scholarly journals Andrographolide Sensitizes the Cytotoxicity of Human Colorectal Carcinoma Cells Toward Cisplatin via Enhancing Apoptosis Pathways In Vitro and In Vivo

2014 ◽  
Vol 139 (1) ◽  
pp. 108-120 ◽  
Author(s):  
Hui-Hsuan Lin ◽  
Ming-Der Shi ◽  
Hsien-Chun Tseng ◽  
Jing-Hsien Chen
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Apoptosis Pathways ◽  
Human Colorectal Carcinoma

scholarly journals Grape Seed Extract Inhibits In vitro and In vivo Growth of Human Colorectal Carcinoma Cells

2006 ◽  
Vol 12 (20) ◽  
pp. 6194-6202 ◽  
Author(s):  
Manjinder Kaur ◽  
Rana P. Singh ◽  
Mallikarjuna Gu ◽  
Rajesh Agarwal ◽  
Chapla Agarwal
Keyword(s):  
Colorectal Carcinoma ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Carcinoma Cells ◽  
Human Colorectal Carcinoma ◽  
In Vivo Growth

scholarly journals Flexicaulin A, An ent-Kaurane Diterpenoid, Activates p21 and Inhibits the Proliferation of Colorectal Carcinoma Cells through a Non-Apoptotic Mechanism

2019 ◽  
Vol 20 (8) ◽  
pp. 1917 ◽  
Author(s):  
Yixuan Xia ◽  
Chu Shing Lam ◽  
Wanfei Li ◽  
Md. Shahid Sarwar ◽  
Kanglun Liu ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Quantitative Polymerase Chain Reaction ◽  
Carcinoma Cells ◽  
Cell Viability Assay ◽  
Human Carcinoma ◽  
Viability Assay ◽  
Human Colorectal Carcinoma ◽  
Apoptotic Mechanism

Natural products, explicitly medicinal plants, are an important source of inspiration of antitumor drugs, because they contain astounding amounts of small molecules that possess diversifying chemical entities. For instance, Isodon (formerly Rabdosia), a genus of the Lamiaceae (formerly Labiatae) family, has been reported as a rich source of natural diterpenes. In the current study, we evaluated the in vitro anti-proliferative property of flexicaulin A (FA), an Isodon diterpenoid with an ent-kaurane structure, in human carcinoma cells, by means of cell viability assay, flow cytometric assessment, quantitative polymerase chain reaction array, Western blotting analysis, and staining experiments. Subsequently, we validated the in vivo antitumor efficacy of FA in a xenograft mouse model of colorectal carcinoma. From our experimental results, FA appears to be a potent antitumor molecule, since it significantly attenuated the proliferation of human colorectal carcinoma cells in vitro and restricted the growth of corresponsive xenograft tumors in vivo without causing any adverse effects. Regarding its molecular mechanism, FA considerably elevated the expression level of p21 and induced cell cycle arrest in the human colorectal carcinoma cells. While executing a non-apoptotic mechanism, we believe the antitumor potential of FA opens up new horizons for the therapy of colorectal malignancy.

scholarly journals Baicalin Induces Apoptosis in SW620 Human Colorectal Carcinoma Cells in Vitro and Suppresses Tumor Growth in Vivo

Molecules ◽  
2012 ◽  
Vol 17 (4) ◽  
pp. 3844-3857 ◽  
Author(s):  
Wen-Cheng Chen ◽  
Tsu-Hsiang Kuo ◽  
Yi-Shiuan Tzeng ◽  
Ying-Chieh Tsai
Keyword(s):  
Colorectal Carcinoma ◽  
Tumor Growth ◽  
Carcinoma Cells ◽  
Human Colorectal Carcinoma

scholarly journals Circadian gene hClock enhances proliferation and inhibits apoptosis of human colorectal carcinoma cells in vitro and in vivo

2015 ◽  
Vol 11 (6) ◽  
pp. 4204-4210 ◽  
Author(s):  
YAPING WANG ◽  
RUIZHE QIAN ◽  
NING SUN ◽  
CHAO LU ◽  
ZONGYOU CHEN ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Circadian Gene ◽  
Human Colorectal Carcinoma

scholarly journals In vivo and in vitro invasion in relation to phenotypic characteristics of human colorectal carcinoma cells

1995 ◽  
Vol 71 (2) ◽  
pp. 271-277 ◽  
Author(s):  
JE de Vries ◽  
WNM Dinjens ◽  
GK De Bruyne ◽  
HW Verspaget ◽  
EPM van der Linden ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Phenotypic Characteristics ◽  
In Vitro Invasion ◽  
Human Colorectal Carcinoma

scholarly journals Increases in c-Src Expression Level and Activity Do Not Promote the Growth of Human Colorectal Carcinoma Cells In Vitro and In Vivo

Neoplasia ◽  
2006 ◽  
Vol 8 (11) ◽  
pp. 905-IN2 ◽  
Author(s):  
Arkadiusz Welman ◽  
Christopher Cawthome ◽  
Lourdes Ponce-Perez ◽  
Jane Barraclough ◽  
Sarah Danson ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Expression Level ◽  
Human Colorectal Carcinoma

Interleukin-8 as a growth factor for human colorectal carcinoma cells in vitro

1997 ◽  
Vol 25 (2) ◽  
pp. 264S-264S ◽  
Author(s):  
ROBERT BREW ◽  
JOHN S. ERIKSON ◽  
DAVID C. WEST ◽  
BRIAN F. FLANAGAN ◽  
STEPHEN E. CHRISTMAS
Keyword(s):  
Growth Factor ◽  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Interleukin 8 ◽  
Human Colorectal Carcinoma

scholarly journals Lentivirus-mediated LIGHT overexpression inhibits human colorectal carcinoma cell growth in vitro and in vivo

2013 ◽  
Vol 6 (4) ◽  
pp. 927-932 ◽  
Author(s):  
HAIBO WANG ◽  
ZHUANG YU ◽  
SHIHAI LIU ◽  
XIANGPING LIU ◽  
AIHUA SUI ◽  
...  
Keyword(s):  
Cell Growth ◽  
Colorectal Carcinoma ◽  
Carcinoma Cell ◽  
Human Colorectal Carcinoma Cell ◽  
Human Colorectal Carcinoma

„IN VITRO“ AND „IN VIVO“ ANTITUMOR ACTIVITY OF PLATINUM(II) COMPLEXES WITH MALONIC ACID ON BREAST AND COLORECTAL CARCINOMA CELL LINES

2021 ◽  
Author(s):  
Andjela Franich ◽  
◽  
Milica Dimitrijević Stojanović ◽  
Snežana Rajković ◽  
Marina Jovanović ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Colorectal Carcinoma ◽  
Cell Lines ◽  
Tumor Model ◽  
Carcinoma Cells ◽  
Spectroscopic Techniques ◽  
Murine Cell Line ◽  
In Vivo Antitumor Activity

Four Pt(II) complexes of the general formula [Pt(L)(5,6-epoxy-1,10-phen)], where L is anion of malonic (mal, Pt1), 2-methylmalonic (Me-mal, Pt2), 2,2-dimethylmalonic (Me2-mal, Pt3) or 1,1- cyclobutanedicarboxylic (CBDCA, Pt4) acid while 5,6-epoxy-1,10-phen is bidentately coordinated 5,6-epoxy-5,6-dihydro-1,10-phenanthroline were synthesized and characterized by elemental microanalysis, IR, UV-Vis and NMR (1H and 13C) spectroscopic techniques. In vitro anticancer activity of novel platinum(II) complexes have been investigated on human and murine cancer cell lines, as well as normal murine cell line by MTT assay. The obtained results indicate that studied platinum(II) complexes exhibited strong cytotoxic activity against murine breast carcinoma cells (4T1), human (HCT116) and murine (CT26) colorectal carcinoma cells. Complex Pt3 display stronger selectivity toward carcinoma cells in comparison to other tested platinum(II) complexes exhibiting beneficial antitumor activity mainly via the induction of apoptosis, as well as inhibition of cell proliferation and migration. Further study showed that Pt3 complex also carry significant in vivo antitumor activity in orthotopical 4T1 tumor model without detected liver, kidney, lung, and heart toxicity. All results imply that these novel platinum(II) complexes have a good anti-tumor effect on breast and colorectal cancer in vivo and in vitro and the affinity to become possible candidates for treatment in anticancer therapy.

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