Bioactive composite bone cement based on α-tricalcium phosphate/tricalcium silicate

2011 ◽  
Vol 100B (1) ◽  
pp. 94-102 ◽  
Author(s):  
Loreley Morejón-Alonso ◽  
Oscar Jacinto Bareiro Ferreira ◽  
Raúl Garcia Carrodeguas ◽  
Luis Alberto dos Santos
Keyword(s):  
Bone Cement ◽  
Tricalcium Phosphate ◽  
Tricalcium Silicate ◽  
Composite Bone

scholarly journals In situ Synchrotron X-ray Powder Diffraction Study of the Early Hydration of α-tricalcium Phosphate/tricalcium Silicate Composite Bone Cement

2015 ◽  
Vol 18 (1) ◽  
pp. 164-169 ◽  
Author(s):  
Loreley Morejón-Alonso ◽  
Mariana Motisuke ◽  
José Raúl Correa ◽  
Raúl García Carrodeguas ◽  
Luis Alberto dos Santos
Keyword(s):  
Bone Cement ◽  
Diffraction Study ◽  
Powder Diffraction ◽  
Tricalcium Phosphate ◽  
Tricalcium Silicate ◽  
Early Hydration ◽  
X Ray ◽  
Composite Bone

A novel degradable tricalcium silicate/calcium polyphosphate/polyvinyl alcohol organic-inorganic composite cement for bone filling

2021 ◽  
pp. 088532822110203
Author(s):  
Rongguang Zhang ◽  
Jinbo Hu ◽  
Hong Chen ◽  
Zhengwen Ding ◽  
Yalan Ouyang ◽  
...  
Keyword(s):  
Polyvinyl Alcohol ◽  
Bone Cement ◽  
Setting Time ◽  
Biological Properties ◽  
Tricalcium Silicate ◽  
Bone Cements ◽  
Matrix Mineralization ◽  
Calcium Polyphosphate ◽  
Composite Bone

In this study, tricalcium silicate (C3S) calcium/polyphosphate/polyvinyl alcohol organic-inorganic self-setting composites were successfully designed. A variety of tests were conducted to characterize their self-setting properties, mechanical properties, degradation properties, and related biological properties. The composite bone cements showed a short setting time (5.5–37.5 min) with a 5:5–6:4 ratio of C3S/CPP to maintain a stable compressive strength (28 MPa). In addition, PVA effectively reduced the brittleness of the inorganic phase. Degradation experiments confirmed the sustainable surface degradation of bone cement. A maximum degradation rate of 49% was reached within 56 days, and the structure remained intact without collapse. Culturing MC3T3 cells with bone cement extracts revealed that the composite bone cements had excellent biological properties in vitro. The original extract showed a proliferation promotion effect on cells, whereas most of the other original extracts of degradable bone cements were toxic to the cells. Meanwhile, extracellular matrix mineralization and alkaline phosphatase expression showed remarkable effects on cell differentiation. In addition, a good level of adhesion of cells to the surfaces of materials was observed. Taken together, these results indicate that C3S/CPP/PVA composite bone cements have great potential in bone defect filling for fast curing.

Quantitative Histology and Mechanical Testing of a Biodegradable Bone Cement

1987 ◽  
Vol 110 ◽  
Author(s):  
Tobin N. Gerhart ◽  
A. A. Renshaw ◽  
W. C. Hayes
Keyword(s):  
Bone Cement ◽  
Tricalcium Phosphate ◽  
Bone Ingrowth ◽  
Particulate Composite ◽  
Polymerization Reaction ◽  
Particulate Phase ◽  
The Matrix ◽  
Temporary Stabilization ◽  
Composite Bone

We have developed a particulate composite bone cement consisting of a particulate phase of tricalcium phosphate (TCP) particles bound together by a polymeric matric phase (PPF). This matrix hardens through a free radical polymerization reaction in vivo within several minutes after mixing. The initial mechanical strength of our particulate composite bone cement results from the matrix, but over time this degrades and the strength is augmented by bone ingrowth and incorporation of the tricalcium phosphate particles. Possible orthopaedic applications include fixation of fractures, augmenting fixation of implants in osteoporetic bone, and temporary stabilization of bone ingrowth prostheses.

scholarly journals Development and characterization of α-tricalcium phosphate/monocalcium aluminate composite bone cement

2012 ◽  
Vol 05 (08) ◽  
pp. 448-456 ◽  
Author(s):  
Loreley Morejón-Alonso ◽  
Raúl García Carrodeguas ◽  
Luis Alberto dos Santos
Keyword(s):  
Bone Cement ◽  
Tricalcium Phosphate ◽  
Composite Bone

Synergistic effects of citric acid - sodium alginate on physicochemical properties of α-tricalcium phosphate bone cement

2019 ◽  
Vol 45 (2) ◽  
pp. 2146-2152 ◽  
Author(s):  
Haishan Shi ◽  
Wenqian Zhang ◽  
Xu Liu ◽  
Shenghui Zeng ◽  
Tao Yu ◽  
...  
Keyword(s):  
Citric Acid ◽  
Physicochemical Properties ◽  
Bone Cement ◽  
Sodium Alginate ◽  
Tricalcium Phosphate ◽  
Synergistic Effects
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