High-intensity exercise attenuates postprandial lipaemia and markers of oxidative stress

2012 ◽  
Vol 123 (5) ◽  
pp. 313-321 ◽  
Author(s):  
Brendan Gabriel ◽  
Aivaras Ratkevicius ◽  
Patrick Gray ◽  
Michael P. Frenneaux ◽  
Stuart R. Gray
Keyword(s):  
Oxidative Stress ◽  
Adhesion Molecule ◽  
High Intensity ◽  
Intermittent Exercise ◽  
Protein Carbonyls ◽  
Moderate Intensity ◽  
High Fat ◽  
Moderate Intensity Exercise ◽  
Markers Of Oxidative Stress ◽  
Fat Meal

Regular exercise can reduce the risk of CVD (cardiovascular disease). Although moderate-intensity exercise can attenuate postprandial TAG (triacylglycerol), high-intensity intermittent exercise might be a more effective method to improve health. We compared the effects of high-intensity intermittent exercise and 30 min of brisk walking on postprandial TAG, soluble adhesion molecules and markers of oxidative stress. Nine men each completed three 2-day trials. On day 1, subjects rested (control), walked briskly for 30 min (walking) or performed 5×30 s maximal sprints (high-intensity). On day 2, subjects consumed a high-fat meal for breakfast and 3 h later for lunch. Blood samples were taken at various times and analysed for TAG, glucose, insulin, ICAM-1 (intracellular adhesion molecule-1), VCAM-1 (vascular adhesion molecule-1), TBARS (thiobarbituric acid- reactive substances), protein carbonyls and β-hydroxybutyrate. On day 2 of the high-intensity trial, there was a lower (P<0.05) incremental TAG AUC (area under the curve; 6.42±2.24 mmol/l per 7 h) compared with the control trial (9.68±4.77 mmol/l per 7 h) with no differences during day 2 of the walking trial (8.98±2.84 mmol/l per 7 h). A trend (P=0.056) for a reduced total TAG AUC was also seen during the high-intensity trial (14.13±2.83 mmol/l per 7 h) compared with control (17.18±3.92 mmol/l per 7 h), walking showed no difference (16.33±3.51 mmol/l per 7 h). On day 2 of the high-intensity trial plasma TBARS and protein carbonyls were also reduced (P<0.05) when compared with the control and walking trials. In conclusion, high-intensity intermittent exercise attenuates postprandial TAG and markers of oxidative stress after the consumption of a high-fat meal.

scholarly journals Effect of exercise intensity on postprandial lipemia, markers of oxidative stress, and endothelial function after a high-fat meal

2016 ◽  
Vol 41 (12) ◽  
pp. 1278-1284 ◽  
Author(s):  
Renata Lopes Krüger ◽  
Bruno Costa Teixeira ◽  
Juliano Boufleur Farinha ◽  
Rodrigo Cauduro Oliveira Macedo ◽  
Francesco Pinto Boeno ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Function ◽  
Acute Exercise ◽  
Postprandial Lipemia ◽  
Moderate Intensity ◽  
Thiobarbituric Acid Reactive Substance ◽  
High Fat ◽  
Moderate Intensity Exercise ◽  
Postprandial Period ◽  
Fat Meal

The aim of this study was to compare the effects of 2 different exercise intensities on postprandial lipemia, oxidative stress markers, and endothelial function after a high-fat meal (HFM). Eleven young men completed 2-day trials in 3 conditions: rest, moderate-intensity exercise (MI-Exercise) and heavy-intensity exercise (HI-Exercise). Subjects performed an exercise bout or no exercise (Rest) on the evening of day 1. On the morning of day 2, an HFM was provided. Blood was sampled at fasting (0 h) and every hour from 1 to 5 h during the postprandial period for triacylglycerol (TAG), thiobarbituric acid reactive substance (TBARS), and nitrite/nitrate (NOx) concentrations. Flow-mediated dilatation (FMD) was also analyzed. TAG concentrations were reduced in exercise conditions compared with Rest during the postprandial period (P < 0.004). TAG incremental area under the curve (iAUC) was smaller after HI-Exercise compared with Rest (P = 0.012). TBARS concentrations were reduced in MI-Exercise compared with Rest (P < 0.041). FMD was higher in exercise conditions than Rest at 0 h (P < 0.02) and NOx concentrations were enhanced in MI-Exercise compared with Rest at 0 h (P < 0.01). These results suggest that acute exercise can reduce lipemia after an HFM. However, HI-Exercise showed to be more effective in reducing iAUC TAG, which might suggest higher protection against postprandial TAG enhancement. Conversely, MI-Exercise can be beneficial to attenuate the susceptibility of oxidative damage induced by an HFM and to increase endothelial function in the fasted state compared with Rest.

scholarly journals Is the effect of prior exercise on postprandial lipaemia the same for a moderate-fat meal as it is for a high-fat meal?

2010 ◽  
Vol 105 (4) ◽  
pp. 506-516 ◽  
Author(s):  
Nicholas M. Hurren ◽  
Frank F. Eves ◽  
Andrew K. Blannin
Keyword(s):  
Test Meal ◽  
Venous Blood ◽  
Exercise Bout ◽  
Moderate Intensity ◽  
High Fat ◽  
Moderate Intensity Exercise ◽  
Postprandial Lipaemia ◽  
Fasted State ◽  
Prior Exercise ◽  
Fat Meal

Moderate-intensity exercise can lower the TAG response to a high-fat meal; however, the British diet is moderate in fat, and no study to date has compared the effect of such exercise on responses to high-fat and moderate-fat meals. The present work investigated the effect of brisk walking performed 13 h before intake of both high-fat and moderate-fat meals on postprandial plasma TAG concentrations. Eight inactive, overweight men completed four separate 2 d trials, i.e. rest (Con) or a 90-min treadmill walk (Ex) on the evening of day 1, followed by the ingestion of a moderate-fat (Mod) or high-fat (High) meal on the morning of day 2. High-fat meals contained 66 % of total energy as fat, while the percentage was 35 % for moderate-fat meals; both the meals were, however, isoenergetic. On day 2, venous blood was sampled in the fasted state, 30 and 60 min after ingesting the test meal and then hourly until 6 h post-meal. Exercise reduced plasma TAG concentrations significantly (P < 0·001), with no exercise × meal interaction (P = 0·459). Walking reduced the total TAG response to a high-fat meal by 29 % (relative to High Con); the same bout of exercise performed before ingesting a moderate-fat meal lowered total TAG by 26 % (compared with Mod Con). The ability of a single moderate-intensity aerobic exercise bout to lower postprandial TAG concentrations is just as great, in percentage terms, when the test meal ingested is of a moderate rather than a high fat content.

Correction: Effect of exercise intensity on postprandial lipemia, markers of oxidative stress, and endothelial function after a high-fat meal

2020 ◽  
Vol 45 (12) ◽  
pp. 1400-1400
Author(s):  
Renata Lopes Krüger ◽  
Bruno Costa Teixeira ◽  
Juliano Boufleur Farinha ◽  
Rodrigo Cauduro Oliveira Macedo ◽  
Francesco Pinto Boeno ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Function ◽  
Exercise Intensity ◽  
Postprandial Lipemia ◽  
High Fat ◽  
Correction Effect ◽  
Markers Of Oxidative Stress ◽  
Fat Meal

Aerobic Exercise Improves Postprandial Inflammatory and Hemostatic Markers After a High-Fat Meal: A Randomized Cross-Over Study

2020 ◽  
Author(s):  
Bruno Costa Teixeira ◽  
Renata L. Krüger ◽  
Juliano Boufleur Farinha ◽  
Francesco P Boeno ◽  
Rodrigo Cauduro Oliveira Macedo ◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Exercise Intensity ◽  
Inflammatory Markers ◽  
Factor Vii ◽  
Moderate Intensity ◽  
High Fat ◽  
Moderate Intensity Exercise ◽  
Postprandial State ◽  
Anti Inflammatory ◽  
Fat Meal

Exercise intensity modulates postprandial lipemia. It is still unknown, however, its effect on hemostatic and pro- and anti-inflammatory markers in the postprandial state. Eleven young males perform a 2-day trial on different conditions: (i) REST: rest for 45 min; (ii) MIE: moderate-intensity exercise; and (iii) HIE: heavy-intensity exercise. Experimental conditions were performed in the evening. On the following morning, blood samples were taken in the fasted state (0 h) and at 1, 3, and 5 h after the consumption of a high-fat meal (HFM). Interleukin-10 (IL-10) levels were higher in the HIE vs. MIE trial at 0 and 1 h (p < 0.033) and IL-10 iAUC was greater in the MIE (p = 0.027) and HIE (p = 0.045) vs. REST. Lower levels of anti-coagulation factor VII (FVII) were observed at 1 h in the MIE condition vs. REST (p = 0.043). In comparison with REST, MIE improved hemostatic (FVII) and anti-inflammatory markers (IL-10 iAUC) whereas HIE enhanced IL-10 in the postprandial state. Regardless of the exercise intensity, aerobic exercise mitigates the deleterious consequences of an HFM. Novelty Bullets: • Prior aerobic exercise at moderate-intensity attenuates next day’s postprandial FVII and IL-10 levels whereas exercise performed at heavy-intensity increases IL-10 levels. • Moderate-intensity exercise may be more beneficial to improve hemostatic (FVII) and anti-inflammatory (IL-10) responses while heavy-intensity exercise may improve anti-inflammatory (IL-10) levels only.

scholarly journals 30 Minutes of Acute Moderate-Intensity Exercise Prior to a High Fat Meal Does not Attenuate Postprandial Triglycerides in Postmenopausal Women

2019 ◽  
Vol 8 (1) ◽  
pp. 72-78
Author(s):  
Nathaniel Glen Bodell ◽  
Trevor Gillum
Keyword(s):  
Heart Rate ◽  
Postmenopausal Women ◽  
Blood Lipids ◽  
Moderate Intensity ◽  
Lipid Levels ◽  
High Fat ◽  
Moderate Intensity Exercise ◽  
Post Feeding ◽  
Postprandial Triglycerides ◽  
Fat Meal

There is an increased instance of circulating triglycerides among older adults which could lead to atherosclerosis; therefore, we sought to determine if 30 minutes of moderate-intensity exercise, prior to a high fat meal, attenuates postprandial triglycerides (PPT) in postmenopausal women. Five postmenopausal women (59.8 years), participated in an exercise trial consisting of 30 minutes of moderate-intensity exercise 60% heart rate reserve (HRR), heart rate, blood pressure, and blood lipids collected. Following exercise participants ingested a high-fat meal (62 grams CHO, and 57 grams fat) and rested for four hours. Lipid levels were collected at 1, 2, 3, and 4 hours post-feeding. The control trial did not exercise and were given the high fat meal followed by rest. A randomized cross-over design was utilized, in which all subjects participated in the control and exercise trial. There was no difference in PPT between the control and exercise trials. PPT increased from pre-exercise in both trials (p<0.05) (pre-feeding 88.4±26.7 con. 93.6±36.8 ex., 1hr 141±51.7 con. 139±65.4 ex., 2hrs 195±32.7 con. 166±82.4 ex., 3hrs 203±52.2 con. 185±78.1 ex., 4hrs 179±22.4 con. 193±50.5 ex). Glucose values were similar between trials; peaking post-feeding followed by a gradual return to baseline in both trials (p<0.05) (prefeeding 86±5.5 con. 84.6±5.8 ex., 1hr 117±11.3 con. 125±23.5 ex., 2hrs 104±4.1 con., 113±16.7 ex., 3hrs 97.4±6.3 con., 88.6±11.6 ex., 4hrs 87.6±6.7 con., 81.2±9 ex). 30 minutes of moderate-intensity exercise does not attenuate PPT in postmenopausal women.

scholarly journals Does Moderate Intensity Exercise Attenuate the Postprandial Lipemic and Airway Inflammatory Response to a High-Fat Meal?

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Stephanie P. Kurti ◽  
Sara K. Rosenkranz ◽  
Morton Levitt ◽  
Brooke J. Cull ◽  
Colby S. Teeman ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Inflammatory Response ◽  
Airway Inflammation ◽  
Exhaled Nitric Oxide ◽  
Moderate Intensity ◽  
High Fat ◽  
Moderate Intensity Exercise ◽  
Postprandial Period ◽  
Acute Bout ◽  
Fat Meal

We investigated whether an acute bout of moderate intensity exercise in the postprandial period attenuates the triglyceride and airway inflammatory response to a high-fat meal (HFM) compared to remaining inactive in the postprandial period. Seventeen (11 M/6 F) physically active (≥150 min/week of moderate-vigorous physical activity (MVPA)) subjects were randomly assigned to an exercise (EX; 60%VO2peak) or sedentary (CON) condition after a HFM (10 kcal/kg, 63% fat). Blood analytes and airway inflammation via exhaled nitric oxide (eNO) were measured at baseline, and 2 and 4 hours after HFM. Airway inflammation was assessed with induced sputum and cell differentials at baseline and 4 hours after HFM. Triglycerides doubled in the postprandial period (~113 ± 18%,P<0.05), but the increase did not differ between EX and CON. Percentage of neutrophils was increased 4 hours after HFM (~17%), but the increase did not differ between EX and CON. Exhaled nitric oxide changed nonlinearly from baseline to 2 and 4 hours after HFM(P<0.05, η2=0.36). Our findings suggest that, in active individuals, an acute bout of moderate intensity exercise does not attenuate the triglyceride or airway inflammatory response to a high-fat meal.

Anti-inflammatory effects of short-term pioglitazone therapy in men with advanced diabetic nephropathy

2006 ◽  
Vol 290 (3) ◽  
pp. F600-F605 ◽  
Author(s):  
Rajiv Agarwal
Keyword(s):  
Oxidative Stress ◽  
Diabetic Nephropathy ◽  
Cardiovascular Risk ◽  
High Rate ◽  
Protein Carbonyls ◽  
Open Label ◽  
End Point ◽  
Tnf Α ◽  
Markers Of Oxidative Stress ◽  
Wbc Count

Patients with diabetic nephropathy have a high rate of cardiovascular events and mortality. Nontraditional cardiovascular risk factors such as oxidative stress and inflammation are thought to be particularly important in mediating these events. Studies suggest that thiazolidinediones (TZDs) can reduce the level of nontraditional cardiovascular risk in people with or without diabetes mellitus. Whether this benefit occurs in patients with diabetic nephropathy is unknown. I hypothesized that the TZD pioglitazone will mitigate oxidative stress and inflammation compared with glipizide in patients with overt diabetic nephropathy. Markers of oxidative stress (plasma and urine albumin carbonyl and total protein carbonyls and malondialdehyde), inflammation [white blood cell (WBC) count, C-reactive protein (CRP), plasma IL-6, TNF-α], and plaque stability [matrix metalloproteinase 9 (MMP-9)] were measured in frozen samples obtained from patients with overt diabetic nephropathy participating in a randomized, open-label, blinded end-point, 16-wk trial with glipizide ( n = 22) or pioglitazone ( n = 22). Pioglitazone therapy in men with advanced diabetic nephropathy reduced WBC count by 1,125/μl ( P < 0.001), CRP by 41% ( P = 0.042), IL-6 by 38% ( P = 0.009), and MMP-9 by 29% ( P = 0.016). Specific differential reductions in WBC count of 1,251/μl ( P = 0.009) and reduction in IL-6 of 58% with pioglitazone ( P = 0.001) were seen compared with glipizide. There were no statistically significant changes observed with plasma TNF-α concentrations or markers of oxidative stress with either hypoglycemic agent. In conclusion, pioglitazone reduces proinflammatory markers in patients with overt diabetic nephropathy, which indicates potentially beneficial effects on overall cardiovascular risk. This surrogate end point needs to be confirmed in trials designed to demonstrate cardiovascular protection.

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