Stromal vascular fraction‐enriched platelet‐rich plasma therapy reverses the effects of androgenetic alopecia

2019 ◽  
Vol 19 (5) ◽  
pp. 1078-1085
Author(s):  
Ghazala Butt ◽  
Ijaz Hussain ◽  
Fridoon Jawad Ahmad ◽  
Mahmood S. Choudhery
Keyword(s):  
Platelet Rich Plasma ◽  
Stromal Vascular Fraction ◽  
Androgenetic Alopecia ◽  
Plasma Therapy

scholarly journals Evaluation of using stromal vascular fraction and platelet rich plasma in the treatment of androgenetic alopecia

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A B Osama ◽  
Elfeky K Ahdallah ◽  
E K M Ali ◽  
N A Mamdouh
Keyword(s):  
Side Effects ◽  
Clinical Improvement ◽  
Platelet Rich Plasma ◽  
Stromal Vascular Fraction ◽  
Androgenetic Alopecia ◽  
Serious Adverse Events ◽  
Terminal Hair ◽  
Significant Difference ◽  
Potential Therapeutic Application ◽  
Fraction Versus

Abstract Background Platelet Rich Plasma (PRP) is based on the release of growth factors stimulating the initiation/extension of anagen phase as well as promoting vascularization, Adipose Derived Stem Cell (AT-ADSCs) treatment through injection of stromal vascular fraction were recently introduced as an alternative potential therapeutic application for hair growth. Purpose This study aims to compare the efficacy, safety and adverse effects of using lipo-aspirate stromal vascular fraction versus Platelet Rich Plasma injection in the treatment of Androgenetic Alopecia (AGA). Patients And Methods Forty randomized patients were treated by PRP, and SVF. Each patient was evaluated. And each lesion was treated by those modalities, patients received three sessions with one month interval for 3 months, follow up after 3 months. Results A highly significant improvement <0.001 in terminal hair count of SVF group evaluated by videodermoscopy assessment of AGA. That were confirmed by highly significant improvement in inter-mediate hair count and mean caliber (<0.001) associated with high incidence of side effects especially headache and erythema. In contrast. PRP group showed significant improvement 0.048 in terminal hair count and non-significant improvement in inter-mediate hair count and of mean caliber with minimum side effects. SVF group showed a significant improvement in terminal hair count than PRP and a highly significant improvement in Inter-mediate hair count. Regard the clinical improvement and photographic assessment, SVF evoked upper hand of clinical improvement than PRP without statistically difference. Also, side effects of SVF showed highly significant pain, headache and erythema but no serious adverse events. Our study suggests that was significant improvement in AGA after PRP and highly significant after SVF therapy, with significant difference of SVF in terminal hair count and highly significant in vellus hair. Both modalities could effectively and safely he used to treat AGA. Conclusion our study suggested that there was significant improvement in AGA after both PRP and highly significant after SVF therapy. The results indicated a significant difference between PRP and SVF regarding terminal hair count and highly significant for vellus hair count, but non-significant difference in hair diameter. Both modalities could effectively and safely be used to treat AGA and there was statistically improvement in AGA after both PRP and SVF therapies.

scholarly journals Morphological substantiation of clinical efficacy of platelet rich plasma in males with androgenic alopecia

2018 ◽  
Vol 20 (3) ◽  
pp. 67-71
Author(s):  
E E Pakhomova ◽  
I O Smirnova ◽  
I N Telichko
Keyword(s):  
Clinical Efficacy ◽  
Growth Parameters ◽  
Platelet Rich Plasma ◽  
Hair Follicles ◽  
Androgenetic Alopecia ◽  
Sweat Glands ◽  
Androgenic Alopecia ◽  
Hair Density ◽  
Plasma Therapy ◽  
Four Levels

Morphological substantiation of the clinical efficacy of platelets rich plasma was carried out in the treatment of 22 men with androgenetic alopecia from the 1st to the 4th stage according to the Norwood-Hamilton scale were included. All patients received intradermal injections of platelets rich plasma 0,15 ml per injection. The course of treatment consisted of 4 procedures with an interval of 4 weeks. Clinical efficacy was assessed by the dynamics of morphometric indices of hair growth. Histological examination was carried out on horizontal sections, stained with hematoxylin and eosin, the morphology of the hair was counted at four levels. Evaluation of morphometric growth parameters conducted before treatment and 4 months after the onset of it. It was established that the therapy of platelet-rich plasma has a pronounced clinical efficacy, consisting in a significant (p=0,00025) increase in hair density by 11% and average hair diameter by 10% (p=0,00766), a 14% decrease in the share of hair follicles (p=0,00959). Histologically, the increase in hair density was significant at the level of the bulb of the hair follicles by 148% (p=0,0034) and at the level of the sweat glands by 65% (p=0,0326), and also by the tendency to increase their number at the level of the sebaceous glands. This was combined with a significant decrease in the proportion of telogen hair at 47% (p=0,0153). Thus, the positive clinical effect of plasma-rich plasma therapy in men suffering from androgenetic alopecia is based on reliable morphofunctional changes in the hair follicles.

scholarly journals Platelet-rich plasma therapy for androgenetic alopecia

2019 ◽  
Vol 64 (5) ◽  
pp. 417 ◽  
Author(s):  
VinodK Sharma ◽  
Neetu Bhari ◽  
Suman Patra ◽  
AnitaSingh Parihar
Keyword(s):  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Plasma Therapy

scholarly journals The efficacy of platelet-rich plasma therapy in the treatment of androgenetic alopecia: a literature review

2020 ◽  
Vol 23 (4) ◽  
pp. 252-257
Author(s):  
A. A. Lepehova ◽  
Maria B. Potapova
Keyword(s):  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
High Tolerance ◽  
Plasma Therapy ◽  
Preparation Methods ◽  
Double Spin ◽  
Current Review ◽  
New Treatment ◽  
Genetically Determined

Androgenetic alopecia is a genetically determined disease characterized by gradual thinning of hair, which subsequently leads to hair loss, and thereby significantly affects a patients quality of life. The existing methods of disease management have a number of side effects and drawbacks. Thus, new treatment methods combining both high tolerance and efficacy are continuously determined. This current review presents an analysis of the effectiveness of single- and double-spin preparation methods of platelet-rich plasma for the management of patients with androgenetic alopecia.

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