Uric Acid Metabolism in a Sample of Egyptian Hypertensive Patients with Normal Kidney Function

2013 ◽  
pp. 608-614 ◽  
Author(s):  
Adel Afifi ◽  
Iman Sarhan ◽  
Magdy El Sharkawy
Keyword(s):  
Uric Acid ◽  
Kidney Function ◽  
Acid Metabolism ◽  
Normal Kidney ◽  
Hypertensive Patients ◽  
Normal Kidney Function

Sex-specific Relationship of Serum Uric Acid with All-cause Mortality in Adults with Normal Kidney Function: An Observational Study

2017 ◽  
Vol 44 (3) ◽  
pp. 380-387 ◽  
Author(s):  
Eunjeong Kang ◽  
Seung-sik Hwang ◽  
Dong Ki Kim ◽  
Kook-Hwan Oh ◽  
Kwon Wook Joo ◽  
...  
Keyword(s):  
Uric Acid ◽  
Risk Factor ◽  
Mortality Rate ◽  
Serum Uric Acid ◽  
Kidney Function ◽  
Reference Group ◽  
Normal Kidney ◽  
Normal Kidney Function ◽  
All Cause Mortality ◽  
Relationship Of

Objective.To explain the clinical effect of serum uric acid (SUA) levels as a risk factor for mortality, considering exclusion of kidney function.Methods.Participants aged over 40 years who underwent health checkups were recruited. Individuals with estimated glomerular filtrations rates < 60 ml/min/1.73 m2 and who received laboratory study and colonoscopy on the same day were excluded.Results.SUA levels were higher in men than in women (5.7 ± 1.2 mg/dl for men and 4.2 ± 0.9 mg/dl for women, p < 0.001). During 12.3 ± 3.6 years of followup, 1402 deaths occurred among 27,490 participants. About 6.9% of men and 3.1% of women died. The overall mortality rate had a U-shaped association with SUA levels, a U-shaped association in men, and no association in women. There was a significant interaction of sex for the SUA-mortality association (p for interaction = 0.049); therefore, survival analysis was conducted by sex. In men, the lower SUA group had a higher mortality rate after adjustment (SUA ≤ 4.0 mg/dl, adjusted HR 1.413, 95% CI 1.158–1.724, p = 0.001) compared with the reference group (SUA 4.1–6.0 mg/dl). A higher SUA contributed to an insignificant increased mortality in men (> 8.0 mg/dl, adjusted HR 1.140, 95% CI 0.794–1.636, p = 0.479). Women failed to show any significant association between SUA and mortality.Conclusion.This study provided novel evidence that SUA-mortality association differed by sex. We demonstrated that a lower SUA was an independent risk factor for all-cause mortality in men with normal kidney function.

scholarly journals Serum uric acid and blood pressure in an European rural population with normal kidney function. Data from the Brisighella heart study (Italy) and ENAH study (Croatia)

2017 ◽  
Vol 12 (3) ◽  
pp. 49-49
Author(s):  
Sandra Karanović ◽  
Vanja Ivković ◽  
Angelo Parini ◽  
Ana Jelaković ◽  
Mirta Abramović Barić ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Kidney Function ◽  
Rural Population ◽  
Normal Kidney ◽  
Normal Kidney Function ◽  
Function Data ◽  
Heart Study

2104-P: Serum Phosphorus Levels Are Associated with the Metabolic Syndrome and Adiponectin Levels in Nondiabetic Women with Normal Kidney Function

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2104-P
Author(s):  
YUKA NATSUKI ◽  
TOMOAKI MORIOKA ◽  
YOSHINORI KAKUTANI ◽  
YUKO YAMAZAKI ◽  
MASAFUMI KURAJOH ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Kidney Function ◽  
Serum Phosphorus ◽  
Normal Kidney ◽  
Normal Kidney Function ◽  
The Metabolic Syndrome ◽  
Phosphorus Levels

scholarly journals Osteoporosis after heart transplantation with reference to immunosuppression and renal function

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
E L Lofdahl ◽  
G R Radegran
Keyword(s):  
Lumbar Spine ◽  
Femoral Neck ◽  
Heart Transplantation ◽  
Immunosuppressive Therapy ◽  
Kidney Function ◽  
Normal Kidney ◽  
Normal Kidney Function ◽  
Ckd Stage ◽  
Negative Predictor

Abstract Background Osteoporosis is commonly found in heart transplantation (HT) recipients, and may develop as an adverse effect of the immunosuppressive therapy, as well as be a consequence of factors associated with heart failure prior to HT. Chronic kidney disease (CKD) is furthermore, like osteoporosis, frequently found in the HT patient population, and may also arise as a side-effect of the immunosuppressive therapy. Aims and method We sought to describe the bone mineral density (BMD) evolution, predictors of osteoporosis, and survival, as well as incidence of osteoporosis in relation to CKD up to 10 years after HT. The project was conducted as a retrospective cohort study including patients who underwent HT at an age of at least 20 years between January 1988 and June 2016 at our center. The project was approved by the local ethics board (approval nos. 2010/114, 2011/777, 2014/92). Results Pre-transplant BMD was a negative predictor of osteoporosis during the first post-operative year, with a HR of 0.13 (95% CI 0.063; 0.26; P&lt;0.001) and 0.54 (95% CI 0.34; 0.85; P&lt;0.001) in the lumbar spine and femoral neck, respectively, adjusted for age, gender, BMI, and immunosuppressive therapy. Similarly, pre-transplant BMD was a negative predictor of osteoporosis also up to 10 years after HT, with a HR of 0.19 (95% CI 0.11; 0.32; P&lt;0.001) and 0.55 (95% CI 0.39; 0.78; P=0.001), in the lumbar spine and femoral neck, respectively, adjusted for age, gender, BMI, and immunosuppressive therapy. CKD stage 3 or worse before HT was associated with a greater gain in BMD after HT compared with CKD stage less than 3 or normal kidney function (−2.5% [−5.6; 0.6] versus −6.6% [−8.8;-4.5], P=0.029), and was not associated with osteoporosis (Figure 1). Also, the cumulative incidence of osteoporosis in the lumbar spine after HT was higher in the group with CKD stage less than 3 or normal kidney function. Conclusions The greatest drop in BMD occurs within the first year after HT. Short- and long-term incidence of osteoporosis is positively associated with pre-transplant bone strength, suggesting that early initiation of osteoporosis preventive treatment, pharmacologically and non-pharmacologically, may be beneficial in preventing long- and short-term fracture-related morbidity and morbidity after HT. Moreover, CKD stage 3 or worse before HT was associated with higher lumbar BMD after HT, and was not a predictor of osteoporosis. CKD stage less than 3 or normal kidney function before HT exhibited a greater BMD loss in the lumbar spine. Finally, the change in GFR during the first postoperative year was not associated with long-term BMD loss or osteoporosis. FUNDunding Acknowledgement Type of funding sources: Foundation. Main funding source(s): Anna-Lisa & Sven-Erik Lundgren's Foundation and ALF's Foundations, Lund, Sweden Figure 1

scholarly journals Correlation between Serum Calcium and Phosphate with Coronary Artery Calcium Scores on Cardiac MSCT Examination

2019 ◽  
Vol 15 (2) ◽  
pp. 120
Author(s):  
Rosita Kai ◽  
Bachtiar Murtala ◽  
Andi Alfian Zainuddin ◽  
Muzakkir Amin ◽  
Muhammad Ilyas
Keyword(s):  
Coronary Artery ◽  
Kidney Function ◽  
Serum Calcium ◽  
Coronary Artery Calcium ◽  
Cross Sectional Study ◽  
Serum Phosphate ◽  
Normal Kidney ◽  
Cross Sectional ◽  
Normal Kidney Function ◽  
The Relationship

Increased serum calcium and phosphate associated with cardiovascular disease in patients with chronic kidney disease, but research on the relationship between coronary artery calcium scores with serum calcium and phosphate in individuals with normal kidney function is lacking. We explore the relationship of serum calcium and phosphate levels with coronary atherosclerosis as assessed by cardiac Multislice Computed Tomography (MSCT) in individuals with normal kidney function. This study aims to assess the correlation of calcium level scores on cardiac MSCT examination with serum calcium and phosphate levels, and assess the association with risk factors for coronary heart disease. This study was a cross-sectional study of 40 subjects who underwent cardiac MSCT examination with normal kidney function, at RSUP Dr. Wahidin Sudirohusodo Makassar during the March-July 2019 period. The results showed an correlation between coronary artery calcium scores with calcium and serum phosphate (serum calcium r = 0.67, serum phosphate r = 0.53, p <0.05).

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