The Study of Interface Bone Formation Resulting from the Use of Intraosseous Titanium Implants

1987 ◽  
Vol 110 ◽  
Author(s):  
Philip J. Boyne
Keyword(s):  
Bone Formation ◽  
Titanium Implants ◽  
Papio Anubis ◽  
Recipient Site ◽  
Metal Implant ◽  
Metal Implants ◽  
Metallic Implants ◽  
Interface Phenomena ◽  
Bone Changes ◽  
The Subject

The histopathologic characteristics of interface phenomena existing along the surfaces of intraosseous metallic implants has been the subject of much discussion in relating the composition and configuration of implant fixtures to maximal osteointegration. (1,2) The purpose of this study was to evaluate and characterize host bone changes to various types of intraosseous metal implants placed in the femurs of six Papio anubis baboons. We wished to evaluate changes in recipient site bone remodeling which could be related to the specifics of configuration and type of metal implant used.

scholarly journals In Vivo Study for Clinical Application of Dental Stem Cell Therapy Incorporated with Dental Titanium Implants

Materials ◽  
2021 ◽  
Vol 14 (2) ◽  
pp. 381
Author(s):  
Hyunmin Choi ◽  
Kyu-Hyung Park ◽  
Narae Jung ◽  
June-Sung Shim ◽  
Hong-Seok Moon ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Formation ◽  
Alveolar Bone ◽  
Human Mesenchymal Stem Cells ◽  
Titanium Implants ◽  
Osteogenic Potential ◽  
Induction Medium ◽  
Radiographic Analysis ◽  
New Bone Formation

The aim of this study was to investigate the behavior of dental-derived human mesenchymal stem cells (d-hMSCs) in response to differently surface-treated implants and to evaluate the effect of d-hMSCs on local osteogenesis around an implant in vivo. d-hMSCs derived from alveolar bone were established and cultured on machined, sandblasted and acid-etched (SLA)-treated titanium discs with and without osteogenic induction medium. Their morphological and osteogenic potential was assessed by scanning electron microscopy (SEM) and real-time polymerase chain reaction (RT-PCR) via mixing of 5 × 106 of d-hMSCs with 1 mL of Metrigel and 20 μL of gel-cell mixture, which was dispensed into the defect followed by the placement of customized mini-implants (machined, SLA-treated implants) in New Zealand white rabbits. Following healing periods of 2 weeks and 12 weeks, the obtained samples in each group were analyzed radiographically, histomorphometrically and immunohistochemically. The quantitative change in osteogenic differentiation of d-hMSCs was identified according to the type of surface treatment. Radiographic analysis revealed that an increase in new bone formation was statistically significant in the d-hMSCs group. Histomorphometric analysis was in accordance with radiographic analysis, showing the significantly increased new bone formation in the d-hMSCs group regardless of time of sacrifice. Human nuclei A was identified near the area where d-hMSCs were implanted but the level of expression was found to be decreased as time passed. Within the limitations of the present study, in this animal model, the transplantation of d-hMSCs enhanced the new bone formation around an implant and the survival and function of the stem cells was experimentally proven up to 12 weeks post-sacrifice.

Effect of RGD peptide coating of titanium implants on periimplant bone formation in the alveolar crest

2002 ◽  
Vol 13 (3) ◽  
pp. 312-319 ◽  
Author(s):  
Henning Schliephake ◽  
Dieter Scharnweber ◽  
Michael Dard ◽  
Sophie Rößler ◽  
Andreas Sewing ◽  
...  
Keyword(s):  
Bone Formation ◽  
Rgd Peptide ◽  
Titanium Implants ◽  
Alveolar Crest ◽  
Peptide Coating

scholarly journals Application of Laser-Induced Bone Therapy by Carbon Dioxide Laser Irradiation in Implant Therapy

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Takahiro Naka ◽  
Satoshi Yokose
Keyword(s):  
Bone Formation ◽  
Laser Irradiation ◽  
Healing Process ◽  
Titanium Implants ◽  
Control Group ◽  
Sham Operation ◽  
Micro Ct ◽  
Rat Tibia ◽  
Implant Therapy ◽  
Laser Group

This study evaluated the application of laser-induced bone therapy (LIBT) to reduce implant healing time in rat tibia. Twenty 10-week-old female Sprague-Dawlay rats were used. The rats received laser irradiation (laser group) or sham operation (control group) on either side of the tibia. Five days after invasion, titanium implants were inserted in proximal tibia. Five, 10, and 20 days after implant placement, tibiae were collected. After taking micro-CT and performing a torque test, the tibiae were decalcified and 8-μm-thick sections were prepared. Specimens were stained with hematoxylin and eosin.Results. Micro-CT images, removal torque values, and histomorphometric analysis data demonstrated a significantly accelerated bone formation in the laser group earlier in the healing process.Conclusion. The use of laser irradiation was effective in promoting bone formation and acquiring osseointegration of titanium implants inserted in rat tibia. LIBT may be suitable for use in implant therapy.

Influence of a Machined Collar on Crestal Bone Changes Around Titanium Implants: A Histometric Study in the Canine Mandible

2011 ◽  
Vol 82 (9) ◽  
pp. 1329-1338 ◽  
Author(s):  
Joachim S. Hermann ◽  
Archie A. Jones ◽  
Lara G. Bakaeen ◽  
Daniel Buser ◽  
John D. Schoolfield ◽  
...  
Keyword(s):  
Titanium Implants ◽  
Bone Changes

Hydroxyapatite nanoparticles in poly-D,L-lactic acid coatings on porous titanium implants conducts bone formation

2010 ◽  
Vol 95A (3) ◽  
pp. 665-672 ◽  
Author(s):  
Thomas Jensen ◽  
Thomas Jakobsen ◽  
Jørgen Baas ◽  
Jens V. Nygaard ◽  
Alireza Dolatshahi-Pirouz ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Bone Formation ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Hydroxyapatite Nanoparticles

scholarly journals Anodisation Increases Integration of Unloaded Titanium Implants in Sheep Mandible

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Warwick J. Duncan ◽  
Min-Ho Lee ◽  
Tae-Sung Bae ◽  
Sook-Jeong Lee ◽  
Jennifer Gay ◽  
...  
Keyword(s):  
Titanium Implant ◽  
Titanium Implants ◽  
Implant Stability ◽  
Bone Implant ◽  
Implant Stability Quotient ◽  
Phosphate Ions ◽  
Surface Control ◽  
Bone Implant Contact ◽  
The Subject ◽  
Clinically Significant

Spark discharge anodic oxidation forms porous TiO2films on titanium implant surfaces. This increases surface roughness and concentration of calcium and phosphate ions and may enhance early osseointegration. To test this, forty 3.75 mm × 13 mm titanium implants (Megagen, Korea) were placed into healed mandibular postextraction ridges of 10 sheep. There were 10 implants per group: RBM surface (control), RBM + anodised, RBM + anodised + fluoride, and titanium alloy + anodised surface. Resonant frequency analysis (RFA) was measured in implant stability quotient (ISQ) at surgery and at sacrifice after 1-month unloaded healing. Mean bone-implant contact (% BIC) was measured in undemineralised ground sections for the best three consecutive threads. One of 40 implants showed evidence of failure. RFA differed between groups at surgery but not after 1 month. RFA values increased nonsignificantly for all implants after 1 month, except for controls. There was a marked difference in BIC after 1-month healing, with higher values for alloy implants, followed by anodised + fluoride and anodised implants. Anodisation increased early osseointegration of rough-surfaced implants by 50–80%. RFA testing lacked sufficient resolution to detect this improvement. Whether this gain in early bone-implant contact is clinically significant is the subject of future experiments.

scholarly journals In vivoelectrical application on titanium implants stimulating bone formation

2016 ◽  
Vol 52 (3) ◽  
pp. 479-484 ◽  
Author(s):  
L. M. Bins-Ely ◽  
E. B. Cordero ◽  
J. C. M. Souza ◽  
W. Teughels ◽  
C. A. M. Benfatti ◽  
...  
Keyword(s):  
Bone Formation ◽  
Titanium Implants
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