments.

scholarly journals Evaluation of Quality of Life in Patients with Chronic Leg Wounds: Can Platelet-rich Plasma Therapy Help?

2020 ◽  
Vol 19 (1-2) ◽  
pp. 42-50
Author(s):  
Domantas Rainys ◽  
Adas Čepas ◽  
Rytis Rimdeika
Keyword(s):  
Quality Of Life ◽  
Sleep Disturbance ◽  
Conventional Treatment ◽  
Platelet Rich Plasma ◽  
Control Group ◽  
Analog Scale ◽  
Plasma Therapy ◽  
Wound Exudate ◽  
Sf 36

Aim. The aim of the study was to evaluate and compare the quality of life (QoL) using platelet-rich plasma gel (PRP) and conventional treatment of chronic leg wounds. Methods. Randomized clinical trial was carried out in Hospital of Lithuanian University of Health Sciences Kaunas Clinics during 2014–2018. Patients (n = 69) included in the study were randomly grouped into 2 groups: 1) PRP, 2) Control. SF-36 questionnaire was used to evaluate QoL, visual analog scale was used to evaluate persistent pain associated with ulcer and wound exudate volume was also evaluated. Statistical analysis were performed with SPSS 23.0 package. Results. Patients in PRP group at the end of the treatment rated their QoL over control group patients (p < 0.05). Wound associated pain (PRP – 1.54; control – 2.85; p = 0.015) and pain associated sleep disturbance (p < 0.001) was lower in PRP group patients. Wound exudate volume was lower in PRP group patients at the end of the treatment (p < 0.05). Conclusion. The treatment with PRP is associated with less wound associated pain, less-common sleep disturbance, reduced wound secretion and improved quality of life compared to conventional treatment.

scholarly journals Morphological substantiation of clinical efficacy of platelet rich plasma in males with androgenic alopecia

2018 ◽  
Vol 20 (3) ◽  
pp. 67-71
Author(s):  
E E Pakhomova ◽  
I O Smirnova ◽  
I N Telichko
Keyword(s):  
Clinical Efficacy ◽  
Growth Parameters ◽  
Platelet Rich Plasma ◽  
Hair Follicles ◽  
Androgenetic Alopecia ◽  
Sweat Glands ◽  
Androgenic Alopecia ◽  
Hair Density ◽  
Plasma Therapy ◽  
Four Levels

Morphological substantiation of the clinical efficacy of platelets rich plasma was carried out in the treatment of 22 men with androgenetic alopecia from the 1st to the 4th stage according to the Norwood-Hamilton scale were included. All patients received intradermal injections of platelets rich plasma 0,15 ml per injection. The course of treatment consisted of 4 procedures with an interval of 4 weeks. Clinical efficacy was assessed by the dynamics of morphometric indices of hair growth. Histological examination was carried out on horizontal sections, stained with hematoxylin and eosin, the morphology of the hair was counted at four levels. Evaluation of morphometric growth parameters conducted before treatment and 4 months after the onset of it. It was established that the therapy of platelet-rich plasma has a pronounced clinical efficacy, consisting in a significant (p=0,00025) increase in hair density by 11% and average hair diameter by 10% (p=0,00766), a 14% decrease in the share of hair follicles (p=0,00959). Histologically, the increase in hair density was significant at the level of the bulb of the hair follicles by 148% (p=0,0034) and at the level of the sweat glands by 65% (p=0,0326), and also by the tendency to increase their number at the level of the sebaceous glands. This was combined with a significant decrease in the proportion of telogen hair at 47% (p=0,0153). Thus, the positive clinical effect of plasma-rich plasma therapy in men suffering from androgenetic alopecia is based on reliable morphofunctional changes in the hair follicles.

scholarly journals Comparison of Two Preparation Methods for Platelet-Rich Plasma Eye Drops for Release of Growth Factors and De-Epithelization Rabbit Model

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Tatsuhiko Kobayashi ◽  
Takashi Suzuki ◽  
Tomohiko Saito ◽  
Takashi Itokawa ◽  
Yuichi Hori
Keyword(s):  
Growth Factors ◽  
Corneal Epithelium ◽  
Platelet Rich Plasma ◽  
Rabbit Model ◽  
Corneal Stroma ◽  
Cell Junctions ◽  
Eye Drops ◽  
Preparation Methods ◽  
Double Spin ◽  
Epithelium Thickness

Purpose. To compare two platelet-rich plasma (PRP) preparation methods (double spin (D-PRP) and TriCell PRP (T-PRP)) for eye drops, concentration yields of platelets and other cells, release of growth factors, and efficacy of the de-epithelization rabbit model. Methods. PRP was extracted by D-PRP and T-PRP from 30 ml blood from healthy adults. After extraction, platelets and leukocytes were counted. D-PRP and T-PRP were preserved during A: 1 h storage at room temperature, B: 1 h storage at −20°C, C: 24 h storage at 4°C, and D: 24 h storage at −20°C. Platelet-derived growth factor (PDGF) was measured. Freezing/thawing PRP eye drops and control were instilled in the de-epithelization rabbit model four times per day for 5 days. Histology was compared between eyes treated with control, D-PRP, and T-PRP. Results. 14 ml of D-PRP and 4 ml of T-PRP were extracted from 30 ml whole blood samples. D-PRP and T-PRP had 41.36 ± 8.43 × 104 and 67.02 ± 13.55 × 104 platelets and 0.41 ± 0.24 × 103/ml and 10.09 ± 4.29 × 103/ml leucocytes, respectively. In the four storage methods, PDGF concentrations in T-PRP were higher than those in D-PRP eye drops. Freezing/thawing D-PRP and T-PRP increased PDGF concentrations. Histology showed corneal epithelium thickness in T-PRP-treated eyes after healing (38.41 ± 9.10 μm) was significantly higher than that in control-treated (27.77 ± 4.76 μm) and D-PRP-treated eyes (18.32 ± 3.14 μm) ( P  < 0.05). There was no corneal damage with inflammation in corneal stroma and epithelium of all tested groups. Electron microscopy revealed strong adhesion between cell junctions in T-PRP-treated eyes. Conclusions. Freezing/thawing of PRP extracted with the T-PRP kit may result in high platelet and leukocyte concentration and produce high PDGF concentration. PRP eye drops including leucocytes could increase thickness of corneal epithelium without corneal inflammation.

scholarly journals Platelet-rich plasma therapy for androgenetic alopecia

2019 ◽  
Vol 64 (5) ◽  
pp. 417 ◽  
Author(s):  
VinodK Sharma ◽  
Neetu Bhari ◽  
Suman Patra ◽  
AnitaSingh Parihar
Keyword(s):  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Plasma Therapy
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