Amifostine-Loaded Dissolving Armored Microneedles for Long-Term Prevention of Ionizing Radiation-Induced Injury

2020 ◽  
Author(s):  
Xiang Yu ◽  
Minshu Li ◽  
Lin Zhu ◽  
Jingfei li ◽  
Guoli Zhang ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Radiation Induced

Amifostine-loaded armored dissolving microneedles for long-term prevention of ionizing radiation-induced injury

2020 ◽  
Vol 112 ◽  
pp. 87-100 ◽  
Author(s):  
Xiang Yu ◽  
Minshu Li ◽  
Lin Zhu ◽  
Jingfei Li ◽  
Guoli Zhang ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Dissolving Microneedles ◽  
Radiation Induced

scholarly journals Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status

Aging Cell ◽  
2010 ◽  
Vol 9 (3) ◽  
pp. 398-409 ◽  
Author(s):  
Oanh N. L. Le ◽  
Francis Rodier ◽  
Francois Fontaine ◽  
Jean-Philippe Coppe ◽  
Judith Campisi ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Immune Status ◽  
Radiation Induced

Ionizing radiation induced long-term alterations in the adult rat rostral migratory stream

2014 ◽  
Vol 116 (1) ◽  
pp. 265-271 ◽  
Author(s):  
Sona Balentova ◽  
Eva Hajtmanova ◽  
Ria Trylcova ◽  
Marian Adamkov ◽  
Jan Lehotsky
Keyword(s):  
Ionizing Radiation ◽  
Rostral Migratory Stream ◽  
Adult Rat ◽  
Radiation Induced ◽  
Migratory Stream

scholarly journals CHORNOBYL CATASTROPHE: CYTOGENETIC EFFECTS OF LOW DOSE IONIZING RADIATION AND THEIR MODIFICATION

2016 ◽  
Vol 38 (4) ◽  
pp. 219-223 ◽  
Author(s):  
E A Domina
Keyword(s):  
Ionizing Radiation ◽  
Low Dose ◽  
Peripheral Blood Lymphocytes ◽  
Long Term Effects ◽  
Cytogenetic Effects ◽  
Exposed Population ◽  
Radiation Induced ◽  
Established Fact ◽  
Relative Biologic Effectiveness

Among the long-term effects of the Chornobyl disaster the greatest concern of international medical and scientific community is given to the established fact of excess of the spontaneous level of cancer incidence in the exposed population. According to modern concepts, the accumulation of chromosome aberrations, especially in radiosensitive cells, could be potentially oncogenic, and low doses of ionizing radiation could be promoters of the radiation-induced carcinogenesis. The results of our studies have shown that such substances as thymalin, inosine, ascorbic acid, caffeine could modify radiation-induced cytogenetic effects in peripheral blood lymphocytes of healthy individuals and exert protective or sensitizing action dependent on their concentrations, cell radiosensitivity, dose of irradiation, and relative biologic effectiveness of ionizing radiation. This article is part of a Special Issue entitled “The Chornobyl Nuclear Accident: Thirty Years After”.

Radiation-induced surface decomposition

1983 ◽  
Vol 41 ◽  
pp. 368-369
Author(s):  
M. L. Knotek
Keyword(s):  
Ionizing Radiation ◽  
Atomic Structure ◽  
Chemical Bonding ◽  
Neutral Species ◽  
Radiation Induced ◽  
Physical And Chemical ◽  
Surface Decomposition ◽  
The Relationship ◽  
Electron And Photon ◽  
Surface Bond

Modern surface analysis is based largely upon the use of ionizing radiation to probe the electronic and atomic structure of the surfaces physical and chemical makeup. In many of these studies the ionizing radiation used as the primary probe is found to induce changes in the structure and makeup of the surface, especially when electrons are employed. A number of techniques employ the phenomenon of radiation induced desorption as a means of probing the nature of the surface bond. These include Electron- and Photon-Stimulated Desorption (ESD and PSD) which measure desorbed ionic and neutral species as they leave the surface after the surface has been excited by some incident ionizing particle. There has recently been a great deal of activity in determining the relationship between the nature of chemical bonding and its susceptibility to radiation damage.

Spinal meningioma after treatment for Hodgkin disease

2001 ◽  
Vol 95 (2) ◽  
pp. 232-235 ◽  
Author(s):  
Andrew J. Martin ◽  
Christopher J. Hammond ◽  
H. Jane Dobbs ◽  
Safa Al-Sarraj ◽  
Nicholas W. M. Thomas
Keyword(s):  
Hodgkin Disease ◽  
Second Primary ◽  
Combined Modality Treatment ◽  
Spinal Meningioma ◽  
Primary Tumors ◽  
Content Type ◽  
Radiation Induced ◽  
Mutagenic Effects ◽  
Long Term Survivors

✓ Long-term survivors of Hodgkin disease may develop second primary tumors caused by the mutagenic effects of radio- and chemotherapy. The authors describe the case of a 35-year-old woman who presented with an unusual meningioma of the cervical spine 9 years after undergoing combined-modality treatment for Hodgkin disease. To the authors' knowledge, this is the first report of spinal meningioma as a complication of such therapy. Whereas radiation-induced intracranial meningiomas are well described in the literature, treatment-induced meningiomas of the spine have not been widely recognized.

Evaluation of the Radioprotective Effects of Melatonin Against Ionizing Radiation-Induced Muscle Tissue Injury

2019 ◽  
Vol 12 (3) ◽  
pp. 247-255 ◽  
Author(s):  
Dheyauldeen Shabeeb ◽  
Mansoor Keshavarz ◽  
Alireza Shirazi ◽  
Gholamreza Hassanzadeh ◽  
Mohammed Reza Hadian ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Gastrocnemius Muscle ◽  
Tissue Injury ◽  
Histopathological Examination ◽  
Compound Action Potential ◽  
Optimal Dose ◽  
Treatment Method ◽  
Major Product ◽  
Muscle Tissues ◽  
Radiation Induced

Background: Radiotherapy (RT) is a treatment method for cancer using ionizing radiation (IR). The interaction between IR with tissues produces free radicals that cause biological damages.As the largest organ in the human body, the skeletal muscles may be affected by detrimental effects of ionizing radiation. To eliminate these side effects, we used melatonin, a major product secreted by the pineal gland in mammals, as a radioprotective agent. Materials and Methods: For this study, a total of sixty male Wistar rats were used. They were allotted to 4 groups: control (C), melatonin (M), radiation (R) and melatonin + radiation (MR). Rats’ right hind legs were irradiated with 30 Gy single dose of gamma radiation, while 100 mg/kg of melatonin was given to them 30 minutes before irradiation and 5 mg/ kg once daily afternoon for 30 days. Five rats in each group were sacrificed 4, 12 and 20 weeks after irradiation for histological and biochemical examinations. Results: Our results showed radiation-induced biochemical, histological and electrophysiological changes in normal rats’ gastrocnemius muscle tissues. Biochemical analysis showed that malondialdehyde (MDA) levels significantly elevated in R group (P<0.001) and reduced significantly in M and MR groups after 4, 12, and 20 weeks (P<0.001), However, the activity of catalase (CAT) and superoxide dismutase(SOD)decreased in the R group and increased in M and MR groups for the same periods of time compared with the C group (P<0.001), while melatonin administration inverted these effects( P<0.001).Histopathological examination showed significant differences between R group for different parameters compared with other groups (P<0.001). However, the administration of melatonin prevented these effects(P<0.001). Electromyography (EMG) examination showed that the compound action potential (CMAP) value in the R group was significantly reduced compared to the effects in the C and M groups after 12 and 20 weeks (P<0.001). The administration of melatonin also reversed these effects (P<0.001). Conclusion: Melatonin can improve biochemical, electrophysiological and morphological features of irradiated gastrocnemius muscle tissues.Our recommendation is that melatonin should be administered in optimal dose. For effective protection of muscle tissues, and increased therapeutic ratio of radiation therapy, this should be done within a long period of time.

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