scholarly journals Serum uric acid and blood pressure in an European rural population with normal kidney function. Data from the Brisighella heart study (Italy) and ENAH study (Croatia)

2017 ◽  
Vol 12 (3) ◽  
pp. 49-49
Author(s):  
Sandra Karanović ◽  
Vanja Ivković ◽  
Angelo Parini ◽  
Ana Jelaković ◽  
Mirta Abramović Barić ◽  
...  
2017 ◽  
Vol 44 (3) ◽  
pp. 380-387 ◽  
Author(s):  
Eunjeong Kang ◽  
Seung-sik Hwang ◽  
Dong Ki Kim ◽  
Kook-Hwan Oh ◽  
Kwon Wook Joo ◽  
...  

Objective.To explain the clinical effect of serum uric acid (SUA) levels as a risk factor for mortality, considering exclusion of kidney function.Methods.Participants aged over 40 years who underwent health checkups were recruited. Individuals with estimated glomerular filtrations rates < 60 ml/min/1.73 m2 and who received laboratory study and colonoscopy on the same day were excluded.Results.SUA levels were higher in men than in women (5.7 ± 1.2 mg/dl for men and 4.2 ± 0.9 mg/dl for women, p < 0.001). During 12.3 ± 3.6 years of followup, 1402 deaths occurred among 27,490 participants. About 6.9% of men and 3.1% of women died. The overall mortality rate had a U-shaped association with SUA levels, a U-shaped association in men, and no association in women. There was a significant interaction of sex for the SUA-mortality association (p for interaction = 0.049); therefore, survival analysis was conducted by sex. In men, the lower SUA group had a higher mortality rate after adjustment (SUA ≤ 4.0 mg/dl, adjusted HR 1.413, 95% CI 1.158–1.724, p = 0.001) compared with the reference group (SUA 4.1–6.0 mg/dl). A higher SUA contributed to an insignificant increased mortality in men (> 8.0 mg/dl, adjusted HR 1.140, 95% CI 0.794–1.636, p = 0.479). Women failed to show any significant association between SUA and mortality.Conclusion.This study provided novel evidence that SUA-mortality association differed by sex. We demonstrated that a lower SUA was an independent risk factor for all-cause mortality in men with normal kidney function.


2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e95
Author(s):  
L. Simicevic ◽  
J. Josipovic ◽  
B. Milicic ◽  
K. Dapic ◽  
N. Bozina ◽  
...  

2018 ◽  
Vol 261 ◽  
pp. 204-208 ◽  
Author(s):  
Arrigo F.G. Cicero ◽  
Masanari Kuwabara ◽  
Richard Johnson ◽  
Marilisa Bove ◽  
Federica Fogacci ◽  
...  

2018 ◽  
Vol 36 ◽  
pp. e130
Author(s):  
Mochammad Sja’bani ◽  
Haidar Alatas ◽  
Mustofa Mustofa ◽  
Ali Ghufron Mukti ◽  
Lucky Azizah Bawazier ◽  
...  

2019 ◽  
Vol 44 (1) ◽  
pp. 33-42 ◽  
Author(s):  
Antonio  Barbato ◽  
Lanfranco  D’Elia ◽  
Ludovica  Perna ◽  
Anna  Molisso ◽  
Roberto  Iacone ◽  
...  

Background/Aims: Association between cigarette smoke and albuminuria (UA) was already demonstrated in cross-sectional studies and in selected population samples (i.e diabetic patients). This study aims to evaluate, prospectively, the relationship between cigarette smoke and UA in a male adult population sample, with basal normal kidney function, participating in the Olivetti Heart Study (OHS). Methods: Among 994 participants, examined in both 1994-95 and 2002-04, were selected those resulted in both visits smokers (n=221) and non-smokers (n=416) and with basal normal kidney function (GFR> 60 mL/min) and basal albumin/creatinine ratio (ACR< 30 mg/g). Results: At baseline, the prevalence of hypertension was 41%, diabetes affected 6.3% and obesity 17% of the whole sample. Smokers showed statistically significant lower levels of systolic (SBP) and diastolic blood pressure (DBP) and BMI (p< 0.001) compared to non-smokers. There were not basal differences in UA, GFR and metabolic profile. However, at follow-up examination, smokers showed a statistically significant increase in SBP and DBP (p< 0.05), but not in GFR and BMI. Moreover, smokers showed a higher risk compared to non-smokers to be in the higher median levels group of UA (OR: 2.17, C.I.95%: 1.51-3.13; p < 0.001), even after correction for major confounding factors. Further adjustment for basal antihypertensive and hypoglycemic treatment did not change these patterns of association. Conclusion: In a selected male adult population sample, cigarette smoke was independently associated with the development of higher levels of albuminuria over time.


2018 ◽  
Vol 19 (5) ◽  
pp. 1014-1019 ◽  
Author(s):  
Bartosz Słomiński ◽  
Maria Skrzypkowska ◽  
Monika Ryba-Stanisławowska ◽  
Agnieszka Brandt

Medicine ◽  
2014 ◽  
Vol 93 (28) ◽  
pp. e250 ◽  
Author(s):  
Vanja Ivković ◽  
Mislav Jelaković ◽  
Mario Laganović ◽  
Ivan Pećin ◽  
Ana Vrdoljak ◽  
...  

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