Fructose-Enhanced Efficacy of Magnetic Nanoparticles against Antibiotic Resistant Biofilms

2013 ◽  
Vol 1498 ◽  
pp. 133-138
Author(s):  
N. Gozde Durmus ◽  
Erik N. Taylor ◽  
Thomas J. Webster
Keyword(s):  
Staphylococcus Aureus ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Antibiotic Resistant ◽  
Hospital Acquired Infections ◽  
Hospital Acquired ◽  
The U.S ◽  
Excess Deaths

ABSTRACTThe emergence of methicillin-resistantStaphylococcus aureus(MRSA) is a major cause of hospital-acquired infections (HAI). HAI affect approximately 1.7 million patients each year in the U.S., resulting in up to 100,000 excess deaths, which leads to an estimated cost of more than $35 billion per year. Hence, there is an urgent clinical need to develop new therapies to reduce infections, without resorting to the use of antibiotics for which bacteria are developing a resistance towards. In this study, we designed superparamagnetic iron-oxide nanoparticles (SPION) to treat antibiotic-resistant biofilms and showed that SPION efficacy increases when they are used in combination with fructose.

Evaluation of Surface-modified Superparamagnetic Iron Oxide Nanoparticles to Optimize Bacterial Immobilization for Bio-separation with the Least Inhibitory Effect on Microorganism Activity

2020 ◽  
Vol 10 (2) ◽  
pp. 166-174
Author(s):  
Mehdi Khoshneviszadeh ◽  
Sarah Zargarnezhad ◽  
Younes Ghasemi ◽  
Ahmad Gholami
Keyword(s):  
Iron Oxide ◽  
Amino Acid ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Surface Coating ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Surface Charges ◽  
Surface Modified

Background: Magnetic cell immobilization has been introduced as a novel, facile and highly efficient approach for cell separation. A stable attachment between bacterial cell wall with superparamagnetic iron oxide nanoparticles (SPIONs) would enable the microorganisms to be affected by an outer magnetic field. At high concentrations, SPIONs produce reactive oxygen species in cytoplasm, which induce apoptosis or necrosis in microorganisms. Choosing a proper surface coating could cover the defects and increase the efficiency. Methods: In this study, asparagine, APTES, lipo-amino acid and PEG surface modified SPIONs was synthesized by co-precipitation method and characterized by FTIR, TEM, VSM, XRD, DLS techniques. Then, their protective effects against four Gram-positive and Gram-negative bacterial strains including Enterococcus faecalis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were examined through microdilution broth and compared to naked SPION. Results: The evaluation of characterization results showed that functionalization of magnetic nanoparticles could change their MS value, size and surface charges. Also, the microbial analysis revealed that lipo-amino acid coated magnetic nanoparticles has the least adverse effect on microbial strain among tested SPIONs. Conclusion: This study showed lipo-amino acid could be considered as the most protective and even promotive surface coating, which is explained by its optimizing effect on cell penetration and negligible reductive effects on magnetic properties of SPIONs. lipo-amino acid coated magnetic nanoparticles could be used in microbial biotechnology and industrial microbiology.

scholarly journals Degraded Hyaluronic Acid-Modified Magnetic Nanoparticles

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Wan Nie ◽  
Baolin Zhang ◽  
Xianjia Yan ◽  
Lichao Su ◽  
Sheng Wang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Hyaluronic Acid ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Functional Groups ◽  
Biomedical Applications ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Potential Applications ◽  
Modified Magnetic Nanoparticles

Superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with hyaluronic acid (HA) functional groups have potential applications as cell targeting materials. However, SPIONs incubated with high-molecular weight HA can result in severe agglomeration. In this work, we found that when modified with degraded HA (hyaluronan oligosaccharides (oHAs)), the nanoparticles were uniformly dispersed with small hydrodynamic sizes, and the oHA-modified SPIONs exerted minimal cytotoxicity. With the same functional groups as HA, the oHA-modified SPIONs may have various biomedical applications.

Metalla-aromatic loaded magnetic nanoparticles for MRI/photoacoustic imaging-guided cancer phototherapy

2018 ◽  
Vol 6 (17) ◽  
pp. 2528-2535 ◽  
Author(s):  
Caixia Yang ◽  
Gan Lin ◽  
Congqing Zhu ◽  
Xin Pang ◽  
Yang Zhang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Cancer Therapy ◽  
Iron Oxide Nanoparticles ◽  
Photoacoustic Imaging ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

In this study, metalla-aromatic agents and a cluster of superparamagnetic iron oxide nanoparticles were loaded inside a micellar carrier and used for MRI/PA imaging-guided PTT/PDT synergistic cancer therapy.

Glyco-copolypeptide grafted magnetic nanoparticles: the interplay between particle dispersion and RNA loading

2016 ◽  
Vol 7 (19) ◽  
pp. 3221-3224 ◽  
Author(s):  
T. Borase ◽  
E. K. Fox ◽  
Fadwa El Haddassi ◽  
S.-A. Cryan ◽  
D. F. Brougham ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Block Copolymer ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Particle Dispersion ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

Lysine-glyco-copolypeptide grafted superparamagnetic iron oxide nanoparticles were prepared through N-carboxyanhydride (NCA) copolymerization. Statistical and block copolymer arrangements were obtained while keeping the overal composition constant.

On the thermotropic and magnetotropic phase behavior of lipid liquid crystals containing magnetic nanoparticles

Nanoscale ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 3480-3488 ◽  
Author(s):  
Marco Mendozza ◽  
Costanza Montis ◽  
Lucrezia Caselli ◽  
Marcell Wolf ◽  
Piero Baglioni ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Liquid Crystals ◽  
Magnetic Nanoparticles ◽  
Magnetic Fields ◽  
Phase Behavior ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Promising Strategy

The inclusion of superparamagnetic iron oxide nanoparticles (SPIONs) in lipid mesophases is a promising strategy for drug-delivery applications, combining the innate biocompatibility of lipid architectures with SPIONs’ response to external magnetic fields.

Superparamagnetic Iron Oxide Nanoparticles (SPION) for the Treatment of Antibiotic-Resistant Biofilms

Small ◽  
2012 ◽  
Vol 8 (19) ◽  
pp. 3016-3027 ◽  
Author(s):  
Erik N. Taylor ◽  
Kim M. Kummer ◽  
Naside Gozde Durmus ◽  
Kohana Leuba ◽  
Keiko M. Tarquinio ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Antibiotic Resistant

scholarly journals Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
David Kovář ◽  
Aneta Malá ◽  
Jitka Mlčochová ◽  
Michal Kalina ◽  
Zdenka Fohlerová ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Magnetic Resonance ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Injection Rate ◽  
Oxide Nanoparticles ◽  
Resonance Imaging ◽  
Average Size

Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. The citrate-stabilised particles were produced with a narrow average size range below 2 nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI) was then evaluated. The relaxivities (r1,r2) and r2/r1 ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T2-contrast probe.

Magnetic Nanoparticles for Hepatocellular Carcinoma Diagnosis and Therapy

2016 ◽  
Vol 25 (3) ◽  
pp. 375-383 ◽  
Author(s):  
Bogdan Silviu Ungureanu ◽  
Cristian-Mihail Teodorescu ◽  
Adrian Săftoiu
Keyword(s):  
Hepatocellular Carcinoma ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Drug Targeting ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Diagnosis And Treatment ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles

Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver, ranking as the second most common cause of death from cancer worldwide. Magnetic nanoparticles (MNPs) have been used so far in tumor diagnosis and treatment, demonstrating great potential and promising results. In principle, three different approaches can be used in the treatment of tumors with superparamagnetic iron oxide nanoparticles: magnetically induced hyperthermia, drug targeting and selective suppression of tumor growth. This review focuses on the use of iron oxide nanoparticles for the diagnosis and treatment of liver cancer and offers a walkthrough from the MNPs imaging applicability to further therapeutic options, including their potential flaws. The MNP unique physical and biochemical properties will be mentioned in close relationship to their subsequent effects on the human body, and, also, their toxic potential will be noted. A presentation of what barriers the MNPs should overcome to be more successful will conclude this review. Abbreviations: AMF: Alternating magnetic field; DOX: Doxorubicin; GD: Gadolinium; HCC: hepatocellular carcinoma; 131I: Iodine 131; MDT: Magnetic drug targeting; ML: Magnetoliposomes; MNP: magnetic nanoparticles; MRI: Magnetic Resonance Imaging; PNIPA: Poly-N-isopropylacrylamide; SPIONS: Superparamagnetic iron oxide nanoparticles; VEGF: Vascular endothelial growth factor.

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