scholarly journals Review: The role of leukaemia inhibitory factor in the establishment of pregnancy

1999 ◽  
Vol 160 (2) ◽  
pp. 181-190 ◽  
Author(s):  
D Vogiagis ◽  
LA Salamonsen
Keyword(s):  
Fetal Development ◽  
Potential Role ◽  
Mammalian Species ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Blastocyst Implantation ◽  
Important Cytokine

Leukaemia inhibitory factor (LIF) is a pleiotrophic cytokine required for blastocyst implantation in mice. Uterine expression of LIF and that of its receptors has been demonstrated in a number of mammalian species indicating that LIF may have widespread importance in the establishment of pregnancy. The variations in the reaction of the uterus in preparation for and during implantation are considerable between species and understanding the differences and similarities assists in the interpretation of how this cytokine functions. Recent studies suggest that reduced endometrial LIF contributes to human infertility. Studies also demonstrate a potential role in placentation and fetal development. Thus, LIF has become an important cytokine warranting further investigation in the human. It is anticipated that when the mechanisms underlying normal embryonic and endometrial development are elucidated, fertility and infertility will be more precisely understood and hence able to be effectively controlled.

scholarly journals Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Naguib Salleh ◽  
Nelli Giribabu
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Growth And Development ◽  
Immune Modulation ◽  
Embryo Implantation ◽  
Critical Role ◽  
Inhibitory Factor ◽  
Trophoblast Invasion ◽  
Leukaemia Inhibitory Factor ◽  
Multiple Processes

Leukaemia inhibitory factor (LIF) plays an indispensible role in embryo implantation. Aberrant LIF production is linked to implantation failure. LIF regulates multiple processes prior to and during implantation such as uterine transformation into a receptive state, decidualization, blastocyst growth and development, embryo-endometrial interaction, trophoblast invasion, and immune modulation. Due to its critical role, LIF has been a target for a nonhormonal contraception. In this review, we summarize up-to-date information on the role of LIF in implantation and its role in contraception.

scholarly journals Leukaemia inhibitory factor in implantation and uterine biology

Reproduction ◽  
2005 ◽  
Vol 130 (2) ◽  
pp. 131-145 ◽  
Author(s):  
Susan J Kimber
Keyword(s):  
Knockout Mouse ◽  
Reproductive Tract ◽  
Inhibitory Factor ◽  
Glandular Epithelium ◽  
Leukaemia Inhibitory Factor ◽  
Luminal Epithelium

Leukaemia inhibitory factor (LIF) is one of the most important cytokines in the reproductive tract. Without expression of LIF in the uterus, implantation of a blastocyst cannot begin. Yet, 13 years after publication of the phenotype of the LIF knockout mouse we are only just beginning to understand how LIF functions in the uterus. This review addresses our knowledge of the role of LIF in regulating implantation through its influence on the luminal epithelium and stromal decidualization, but also its influence on reproductive tract cells such as leukocytes and glandular epithelium, during the pre-implantation phase of pregnancy.

scholarly journals Receptor-Dependent Coronavirus Infection of Dendritic Cells

2004 ◽  
Vol 78 (10) ◽  
pp. 5486-5490 ◽  
Author(s):  
Brian C. Turner ◽  
Erin M. Hemmila ◽  
Nicole Beauchemin ◽  
Kathryn V. Holmes
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Immune Modulation ◽  
Potential Role ◽  
Mammalian Species ◽  
Dc Line ◽  
Coronavirus Infection ◽  
Dependent Pathway ◽  
Murine Coronavirus

ABSTRACT In several mammalian species, including humans, coronavirus infection can modulate the host immune response. We show a potential role of dendritic cells (DC) in murine coronavirus-induced immune modulation and pathogenesis by demonstrating that the JAW SII DC line and primary DC from BALB/c mice and p/p mice with reduced expression of the murine coronavirus receptor, murine CEACAM1a, are susceptible to murine coronavirus infection by a receptor-dependent pathway.

Potential role of microRNAs in mammalian female fertility

2017 ◽  
Vol 29 (1) ◽  
pp. 8 ◽  
Author(s):  
Dawit Tesfaye ◽  
Dessie Salilew-Wondim ◽  
Samuel Gebremedhn ◽  
Md Mahmodul Hasan Sohel ◽  
Hari Om Pandey ◽  
...  
Keyword(s):  
Embryo Development ◽  
Oocyte Maturation ◽  
Potential Role ◽  
Mammalian Species ◽  
Female Fertility ◽  
Conditional Knockout ◽  
Female Reproduction ◽  
Extracellular Mirnas ◽  
Mammalian Female

Since the first evidence for the involvement of microRNAs (miRNAs) in various reproductive processes through conditional knockout of DICER, several studies have been conducted to investigate the expression pattern and role of miRNAs in ovarian follicular development, oocyte maturation, embryo development, embryo–maternal communication, pregnancy establishment and various reproductive diseases. Although advances in sequencing technology have fuelled miRNA studies in mammalian species, the presence of extracellular miRNAs in various biological fluids, including follicular fluid, blood plasma, urine and milk among others, has opened a new door in miRNA research for their use as diagnostic markers. This review presents data related to the identification and expression analysis of cellular miRNA in mammalian female fertility associated with ovarian folliculogenesis, oocyte maturation, preimplantation embryo development and embryo implantation. In addition, the relevance of miRNAs to female reproductive disorders, including polycystic ovary syndrome (PCOS), endometritis and abnormal pregnancies, is discussed for various mammalian species. Most importantly, the mechanism of release and the role of extracellular miRNAs in cell–cell communication and their potential role as non-invasive markers in female fertility are discussed in detail. Understanding this layer of regulation in female reproduction processes will pave the way to understanding the genetic regulation of female fertility in mammalian species.

To implant or not to implant: the role of leukaemia inhibitory factor

2005 ◽  
pp. 185-202
Author(s):  
Susan J Kimber ◽  
Ali A Fouladi-Nashta ◽  
Lisa Mohamet ◽  
Carolyn Jp Jones ◽  
Gemma Schofield
Keyword(s):  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor

scholarly journals The potential role of stem cell factor and its receptor c-kit in the mouse blastocyst implantation

1999 ◽  
Vol 5 (9) ◽  
pp. 874-879 ◽  
Author(s):  
Masahiro Mitsunari ◽  
Tasuku Harada ◽  
Masahiro Tanikawa ◽  
Tomio Iwabe ◽  
Fuminori Taniguchi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Factor ◽  
Potential Role ◽  
Mouse Blastocyst ◽  
Blastocyst Implantation

Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

Nature ◽  
1992 ◽  
Vol 359 (6390) ◽  
pp. 76-79 ◽  
Author(s):  
Colin L. Stewart ◽  
Petr Kaspar ◽  
Lisa J. Brunet ◽  
Harshida Bhatt ◽  
Inder Gadi ◽  
...  
Keyword(s):  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Maternal Expression ◽  
Blastocyst Implantation

The effect of leukaemia inhibitory factor (LIF) on embryogenesis

1992 ◽  
Vol 4 (4) ◽  
pp. 449 ◽  
Author(s):  
RC Fry
Keyword(s):  
Embryonic Stem ◽  
Implantation Rate ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Leukaemia Cell ◽  
Embryo Survival ◽  
Murine Embryonic Stem Cells ◽  
Therapeutic Uses ◽  
Blastocyst Implantation

Leukaemia inhibitory factor (LIF) was originally identified as a haemopoetic factor that induced the differentiation of certain myeloid leukaemia cell lines. In contrast to this action, LIF was subsequently shown to inhibit the spontaneous differentiation of murine embryonic stem cells in culture, thus maintaining their pluripotency and ability to contribute to the germline of chimaeric mice. In the mouse, mRNA for LIF is expressed by the endometrial glands of the uterus coincident with the time of blastocyst implantation and receptors have been found on the preimplantation blastocyst. The signal for LIF expression appears to be of maternal origin, perhaps regulated by oestradiol. Recombinant LIF improves the development of murine and ovine blastocysts in culture although there is some species specificity with respect to the type of LIF that is bioactive. It is proposed here that LIF acts on the trophectoderm of the rapidly expanding blastocyst and improves the implantation rate of otherwise compromised embryos. Further studies in livestock should elicit therapeutic uses for LIF in embryo culture, embryo transfer and embryo survival in vivo.

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