scholarly journals Degraded Hyaluronic Acid-Modified Magnetic Nanoparticles

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Wan Nie ◽  
Baolin Zhang ◽  
Xianjia Yan ◽  
Lichao Su ◽  
Sheng Wang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Hyaluronic Acid ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Functional Groups ◽  
Biomedical Applications ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Potential Applications ◽  
Modified Magnetic Nanoparticles

Superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with hyaluronic acid (HA) functional groups have potential applications as cell targeting materials. However, SPIONs incubated with high-molecular weight HA can result in severe agglomeration. In this work, we found that when modified with degraded HA (hyaluronan oligosaccharides (oHAs)), the nanoparticles were uniformly dispersed with small hydrodynamic sizes, and the oHA-modified SPIONs exerted minimal cytotoxicity. With the same functional groups as HA, the oHA-modified SPIONs may have various biomedical applications.

Evaluation of Surface-modified Superparamagnetic Iron Oxide Nanoparticles to Optimize Bacterial Immobilization for Bio-separation with the Least Inhibitory Effect on Microorganism Activity

2020 ◽  
Vol 10 (2) ◽  
pp. 166-174
Author(s):  
Mehdi Khoshneviszadeh ◽  
Sarah Zargarnezhad ◽  
Younes Ghasemi ◽  
Ahmad Gholami
Keyword(s):  
Iron Oxide ◽  
Amino Acid ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Surface Coating ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Surface Charges ◽  
Surface Modified

Background: Magnetic cell immobilization has been introduced as a novel, facile and highly efficient approach for cell separation. A stable attachment between bacterial cell wall with superparamagnetic iron oxide nanoparticles (SPIONs) would enable the microorganisms to be affected by an outer magnetic field. At high concentrations, SPIONs produce reactive oxygen species in cytoplasm, which induce apoptosis or necrosis in microorganisms. Choosing a proper surface coating could cover the defects and increase the efficiency. Methods: In this study, asparagine, APTES, lipo-amino acid and PEG surface modified SPIONs was synthesized by co-precipitation method and characterized by FTIR, TEM, VSM, XRD, DLS techniques. Then, their protective effects against four Gram-positive and Gram-negative bacterial strains including Enterococcus faecalis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were examined through microdilution broth and compared to naked SPION. Results: The evaluation of characterization results showed that functionalization of magnetic nanoparticles could change their MS value, size and surface charges. Also, the microbial analysis revealed that lipo-amino acid coated magnetic nanoparticles has the least adverse effect on microbial strain among tested SPIONs. Conclusion: This study showed lipo-amino acid could be considered as the most protective and even promotive surface coating, which is explained by its optimizing effect on cell penetration and negligible reductive effects on magnetic properties of SPIONs. lipo-amino acid coated magnetic nanoparticles could be used in microbial biotechnology and industrial microbiology.

Facile synthesis of novel hydrophilic and carboxyl-amine functionalized superparamagnetic iron oxide nanoparticles for biomedical applications

RSC Advances ◽  
2016 ◽  
Vol 6 (102) ◽  
pp. 99948-99959 ◽  
Author(s):  
Ganeshlenin Kandasamy ◽  
Sreeraj Surendran ◽  
Anindita Chakrabarty ◽  
S. N. Kale ◽  
Dipak Maity
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Superparamagnetic Iron Oxide ◽  
Water Soluble ◽  
Oxide Nanoparticles ◽  
Facile Synthesis ◽  
Amine Functionalized ◽  
One Step ◽  
Cancer Theranostics

We report a one-step facile synthesis of novel water-soluble and functionalized SPIONs, which could be promising candidates for cancer theranostics.

Stable polymersomes based on ionic–zwitterionic block copolymers modified with superparamagnetic iron oxide nanoparticles for biomedical applications

2015 ◽  
Vol 3 (27) ◽  
pp. 5523-5531 ◽  
Author(s):  
Gabriela Kania ◽  
Urszula Kwolek ◽  
Keita Nakai ◽  
Shin-ichi Yusa ◽  
Jan Bednar ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Block Copolymers ◽  
Iron Oxide Nanoparticles ◽  
Biomedical Applications ◽  
Superparamagnetic Iron Oxide ◽  
Delivery Systems ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

Novel biocompatible polymersomes with semipermeable ionic membranes were used as promising delivery systems.

scholarly journals Synthesis of water-soluble chitosan for biomedical applications

2015 ◽  
Vol 18 (3) ◽  
pp. 170-180
Author(s):  
Anh Thi Tram Tu ◽  
Huy Thuc Ha
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Iron Oxide ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Water Soluble ◽  
Oxide Nanoparticles ◽  
Wide Ph Range ◽  
Ft Ir ◽  
Ph Range

Highly deacetylated chitosan (CS) reacted with anhydride acetic (Ac2O) to produce chitosan with various degree of deacetylation (DDA) depending on the CS/Ac2O ratios. The structure of products was characterized by FT-IR, 1H NMR, 13C NMR, and the molecular weight was identified by GPC. The DDA of products decreases as the CS/Ac2O ratio increases. The products with less than 80 % DDA were soluble in water with a wide pH range. The water-soluble chitosan can be used in many biomedical applications such as manufacturing drug delivery systems or functionalized iron oxide nanoparticles.

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