Regenerative Engineering-The Convergence Quest

MRS Advances ◽  
2018 ◽  
Vol 3 (30) ◽  
pp. 1665-1670 ◽  
Author(s):  
Cato Laurencin ◽  
Naveen Nagiah
Keyword(s):  
Materials Science ◽  
Advanced Materials ◽  
Biological Factor ◽  
Disease Treatment ◽  
Regenerative Engineering ◽  
Grand Challenges ◽  
Relevant Today ◽  
Organ Regeneration ◽  
Low Levels ◽  
Stem Cell Science

ABSTRACTWe define Regenerative Engineering as a Convergence of Advanced Materials Science, Stem Cell Science, Physics, Developmental Biology, and Clinical Translation. We believe that an “un-siloed’ technology approach will be important in the future to realize grand challenges such as limb and organ regeneration. We also believe that biomaterials will play a key role in achieving overall translational goals. Through convergence of a number of technologies, with advanced materials science playing an important role, we believe the prospect of engaging future grand challenges is possible. Regenerative Engineering as a field is particularly suited for solving clinical problems that are relevant today. The paradigms utilized can be applied to the regeneration of tissue in the shoulder where tendon and muscle currently have low levels of regenerative capability, and the consequences, especially in alternative surgical solutions for massive tendon and muscle loss at the shoulder have demonstrated significant morbidity. Polymer, polymer-cell, and polymer biological factor, and polymer-physical systems can be utilized to propose a range of solutions to shoulder tissue regeneration. The approaches, possibilities, limitations and future strategies, allow for a variety of clinical solutions in musculoskeletal disease treatment.

scholarly journals Musculoskeletal Regenerative Engineering: Biomaterials, Structures, and Small Molecules

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Roshan James ◽  
Cato T. Laurencin
Keyword(s):  
Stem Cell ◽  
Materials Science ◽  
Musculoskeletal Tissue ◽  
Tissue Repair And Regeneration ◽  
Musculoskeletal Tissues ◽  
Organ Regeneration ◽  
Organ Systems ◽  
Cell Niche ◽  
Stem Cell Science ◽  
Advanced Biomaterials

Musculoskeletal tissues are critical to the normal functioning of an individual and following damage or degeneration they show extremely limited endogenous regenerative capacity. The future of regenerative medicine is the combination of advanced biomaterials, structures, and cues to re-engineer/guide stem cells to yield the desired organ cells and tissues. Tissue engineering strategies were ideally suited to repair damaged tissues; however, the substitution and regeneration of large tissue volumes and multi-level tissues such as complex organ systems integrated into a single phase require more than optimal combinations of biomaterials and biologics. We highlight bioinspired advancements leading to novel regenerative scaffolds especially for musculoskeletal tissue repair and regeneration. Tissue and organ regeneration relies on the spatial and temporal control of biophysical and biochemical cues, including soluble molecules, cell-cell contacts, cell-extracellular matrix contacts, and physical forces. Strategies that recapitulate the complexity of the local microenvironment of the tissue and the stem cell niche play a crucial role in regulating cell self-renewal and differentiation. Biomaterials and scaffolds based on biomimicry of the native tissue will enable convergence of the advances in materials science, the advances in stem cell science, and our understanding of developmental biology.

Regenerative engineering and advanced materials science

MRS Bulletin ◽  
2017 ◽  
Vol 42 (08) ◽  
pp. 600-607
Author(s):  
Roshan James ◽  
Cato T. Laurencin
Keyword(s):  
Materials Science ◽  
Advanced Materials ◽  
Regenerative Engineering ◽  
Image Position

Abstract

scholarly journals Up Close: Center for Advanced Materials at Lawrence Berkeley Laboratory

MRS Bulletin ◽  
1986 ◽  
Vol 11 (4) ◽  
pp. 27-27 ◽  
Author(s):  
John J. Gilman
Keyword(s):  
Materials Science ◽  
Magnetic Moments ◽  
National Laboratory ◽  
National Policy ◽  
Chemical Properties ◽  
Educational Process ◽  
University Of California ◽  
Advanced Materials ◽  
Lawrence Berkeley Laboratory ◽  
The University

The boundaries between the present performance of materials and the requirements of device designers have for centuries been moving forward. The steps taken to draw these two together are sometimes large; more often they are small. As they occur, we find materials that are stronger, have larger magnetic moments, have higher electron mobilities, etc. Each time the property profile improves, understanding of the physical and chemical properties advances, and new engineering devices based on the improved profile are invented and developed.The purpose of the Center for Advanced Materials (CAM) at the Lawrence Berkeley Laboratory (LBL) is to enhance the inter-play between advances in the property profiles of materials and advances in the chemical and physical understanding of them. For this purpose, the location of CAM can be described as ideal. The proximity of this national laboratory to the campus of the University of California at Berkeley provides an unusually rich intellectual setting for the Center. It also provides unique opportunities for the University students and faculty who conduct materials-related research. Indeed, the arrangement should be a model for similar organizations, and it represents a solid method for strengthening materials science and technology throughout the nation.National policy in critical materials has given the national laboratories—including LBL—strong direction and incentive to collaborate with industry and the research universities. This incentive led to the establishment of CAM in order to build on the symbiosis between LBL and the University of California at Berkeley. It strives to extend this symbiosis by bringing industry into the ongoing educational process and by making its special facilities more readily available to industrial researchers.

Nanotechnology Applications in Stem Cell Science for Regenerative Engineering

2016 ◽  
Vol 16 (9) ◽  
pp. 8953-8965 ◽  
Author(s):  
Varadraj N Vernekar ◽  
Roshan James ◽  
Kevin J Smith ◽  
Cato T Laurencin
Keyword(s):  
Stem Cell ◽  
Regenerative Engineering ◽  
Stem Cell Science

Five-Membered Hetarene N-Oxides: Recent Advances in Synthesis and Reactivity

Synthesis ◽  
2021 ◽  
Author(s):  
Leonid Fershtat ◽  
Fedor Teslenko
Keyword(s):  
Transition Metal ◽  
Medicinal Chemistry ◽  
Materials Science ◽  
State Of The Art ◽  
Short Review ◽  
Advanced Materials ◽  
Metal Free ◽  
Recent Advances ◽  
Application Potential ◽  
Metal Catalyzed

Five-membered heterocyclic N-oxides attracted special attention due to their strong application potential in medicinal chemistry and advanced materials science. In this regard, novel methods for their synthesis and functionalization are constantly required. In this short review, recent state-of-the-art achievements in the chemistry of isoxazoline N-oxides, 1,2,3-triazole 1-oxides and 1,2,5-oxadiazole 2-oxides are briefly summarized. Main routes to transition-metal-catalyzed and metal-free functionalization protocols along with mechanistic considerations are outlined. Transformation patterns of the hetarene N-oxide rings as precursors to other nitrogen heterocyclic systems are also presented.

Research progress in materials-oriented chemical engineering in China

2019 ◽  
Vol 35 (8) ◽  
pp. 917-927 ◽  
Author(s):  
Hao Jiang ◽  
Yongsheng Han ◽  
Qiang Zhang ◽  
Jiexin Wang ◽  
Yiqun Fan ◽  
...  
Keyword(s):  
Chemical Engineering ◽  
Materials Science ◽  
Industrial Applications ◽  
Advanced Materials ◽  
Research Progress ◽  
Material Research ◽  
Engineering Science ◽  
New Materials ◽  
Engineering Development ◽  
Recent Advances

Abstract Materials-oriented chemical engineering involves the intersection of materials science and chemical engineering. Development of materials-oriented chemical engineering not only contributes to material research and industrialization techniques but also opens new avenues for chemical engineering science. This review details the major achievements of materials-oriented chemical engineering fields in China, including preparation strategies for advanced materials based on the principles of chemical engineering as well as innovative separation and reaction techniques determined by new materials. Representative industrial applications are also illustrated, highlighting recent advances in the field of materials-oriented chemical engineering technologies. In addition, we also look at the ongoing trends in materials-oriented chemical engineering in China.

scholarly journals LA SCIENZA DEI MATERIALI

2015 ◽  
Author(s):  
Antonio Papagni
Keyword(s):  
Environmental Impact ◽  
Everyday Life ◽  
Materials Science ◽  
Advanced Materials ◽  
Fundamental Aspect ◽  
Organic Polymers ◽  
Scientific Disciplines ◽  
Application Potential ◽  
Low Costs

Materials Science represents the natural convergence of hard scientific disciplines such as Physics Mathematics and Chemistry whom synergic contribution to its definition and evolution is at the basis of huge technologic development observed during the last few decades. The wide variety of materials under investigation by this discipline is both strategic for the economy of a Nation as well as a fundamental aspect of everyday life. Among the most relevant ones so far proposed, many advanced materials are organic-based or, in other words, constituted by molecules or organic polymers, not only for their application potential, low costs and preparation flexibility but also for their processability and limited environmental impact.

Up Close: Northwestern University Materials Research Center

MRS Bulletin ◽  
1986 ◽  
Vol 11 (5) ◽  
pp. 36-36
Author(s):  
Stephen H. Carr
Keyword(s):  
Federal Government ◽  
National Science Foundation ◽  
Chemical Engineering ◽  
Materials Science ◽  
Advanced Materials ◽  
Research Center ◽  
Northwestern University ◽  
National Science ◽  
Materials Research ◽  
Materials Science And Engineering

The Materials Research Center at Northwestern University is an interdisciplinary center that supports theoretical and applied research on experimental advanced materials. Conceived during the post-Sputnik era, it is now in its 26th year.The Center, housed in the university's Technological Institute, was one of the first three centers funded at selected universities by the federal government in 1960. The federal government, through the National Science Foundation, now supplies $2.4 million annually toward the Center's budget, and Northwestern University supplements this amount. Approximately one third of the money is used for a central pool of essential equipment, and the other two thirds is granted to professors for direct support of their research. Large amounts of time on supercomputers are also awarded to the Materials Research Center from the National Science Foundation and other sources.The Center's role enables it to provide partial support for Northwestern University faculty working at the frontiers of materials research and to purchase expensive, sophisticated equipment. All members of the Center are Northwestern University investigators in the departments of materials science and engineering, chemical engineering, electrical engineering, chemistry, or physics. The Materials Research Center is a major agent in fostering cross-departmental research efforts, thereby assuring that materials research at Northwestern University includes carefully chosen groups of faculty in physics, chemistry, and various engineering departments.

The Changing Paradigm for Business Success in Advanced Materials and Components Manufacturing

MRS Bulletin ◽  
1992 ◽  
Vol 17 (4) ◽  
pp. 35-37 ◽  
Author(s):  
B. Barnett ◽  
H.K. Bowen ◽  
K. Clark
Keyword(s):  
Materials Science ◽  
Electronic Materials ◽  
Dielectric Materials ◽  
Time Frame ◽  
Molecular Engineering ◽  
Advanced Materials ◽  
Business Success ◽  
Massachusetts Institute Of Technology ◽  
Science And Engineering ◽  
Institute Of Technology

The use of manmade materials progressed rather slowly until the science and technology of metals, refractories, and glass burst forth in the mid-1800s and continued its infancy through the first decades of the 20th century. In fact, much of the scientific wherewithal in industrial nations focused on the development of manmade materials from the standpoint of properties and fabrication processes. From the discipline of metal physics, which emerged in the 1930s, and from the scientific activities in ceramics, polymers, and electronic materials that blossomed in the 1940s and 1950s, a science and engineering base was established, enabling advanced materials and components to be fabricated, often for specific end-user applications. The molecular engineering of crystals, for example, has its roots in von Hippel's studies of dielectric materials at the Massachusetts Institute of Technology, which began in the 1930s. In this time frame, society, which had primarily used such materials as wood, gypsum, clay, copper, zinc, lead, and iron, turned to a broader set of materials to meet new uses. These new applications required an understanding not only of the composition of matter, but of novel and difficult processes as well. Research specialties broadened.From the late 1950s to the present, the knowledge base for materials and components has exploded. In this period, the scientific and technological field of endeavor—materials science and engineering (MS&E) — evolved from a collection of discrete, disparate arts and crafts with varied amounts of science and practitioners who generally did not stray from their own specialties to a more diffuse field where researchers take a broader approach to materials research and practice.

Sign in / Sign up

Export Citation Format

Share Document