On the thermotropic and magnetotropic phase behavior of lipid liquid crystals containing magnetic nanoparticles

Nanoscale ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 3480-3488 ◽  
Author(s):  
Marco Mendozza ◽  
Costanza Montis ◽  
Lucrezia Caselli ◽  
Marcell Wolf ◽  
Piero Baglioni ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Liquid Crystals ◽  
Magnetic Nanoparticles ◽  
Magnetic Fields ◽  
Phase Behavior ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Promising Strategy

The inclusion of superparamagnetic iron oxide nanoparticles (SPIONs) in lipid mesophases is a promising strategy for drug-delivery applications, combining the innate biocompatibility of lipid architectures with SPIONs’ response to external magnetic fields.

Evaluation of Surface-modified Superparamagnetic Iron Oxide Nanoparticles to Optimize Bacterial Immobilization for Bio-separation with the Least Inhibitory Effect on Microorganism Activity

2020 ◽  
Vol 10 (2) ◽  
pp. 166-174
Author(s):  
Mehdi Khoshneviszadeh ◽  
Sarah Zargarnezhad ◽  
Younes Ghasemi ◽  
Ahmad Gholami
Keyword(s):  
Iron Oxide ◽  
Amino Acid ◽  
Magnetic Nanoparticles ◽  
Iron Oxide Nanoparticles ◽  
Surface Coating ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Surface Charges ◽  
Surface Modified

Background: Magnetic cell immobilization has been introduced as a novel, facile and highly efficient approach for cell separation. A stable attachment between bacterial cell wall with superparamagnetic iron oxide nanoparticles (SPIONs) would enable the microorganisms to be affected by an outer magnetic field. At high concentrations, SPIONs produce reactive oxygen species in cytoplasm, which induce apoptosis or necrosis in microorganisms. Choosing a proper surface coating could cover the defects and increase the efficiency. Methods: In this study, asparagine, APTES, lipo-amino acid and PEG surface modified SPIONs was synthesized by co-precipitation method and characterized by FTIR, TEM, VSM, XRD, DLS techniques. Then, their protective effects against four Gram-positive and Gram-negative bacterial strains including Enterococcus faecalis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were examined through microdilution broth and compared to naked SPION. Results: The evaluation of characterization results showed that functionalization of magnetic nanoparticles could change their MS value, size and surface charges. Also, the microbial analysis revealed that lipo-amino acid coated magnetic nanoparticles has the least adverse effect on microbial strain among tested SPIONs. Conclusion: This study showed lipo-amino acid could be considered as the most protective and even promotive surface coating, which is explained by its optimizing effect on cell penetration and negligible reductive effects on magnetic properties of SPIONs. lipo-amino acid coated magnetic nanoparticles could be used in microbial biotechnology and industrial microbiology.

scholarly journals Cisplatin drug delivery using gold-coated iron oxide nanoparticles for enhanced tumour targeting with external magnetic fields

2012 ◽  
Vol 393 ◽  
pp. 328-333 ◽  
Author(s):  
Amelia J. Wagstaff ◽  
Sarah D. Brown ◽  
Megan R. Holden ◽  
Gemma E. Craig ◽  
Jane A. Plumb ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
Magnetic Fields ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Tumour Targeting

ß-Amido Acid Functionalised Superparamagnetic Iron Oxide Nanoparticles as a Novel Carrier for Efficient Delivery of Doxorubicine

2017 ◽  
Vol 41 (3) ◽  
pp. 129-135
Author(s):  
Fatemeh Ebrahimi ◽  
Maryam Karimi ◽  
Hasan Sereshti ◽  
Mohsen Yousefifar
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Superparamagnetic Iron Oxide Nanoparticles ◽  
Precipitation Method ◽  
Hydrodynamic Diameter ◽  
Oxide Nanoparticles ◽  
Amido Acid

Superparamagnetic iron oxide nanoparticles are increasingly used in medical applications due to their unique physical properties. They are useful carriers for delivering antitumour drugs in targeted cancer treatment. In this study, amido acid-functionalised magnetic nanoparticles (AAFMNs) are used as drug-delivery vehicles for doxorubicine as an efficient tool for the treatment of cancer. Magnetic iron oxide nanoparticles were synthesised using a co-precipitation method. The prepared iron oxide nanoparticles were then functionalised with amido acid functional groups. Finally, the synthesised AAFMNs were used for the delivery of doxorubicine. AAFMNs were characterised by Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis and zeta potential. An in vitro-determined hydrodynamic diameter of ∼80 nm suggested their applicability for this purpose. The findings show that AAFMNs are a promising tool for potential magnetic drug delivery.

scholarly journals Interaction of superparamagnetic iron oxide nanoparticles with DNA and BSA

2019 ◽  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Concentration Ratio ◽  
Sodium Citrate ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Protein Solution ◽  
Control Protein

Background: Superparamagnetic iron oxide nanoparticles (SPION) are widely used in various biomedical technologies, in particular, as carriers for drug delivery to the target. Since SPION-drug complexes are planned to be used in vivo, it is necessary to find out if competitive binding of nanoparticles with biologically important macromolecules (nucleic acids and proteins) is possible. Objectives: To investigate the possibility of complexation of iron oxide nanoparticles with DNA and serum albumin. Materials and methods: Bare and sodium citrate coated SPION with different surface charges, bovine serum albumin (BSA) and calf thymus DNA were used. The complexes of SPION and macromolecules were precipitated by an external magnetic field. The research was carried out by spectrophotometry in visible and ultraviolet ranges. Results: To study SPION interactions with DNA and BSA, the spectra of supernatants of the binary systems were compared with the spectra of the corresponding control macromolecules solutions. In the DNA-SPION systems, a decrease in the DNA absorption is observed only for bare nanoparticles. Our estimation shows that the maximum possible concentration ratio of bound DNA to SPION is about 2.5×10-4 mol/g. The addition of sodium citrate coated SPION to the DNA solution does not cause any spectral changes of the supernatant. The interaction of BSA with SPION, coated with sodium citrate, leads to a slight increase in supernatant absorption compared with the one of the control protein solution. It can be caused by the fact that the resulting complexes are not precipitated by a magnetic field. No difference between the spectrum of the supernatant of BSA-bare SPION system and the control protein solution was observed. Conclusions: The obtained spectrophotometric results demonstrate the formation of complexes between DNA and bare iron oxide nanoparticles as well as between BSA and the nanoparticles, coated with sodium citrate. The maximum concentration ratio of bound DNA and bare SPION was obtained for the investigated system. It is necessary to take into account when SPION are used as carriers for drug delivery.

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