Hydroxyapatite nanoparticles in poly-D,L-lactic acid coatings on porous titanium implants conducts bone formation

2010 ◽  
Vol 95A (3) ◽  
pp. 665-672 ◽  
Author(s):  
Thomas Jensen ◽  
Thomas Jakobsen ◽  
Jørgen Baas ◽  
Jens V. Nygaard ◽  
Alireza Dolatshahi-Pirouz ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Bone Formation ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Hydroxyapatite Nanoparticles

Lactic acid of PLGA coating promotes angiogenesis on the interface between porous titanium and diabetic bone

2018 ◽  
Vol 6 (15) ◽  
pp. 2274-2288 ◽  
Author(s):  
Xiao-Fan Hu ◽  
Ya-Fei Feng ◽  
Geng Xiang ◽  
Wei Lei ◽  
Lin Wang
Keyword(s):  
Lactic Acid ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Bone Implant ◽  
3D Printed

PLGA-coating on 3D-printed porous titanium implants promoted the angiogenesis and osteointegration at bone-implant interface in diabetes by releasing lactic acid.

Migration, Matrix Production and Lamellar Bone Formation of Human Osteoblast-Like Cells in Porous Titanium Implants

2002 ◽  
Vol 170 (4) ◽  
pp. 214-227 ◽  
Author(s):  
K.-H. Frosch ◽  
F. Barvencik ◽  
C.H. Lohmann ◽  
V. Viereck ◽  
H. Siggelkow ◽  
...  
Keyword(s):  
Bone Formation ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Human Osteoblast ◽  
Lamellar Bone ◽  
Matrix Production

Bone Growth in Porous Titanium Implants Made by Rapid Prototyping

2006 ◽  
Vol 309-311 ◽  
pp. 1099-1104 ◽  
Author(s):  
Marco A. Lopez-Heredia ◽  
Eric Goyenvalle ◽  
Eric Aguado ◽  
C. Leroux ◽  
M. Dorget ◽  
...  
Keyword(s):  
Compressive Strength ◽  
New Zealand ◽  
Bone Formation ◽  
Rapid Prototyping ◽  
Porous Structure ◽  
Bone Growth ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Interconnected Pore ◽  
New Zealand Rabbits

Two porous titanium implants with interconnected pore size of 800 and 1200 m in diameter, were fabricated by a rapid prototyping method. Their dimensions and structure accomplished the expected design with accuracy and reproducibility. The porosity of titanium was around 60%. The compressive strength and Young’s modulus were comparable to those of cortical bone with values around 80 MPa and 2.7 GPa, respectively. The implants were implanted bilaterally in the femoral epiphysis of 12 New Zealand Rabbits. After 3 and 8 weeks, abundant bone formation was found in the titanium porous structure. This work demonstrates that macroporous titanium with controlled shape and porosity is a good candidate for orthopaedic and maxilofacial applications.

The Effect of Hydroxyapatite on Bone Ingrowth into Porous-Coated Titanium Implants

2002 ◽  
Vol 12 (2) ◽  
pp. 153-157 ◽  
Author(s):  
A. Moroni ◽  
C. Faldini ◽  
F. Pegreffi ◽  
S. Giannini
Keyword(s):  
Electron Microscopy ◽  
Bone Formation ◽  
Cancellous Bone ◽  
Bone Ingrowth ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Press Fit ◽  
Ha Coating ◽  
Backscattered Electron ◽  
Bead Diameter

Two different groups of hydroxyapatite (HA) coated and uncoated porous titanium implants, 250–350 μm and 500–700 μm diameter beads, were press-fit in femoral canine cancellous bone. After 12 weeks, the dogs were euthanized and histomorphometric backscattered electron microscopy studies were carried out. Comparing HA-coated versus uncoated implants in the 250–350 μm bead diameter group percentage of bone (P=0.01) and bone index (P=0.01), were higher in the HA-coated implants. Comparing HA-coated versus uncoated implants in the 500–700 μm bead diameter group bone ingrowth (P=0.01) and bone depth penetration (P=0.008), were higher in HA-coated samples. It can be concluded that the HA coating was an effective method to improve bone formation and ingrowth in the porous implants.

scholarly journals In Vivo Study for Clinical Application of Dental Stem Cell Therapy Incorporated with Dental Titanium Implants

Materials ◽  
2021 ◽  
Vol 14 (2) ◽  
pp. 381
Author(s):  
Hyunmin Choi ◽  
Kyu-Hyung Park ◽  
Narae Jung ◽  
June-Sung Shim ◽  
Hong-Seok Moon ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Formation ◽  
Alveolar Bone ◽  
Human Mesenchymal Stem Cells ◽  
Titanium Implants ◽  
Osteogenic Potential ◽  
Induction Medium ◽  
Radiographic Analysis ◽  
New Bone Formation

The aim of this study was to investigate the behavior of dental-derived human mesenchymal stem cells (d-hMSCs) in response to differently surface-treated implants and to evaluate the effect of d-hMSCs on local osteogenesis around an implant in vivo. d-hMSCs derived from alveolar bone were established and cultured on machined, sandblasted and acid-etched (SLA)-treated titanium discs with and without osteogenic induction medium. Their morphological and osteogenic potential was assessed by scanning electron microscopy (SEM) and real-time polymerase chain reaction (RT-PCR) via mixing of 5 × 106 of d-hMSCs with 1 mL of Metrigel and 20 μL of gel-cell mixture, which was dispensed into the defect followed by the placement of customized mini-implants (machined, SLA-treated implants) in New Zealand white rabbits. Following healing periods of 2 weeks and 12 weeks, the obtained samples in each group were analyzed radiographically, histomorphometrically and immunohistochemically. The quantitative change in osteogenic differentiation of d-hMSCs was identified according to the type of surface treatment. Radiographic analysis revealed that an increase in new bone formation was statistically significant in the d-hMSCs group. Histomorphometric analysis was in accordance with radiographic analysis, showing the significantly increased new bone formation in the d-hMSCs group regardless of time of sacrifice. Human nuclei A was identified near the area where d-hMSCs were implanted but the level of expression was found to be decreased as time passed. Within the limitations of the present study, in this animal model, the transplantation of d-hMSCs enhanced the new bone formation around an implant and the survival and function of the stem cells was experimentally proven up to 12 weeks post-sacrifice.

scholarly journals Understanding long-term silver release from surface modified porous titanium implants

2017 ◽  
Vol 58 ◽  
pp. 550-560 ◽  
Author(s):  
Anish Shivaram ◽  
Susmita Bose ◽  
Amit Bandyopadhyay
Keyword(s):  
Porous Titanium ◽  
Titanium Implants ◽  
Silver Release ◽  
Surface Modified

Effect of RGD peptide coating of titanium implants on periimplant bone formation in the alveolar crest

2002 ◽  
Vol 13 (3) ◽  
pp. 312-319 ◽  
Author(s):  
Henning Schliephake ◽  
Dieter Scharnweber ◽  
Michael Dard ◽  
Sophie Rößler ◽  
Andreas Sewing ◽  
...  
Keyword(s):  
Bone Formation ◽  
Rgd Peptide ◽  
Titanium Implants ◽  
Alveolar Crest ◽  
Peptide Coating
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