scholarly journals Mechanisms of action for aryl hydrocarbon receptor ligands in the PLHC-1 cell line

1999 ◽  
Author(s):  
Eli V. Hestermann
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Cell Line ◽  
Mechanisms Of Action ◽  
Receptor Ligands ◽  
Aryl Hydrocarbon

scholarly journals Establishment of a Rat Hepatic Cell Line, KanR2-XL8, for a Reporter Gene Assay of Aryl Hydrocarbon Receptor Ligands

2004 ◽  
Vol 50 (5) ◽  
pp. 530-536 ◽  
Author(s):  
Masashi Sekimoto ◽  
Miho Iwamoto ◽  
Shoji Miyajima ◽  
Kiyomitsu Nemoto ◽  
Masakuni Degawa
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Cell Line ◽  
Reporter Gene ◽  
Reporter Gene Assay ◽  
Hepatic Cell ◽  
Receptor Ligands ◽  
Aryl Hydrocarbon ◽  
Hepatic Cell Line ◽  
Gene Assay

Analysis of aryl hydrocarbon receptor ligands in kraft mill effluents by a combination of yeast bioassays and CG-MS chemical determinations

2013 ◽  
Vol 48 (2) ◽  
pp. 145-151 ◽  
Author(s):  
Soledad Chamorro ◽  
Elizabeth Monsalvez ◽  
Benjamín Piña ◽  
Alba Olivares ◽  
Víctor Hernández ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Ligands ◽  
Aryl Hydrocarbon ◽  
Kraft Mill

Reduction of CC-chemokine ligand 5 by aryl hydrocarbon receptor ligands

2013 ◽  
Vol 72 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Saori Morino-Koga ◽  
Hiroshi Uchi ◽  
Gaku Tsuji ◽  
Masakazu Takahara ◽  
Junboku Kajiwara ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Ligands ◽  
Cc Chemokine ◽  
Aryl Hydrocarbon ◽  
Chemokine Ligand

Influence of cellular redox environment on aryl hydrocarbon receptor ligands induced melanogenesis

2021 ◽  
pp. 105282
Author(s):  
Ali Ghaffarian-Bahraman ◽  
Mohammad-Reza Arabnezhad ◽  
Majid Keshavarzi ◽  
Dorna Davani-Davari ◽  
Akram Jamshidzadeh ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Ligands ◽  
Cellular Redox ◽  
Redox Environment ◽  
Aryl Hydrocarbon ◽  
Cellular Redox Environment

scholarly journals E-cigarette Aerosol Condensate Enhances Metabolism of Benzo(a)pyrene to Genotoxic Products, and Induces CYP1A1 and CYP1B1, Likely by Activation of the Aryl Hydrocarbon Receptor

2019 ◽  
Vol 16 (14) ◽  
pp. 2468 ◽  
Author(s):  
Yuan-Wan Sun ◽  
Wieslawa Kosinska ◽  
Joseph B. Guttenplan
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Cell Line ◽  
Tobacco Smoke ◽  
Genotoxic Effects ◽  
Aryl Hydrocarbon ◽  
Hydrolysis Products ◽  
Spontaneous Hydrolysis ◽  
Tobacco Carcinogen ◽  
Keratinocyte Cell ◽  
Carcinogenic Metabolite

E-cigarette aerosol contains lower levels of most known carcinogens than tobacco smoke, but many users of e-cigarettes are also smokers, and these individuals may be vulnerable to possible promoting and/or cocarcinogenic effects of e-cigarettes. We investigated the possibility that a condensate of e-cigarette aerosol (EAC) enhances the metabolism of the tobacco carcinogen, benzo(a)pyrene (BaP), to genotoxic products in a human oral keratinocyte cell line. Cells were pretreated with EAC from two popular e-cigs and then with BaP. Metabolism to its ultimate carcinogenic metabolite, anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydro B[a]P (BPDE), was assayed by measuring isomers of its spontaneous hydrolysis products, BaP tetrols. The pretreatment of cells with EAC enhanced the rate of BaP tetrol formation several fold. Pretreatment with the e-liquid resulted in a smaller enhancement. The treatment of cells with EAC induced CYP1A1/1B1 mRNA and protein. The enhancement of BaP tetrol formation was inhibited by the aryl hydrocarbon receptor (AhR) inhibitor, α-napthoflavone, indicating EAC likely induces CYP1A1/1B1 and enhances BaP metabolism by activating the AhR. To our knowledge, this is first report demonstrating that e-cigarettes can potentiate the genotoxic effects of a tobacco smoke carcinogen.

Aryl Hydrocarbon Receptor Ligands Inhibit TGF² Induced Myofibroblast Differentiation

2012 ◽  
Author(s):  
Robert M. Kottmann ◽  
Thomas H. Thatcher ◽  
Elizabeth Lyda ◽  
Amali Epa ◽  
Richard P. Phipps ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Myofibroblast Differentiation ◽  
Receptor Ligands ◽  
Aryl Hydrocarbon
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