scholarly journals Stimuli-Responsive Photoacoustic Nanoswitch for in Vivo Sensing Applications

ACS Nano ◽  
2014 ◽  
Vol 8 (8) ◽  
pp. 8363-8373 ◽  
Author(s):  
Kenneth K. Ng ◽  
Mojdeh Shakiba ◽  
Elizabeth Huynh ◽  
Robert A. Weersink ◽  
Áron Roxin ◽  
...  
Keyword(s):  
Stimuli Responsive ◽  
Sensing Applications ◽  
In Vivo Sensing

A miniature fiber Bragg grating pressure sensor for in-vivo sensing applications

2012 ◽  
Author(s):  
David Hsiao-Chuan Wang ◽  
Andrew Abbott ◽  
Simon A. Maunder ◽  
Neil G. Blenman ◽  
John W. Arkwright
Keyword(s):  
Fiber Bragg Grating ◽  
Pressure Sensor ◽  
Bragg Grating ◽  
Sensing Applications ◽  
In Vivo Sensing

Imaging-aided Temperature Measurements with a Single Optical Fiber for in-vivo Sensing Applications

2018 ◽  
Author(s):  
Erik Schartner ◽  
Jiawen Li ◽  
Stefan Musolino ◽  
Bryden C. Quirk ◽  
Rodney W. Kirk ◽  
...  
Keyword(s):  
Optical Fiber ◽  
Temperature Measurements ◽  
Sensing Applications ◽  
In Vivo Sensing

scholarly journals A Biocompatible SiC RF Antenna for In-Vivo Sensing Applications

2012 ◽  
Vol 1433 ◽  
Author(s):  
Shamima Afroz ◽  
Sylvia W Thomas ◽  
Gokhan Mumcu ◽  
Christopher W. Locke ◽  
Stephen E Saddow
Keyword(s):  
Silicon Carbide ◽  
Patch Antenna ◽  
Glucose Monitoring ◽  
Semiconducting Materials ◽  
Sensing Applications ◽  
Thick Oxide Layer ◽  
Rf Antenna ◽  
In Vivo Sensing ◽  
Cubic Silicon Carbide

ABSTRACTIn this study, we present a small-size implantable RF antenna (biosensor) which is made of fully biocompatible material, cubic silicon carbide. Silicon Carbide is one of the few semiconducting materials that combine biocompatibility and sensing potentiality. The hypothesis of a SiC based antenna, to be used for glucose monitoring, is that the changes in the medium surrounding the antenna affect the antenna properties such as input impedance and resonance frequency, and these changes can be used to estimate the patient’s plasma glucose level. An all-SiC patch antenna has been designed, simulated and fabricated with a target frequency of operation of 10 GHz. A Cu patch antenna was fabricated on SiC to serve as a reference antenna. The all-SiC antenna was realized by growing a poly-crystalline 3C-SiC film using CVD on a thick oxide layer that had been coated with poly-Si to serve as a growth template. A semi-insulating 4H-SiC substrate was used to minimize RF losses during operation.

scholarly journals Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 71
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Agents ◽  
Metal Species ◽  
Stimuli Responsive ◽  
Combination Drug ◽  
Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

scholarly journals Drug Delivery by Ultrasound-Responsive Nanocarriers for Cancer Treatment

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1135
Author(s):  
Kristin Entzian ◽  
Achim Aigner
Keyword(s):  
Drug Delivery ◽  
Biological Effects ◽  
Invasive Technique ◽  
Stimuli Responsive ◽  
Comprehensive Overview ◽  
Drug Concentrations ◽  
Therapeutic Outcomes ◽  
Cost Efficient ◽  
Safety Considerations

Conventional cancer chemotherapies often exhibit insufficient therapeutic outcomes and dose-limiting toxicity. Therefore, there is a need for novel therapeutics and formulations with higher efficacy, improved safety, and more favorable toxicological profiles. This has promoted the development of nanomedicines, including systems for drug delivery, but also for imaging and diagnostics. Nanoparticles loaded with drugs can be designed to overcome several biological barriers to improving efficiency and reducing toxicity. In addition, stimuli-responsive nanocarriers are able to release their payload on demand at the tumor tissue site, preventing premature drug loss. This review focuses on ultrasound-triggered drug delivery by nanocarriers as a versatile, cost-efficient, non-invasive technique for improving tissue specificity and tissue penetration, and for achieving high drug concentrations at their intended site of action. It highlights aspects relevant for ultrasound-mediated drug delivery, including ultrasound parameters and resulting biological effects. Then, concepts in ultrasound-mediated drug delivery are introduced and a comprehensive overview of several types of nanoparticles used for this purpose is given. This includes an in-depth compilation of the literature on the various in vivo ultrasound-responsive drug delivery systems. Finally, toxicological and safety considerations regarding ultrasound-mediated drug delivery with nanocarriers are discussed.

scholarly journals Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1285
Author(s):  
Louise Van Gheluwe ◽  
Igor Chourpa ◽  
Coline Gaigne ◽  
Emilie Munnier
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Smart Drug ◽  
Smart Drug Delivery

Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

scholarly journals Smart Stimuli-Responsive Liposomal Nanohybrid Systems: A Critical Review of Theranostic Behavior in Cancer

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 355
Author(s):  
Jana K. Alwattar ◽  
Amina T. Mneimneh ◽  
Kawthar K. Abla ◽  
Mohammed M. Mehanna ◽  
Ahmed N. Allam
Keyword(s):  
Drug Toxicity ◽  
Therapeutic Agents ◽  
Site Specificity ◽  
Loading Capacity ◽  
Therapeutic Activity ◽  
Stimuli Responsive ◽  
Cellular Toxicity ◽  
Current Review ◽  
Physical Instability

The epoch of nanotechnology has authorized novel investigation strategies in the area of drug delivery. Liposomes are attractive biomimetic nanocarriers characterized by their biocompatibility, high loading capacity, and their ability to reduce encapsulated drug toxicity. Nevertheless, various limitations including physical instability, lack of site specificity, and low targeting abilities have impeded the use of solo liposomes. Metal nanocarriers are emerging moieties that can enhance the therapeutic activity of many drugs with improved release and targeted potential, yet numerous barriers, such as colloidal instability, cellular toxicity, and poor cellular uptake, restrain their applicability in vivo. The empire of nanohybrid systems has shelled to overcome these curbs and to combine the criteria of liposomes and metal nanocarriers for successful theranostic delivery. Metallic moieties can be embedded or functionalized on the liposomal systems. The current review sheds light on different liposomal-metal nanohybrid systems that were designed as cellular bearers for therapeutic agents, delivering them to their targeted terminus to combat one of the most widely recognized diseases, cancer.

In vivo sensing of cutaneous edema: a comparative study of diffuse reflectance, Raman spectroscopy, and multispectral imaging

2021 ◽  
Author(s):  
Gleb S. Budylin ◽  
Denis A. Davydov ◽  
Nadezhda V. Zlobina ◽  
Alexey V. Baev ◽  
Vyacheslav G. Artyushenko ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Comparative Study ◽  
Diffuse Reflectance ◽  
Multispectral Imaging ◽  
In Vivo Sensing

In Vivo Sensing Using SERS Nanosensors

2017 ◽  
pp. 695-702
Author(s):  
Janna K. Register ◽  
Andrew M. Fales ◽  
Hsin-Neng Wang ◽  
Gregory M. Palmer ◽  
Bruce Klitzman ◽  
...  
Keyword(s):  
In Vivo Sensing
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