scholarly journals Cigarette Smoking does not Induce Plasma or Pulmonary Oxidative Stress after Moderate-intensity Exercise

2014 ◽  
Vol 26 (3) ◽  
pp. 413-415 ◽  
Author(s):  
Shunsuke Taito ◽  
Sayaka Domen ◽  
Kiyokazu Sekikawa ◽  
Norimichi Kamikawa ◽  
Keisuke Oura ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cigarette Smoking ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Induce Plasma

Prolonged Low-moderate Intensity Exercise On Physiological Markers Of Metabolic And Oxidative Stress

2018 ◽  
Vol 50 (5S) ◽  
pp. 248-249
Author(s):  
Dominique Gagnon ◽  
Sandra Dorman ◽  
Stephen Ritchie ◽  
Shivaprakash Jagalur Mutt ◽  
Ville Stenbäck ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Physiological Markers ◽  
And Oxidative Stress

Moderate Intensity Exercise Decreases Oxidative Stress in Metallothionein Deficient Mice

2010 ◽  
Vol 42 ◽  
pp. 306-307
Author(s):  
Scott R. Collier ◽  
Keith DeRuisseau ◽  
Vincent Frechette ◽  
Hong Ji ◽  
W Zheng ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Deficient Mice

scholarly journals Effect of Exercise on Kidney Function, Oxidative Stress, and Inflammation in Type 2 Diabetic KK-AyMice

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Yuji Ishikawa ◽  
Tomohito Gohda ◽  
Mitsuo Tanimoto ◽  
Keisuke Omote ◽  
Masako Furukawa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Body Weight Loss ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Beneficial Effects ◽  
Low Intensity ◽  
Exercise Regimen ◽  
Type 2 Diabetic

Exercise is recommended for the management of type 2 diabetes, but its effects on diabetic nephropathy (DN) are still unknown. We hypothesized that appropriate exercise improves early DN via attenuation of inflammation and oxidative damage. Type 2 diabetic KK-Aymice, a spontaneous DN model, underwent two different kinds of exercise (i.e., moderate and low intensity). Sedentary mice or those undergoing an exercise regimen causing no significant body weight loss were used. We examined the urinary excretion of albumin, number of podocytes and macrophages, renal expressions of HIF-1αand MCP-1, and biomarkers of oxidative stress such as urinary 8-OHdG and serum SOD. Exercise reduced urinary levels of albumin and also maintained the number of podocytes in the exercised KK-Aymice independently of improvements of overweight and hyperglycemia, although moderate-intensity exercise increased expression of HIF-1α. Sedentary KK-Aymice showed increased expression of MCP-1 and infiltration of macrophage, increased urinary 8-OhdG, and decreased serum SOD levels compared with exercised KK-Aymice. On the whole, low-intensity exercise attenuates progression of early DN without affecting marked renal ischemia. Reduction rates of urinary albumin and maintained podocyte numbers, with parallel improvements in oxidative damage and inflammation, are related to beneficial effects of exercise in diabetic kidney disease.

scholarly journals Creatine Supplementation, Physical Exercise and Oxidative Stress Markers: A Review of the Mechanisms and Effectiveness

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 869
Author(s):  
Hamid Arazi ◽  
Ehsan Eghbali ◽  
Katsuhiko Suzuki
Keyword(s):  
Oxidative Stress ◽  
Physical Exercise ◽  
Oxidative Damage ◽  
Creatine Supplementation ◽  
Essential Amino Acids ◽  
Moderate Intensity ◽  
Energy Status ◽  
Moderate Intensity Exercise ◽  
Positive Effects ◽  
Cell Energy

Oxidative stress is the result of an imbalance between the generation of reactive oxygen species (ROS) and their elimination by antioxidant mechanisms. ROS degrade biogenic substances such as deoxyribonucleic acid, lipids, and proteins, which in turn may lead to oxidative tissue damage. One of the physiological conditions currently associated with enhanced oxidative stress is exercise. Although a period of intense training may cause oxidative damage to muscle fibers, regular exercise helps increase the cells’ ability to reduce the ROS over-accumulation. Regular moderate-intensity exercise has been shown to increase antioxidant defense. Endogenous antioxidants cannot completely prevent oxidative damage under the physiological and pathological conditions (intense exercise and exercise at altitude). These conditions may disturb the endogenous antioxidant balance and increase oxidative stress. In this case, the use of antioxidant supplements such as creatine can have positive effects on the antioxidant system. Creatine is made up of two essential amino acids, arginine and methionine, and one non-essential amino acid, glycine. The exact action mechanism of creatine as an antioxidant is not known. However, it has been shown to increase the activity of antioxidant enzymes and the capability to eliminate ROS and reactive nitrogen species (RNS). It seems that the antioxidant effects of creatine may be due to various mechanisms such as its indirect (i.e., increased or normalized cell energy status) and direct (i.e., maintaining mitochondrial integrity) mechanisms. Creatine supplement consumption may have a synergistic effect with training, but the intensity and duration of training can play an important role in the antioxidant activity. In this study, the researchers attempted to review the literature on the effects of creatine supplementation and physical exercise on oxidative stress.

PSX-A-18 Late-Breaking: Oxidative stress biomarkers in blood plasma of moderately exercised horses

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 372-372
Author(s):  
Elizabeth Ott ◽  
Clay A Cavinder ◽  
Caleb O Lemley ◽  
Thu Dinh
Keyword(s):  
Oxidative Stress ◽  
Blood Plasma ◽  
Repeated Measures ◽  
Fixed Effects ◽  
Moderate Intensity ◽  
Thiobarbituric Acid Reactive Substance ◽  
Moderate Intensity Exercise ◽  
Oxidative Stress Biomarkers ◽  
Post Exercise ◽  
In Blood Plasma

Abstract Oxidative stress by physical stressors negatively impacts the performance of equine athletes. The present study was aimed to determine oxidative biomarkers in blood plasma of exercising horses. Stock-type horses were subject to a standardized moderate intensity exercise protocol following NRC guidelines 3 times per wk for 8 wk. Blood plasma was collected in wk 1, 2, 7, and 8 immediately before and 0, 30, 60, and 90 min after exercise and analyzed for total antioxidant capacity (TAC), thiobarbituric acid reactive substance (TBARS), glutathione peroxidase activity (GPx), and superoxide dismutase activity (SOD). Data were analyzed as repeated measures with wk, d, time, and their interactions as fixed effects. The TAC on d 2 (0.40 mM trolox) were 7.5% greater than that on d 3 (P = 0.013). There were wk × d × time interactions for SOD, TBARS, and GPx (P < 0.001). The TBARS remained at d-1 wk-1 pre-exercise baseline (2.70 µM malondialdehyde) for most collection times within wk 1, 7, and 8 (P ≥ 0.058); however, TBARS increased by 0.24 to 0.41 µM on d 2 of wk 2 post-exercise (P < 0.001) and remained similarly elevated on d 3 pre- and immediately post-exercise (P < 0.001). The GPx similarly remained at baseline (172.57 µM/min; P ≥ 0.621) but increased by 48.18 to 83.36 µM/min at most collection times on d 1 and 2 of wk 2 (P ≤ 0.023). The SOD remained at baseline (167.21 µM/min; P ≥ 0.055) until increasing by 11.28 to 15.61 µM/min at 30 min post-exercise on d 1, wk 1 and at most collection times on d 3, wk 8 (P ≤ 0.043). The current study indicates the time-dependent nature of oxidative stress in relation to persistent stressors such as exercise.

High-intensity exercise attenuates postprandial lipaemia and markers of oxidative stress

2012 ◽  
Vol 123 (5) ◽  
pp. 313-321 ◽  
Author(s):  
Brendan Gabriel ◽  
Aivaras Ratkevicius ◽  
Patrick Gray ◽  
Michael P. Frenneaux ◽  
Stuart R. Gray
Keyword(s):  
Oxidative Stress ◽  
Adhesion Molecule ◽  
High Intensity ◽  
Intermittent Exercise ◽  
Protein Carbonyls ◽  
Moderate Intensity ◽  
High Fat ◽  
Moderate Intensity Exercise ◽  
Markers Of Oxidative Stress ◽  
Fat Meal

Regular exercise can reduce the risk of CVD (cardiovascular disease). Although moderate-intensity exercise can attenuate postprandial TAG (triacylglycerol), high-intensity intermittent exercise might be a more effective method to improve health. We compared the effects of high-intensity intermittent exercise and 30 min of brisk walking on postprandial TAG, soluble adhesion molecules and markers of oxidative stress. Nine men each completed three 2-day trials. On day 1, subjects rested (control), walked briskly for 30 min (walking) or performed 5×30 s maximal sprints (high-intensity). On day 2, subjects consumed a high-fat meal for breakfast and 3 h later for lunch. Blood samples were taken at various times and analysed for TAG, glucose, insulin, ICAM-1 (intracellular adhesion molecule-1), VCAM-1 (vascular adhesion molecule-1), TBARS (thiobarbituric acid- reactive substances), protein carbonyls and β-hydroxybutyrate. On day 2 of the high-intensity trial, there was a lower (P<0.05) incremental TAG AUC (area under the curve; 6.42±2.24 mmol/l per 7 h) compared with the control trial (9.68±4.77 mmol/l per 7 h) with no differences during day 2 of the walking trial (8.98±2.84 mmol/l per 7 h). A trend (P=0.056) for a reduced total TAG AUC was also seen during the high-intensity trial (14.13±2.83 mmol/l per 7 h) compared with control (17.18±3.92 mmol/l per 7 h), walking showed no difference (16.33±3.51 mmol/l per 7 h). On day 2 of the high-intensity trial plasma TBARS and protein carbonyls were also reduced (P<0.05) when compared with the control and walking trials. In conclusion, high-intensity intermittent exercise attenuates postprandial TAG and markers of oxidative stress after the consumption of a high-fat meal.

scholarly journals One-week cocoa flavanol intake increases prefrontal cortex oxygenation at rest and during moderate-intensity exercise in normoxia and hypoxia

2018 ◽  
Vol 125 (1) ◽  
pp. 8-18 ◽  
Author(s):  
Lieselot Decroix ◽  
Cajsa Tonoli ◽  
Elodie Lespagnol ◽  
Constantino Balestra ◽  
Amandine Descat ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Endothelial Function ◽  
Antioxidant Capacity ◽  
Near Infrared ◽  
Tissue Oxygenation ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Double Blind ◽  
Exercise Induced

During exercise in hypoxia, O2 delivery to brain and muscle is compromised, and oxidative stress is elicited. Cocoa flavanols (CF) have antioxidant capacities and can increase blood flow by stimulating endothelial function. We aimed to examine the effects of 7-day CF intake on oxidative stress, nitric oxide production, and tissue oxygenation in response to exercise in normobaric hypoxia (14.3% O2). In a randomized, double-blind, cross-over study, 14 well-trained male cyclists completed four trials: exercise in normoxia or hypoxia, after 7-day CF or placebo intake. Flow-mediated dilation (FMD) was measured before intake of the last dose CF or placebo. One hundred minutes later, 20-min steady-state (SS; 45% V̇o2max) and 20-min time trial (TT) (cycling) were performed. Blood samples were taken. Prefrontal and muscular oxygenation was assessed by near-infrared spectroscopy. At baseline, FMD was increased by CF. Hypoxia increased exercise-induced elevations in lipid peroxidation and antioxidant capacity. CF suppressed exercise-induced lipid peroxidation but did not influence antioxidant capacity. At rest and during SS, prefrontal and muscular oxygenation was decreased by hypoxia. CF elevated prefrontal oxygenation but did not impact muscular oxygenation. During TT, hypoxia accelerated the exercise-induced decrease in prefrontal oxygenation, but not in muscular oxygenation. During TT, CF did not alter prefrontal and muscular oxygenation. CF did not change plasma nitrite, nitrate, and arginine:citrulline. During high-intensity exercise, CF improved neither tissue oxygenation nor performance in well-trained athletes. At rest and during moderate-intensity exercise, CF reduced exercise-induced lipid peroxidation and partially restored the hypoxia-induced decline in prefrontal oxygenation. NEW & NOTEWORTHY For the first time, we showed that CF had beneficial effects on endothelial function at rest, as well as on prefrontal oxygenation at rest and during moderate-intensity exercise, both in normoxia and hypoxia. Moreover, we showed that CF intake inhibited oxidative stress during exhaustive exercise in hypoxia.

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