scholarly journals Leukaemia inhibitory factor in implantation and uterine biology

Reproduction ◽  
2005 ◽  
Vol 130 (2) ◽  
pp. 131-145 ◽  
Author(s):  
Susan J Kimber
Keyword(s):  
Knockout Mouse ◽  
Reproductive Tract ◽  
Inhibitory Factor ◽  
Glandular Epithelium ◽  
Leukaemia Inhibitory Factor ◽  
Luminal Epithelium

Leukaemia inhibitory factor (LIF) is one of the most important cytokines in the reproductive tract. Without expression of LIF in the uterus, implantation of a blastocyst cannot begin. Yet, 13 years after publication of the phenotype of the LIF knockout mouse we are only just beginning to understand how LIF functions in the uterus. This review addresses our knowledge of the role of LIF in regulating implantation through its influence on the luminal epithelium and stromal decidualization, but also its influence on reproductive tract cells such as leukocytes and glandular epithelium, during the pre-implantation phase of pregnancy.

scholarly journals Leukemia Inhibitory Factor: Roles in Embryo Implantation and in Nonhormonal Contraception

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Naguib Salleh ◽  
Nelli Giribabu
Keyword(s):  
Leukemia Inhibitory Factor ◽  
Growth And Development ◽  
Immune Modulation ◽  
Embryo Implantation ◽  
Critical Role ◽  
Inhibitory Factor ◽  
Trophoblast Invasion ◽  
Leukaemia Inhibitory Factor ◽  
Multiple Processes

Leukaemia inhibitory factor (LIF) plays an indispensible role in embryo implantation. Aberrant LIF production is linked to implantation failure. LIF regulates multiple processes prior to and during implantation such as uterine transformation into a receptive state, decidualization, blastocyst growth and development, embryo-endometrial interaction, trophoblast invasion, and immune modulation. Due to its critical role, LIF has been a target for a nonhormonal contraception. In this review, we summarize up-to-date information on the role of LIF in implantation and its role in contraception.

scholarly journals Review: The role of leukaemia inhibitory factor in the establishment of pregnancy

1999 ◽  
Vol 160 (2) ◽  
pp. 181-190 ◽  
Author(s):  
D Vogiagis ◽  
LA Salamonsen
Keyword(s):  
Fetal Development ◽  
Potential Role ◽  
Mammalian Species ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Blastocyst Implantation ◽  
Important Cytokine

Leukaemia inhibitory factor (LIF) is a pleiotrophic cytokine required for blastocyst implantation in mice. Uterine expression of LIF and that of its receptors has been demonstrated in a number of mammalian species indicating that LIF may have widespread importance in the establishment of pregnancy. The variations in the reaction of the uterus in preparation for and during implantation are considerable between species and understanding the differences and similarities assists in the interpretation of how this cytokine functions. Recent studies suggest that reduced endometrial LIF contributes to human infertility. Studies also demonstrate a potential role in placentation and fetal development. Thus, LIF has become an important cytokine warranting further investigation in the human. It is anticipated that when the mechanisms underlying normal embryonic and endometrial development are elucidated, fertility and infertility will be more precisely understood and hence able to be effectively controlled.

To implant or not to implant: the role of leukaemia inhibitory factor

2005 ◽  
pp. 185-202
Author(s):  
Susan J Kimber ◽  
Ali A Fouladi-Nashta ◽  
Lisa Mohamet ◽  
Carolyn Jp Jones ◽  
Gemma Schofield
Keyword(s):  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor

Expression of leukaemia inhibitory factor at the conceptus–maternal interface during preimplantation development and in the endometrium during the oestrous cycle in the mare

2016 ◽  
Vol 28 (10) ◽  
pp. 1642 ◽  
Author(s):  
M. de Ruijter-Villani ◽  
C. Deelen ◽  
T. A. E. Stout
Keyword(s):  
Early Pregnancy ◽  
Critical Role ◽  
Endometrial Receptivity ◽  
Oestrous Cycle ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Luminal Epithelium ◽  
Signal Transducer ◽  
Blastocyst Development ◽  
Mrna And Protein Expression

Leukaemia inhibitory factor (LIF) plays a critical role in blastocyst development and implantation in several species. The present study investigated mRNA and protein expression for LIF, as well as the low-affinity LIF receptor (LIFR) and interleukin-6 signal transducer (IL6ST), in equine endometrium, trophoblast and histotroph during early pregnancy and in the endometrium during the oestrous cycle. Endometrial LIF mRNA expression was upregulated after Day 21 of pregnancy, whereas LIF immunoreactivity increased in the endometrium on Day 28. Expression of LIF mRNA in the yolk sac membrane increased from Day 21 of pregnancy, whereas LIF immunoreactivity increased from Day 28 in the trophoblast. LIFR and IL6ST mRNA was expressed in the endometrium during both the oestrous cycle and early pregnancy and, although LIFR and IL6ST protein were localised to the glandular epithelium during the cycle and first 14 days of pregnancy, from Day 21 they were located in the luminal epithelium. Trophoblast expression of LIFR and IL6ST increased as pregnancy proceeded. In conclusion, LIF expression increased at the conceptus–maternal interface during capsule attenuation. Because contemporaneous upregulation of both LIFR and IL6ST was also observed in the trophoblast, we propose that LIF plays an important role in the development of endometrial receptivity for trophoblast growth, apposition and adhesion in mares.

Role of leukaemia inhibitory factor in the induction of pluripotent stem cells in mice

2010 ◽  
Vol 34 (8) ◽  
pp. 791-797 ◽  
Author(s):  
Jie Xu ◽  
Feng Wang ◽  
Zhouping Tang ◽  
Yanqiang Zhan ◽  
Jinping Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor

Leukaemia inhibitory factor mediated proliferation of HTR-8/SVneo trophoblast cells is dependent on activation of extracellular signal-regulated kinase 1/2

2011 ◽  
Vol 23 (5) ◽  
pp. 714 ◽  
Author(s):  
Golla Jaya Prakash ◽  
Pankaj Suman ◽  
Diana M. Morales Prieto ◽  
Udo R. Markert ◽  
Satish K. Gupta
Keyword(s):  
Embryo Implantation ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Signal Transducer ◽  
Extracellular Signal Regulated Kinase ◽  
Cell Numbers ◽  
Extracellular Signal ◽  
M Phase ◽  
Stimulation Of

Leukaemia inhibitory factor (LIF) is one of the cytokines that is indispensable for embryo implantation. The aim of the present study was to investigate the role of activation of extracellular signal-regulated kinase (ERK) 1/2 in LIF-mediated proliferation of HTR-8/SVneo cells. Stimulation of HTR-8/SVneo cells with LIF (50 ng mL–1) resulted in an increase in cell proliferation (P < 0.05) via increased transition of cells to the G2/M phase of cell cycle. Stimulation with LIF resulted in the activation of both signal transducer and activator of transcription (STAT) 3 Tyr705 and ERK1/2, but inhibition of ERK1/2 signalling by pretreatment of cells with U0126 (10 µM) for 2 h resulted in abrogation of LIF-mediated increases in G2/M transition, with a significant decrease (P < 0.05) in absolute cell numbers compared with control. Although STAT3 silencing had no effect on LIF-dependent proliferation of HTR-8/SVneo cells, it did result in an increase in cell apoptosis, which increased further upon inhibition of ERK1/2 activation irrespective of LIF stimulation. Stimulation of cells with LIF increased the Bcl-2/Bax ratio, whereas ERK1/2 inhibition decreased the Bcl-2/Bax ratio, even after LIF stimulation. Hence, it can be inferred that ERK1/2 activation is essential for LIF-mediated increases in proliferation and that both STAT3 and ERK1/2 activation are important for the survival of HTR-8/SVneo cells.

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