scholarly journals Increases in c-Src Expression Level and Activity Do Not Promote the Growth of Human Colorectal Carcinoma Cells In Vitro and In Vivo

Neoplasia ◽  
2006 ◽  
Vol 8 (11) ◽  
pp. 905-IN2 ◽  
Author(s):  
Arkadiusz Welman ◽  
Christopher Cawthome ◽  
Lourdes Ponce-Perez ◽  
Jane Barraclough ◽  
Sarah Danson ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Expression Level ◽  
Human Colorectal Carcinoma

scholarly journals Grape Seed Extract Inhibits In vitro and In vivo Growth of Human Colorectal Carcinoma Cells

2006 ◽  
Vol 12 (20) ◽  
pp. 6194-6202 ◽  
Author(s):  
Manjinder Kaur ◽  
Rana P. Singh ◽  
Mallikarjuna Gu ◽  
Rajesh Agarwal ◽  
Chapla Agarwal
Keyword(s):  
Colorectal Carcinoma ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Carcinoma Cells ◽  
Human Colorectal Carcinoma ◽  
In Vivo Growth

scholarly journals Flexicaulin A, An ent-Kaurane Diterpenoid, Activates p21 and Inhibits the Proliferation of Colorectal Carcinoma Cells through a Non-Apoptotic Mechanism

2019 ◽  
Vol 20 (8) ◽  
pp. 1917 ◽  
Author(s):  
Yixuan Xia ◽  
Chu Shing Lam ◽  
Wanfei Li ◽  
Md. Shahid Sarwar ◽  
Kanglun Liu ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Quantitative Polymerase Chain Reaction ◽  
Carcinoma Cells ◽  
Cell Viability Assay ◽  
Human Carcinoma ◽  
Viability Assay ◽  
Human Colorectal Carcinoma ◽  
Apoptotic Mechanism

Natural products, explicitly medicinal plants, are an important source of inspiration of antitumor drugs, because they contain astounding amounts of small molecules that possess diversifying chemical entities. For instance, Isodon (formerly Rabdosia), a genus of the Lamiaceae (formerly Labiatae) family, has been reported as a rich source of natural diterpenes. In the current study, we evaluated the in vitro anti-proliferative property of flexicaulin A (FA), an Isodon diterpenoid with an ent-kaurane structure, in human carcinoma cells, by means of cell viability assay, flow cytometric assessment, quantitative polymerase chain reaction array, Western blotting analysis, and staining experiments. Subsequently, we validated the in vivo antitumor efficacy of FA in a xenograft mouse model of colorectal carcinoma. From our experimental results, FA appears to be a potent antitumor molecule, since it significantly attenuated the proliferation of human colorectal carcinoma cells in vitro and restricted the growth of corresponsive xenograft tumors in vivo without causing any adverse effects. Regarding its molecular mechanism, FA considerably elevated the expression level of p21 and induced cell cycle arrest in the human colorectal carcinoma cells. While executing a non-apoptotic mechanism, we believe the antitumor potential of FA opens up new horizons for the therapy of colorectal malignancy.

scholarly journals Baicalin Induces Apoptosis in SW620 Human Colorectal Carcinoma Cells in Vitro and Suppresses Tumor Growth in Vivo

Molecules ◽  
2012 ◽  
Vol 17 (4) ◽  
pp. 3844-3857 ◽  
Author(s):  
Wen-Cheng Chen ◽  
Tsu-Hsiang Kuo ◽  
Yi-Shiuan Tzeng ◽  
Ying-Chieh Tsai
Keyword(s):  
Colorectal Carcinoma ◽  
Tumor Growth ◽  
Carcinoma Cells ◽  
Human Colorectal Carcinoma

scholarly journals Circadian gene hClock enhances proliferation and inhibits apoptosis of human colorectal carcinoma cells in vitro and in vivo

2015 ◽  
Vol 11 (6) ◽  
pp. 4204-4210 ◽  
Author(s):  
YAPING WANG ◽  
RUIZHE QIAN ◽  
NING SUN ◽  
CHAO LU ◽  
ZONGYOU CHEN ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Circadian Gene ◽  
Human Colorectal Carcinoma

scholarly journals In vivo and in vitro invasion in relation to phenotypic characteristics of human colorectal carcinoma cells

1995 ◽  
Vol 71 (2) ◽  
pp. 271-277 ◽  
Author(s):  
JE de Vries ◽  
WNM Dinjens ◽  
GK De Bruyne ◽  
HW Verspaget ◽  
EPM van der Linden ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Phenotypic Characteristics ◽  
In Vitro Invasion ◽  
Human Colorectal Carcinoma

scholarly journals The inhibitory effect of silencing CDCA3 on migration and proliferation in bladder urothelial carcinoma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dexin Shen ◽  
Yayun Fang ◽  
Fenfang Zhou ◽  
Zhao Deng ◽  
Kaiyu Qian ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Urothelial Carcinoma ◽  
Carcinoma Cells ◽  
Expression Level ◽  
Tumor Cell Growth ◽  
Migration Ability ◽  
Bladder Urothelial Carcinoma ◽  
Related Proteins

Abstract Background CDCA3 is an important component of the E3 ligase complex with SKP1 and CUL1, which could regulate the progress of cell mitosis. CDCA3 has been widely identified as a proto-oncogene in multiple human cancers, however, its role in promoting human bladder urothelial carcinoma has not been fully elucidated. Methods Bioinformatic methods were used to analyze the expression level of CDCA3 in human bladder urothelial carcinoma tissues and the relationship between its expression level and key clinical characteristics. In vitro studies were performed to validate the specific functions of CDCA3 in regulating cell proliferation, cell migration and cell cycle process. Alterations of related proteins was investigated by western blot assays. In vivo studies were constructed to validate whether silencing CDCA3 could inhibit the proliferation rate in mice model. Results Bioinformatic analysis revealed that CDCA3 was significantly up-regulated in bladder urothelial carcinoma samples and was related to key clinical characteristics, such as tumor grade and metastasis. Moreover, patients who had higher expression level of CDCA3 tend to show a shorter life span. In vitro studies revealed that silencing CDCA3 could impair the migration ability of tumor cells via down-regulating EMT-related proteins such as MMP9 and Vimentin and inhibit tumor cell growth via arresting cells in the G1 cell cycle phase through regulating cell cycle related proteins like p21. In vivo study confirmed that silencing CDCA3 could inhibit the proliferation of bladder urothelial carcinoma cells. Conclusions CDCA3 is an important oncogene that could strengthen the migration ability of bladder urothelial carcinoma cells and accelerate tumor cell growth via regulating cell cycle progress and is a potential biomarker of bladder urothelial carcinoma.

Interleukin-8 as a growth factor for human colorectal carcinoma cells in vitro

1997 ◽  
Vol 25 (2) ◽  
pp. 264S-264S ◽  
Author(s):  
ROBERT BREW ◽  
JOHN S. ERIKSON ◽  
DAVID C. WEST ◽  
BRIAN F. FLANAGAN ◽  
STEPHEN E. CHRISTMAS
Keyword(s):  
Growth Factor ◽  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Interleukin 8 ◽  
Human Colorectal Carcinoma

scholarly journals Lentivirus-mediated LIGHT overexpression inhibits human colorectal carcinoma cell growth in vitro and in vivo

2013 ◽  
Vol 6 (4) ◽  
pp. 927-932 ◽  
Author(s):  
HAIBO WANG ◽  
ZHUANG YU ◽  
SHIHAI LIU ◽  
XIANGPING LIU ◽  
AIHUA SUI ◽  
...  
Keyword(s):  
Cell Growth ◽  
Colorectal Carcinoma ◽  
Carcinoma Cell ◽  
Human Colorectal Carcinoma Cell ◽  
Human Colorectal Carcinoma
Sign in / Sign up

Export Citation Format

Share Document