scholarly journals A Biocompatible SiC RF Antenna for In-Vivo Sensing Applications

2012 ◽  
Vol 1433 ◽  
Author(s):  
Shamima Afroz ◽  
Sylvia W Thomas ◽  
Gokhan Mumcu ◽  
Christopher W. Locke ◽  
Stephen E Saddow
Keyword(s):  
Silicon Carbide ◽  
Patch Antenna ◽  
Glucose Monitoring ◽  
Semiconducting Materials ◽  
Sensing Applications ◽  
Thick Oxide Layer ◽  
Rf Antenna ◽  
In Vivo Sensing ◽  
Cubic Silicon Carbide

ABSTRACTIn this study, we present a small-size implantable RF antenna (biosensor) which is made of fully biocompatible material, cubic silicon carbide. Silicon Carbide is one of the few semiconducting materials that combine biocompatibility and sensing potentiality. The hypothesis of a SiC based antenna, to be used for glucose monitoring, is that the changes in the medium surrounding the antenna affect the antenna properties such as input impedance and resonance frequency, and these changes can be used to estimate the patient’s plasma glucose level. An all-SiC patch antenna has been designed, simulated and fabricated with a target frequency of operation of 10 GHz. A Cu patch antenna was fabricated on SiC to serve as a reference antenna. The all-SiC antenna was realized by growing a poly-crystalline 3C-SiC film using CVD on a thick oxide layer that had been coated with poly-Si to serve as a growth template. A semi-insulating 4H-SiC substrate was used to minimize RF losses during operation.

scholarly journals Laser writing of nitrogen-doped silicon carbide for biological modulation

2020 ◽  
Vol 6 (34) ◽  
pp. eaaz2743
Author(s):  
Vishnu Nair ◽  
Jaeseok Yi ◽  
Dieter Isheim ◽  
Menahem Rotenberg ◽  
Lingyuan Meng ◽  
...  
Keyword(s):  
Silicon Carbide ◽  
Semiconducting Materials ◽  
Laser Writing ◽  
Photoelectrochemical Activity ◽  
Nitrogen Doped ◽  
Isolated Hearts ◽  
Composite Configuration ◽  
Polymeric Substrates ◽  
Cubic Silicon Carbide ◽  
Inexpensive Technique

Conducting or semiconducting materials embedded in insulating polymeric substrates can be useful in biointerface applications; however, attainment of this composite configuration by direct chemical processes is challenging. Laser-assisted synthesis has evolved as a fast and inexpensive technique to prepare various materials, but its utility in the construction of biophysical tools or biomedical devices is less explored. Here, we use laser writing to convert portions of polydimethylsiloxane (PDMS) into nitrogen-doped cubic silicon carbide (3C-SiC). The dense 3C-SiC surface layer is connected to the PDMS matrix via a spongy graphite layer, facilitating electrochemical and photoelectrochemical activity. We demonstrate the fabrication of arbitrary two-dimensional (2D) SiC-based patterns in PDMS and freestanding 3D constructs. To establish the functionality of the laser-produced composite, we apply it as flexible electrodes for pacing isolated hearts and as photoelectrodes for local peroxide delivery to smooth muscle sheets.

A miniature fiber Bragg grating pressure sensor for in-vivo sensing applications

2012 ◽  
Author(s):  
David Hsiao-Chuan Wang ◽  
Andrew Abbott ◽  
Simon A. Maunder ◽  
Neil G. Blenman ◽  
John W. Arkwright
Keyword(s):  
Fiber Bragg Grating ◽  
Pressure Sensor ◽  
Bragg Grating ◽  
Sensing Applications ◽  
In Vivo Sensing

Imaging-aided Temperature Measurements with a Single Optical Fiber for in-vivo Sensing Applications

2018 ◽  
Author(s):  
Erik Schartner ◽  
Jiawen Li ◽  
Stefan Musolino ◽  
Bryden C. Quirk ◽  
Rodney W. Kirk ◽  
...  
Keyword(s):  
Optical Fiber ◽  
Temperature Measurements ◽  
Sensing Applications ◽  
In Vivo Sensing

scholarly journals Stimuli-Responsive Photoacoustic Nanoswitch for in Vivo Sensing Applications

ACS Nano ◽  
2014 ◽  
Vol 8 (8) ◽  
pp. 8363-8373 ◽  
Author(s):  
Kenneth K. Ng ◽  
Mojdeh Shakiba ◽  
Elizabeth Huynh ◽  
Robert A. Weersink ◽  
Áron Roxin ◽  
...  
Keyword(s):  
Stimuli Responsive ◽  
Sensing Applications ◽  
In Vivo Sensing

scholarly journals Near infrared fluorescent sensors and their use in vivo

2017 ◽  
Author(s):  
◽  
Nicholas P. Cooley
Keyword(s):  
Boronic Acid ◽  
Near Infrared ◽  
Glucose Monitoring ◽  
Aqueous Solubility ◽  
Fluorescent Sensors ◽  
Ph Sensitive ◽  
Water Soluble ◽  
Boronic Acid Derivatives ◽  
In Vivo Sensing

In an effort to design near-infrared (NIR), water soluble glucose sensors, several pH sensitive NIR cyanine derivates were designed and synthesized to provide insight into the viability of the cyanine platform as the fluorophore core for performing minimally invasive long term glucose monitoring in vivo. Many previous efforts to build effective fluorescent sensors for glucose have provided guidance towards the architecture of binding groups and fluorescent response required to achieve this goal, but have not provided appropriate solubility, or excitation and emission characteristics for in vivo sensing. In an effort to address the aqueous solubility of the highly rigid cyanine platform, a tetra sulfonated core was chosen for this work. Though fully water soluble, pH sensitive derivates still showed some aggregation characteristics. Simple sugarbinding boronic acid derivatives showed appropriate fluorescent responses, but poor binding. Efforts to improve binding through synthesis of bis-boronic acid compounds proved elusive.

SiC RF Sensor for Continuous Glucose Monitoring

MRS Advances ◽  
2016 ◽  
Vol 1 (55) ◽  
pp. 3691-3696 ◽  
Author(s):  
Fabiola Araujo Cespedes ◽  
Gokhan Mumcu ◽  
Stephen E. Saddow
Keyword(s):  
Blood Glucose ◽  
Resonant Frequency ◽  
Continuous Glucose Monitoring ◽  
Glucose Monitoring ◽  
Fatty Tissue ◽  
Glucose Levels ◽  
Active Sensor ◽  
Passive Sensor ◽  
Rf Antenna

ABSTRACTIt has been shown that changes in blood glucose can be sensed with an RF antenna made from silicon carbide (SiC) operating at 10 GHz. Therefore a SiC antenna patch could operate as an active sensor or as a passive sensor at 5.8 GHz for a continuous glucose monitoring system. The properties of SiC make this material ideal for biomedical applications and devices as it is not only biocompatible but also has great sensing capability. The permittivity and conductivity of the blood is glucose dependent. Thus implanting the antenna in the fatty tissue facing the muscle and blood results should result in a shift of the resonant frequency of the antenna with glucose levels. In the active sensor approach, a power supply and internal in-vivo circuitry with protection would be required. In the passive sensor approach, external circuitry sends a signal to the implanted antenna and is received back again, detecting any signal variations. Simulations in HFSS™ show that that an implanted sensor placed 2 mm from the muscle in fatty tissue would experience an approximate shift in resonant frequency of 12.3 MHz for a blood glucose change of 500 mg/dl.

Theoretical study of intrinsic defects in cubic silicon carbide 3C -SiC

2021 ◽  
Vol 103 (19) ◽  
Author(s):  
Peter A. Schultz ◽  
Renee M. Van Ginhoven ◽  
Arthur H. Edwards
Keyword(s):  
Silicon Carbide ◽  
Theoretical Study ◽  
Intrinsic Defects ◽  
Cubic Silicon Carbide
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