scholarly journals EFFECT OF LONG-TERM LOW-INTENSITY IONIZING RADIATION AND COLD FACTOR ON MORPHOFUNCTIONAL INDICATORS OF THE ADRENAL CORTEX IN MOUSSEID RODS

2021 ◽  
pp. 59
Author(s):  
Ольга Владимировна Ермакова ◽  
Olga Ermakova
Keyword(s):  
Ionizing Radiation ◽  
Adrenal Cortex ◽  
Low Intensity

Amifostine-Loaded Dissolving Armored Microneedles for Long-Term Prevention of Ionizing Radiation-Induced Injury

2020 ◽  
Author(s):  
Xiang Yu ◽  
Minshu Li ◽  
Lin Zhu ◽  
Jingfei li ◽  
Guoli Zhang ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Radiation Induced

scholarly journals Effect of ionizing radiation on human skeletal muscle precursor cells

2013 ◽  
Vol 47 (4) ◽  
pp. 376-381 ◽  
Author(s):  
Mihaela Jurdana ◽  
Maja Cemazar ◽  
Katarina Pegan ◽  
Tomaz Mars
Keyword(s):  
Skeletal Muscle ◽  
Stress Response ◽  
Ionizing Radiation ◽  
Human Skeletal Muscle ◽  
Long Term Effects ◽  
Post Irradiation ◽  
Acute Response ◽  
Proliferation Capacity ◽  
Myoblast Proliferation

Abstract Background. Long term effects of different doses of ionizing radiation on human skeletal muscle myoblast proliferation, cytokine signalling and stress response capacity were studied in primary cell cultures. Materials and methods. Human skeletal muscle myoblasts obtained from muscle biopsies were cultured and irradiated with a Darpac 2000 X-ray unit at doses of 4, 6 and 8 Gy. Acute effects of radiation were studied by interleukin - 6 (IL-6) release and stress response detected by the heat shock protein (HSP) level, while long term effects were followed by proliferation capacity and cell death. Results. Compared with non-irradiated control and cells treated with inhibitor of cell proliferation Ara C, myoblast proliferation decreased 72 h post-irradiation, this effect was more pronounced with increasing doses. Post-irradiation myoblast survival determined by measurement of released LDH enzyme activity revealed increased activity after exposure to irradiation. The acute response of myoblasts to lower doses of irradiation (4 and 6 Gy) was decreased secretion of constitutive IL-6. Higher doses of irradiation triggered a stress response in myoblasts, determined by increased levels of stress markers (HSPs 27 and 70). Conclusions. Our results show that myoblasts are sensitive to irradiation in terms of their proliferation capacity and capacity to secret IL-6. Since myoblast proliferation and differentiation are a key stage in muscle regeneration, this effect of irradiation needs to be taken in account, particularly in certain clinical conditions.

scholarly journals Comprehensive Detection, Grading, and Growth Behavior Evaluation of Subthreshold and Low Intensity Photocoagulation Lesions by Optical Coherence Tomographic and Infrared Image Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Stefan Koinzer ◽  
Amke Caliebe ◽  
Lea Portz ◽  
Mark Saeger ◽  
Yoko Miura ◽  
...  
Keyword(s):  
Treatment Efficacy ◽  
Clinical Effect ◽  
Infrared Image ◽  
Growth Behavior ◽  
Retinal Damage ◽  
Optical Coherence ◽  
Retinal Area ◽  
Low Intensity ◽  
Irradiation Power

Purpose. To correlate the long-term clinical effect of photocoagulation lesions after 6 months, as measured by their retinal damage size, to exposure parameters. We used optical coherence tomographic (OCT)-based lesion classes in order to detect and assess clinically invisible and mild lesions.Methods. In this prospective study, 488 photocoagulation lesions were imaged in 20 patients. We varied irradiation diameters (100/300 µm), exposure-times (20–200 ms), and power. Intensities were classified in OCT images after one hour, and we evaluated OCT and infrared (IR) images over six months after exposure.Results. For six consecutive OCT-based lesion classes, the following parameters increased with the class: ophthalmoscopic, OCT and IR visibility rate, fundus and OCT diameter, and IR area, but not irradiation power. OCT diameters correlated with exposure-time, irradiation diameter, and OCT class. OCT classes discriminated the largest bandwidth of OCT diameters.Conclusion. OCT classes represent objective and valid endpoints of photocoagulation intensity even for “subthreshold” intensities. They are suitable to calculate the treated retinal area. As the area is critical for treatment efficacy, OCT classes are useful to define treatment intensity, calculate necessary lesion numbers, and universally categorize lesions in clinical studies.

Long-term cytogenetic follow-up studies on humans after internal and external exposures to ionizing radiation

2021 ◽  
Author(s):  
Adayabalam Sambasivan Balajee ◽  
Gordon K Livingston ◽  
Maria B Escalona ◽  
Terri L Ryan ◽  
Ronald E Goans ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Follow Up Studies ◽  
External Exposures

Cell and Tissue Damage after Skin Exposure to Ionizing Radiation: Short- and Long-Term Effects after a Single and Fractional Doses

2014 ◽  
Vol 200 (3-4) ◽  
pp. 240-252 ◽  
Author(s):  
Kahori Kinoshita ◽  
Hisako Ishimine ◽  
Kenshiro Shiraishi ◽  
Harunosuke Kato ◽  
Kentaro Doi ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Tissue Damage ◽  
Long Term Effects ◽  
Skin Exposure ◽  
Short And Long Term

scholarly journals Effects of Ionizing Radiation and Long-Term Storage on Hydrated vs. Dried Cell Samples of Extremophilic Microorganisms

2022 ◽  
Vol 10 (1) ◽  
pp. 190
Author(s):  
Ida Romano ◽  
Carlo Camerlingo ◽  
Lisa Vaccari ◽  
Giovanni Birarda ◽  
Annarita Poli ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Galactic Cosmic Rays ◽  
Cellular Growth ◽  
Space Environment ◽  
Water Medium ◽  
Space Condition ◽  
Long Term Storage ◽  
Extremophilic Microorganisms ◽  
Term Storage

A main factor hampering life in space is represented by high atomic number nuclei and energy (HZE) ions that constitute about 1% of the galactic cosmic rays. In the frame of the “STARLIFE” project, we accessed the Heavy Ion Medical Accelerator (HIMAC) facility of the National Institute of Radiological Sciences (NIRS) in Chiba, Japan. By means of this facility, the extremophilic species Haloterrigena hispanica and Parageobacillus thermantarcticus were irradiated with high LET ions (i.e., Fe, Ar, and He ions) at doses corresponding to long permanence in the space environment. The survivability of HZE-treated cells depended upon either the storage time and the hydration state during irradiation; indeed, dry samples were shown to be more resistant than hydrated ones. With particular regard to spores of the species P. thermantarcticus, they were the most resistant to irradiation in a water medium: an analysis of the changes in their biochemical fingerprinting during irradiation showed that, below the survivability threshold, the spores undergo to a germination-like process, while for higher doses, inactivation takes place as a consequence of the concomitant release of the core’s content and a loss of integrity of the main cellular components. Overall, the results reported here suggest that the selected extremophilic microorganisms could serve as biological model for space simulation and/or real space condition exposure, since they showed good resistance to ionizing radiation exposure and were able to resume cellular growth after long-term storage.

Conclusion

2018 ◽  
pp. 273-289
Author(s):  
Sudha Pai ◽  
Sajjan Kumar
Keyword(s):  
Social Inequalities ◽  
Right Wing ◽  
Profound Change ◽  
Grass Roots ◽  
Low Intensity ◽  
The Relationship

The book concludes that the pattern of communalism and riots in the 2000s marks a new chapter in UP society. The reasons lie in momentous changes within UP society, and a ‘new’ BJP, its leadership, re-invented ideology and strategies. Our model of ‘institutionalization of everyday communalism’ suggests that the relationship between communalism and riots has undergone profound change: it is not riots that promote communalism; rather it is the steady and long-term work at the grass roots by right-wing forces that promotes the growth of constant communal tension. Rather than big riots, the aim is to communalize trivial, daily incidents and create small, low-intensity, calibrated incidents whose purpose is to create deep-seated Hindu–Muslim polarization. UP with its divisive communal past, economic backwardness, pervasive social inequalities, continuing conservative outlook and entrenched caste/communal identities, has produced a specific variant of communalism that will impact on the democratic fabric of our country.

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