Sex-related association of serum uric acid with inflammation, kidney function and blood pressure in type 1 diabetic patients

2018 ◽  
Vol 19 (5) ◽  
pp. 1014-1019 ◽  
Author(s):  
Bartosz Słomiński ◽  
Maria Skrzypkowska ◽  
Monika Ryba-Stanisławowska ◽  
Agnieszka Brandt
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Kidney Function ◽  
Diabetic Patients ◽  
Type 1 Diabetic Patients ◽  
Related Association

scholarly journals Plasma osteoprotegerin levels are associated with glycaemic status, systolic blood pressure, kidney function and cardiovascular morbidity in type 1 diabetic patients

2006 ◽  
Vol 154 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Lars Melholt Rasmussen ◽  
Lise Tarnow ◽  
Troels Krarup Hansen ◽  
Hans-Henrik Parving ◽  
Allan Flyvbjerg
Keyword(s):  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Systolic Blood Pressure ◽  
Kidney Function ◽  
Vascular Complications ◽  
Diabetic Patients ◽  
Diabetic Vascular Complications ◽  
Patients With Diabetes ◽  
Type 1 Diabetic Patients

Objective: The bone-related peptide osteoprotegerin (OPG) has recently been found in increased amounts in the vasculature in diabetes. It is produced by vascular smooth muscle and endothelial cells, and may be implicated in the development of vascular calcifications. OPG is present in the circulation, where increased amounts have been observed in patients with diabetes. In this study, we examined whether plasma OPG is associated with the glycaemic and vascular status of patients with type 1 diabetes. Methods: Two gender-, age- and duration-comparable groups of type 1 diabetic patients either with (n = 199) or without (n = 192) signs of diabetic nephropathy were studied. Plasma OPG was determined by an ELISA. Results: The plasma OPG concentration was significantly higher in patients with nephropathy than those without (3.11 (2.49–3.99) vs 2.57 (2.19–3.21) (median (interquartiles), ng/ml), P < 0.001). Plasma OPG correlated with haemoglobin A1c (HbA1c), systolic blood pressure and age in both groups and, in addition, with kidney function in the nephropathic group. These correlations remained significant in multivariate models. In addition, we found that plasma OPG concentrations were increased among patients with cardiovascular diseases (CVD), both in the normoalbuminuric and the nephropathic groups. The differences between nephropathic and normoalbuminuric, as well as subgroups with and without CVD, could largely be ascribed to changes in HbA1c, age, systolic blood pressure and creatinine. Conclusion: OPG is associated with glycaemic control and CVD in patients with type 1 diabetes, compatible with the hypothesis that OPG is associated with the development of diabetic vascular complications.

Night Blood Pressure: Relation to Organ Lesions in Microalbuminuric Type 1 Diabetic Patients

1995 ◽  
Vol 12 (1) ◽  
pp. 42-45 ◽  
Author(s):  
K. W. Hansen ◽  
K. Sørensen ◽  
P. D. Christensen ◽  
E. B. Pedersen ◽  
J. S. Christiansen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diabetic Patients ◽  
Type 1 Diabetic Patients

A cross-over evaluation of different methods and devices to measure blood pressure in type 1 diabetic patients with nephropathy

2000 ◽  
Vol 5 (3) ◽  
pp. 175-180 ◽  
Author(s):  
Tim Heise ◽  
Kai Magnusson ◽  
Bernd Gröbel ◽  
Lutz Heinemann ◽  
Klaus Rave ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diabetic Patients ◽  
Measure Blood Pressure ◽  
Type 1 Diabetic Patients

Diurnal blood pressure variations in normoalbuminuric type 1 diabetic patients

1993 ◽  
Vol 234 (2) ◽  
pp. 175-180 ◽  
Author(s):  
K. W. HANSEN ◽  
M. M. PEDERSEN ◽  
J. S. CHRISTIANSEN ◽  
C. E. MOGENSEN
Keyword(s):  
Blood Pressure ◽  
Diabetic Patients ◽  
Type 1 Diabetic Patients

scholarly journals Independent Determinants of Urinary Albumin Excretion and Confounding Variables in Type 2 Diabetic Patient

2016 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Risk Factor ◽  
Serum Uric Acid ◽  
Biochemical Parameters ◽  
Urinary Albumin Excretion ◽  
Urinary Albumin ◽  
Diabetic Patients ◽  
Albumin Excretion ◽  
Confounding Variables

Background: Microalbuminuria is a known risk factor for the development of clinical nephropathy in diabetes and also an independent risk factor for cardiovascular disease. Microalbuminuria is a marker of a pathophysiological process that causes both increased renal albumin loss and atherothrombosis. Microalbuminuria is hallmark for early detection of diabetic nephropathy. An elevated urinary albumin excretion is a marker of endothelial dysfunction that symbolizes the kidney’s way to translate the existence of vascular damage. The aim of this study was to evaluate the independent determinants of urinary albumin excretion, and association between biochemical parameters and socio-demographic factors in Diabetic patients. Materials and Methods: This is a hospital based cross sectional study included diagnosed case of Diabetic patients. Serum uric acid concentrations were measured by enzymatic method (uricase-peroxidase), HbA1c was measured using the principle of dry chemistry, Blood Sugar measured by Glucose oxidase peroxidase (GOD/POD) method and urinary albumin excretion was measured with an immunoturbidometric assay. Results: Based on categorization of Urinary albumin excretion, 65% normoalbuminuric, 27% microalbuminuric and 8% macroalbuminuric are found in our study population. The frequency of hyperuricemia was found to be 43%. The prevalence of albuminuria ncreased significantly with increasing glycaemia. Pearsons Correlation coefficient by bivariate analysis of Urinary albumin excretion with confounding variables shows significant positive correlation with onset of DM (r=0.203, P=0.013), Systolic Blood Pressure (r=0.355, P=0.001), Diastolic Blood Pressure (r=0.405, P=0.001), Uricacid (r=0.352, P=0.001), HbA1c (r=0.212, P=0.005) and Smoking (r=0.265, P=0.01). Multiple regression test shows that independent determinant of UAE are Blood Pressure {Diastolic (β=0.313, P=0.006) /Systolic (β=0.309, P=0.002)}, HbA1c (β=0.187, P=0.010), Uric acid (β=0.331, P=0.0001) and Onset of DM (β=0.199,P=0.041). Conclusion: Albuminuria is therefore an important risk factor to measure in patients at risk. The findings extend the relationship between confounding variables and the urinary albumin excretion which emphasize on the importance of screening for icroalbuminuria, Serum Uric Acid to prevent renal dysfunction, HbA1c measurement on a regular interval for good glycemic control and the other variables for regular physiological process of body. Further examination is needed in a large population size to clarify the validity between the biochemical parameters

A4494 The effect of soursop supplement on blood pressure, serum uric acid and kidney function in prehypertensive patients for more than ten years in javanese population of Indonesia

2018 ◽  
Vol 36 ◽  
pp. e130
Author(s):  
Mochammad Sja’bani ◽  
Haidar Alatas ◽  
Mustofa Mustofa ◽  
Ali Ghufron Mukti ◽  
Lucky Azizah Bawazier ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Kidney Function

scholarly journals Increased QTc Dispersion Is Related to Blunted Circadian Blood Pressure Variation in Normoalbuminuric Type 1 Diabetic Patients

Diabetes ◽  
2001 ◽  
Vol 50 (4) ◽  
pp. 837-842 ◽  
Author(s):  
P. L. Poulsen ◽  
E. Ebbehoj ◽  
H. Arildsen ◽  
S. T. Knudsen ◽  
K. W. Hansen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pressure Variation ◽  
Diabetic Patients ◽  
Qtc Dispersion ◽  
Circadian Blood Pressure ◽  
Blood Pressure Variation ◽  
Type 1 Diabetic Patients

scholarly journals Dopamine D3 receptor gene polymorphisms, blood pressure and nephropathy in type 1 diabetic patients

2004 ◽  
Vol 19 (6) ◽  
pp. 1432-1436 ◽  
Author(s):  
K. J. Pettersson-Fernholm ◽  
C. M. Forsblom ◽  
M. Perola ◽  
J. A. Fagerudd ◽  
P.-H. Groop
Keyword(s):  
Blood Pressure ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Diabetic Patients ◽  
Dopamine D3 Receptor ◽  
D3 Receptor ◽  
Dopamine D3 ◽  
Receptor Gene Polymorphisms ◽  
Type 1 Diabetic Patients
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