scholarly journals In vivo and in vitro invasion in relation to phenotypic characteristics of human colorectal carcinoma cells

1995 ◽  
Vol 71 (2) ◽  
pp. 271-277 ◽  
Author(s):  
JE de Vries ◽  
WNM Dinjens ◽  
GK De Bruyne ◽  
HW Verspaget ◽  
EPM van der Linden ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Phenotypic Characteristics ◽  
In Vitro Invasion ◽  
Human Colorectal Carcinoma

scholarly journals Grape Seed Extract Inhibits In vitro and In vivo Growth of Human Colorectal Carcinoma Cells

2006 ◽  
Vol 12 (20) ◽  
pp. 6194-6202 ◽  
Author(s):  
Manjinder Kaur ◽  
Rana P. Singh ◽  
Mallikarjuna Gu ◽  
Rajesh Agarwal ◽  
Chapla Agarwal
Keyword(s):  
Colorectal Carcinoma ◽  
Grape Seed Extract ◽  
Grape Seed ◽  
Seed Extract ◽  
Carcinoma Cells ◽  
Human Colorectal Carcinoma ◽  
In Vivo Growth

scholarly journals Flexicaulin A, An ent-Kaurane Diterpenoid, Activates p21 and Inhibits the Proliferation of Colorectal Carcinoma Cells through a Non-Apoptotic Mechanism

2019 ◽  
Vol 20 (8) ◽  
pp. 1917 ◽  
Author(s):  
Yixuan Xia ◽  
Chu Shing Lam ◽  
Wanfei Li ◽  
Md. Shahid Sarwar ◽  
Kanglun Liu ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Quantitative Polymerase Chain Reaction ◽  
Carcinoma Cells ◽  
Cell Viability Assay ◽  
Human Carcinoma ◽  
Viability Assay ◽  
Human Colorectal Carcinoma ◽  
Apoptotic Mechanism

Natural products, explicitly medicinal plants, are an important source of inspiration of antitumor drugs, because they contain astounding amounts of small molecules that possess diversifying chemical entities. For instance, Isodon (formerly Rabdosia), a genus of the Lamiaceae (formerly Labiatae) family, has been reported as a rich source of natural diterpenes. In the current study, we evaluated the in vitro anti-proliferative property of flexicaulin A (FA), an Isodon diterpenoid with an ent-kaurane structure, in human carcinoma cells, by means of cell viability assay, flow cytometric assessment, quantitative polymerase chain reaction array, Western blotting analysis, and staining experiments. Subsequently, we validated the in vivo antitumor efficacy of FA in a xenograft mouse model of colorectal carcinoma. From our experimental results, FA appears to be a potent antitumor molecule, since it significantly attenuated the proliferation of human colorectal carcinoma cells in vitro and restricted the growth of corresponsive xenograft tumors in vivo without causing any adverse effects. Regarding its molecular mechanism, FA considerably elevated the expression level of p21 and induced cell cycle arrest in the human colorectal carcinoma cells. While executing a non-apoptotic mechanism, we believe the antitumor potential of FA opens up new horizons for the therapy of colorectal malignancy.

scholarly journals Baicalin Induces Apoptosis in SW620 Human Colorectal Carcinoma Cells in Vitro and Suppresses Tumor Growth in Vivo

Molecules ◽  
2012 ◽  
Vol 17 (4) ◽  
pp. 3844-3857 ◽  
Author(s):  
Wen-Cheng Chen ◽  
Tsu-Hsiang Kuo ◽  
Yi-Shiuan Tzeng ◽  
Ying-Chieh Tsai
Keyword(s):  
Colorectal Carcinoma ◽  
Tumor Growth ◽  
Carcinoma Cells ◽  
Human Colorectal Carcinoma

scholarly journals Circadian gene hClock enhances proliferation and inhibits apoptosis of human colorectal carcinoma cells in vitro and in vivo

2015 ◽  
Vol 11 (6) ◽  
pp. 4204-4210 ◽  
Author(s):  
YAPING WANG ◽  
RUIZHE QIAN ◽  
NING SUN ◽  
CHAO LU ◽  
ZONGYOU CHEN ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Circadian Gene ◽  
Human Colorectal Carcinoma

scholarly journals Increases in c-Src Expression Level and Activity Do Not Promote the Growth of Human Colorectal Carcinoma Cells In Vitro and In Vivo

Neoplasia ◽  
2006 ◽  
Vol 8 (11) ◽  
pp. 905-IN2 ◽  
Author(s):  
Arkadiusz Welman ◽  
Christopher Cawthome ◽  
Lourdes Ponce-Perez ◽  
Jane Barraclough ◽  
Sarah Danson ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Expression Level ◽  
Human Colorectal Carcinoma

Interleukin-8 as a growth factor for human colorectal carcinoma cells in vitro

1997 ◽  
Vol 25 (2) ◽  
pp. 264S-264S ◽  
Author(s):  
ROBERT BREW ◽  
JOHN S. ERIKSON ◽  
DAVID C. WEST ◽  
BRIAN F. FLANAGAN ◽  
STEPHEN E. CHRISTMAS
Keyword(s):  
Growth Factor ◽  
Colorectal Carcinoma ◽  
Carcinoma Cells ◽  
Interleukin 8 ◽  
Human Colorectal Carcinoma

scholarly journals Lentivirus-mediated LIGHT overexpression inhibits human colorectal carcinoma cell growth in vitro and in vivo

2013 ◽  
Vol 6 (4) ◽  
pp. 927-932 ◽  
Author(s):  
HAIBO WANG ◽  
ZHUANG YU ◽  
SHIHAI LIU ◽  
XIANGPING LIU ◽  
AIHUA SUI ◽  
...  
Keyword(s):  
Cell Growth ◽  
Colorectal Carcinoma ◽  
Carcinoma Cell ◽  
Human Colorectal Carcinoma Cell ◽  
Human Colorectal Carcinoma

Inhibitory effects of green tea infusion on in vitro invasion and in vivo metastasis of mouse lung carcinoma cells

1995 ◽  
Vol 98 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Masaki Sazuka ◽  
So Murakami ◽  
Mamoru Isemura ◽  
Ken Satoh ◽  
Toshihiro Nukiwa
Keyword(s):  
Green Tea ◽  
Lung Carcinoma ◽  
Carcinoma Cells ◽  
Mouse Lung ◽  
Inhibitory Effects ◽  
Tea Infusion ◽  
Lung Carcinoma Cells ◽  
In Vitro Invasion
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