Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

Nature ◽  
1992 ◽  
Vol 359 (6390) ◽  
pp. 76-79 ◽  
Author(s):  
Colin L. Stewart ◽  
Petr Kaspar ◽  
Lisa J. Brunet ◽  
Harshida Bhatt ◽  
Inder Gadi ◽  
...  
Keyword(s):  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Maternal Expression ◽  
Blastocyst Implantation

scholarly journals Review: The role of leukaemia inhibitory factor in the establishment of pregnancy

1999 ◽  
Vol 160 (2) ◽  
pp. 181-190 ◽  
Author(s):  
D Vogiagis ◽  
LA Salamonsen
Keyword(s):  
Fetal Development ◽  
Potential Role ◽  
Mammalian Species ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Blastocyst Implantation ◽  
Important Cytokine

Leukaemia inhibitory factor (LIF) is a pleiotrophic cytokine required for blastocyst implantation in mice. Uterine expression of LIF and that of its receptors has been demonstrated in a number of mammalian species indicating that LIF may have widespread importance in the establishment of pregnancy. The variations in the reaction of the uterus in preparation for and during implantation are considerable between species and understanding the differences and similarities assists in the interpretation of how this cytokine functions. Recent studies suggest that reduced endometrial LIF contributes to human infertility. Studies also demonstrate a potential role in placentation and fetal development. Thus, LIF has become an important cytokine warranting further investigation in the human. It is anticipated that when the mechanisms underlying normal embryonic and endometrial development are elucidated, fertility and infertility will be more precisely understood and hence able to be effectively controlled.

The effect of leukaemia inhibitory factor (LIF) on embryogenesis

1992 ◽  
Vol 4 (4) ◽  
pp. 449 ◽  
Author(s):  
RC Fry
Keyword(s):  
Embryonic Stem ◽  
Implantation Rate ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Leukaemia Cell ◽  
Embryo Survival ◽  
Murine Embryonic Stem Cells ◽  
Therapeutic Uses ◽  
Blastocyst Implantation

Leukaemia inhibitory factor (LIF) was originally identified as a haemopoetic factor that induced the differentiation of certain myeloid leukaemia cell lines. In contrast to this action, LIF was subsequently shown to inhibit the spontaneous differentiation of murine embryonic stem cells in culture, thus maintaining their pluripotency and ability to contribute to the germline of chimaeric mice. In the mouse, mRNA for LIF is expressed by the endometrial glands of the uterus coincident with the time of blastocyst implantation and receptors have been found on the preimplantation blastocyst. The signal for LIF expression appears to be of maternal origin, perhaps regulated by oestradiol. Recombinant LIF improves the development of murine and ovine blastocysts in culture although there is some species specificity with respect to the type of LIF that is bioactive. It is proposed here that LIF acts on the trophectoderm of the rapidly expanding blastocyst and improves the implantation rate of otherwise compromised embryos. Further studies in livestock should elicit therapeutic uses for LIF in embryo culture, embryo transfer and embryo survival in vivo.

Leukaemia inhibitory factor in human endometrium throughout the menstrual cycle

1996 ◽  
Vol 148 (1) ◽  
pp. 95-102 ◽  
Author(s):  
D Vogiagis ◽  
M M Marsh ◽  
R C Fry ◽  
L A Salamonsen
Keyword(s):  
Menstrual Cycle ◽  
Blot Analysis ◽  
Messenger Rna ◽  
Northern Blot Analysis ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Blastocyst Implantation ◽  
Secretory Tissue ◽  
Endometrial Epithelium ◽  
Rna Transcript

Abstract Leukaemia inhibitory factor (LIF) is a pleiotropic cytokine previously demonstrated to be essential for blastocyst implantation in mice. Samples of endometrium from normal cyclic women throughout the menstrual cycle were tested for LIF messenger RNA by Northern blot analysis and the corresponding protein was localised immunohistochemically with a polyclonal antibody to LIF. Western blot analysis detected a 45 kDa LIF protein in an extract from late secretory tissue. The expression of LIF messenger RNA transcript was detected only during the mid and late secretory phases of the cycle after day 20. Immunoreactive LIF was observed in all human endometrial samples. In the stroma there were moderate to high levels of immunohistochemical staining throughout the cycle with considerable variation between individuals but no cyclical variation. Epithelial staining, both luminal and glandular, was also present throughout the cycle but this was relatively low in the proliferative phase and strongest in the mid to late secretory phases. The marked cyclical changes of immunoreactive LIF in the human endometrial epithelium suggest a paracrine/autocrine role for LIF in endometrial function. Whether LIF is essential for implantation in the human remains to be established. Journal of Endocrinology (1996) 148, 95–102

scholarly journals Leukaemia inhibitory factor enhances tissue factor expression in human monocyte-derived macrophages: a gp130-mediated mechanism

1999 ◽  
Vol 107 (4) ◽  
pp. 747-755 ◽  
Author(s):  
Simcha R. Meisel ◽  
Ilan Shimon ◽  
Thomas S. Edgington ◽  
Shlomo Melmed ◽  
Bojan Cercek ◽  
...  
Keyword(s):  
Tissue Factor ◽  
Human Monocyte ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Tissue Factor Expression ◽  
Factor Expression

D-factor/leukaemia inhibitory factor: Evidence for its role as a mediator in acute and chronic inflammatory disease

Cytokine ◽  
1994 ◽  
Vol 6 (6) ◽  
pp. 589-596 ◽  
Author(s):  
H.Richard Alexander ◽  
Kevin G. Billingsley ◽  
Mark I. Block ◽  
Douglas L. Fraker
Keyword(s):  
Inflammatory Disease ◽  
Chronic Inflammatory Disease ◽  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor
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