Efficient Upconverting Nanophosphors for Imaging and Photodynamic Therapy

2012 ◽  
Vol 1471 ◽  
Author(s):  
Brian G. Yust ◽  
Gangadharan Ajith Kumar ◽  
Lawrence C. Mimun ◽  
Dhiraj K. Sardar
Keyword(s):  
Photodynamic Therapy ◽  
Rare Earth ◽  
Biomedical Applications ◽  
Near Infrared ◽  
High Efficiency ◽  
Synthesis Method ◽  
Spectroscopic Properties ◽  
Sodium Potassium ◽  
Infrared Excitation ◽  
Upconverting Nanophosphors

ABSTRACTErbium-Ytterbium codoped nanophosphor systems are explored for high efficiency upconversion. The NIR to visible upconversion from 1550 nm and 980 nm excitation are of particular interest to us for biomedical applications such as imaging, sensing, and photodynamic therapy. Variations in synthesis method and rare earth concentration are carried out in sodium, potassium, and transition metal based phosphor materials. The spectroscopic properties of the material dry and in biologically appropriate solution are taken. After bioconjugation, these particles will be used in a mouse model to demonstrate that cancer imaging with a near-infrared excitation source is possible.

Photosensitizer coated upconversion nanoparticles for triggering reactive oxygen species under 980 nm near-infrared excitation

2019 ◽  
Vol 7 (46) ◽  
pp. 7306-7313 ◽  
Author(s):  
Jinhua Wu ◽  
Shanshan Du ◽  
Yuhua Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Rare Earth ◽  
Near Infrared ◽  
Reactive Oxygen ◽  
Great Promise ◽  
Upconversion Nanoparticles ◽  
Oxygen Species ◽  
Infrared Excitation

Rare-earth-based upconversion nanotechnology has recently shown great promise for photodynamic therapy (PDT).

Red-Emitting Upconverting Nanoparticles for Photodynamic Therapy in Cancer Cells Under Near-Infrared Excitation

Small ◽  
2012 ◽  
Vol 9 (11) ◽  
pp. 1929-1938 ◽  
Author(s):  
Gan Tian ◽  
Wenlu Ren ◽  
Liang Yan ◽  
Shan Jian ◽  
Zhanjun Gu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Near Infrared ◽  
Infrared Excitation

scholarly journals Upconversion: Red-Emitting Upconverting Nanoparticles for Photodynamic Therapy in Cancer Cells Under Near-Infrared Excitation (Small 11/2013)

Small ◽  
2013 ◽  
Vol 9 (11) ◽  
pp. 1928-1928 ◽  
Author(s):  
Gan Tian ◽  
Wenlu Ren ◽  
Liang Yan ◽  
Shan Jian ◽  
Zhanjun Gu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Near Infrared ◽  
Infrared Excitation

scholarly journals Near infrared excitation and emission in rare earth MOFs via encapsulation of organic dyes

2018 ◽  
Vol 9 (42) ◽  
pp. 8099-8102 ◽  
Author(s):  
Chong Liu ◽  
Svetlana V. Eliseeva ◽  
Tian-Yi Luo ◽  
Patrick F. Muldoon ◽  
Stéphane Petoud ◽  
...  
Keyword(s):  
Rare Earth ◽  
Near Infrared ◽  
Organic Dyes ◽  
Biological Imaging ◽  
Diagnostic Window ◽  
Infrared Excitation

Dye RE3+-MOF hybrid exhibits both NIR excitation and emission within the biological diagnostic window, highlighting its potential for biological imaging.

scholarly journals A near infrared dye-coated silver nanoparticle/carbon dot nanocomposite for targeted tumor imaging and enhanced photodynamic therapy

2020 ◽  
Vol 2 (1) ◽  
pp. 489-494 ◽  
Author(s):  
Rongjun Liu ◽  
Zhengmin Yang ◽  
Liangliang Zhang ◽  
Jingjin Zhao ◽  
Cheng Hou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Silver Nanoparticle ◽  
Near Infrared ◽  
High Efficiency ◽  
Tumor Imaging ◽  
Nano Composite ◽  
Clinical Imaging ◽  
Carbon Dot ◽  
Near Infrared Dye ◽  
Nir Dye

A NIR dye-coated silver nanoparticle/carbon dot nano-composite (CyOH–AgNP/CD) was synthetized as a novel nanophotosensitizer for targeted tumor imaging and high-efficiency PDT. The CyOH–AgNP/CD exhibit potential for future clinical imaging-guided PDT.

scholarly journals Submicron-sized phosphors based on hexagonal rare earth oxycarbonate for near-infrared excitation and emission

2019 ◽  
Vol 7 (4) ◽  
pp. 502-508
Author(s):  
Mizuki Watanabe ◽  
Yasuhiro Sejima ◽  
Ryohei Oka ◽  
Shintaro Ida ◽  
Toshiyuki Masui
Keyword(s):  
Rare Earth ◽  
Near Infrared ◽  
Infrared Excitation

scholarly journals Luminescent Hydroxyapatite Doped with Rare Earth Elements for Biomedical Applications

Nanomaterials ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 239 ◽  
Author(s):  
Ionela Andreea Neacsu ◽  
Alexandra Elena Stoica ◽  
Bogdan Stefan Vasile ◽  
Ecaterina Andronescu
Keyword(s):  
Rare Earth ◽  
Rare Earth Elements ◽  
Biomedical Applications ◽  
High Efficiency ◽  
Luminescent Materials ◽  
Apatite Structure ◽  
Inorganic Component ◽  
Medical Field ◽  
Fluorescent Materials ◽  
Interesting Area

One new, promising approach in the medical field is represented by hydroxyapatite doped with luminescent materials for biomedical luminescence imaging. The use of hydroxyapatite-based luminescent materials is an interesting area of research because of the attractive characteristics of such materials, which include biodegradability, bioactivity, biocompatibility, osteoconductivity, non-toxicity, and their non-inflammatory nature, as well their accessibility for surface adaptation. It is well known that hydroxyapatite, the predominant inorganic component of bones, serves a substantial role in tissue engineering, drug and gene delivery, and many other biomedical areas. Hydroxyapatite, to the detriment of other host matrices, has attracted substantial attention for its ability to bind to luminescent materials with high efficiency. Its capacity to integrate a large assortment of substitutions for Ca2+, PO43−, and/or OH− ions is attributed to the versatility of its apatite structure. This paper summarizes the most recently developed fluorescent materials based on hydroxyapatite, which use rare earth elements (REEs) as dopants, such as terbium (Tb3+), erbium (Er3+), europium (Eu3+), lanthanum (La3+), or dysprosium (Dy3+), that have been developed in the biomedical field.

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