Quantitative Histology and Mechanical Testing of a Biodegradable Bone Cement

1987 ◽  
Vol 110 ◽  
Author(s):  
Tobin N. Gerhart ◽  
A. A. Renshaw ◽  
W. C. Hayes
Keyword(s):  
Bone Cement ◽  
Tricalcium Phosphate ◽  
Bone Ingrowth ◽  
Particulate Composite ◽  
Polymerization Reaction ◽  
Particulate Phase ◽  
The Matrix ◽  
Temporary Stabilization ◽  
Composite Bone

We have developed a particulate composite bone cement consisting of a particulate phase of tricalcium phosphate (TCP) particles bound together by a polymeric matric phase (PPF). This matrix hardens through a free radical polymerization reaction in vivo within several minutes after mixing. The initial mechanical strength of our particulate composite bone cement results from the matrix, but over time this degrades and the strength is augmented by bone ingrowth and incorporation of the tricalcium phosphate particles. Possible orthopaedic applications include fixation of fractures, augmenting fixation of implants in osteoporetic bone, and temporary stabilization of bone ingrowth prostheses.

In vivo histologic and biomechanical characterization of a biodegradable particulate composite bone cement

1989 ◽  
Vol 23 (1) ◽  
pp. 1-16 ◽  
Author(s):  
Tobin N. Gerhart ◽  
Andrew A. Renshaw ◽  
Richard L. Miller ◽  
Robert J. Noecker ◽  
Wilson C. Hayes
Keyword(s):  
Bone Cement ◽  
Particulate Composite ◽  
Composite Bone

In-Vivo Degradation of a Poly(Propylene-Fumarate) Biodegradable, Particulate Composite Bone Cement

1995 ◽  
Vol 394 ◽  
Author(s):  
Daveed D. Frazier ◽  
Vijay K. Lathi ◽  
Tobin N. Gerhart ◽  
David E. Altobelli ◽  
Wilson C. Hayes
Keyword(s):  
Bone Cement ◽  
Ex Vivo ◽  
Particulate Composite ◽  
Structural Reinforcement ◽  
Age Related ◽  
Poly Propylene ◽  
Osseous Defects ◽  
Sufficient Strength ◽  
Composite Bone

AbstractWe have developed a biodegradable particulate composite bone cement consisting of a poly(propylene glycol-fumarate)-(methylmethacrylate) matrix mixed with calcium carbonate and tricalcium phosphate particulates. Previous ex-vivo studies suggest that this system provides sufficient strength for a number of potential clinical applications including structural reinforcement of osseous defects, supplementation of internal fixation of age-related fractures, and delivery of antibiotics to treat osteomyelitis. Ex-vivo degradation assays have also shown that the cement approximates physiologic conditions of bone remodeling as it degrades. In order to evaluate the in-vivo responses to this material, we implanted cement specimens subcutaneously in rats for up to 84 days. Compressive strength of the subcutaneous implants increased linearly through day 21 to 4.91 MPa, then decreased linearly by day 84 to less than 1 MPa. We conclude that this PPFMMA system is biocompatible and biodegradable, and has the potential for use as an orthopedic bone cement. Future studies will be directed toward characterizing the intraosseous histological response and at coordinating the rate of cement degradation with bony ingrowth.

Improved bone ingrowth of tricalcium phosphate filled Poly(methyl methacrylate) (PMMA) bone cements in vivo

2019 ◽  
Vol 76 ◽  
pp. 513-521 ◽  
Author(s):  
Shan Gao ◽  
Yang Lv ◽  
Liang Yuan ◽  
Huihui Ren ◽  
Teng Wu ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Tricalcium Phosphate ◽  
Bone Ingrowth ◽  
Bone Cements ◽  
Poly Methyl Methacrylate

Preparation and in vivo evaluation of a silicate-based composite bone cement

2017 ◽  
Vol 32 (2) ◽  
pp. 257-264 ◽  
Author(s):  
Bing Ma ◽  
Zhiguang Huan ◽  
Chen Xu ◽  
Nan Ma ◽  
Haibo Zhu ◽  
...  
Keyword(s):  
Bone Cement ◽  
In Vivo Evaluation ◽  
Composite Bone

Osteogenic biphasic calcium sulphate dihydrate/iron-modified α-tricalcium phosphate bone cement for spinal applications: In vivo study

2010 ◽  
Vol 6 (2) ◽  
pp. 607-616 ◽  
Author(s):  
M.D. Vlad ◽  
E.V. Şindilar ◽  
M.L. Mariñoso ◽  
I. Poeată ◽  
R. Torres ◽  
...  
Keyword(s):  
Bone Cement ◽  
Tricalcium Phosphate ◽  
Calcium Sulphate ◽  
In Vivo Study

Bioactive composite bone cement based on α-tricalcium phosphate/tricalcium silicate

2011 ◽  
Vol 100B (1) ◽  
pp. 94-102 ◽  
Author(s):  
Loreley Morejón-Alonso ◽  
Oscar Jacinto Bareiro Ferreira ◽  
Raúl Garcia Carrodeguas ◽  
Luis Alberto dos Santos
Keyword(s):  
Bone Cement ◽  
Tricalcium Phosphate ◽  
Tricalcium Silicate ◽  
Composite Bone

scholarly journals In situ Synchrotron X-ray Powder Diffraction Study of the Early Hydration of α-tricalcium Phosphate/tricalcium Silicate Composite Bone Cement

2015 ◽  
Vol 18 (1) ◽  
pp. 164-169 ◽  
Author(s):  
Loreley Morejón-Alonso ◽  
Mariana Motisuke ◽  
José Raúl Correa ◽  
Raúl García Carrodeguas ◽  
Luis Alberto dos Santos
Keyword(s):  
Bone Cement ◽  
Diffraction Study ◽  
Powder Diffraction ◽  
Tricalcium Phosphate ◽  
Tricalcium Silicate ◽  
Early Hydration ◽  
X Ray ◽  
Composite Bone

In vitro and in vivo effectiveness of a novel injectable calcitonin-loaded collagen/ceramic bone substitute

2021 ◽  
pp. 088532822198998
Author(s):  
Karl Wu ◽  
Yu-Chun Chen ◽  
Shang M Lin ◽  
Chih-Hung Chang
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Degradation Rate ◽  
Rabbit Model ◽  
Type I ◽  
Calcium Phosphate Bone Cement ◽  
Osteogenic Effect ◽  
Composite Bone

This study aimed to evaluate the effectiveness of a novel calcitonin-loaded calcium phosphate composite bone cement in vitro and in vivo. The novel composite bone cements were composed of NuROs injectable bone graft substitute, type I collagen, and/or salmon calcitonin. The setting time, porosity, wettability, compressive strength, compressive modulus, and crystallographic structures of cement specimens were determined. Degradation rate, calcitonin release rate, and osteoinductivity were assessed in vitro. In addition, osteogenic effect was examined in a rabbit model of femoral defect. The results revealed that addition of collagen/calcitonin did not substantially alter physical properties and degradation rate of bone cement specimens. Calcitonin was released into culture medium in a two-phase manner. Osteogenic effect of conditioned medium derived from calcitonin containing bone cement was observed. Finally, de novo bone growth and bone mineralization across the bone defect area were observed in rabbits after implantation of composite bone cement specimens. In conclusion, this novel calcitonin-loaded composite calcium phosphate bone cement exhibits biocompatibility, bioresorbability, osteoinductivity, and osteoconductivity, which may be suitable for clinical use.

scholarly journals Comparative evaluation of polymethylmethacrylate and composite bone cements. Review of the experimental studies results

2021 ◽  
pp. 86-91
Author(s):  
Oleg Vyrva ◽  
Olexii Goncharuk ◽  
Natalia Lysenko
Keyword(s):  
Bone Cement ◽  
Bone Tissue ◽  
Experimental Studies ◽  
Bone Cements ◽  
Main Task ◽  
Composite Cement ◽  
Bone Fragments ◽  
Intensive Work ◽  
Composite Bone

Current article is a review of experimental studies of different bone cements types and their combinations. Providing of bone fragments  stable fixation  at osteosynthesis  in cases of difficult multifragmental fractures, arthroplasties and other implants using especially in the osteoporosis conditions is a main task of orthopaedic surgery procedures. Polymethylmethacrylate (PMMA) is the first material that is answered to these requirements. The evolution of bone cements resulted in creation of a new composite substance — combination of PMMA and β-threecalciumphosfates (β-TCPh). Combination of these two components allowed to provide high bioabsorbal, osteoconductive and osteointegrative properties along with sufficient durability. In the analyzed works the properties of composite cement CalCemex were evaluated in vivo experiment. It was found that in the case of PMMA penetration of bone tissue into the polymer structure did not occur. Under the conditions of using bone cement with β-TCF admixture, the formation of bone tissue was observed not only on the surface of the implant, but also in the external and internal pores. It is the presence of pores in CalCemex that the authors explain the possibility of penetration of cellular elements, blood vessels and bone formation. Moreover, β-TCPh is included into this material and it is bioresorbed by osteoclasts. This leads to the release of calcium and phosphorus ions and, consequently, simplifies the attachment of the newly formed bone to the bone cement. We assume that composite cement like CalCemex type is a promising material for the treatment of various types of fractures and replacement of bone defects. It should be mentioned that research in this area is ongoing and intensive work is underway to synthesize and study the results of clinical application of composite bone cements with maximum bioactive properties that will not only strengthen bone tissue but also perform osteointegrative function. Key words. Bone cement, polymethylmethacrylate, β-threecalciumphosfates, experiment.

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