Improved bone ingrowth of tricalcium phosphate filled Poly(methyl methacrylate) (PMMA) bone cements in vivo

2019 ◽  
Vol 76 ◽  
pp. 513-521 ◽  
Author(s):  
Shan Gao ◽  
Yang Lv ◽  
Liang Yuan ◽  
Huihui Ren ◽  
Teng Wu ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Tricalcium Phosphate ◽  
Bone Ingrowth ◽  
Bone Cements ◽  
Poly Methyl Methacrylate

scholarly journals Incorporation of surface-modified hydroxyapatite into poly(methyl methacrylate) to improve biological activity and bone ingrowth

2019 ◽  
Vol 6 (5) ◽  
pp. 182060 ◽  
Author(s):  
Kuan-Lin Ku ◽  
Yu-Shan Wu ◽  
Chi-Yun Wang ◽  
Ding-Wei Hong ◽  
Zong-Xing Chen ◽  
...  
Keyword(s):  
Biological Activity ◽  
Ethylene Glycol ◽  
Methyl Methacrylate ◽  
Bone Ingrowth ◽  
Poly Methyl Methacrylate ◽  
Pmma Bone Cement ◽  
Ring Opening Reaction ◽  
Surface Modified

Poly(methyl methacrylate) (PMMA) is the most frequently used bone void filler in orthopedic surgery. However, the interface between the PMMA-based cement and adjacent bone tissue is typically weak as PMMA bone cement is inherently bioinert and not ideal for bone ingrowth. The present study aims to improve the affinity between the polymer and ceramic interphases. By surface modifying nano-sized hydroxyapatite (nHAP) with ethylene glycol and poly(ɛ-caprolactone) (PCL) sequentially via a two-step ring opening reaction, affinity was improved between the polymer and ceramic interphases of PCL-grafted ethylene glycol-HAP (gHAP) in PMMA. Due to better affinity, the compressive strength of gHAP/PMMA was significantly enhanced compared with nHAP/PMMA. Furthermore, PMMA with 20 wt.% gHAP promoted pre-osteoblast cell proliferation in vitro and showed the best osteogenic activity between the composites tested in vivo . Taken together, gHAP/PMMA not only improves the interfacial adhesion between the nanoparticles and cement, but also increases the biological activity and affinity between the osteoblast cells and PMMA composite cement. These results show that gHAP and its use in polymer/bioceramic composite has great potential to improve the functionality of PMMA cement.

scholarly journals Mixed Amphiphilic Polymeric Nanoparticles of Chitosan, Poly(vinyl alcohol) and Poly(methyl methacrylate) for Intranasal Drug Delivery: A Preliminary In Vivo Study

Molecules ◽  
2020 ◽  
Vol 25 (19) ◽  
pp. 4496 ◽  
Author(s):  
Inbar Schlachet ◽  
Hen Moshe Halamish ◽  
Alejandro Sosnik
Keyword(s):  
Methyl Methacrylate ◽  
Vinyl Alcohol ◽  
Sodium Tripolyphosphate ◽  
Brain Regions ◽  
Poly Vinyl Alcohol ◽  
Drug Bioavailability ◽  
Poly Methyl Methacrylate ◽  
Target Organs ◽  
The Brain

Intranasal (i.n.) administration became an alternative strategy to bypass the blood–brain barrier and improve drug bioavailability in the brain. The main goal of this work was to preliminarily study the biodistribution of mixed amphiphilic mucoadhesive nanoparticles made of chitosan-g-poly(methyl methacrylate) and poly(vinyl alcohol)-g-poly(methyl methacrylate) and ionotropically crosslinked with sodium tripolyphosphate in the brain after intravenous (i.v.) and i.n. administration to Hsd:ICR mice. After i.v. administration, the highest nanoparticle accumulation was detected in the liver, among other peripheral organs. After i.n. administration of a 10-times smaller nanoparticle dose, the accumulation of the nanoparticles in off-target organs was much lower than after i.v. injection. In particular, the accumulation of the nanoparticles in the liver was 20 times lower than by i.v. When brains were analyzed separately, intravenously administered nanoparticles accumulated mainly in the “top” brain, reaching a maximum after 1 h. Conversely, in i.n. administration, nanoparticles were detected in the “bottom” brain and the head (maximum reached after 2 h) owing to their retention in the nasal mucosa and could serve as a reservoir from which the drug is released and transported to the brain over time. Overall, results indicate that i.n. nanoparticles reach similar brain bioavailability, though with a 10-fold smaller dose, and accumulate in off-target organs to a more limited extent and only after redistribution through the systemic circulation. At the same time, both administration routes seem to lead to differential accumulation in brain regions, and thus, they could be beneficial in the treatment of different medical conditions.

Acrylic bone cements: Effects of the poly(methyl methacrylate) powder size and chitosan addition on their properties

2013 ◽  
Vol 131 (3) ◽  
pp. n/a-n/a ◽  
Author(s):  
Tugba Endogan ◽  
Aysel Kiziltay ◽  
Gamze Torun Kose ◽  
Nil Comunoglu ◽  
Tahsin Beyzadeoglu ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Bone Cements ◽  
Powder Size ◽  
Poly Methyl Methacrylate

Poly(methyl methacrylate)-Based Composite Bone Cements With Different Types of Reinforcement Agents

2021 ◽  
Author(s):  
Sanaz Soleymani Eil Bakhtiari ◽  
Hamid Reza Bakhsheshi-Rad ◽  
Saeed Karbasi ◽  
Ahmad Fauzi Ismail ◽  
Safian Sharif ◽  
...  
Keyword(s):  
Methyl Methacrylate ◽  
Bone Cements ◽  
Poly Methyl Methacrylate ◽  
Different Types ◽  
Composite Bone
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