scholarly journals Гістологічні зміни в котів за хламідіозу

2017 ◽  
Vol 19 (78) ◽  
pp. 158-161
Author(s):  
V. Lisova ◽  
A. Savchenko
Keyword(s):  
Lymph Nodes ◽  
Interstitial Pneumonia ◽  
Chlamydial Infection ◽  
Histopathological Examination ◽  
Clinical Manifestations ◽  
Bronchial Epithelium ◽  
Histological Structure ◽  
Regional Lymph Nodes ◽  
Morphological Criteria ◽  
Hematoxylin And Eosin

The article presents the results of the study of histological changes in organs and tissues of cats for chlamydial infection. The histopathological examination of the postmortem cases of cats (n = 8) of different breeds between the ages of 3 to 6 years old, who lives with the laboratory methods have been diagnosed and identified the pathogen Chlamydia felis. According to historical data from sick animals were recorded various nature and degree of conjunctivitis and pronounced signs of a lesion of the respiratory tract (rhinitis, bronchitis, pneumonia). The made histological sections were stained with hematoxylin and eosin according to routine standard methods. The general histological structure and microstructural changes in histological preparations were studied under a light microscope. The histopathological examination were confirmed and specified the pathoanatomical diagnoses, established after autopsy of dead animals. It is shown that the most pronounced damage and characteristic changes all dead cats fixed contact in lung tissues and regional lymph nodes (mediastinal and bronchial), and in the spleen. The morphological criteria of chlamydial infection in the studied dead animals at the microscopic level were as follows:1) interstitial pneumonia; 2) pulmonary fibrosis; 3) fibrinous-purulent pleuropneumonia; 4) hyperplasia and serous lymphadenitis of the mediastinal and bronchial lymph nodes; 5) hyperplasia of lymphoid nodules of the spleen; 6) passive venous congestion of the liver and kidneys; 7) fatty and granular liver dystrophy. The results of our study, the pathomorphological diagnosis of chlamydial infection in most of the cats that died was based on changes characteristic of interstitial pneumonia followed pneumosclerosis or fibrinous-purulent pleuropneumonia, with deep affection of the bronchial epithelium. Consequently, the features of chlamydial infection are such that the clinical picture does not always correspond to the severity of morphological manifestations and complications of infection. Weak clinical manifestations can be combined with significant destructive, degenerative and necrotic changes in organs and tissues.

scholarly journals Diffuse Alveolar Damage of the Lungs in Forensic Autopsies: Assessment of Histopathological Stages and Causes of Death

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Halide Nur Urer ◽  
Gokhan Ersoy ◽  
Emine Dilek Yılmazbayhan
Keyword(s):  
Interstitial Pneumonia ◽  
Histopathological Examination ◽  
Diffuse Alveolar Damage ◽  
Lung Damage ◽  
European Respiratory Society ◽  
Acute Interstitial Pneumonia ◽  
Morphological Criteria ◽  
Hematoxylin And Eosin ◽  
Independent Variable ◽  
Lung Biopsies

Introduction. Diffuse alveolar damage (DAD) is a morphological prototype of acute interstitial pneumonia. Hospital autopsies or open-lung biopsies are used to monitor common alveolar damage and hyaline membrane (HM) development histopathologically. The aim of this study was to detect histopathological profiles and frequency of DAD and HM in adult forensic autopsies.Materials and Methods. In total, 6813 reports with histopathological samples in 12,504 cases on which an autopsy was performed between 2006 and 2008 were investigated. Sixty-six individuals >18 years of age who were diagnosed with DAD were included. Hematoxylin- and eosin-stained lung preparations were reexamined in line with the 2002 American Thoracic Society/European Respiratory Society idiopathic interstitial pneumonia consensus criteria.Results. Histopathological examination revealed that 50 cases (75.7%) were in the exudative phase and 16 (24.2%) were in the proliferative phase. Only the rate of alveolar exudate/oedema in exudative phase cases (); those of alveolar histiocytic desquamation (), alveolar fibrosis (), chronic inflammation (), and alveolar fibrin () in proliferative cases were significantly higher. The presence of alveolar fibrin was the only independent variable in favour of proliferative cases ().Conclusion. The detection of all DAD morphological criteria with the same intensity is not always possible in each case. Forensic autopsies may provide a favourable means for expanding our knowledge about acute lung damage, DAD, and interstitial lung disease.

Sentinel lymph node in colorectal cancer — 5 years follow up

Open Medicine ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. 271-278
Author(s):  
Jacek Zielinski ◽  
Radoslaw Jaworski ◽  
Pawel Kabata ◽  
Robert Rzepko ◽  
Wiesław Kruszewski ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Nodes ◽  
Histopathological Examination ◽  
Survival Rates ◽  
Surgical Oncology ◽  
Blue Dye ◽  
Chi Square ◽  
Regional Lymph Nodes ◽  
Term Survival ◽  
The Impact

AbstractTo assess the impact of micrometastases in sentinel and non-sentinel lymph nodes on long-term survival rates of patients treated for colorectal cancer (CRC). Data of 57 patients diagnosed with CRC and treated in the Department of Surgical Oncology in Gdansk in the years 2002–2006 were retrospectively analyzed. Clinico-histopathological data were analyzed using chi-square tests. The effect on long-time survival rates was analyzed using Kaplan-Meier survival probability estimates. Identification of the SLN was performed using the blue dye staining method. All regional lymph nodes were subject to standard histopathological examination. Additionally in 32(56.14%) patients whose nodes were found negative for metastases on standard staining further immunohistochemical analyses were performed. In the analyzed group SLNB was performed in 42(73.7%) patients with colon cancer and in 15(26.3%) with rectal cancer. Identification of the SLN was possible in 45(78.9%) patients. The sensitivity of SLNB was 33%. False negatives were found in 66%. SLNB is a feasible method in CRC patients. We presume that lack of micrometastases in the SLN and non-SLN cannot be regarded as a prognostic factor.

scholarly journals Патоморфологічна характеристика хламідіозу в котів

2017 ◽  
Vol 19 (77) ◽  
pp. 11-14
Author(s):  
V. Lisova ◽  
A. Savchenko
Keyword(s):  
Lymph Nodes ◽  
Chlamydial Infection ◽  
Historical Data ◽  
Underlying Disease ◽  
Regional Lymph Nodes ◽  
Laboratory Methods ◽  
Main Research ◽  
Pathological Material ◽  
The Right ◽  
Lymphoid Nodules

The results of the study of the morphological features of pathological processes in organs and tissues of dead cats from chlamydial infection. A study of cadavers (n = 8), cats of different breeds aged from 3 to 6 years old, who lives with the laboratory methods have been diagnosed and identified the pathogen Chlamydia felis. According to historical data from sick animals were recorded various nature and degree of conjunctivitis and pronounced signs of a lesion of the respiratory tract (rhinitis, bronchitis, pneumonia). The main research method was mortem examination, during which the fixed and described the macroscopic changes in the affected organs and tissues. The autopsy was carried out partial evisceration, while selected pathological material for further histological studies. It is shown that the most pronounced damage and characteristic macroscopic changes all dead cats fixed contact in lung tissues and regional lymph nodes (mediastinal and bronchial), and in the spleen. Macroscopic picture of lungs affected varied somewhat depending on the degree of damage and stages of morphogenesis. In most cases (n = 6) lesions in the lungs looked like multiple well-defined lesions that are localized in all lobes of the lungs. Morphological manifestations of chlamydial infection in the investigated dead cats on the macroscopic level following features are: 1) productive inflammation in the lungs in a subtotal and total interstitial pneumonia and pulmonary fibrosis; 2) catarrhal bronchitis; 3) hyperplasia and serous lymphadenitis of the mediastinal and bronchial lymph nodes; 4) hyperplasia of lymphoid nodules of the spleen; 5) serous conjunctivitis. Also, a disease accompanied by nonspecific general pathological processes, such as: passive venous congestion of the liver and kidneys; degenerative changes in the liver; dilation of the right ventricle of the heart, which occurs as a complication of the underlying disease. While studies of other organs and tissues of dead animals we have not found any macroscopic changes.

scholarly journals A Case of Gastric Cancer with Residual Tumor Only in the Para-Aortic Lymph Nodes after Systemic Chemotherapy followed by Conversion Surgery

2015 ◽  
Vol 8 (2) ◽  
pp. 312-322 ◽  
Author(s):  
Masayuki Tsutsuyama ◽  
Seiji Ito ◽  
Yuichi Ito ◽  
Kazunari Misawa ◽  
Jiro Kawakami ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Nodes ◽  
Systemic Chemotherapy ◽  
Histopathological Examination ◽  
Gastric Wall ◽  
Stage Iv ◽  
Residual Tumor ◽  
Gastric Body ◽  
Upper Gastrointestinal Endoscopy ◽  
Regional Lymph Nodes

We report the case of a 60-year-old male who was diagnosed with gastric cancer. Upper gastrointestinal endoscopy indicated advanced cancer in the posterior wall of the gastric body. Biopsy revealed poorly differentiated adenocarcinoma. Abdominal computed tomography demonstrated thickening of the gastric wall and enlargement of the regional lymph nodes and of the para-aortic lymph nodes (PAN). The involvement of the PAN extended from the celiac axis to the caudal area of the inferior mesenteric artery [cT3N3aH0P0M1(LYM), stage IV]. Systemic chemotherapy was initiated. After 3 courses of S-1 plus cisplatin combination chemotherapy, the primary lesion and the enlarged lymph nodes revealed marked regression except for a minute residual lesion in the lymph nodes. Upon obtaining informed consent, open distal gastrectomy, D2 lymphadenectomy with PAN dissection, and Roux-en-Y reconstruction were performed. The patient was discharged from the hospital 35 days after the operation. Histopathological examination of the resected samples revealed malignant cells only in the PAN, not in the stomach or in the regional lymph nodes [ypT0N0M1(LYM), stage IV]. Currently, the patient is undergoing postoperative adjuvant chemotherapy with S-1 and has remained well without any recurrence after 6 months following surgery.

scholarly journals Assessment of Density of Neovascularization in Lower Lip Squamous Cell Carcinoma in Relation To Neoplasm Differentiation Grade in Patients with and without Neck Lymph Nodes Metastasis

2019 ◽  
Vol 7 (1) ◽  
pp. 19-23
Author(s):  
Lena Kakasheva-Mazhenkovska ◽  
Marko Kostovski ◽  
Gjorgje Gjokik ◽  
Vesna Janevska
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Histopathological Examination ◽  
Tumour Progression ◽  
Regional Lymph Nodes ◽  
Lower Lip ◽  
Neck Metastasis ◽  
Significant Difference

BACKGROUND: Squamous cell carcinoma (SCC) of the lower lip is a relatively rare carcinoma, with the incidence of 1 to 2%, but it is the most common carcinoma in the oral cavity accounting for 25-30% of all malignant oral tumours. AIM: This study aimed to determine the role of neovascularisation in the process of tumour progression. METHODS: We analysed the surgical specimens obtained from 60 patients with squamous cell carcinoma (SCC) of the lower lip. The examined group consisted of 45 specimens of patients without metastasis and 15 specimens of patients with metastasis in the regional lymph nodes. Histopathological slides were immunohistochemically stained with an antibody against CD34 and by hematoxylin & eosin staining for routine histopathological examination. RESULTS: The results obtained showed a statistically significant difference in the density of neovascularisation between groups of the SCC with different grade of differentiation (Kruskal-Wallis test: H (2, N = 60) = 30.0943, p = 0.00001). Statistical analysis also showed a significant difference in the density of vascularisation of lower lip SCC between patients without metastasis and patients with neck metastasis (Mann-Whitney U test, p = 0.000198). Applying Pearson’s chi-square test, we found a highly significant statistical difference in grade of SCC differentiation in patients with and without neck metastasis (p = 0.0000). CONCLUSION: In conclusion, the density of neoangiogenesis is increased in tumours with poorer differentiation and in patients with neck metastasis. So, the density of neovascularisation of the primary lip SCC may predict the tumour progression.

Gangliocytic paraganglioma of the gastrointestinal tract; a case report of cecal origin

2021 ◽  
Vol 17 ◽  
Author(s):  
Geojeong Seo ◽  
Jinyoung Park ◽  
Eunjoo Lee ◽  
Jiyeon Han ◽  
Dasom Kim ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Histopathological Examination ◽  
Case Reports ◽  
Wedge Resection ◽  
Radical Resection ◽  
Additional Treatment ◽  
Gangliocytic Paraganglioma ◽  
Regional Lymph Nodes ◽  
Small Series ◽  
Uncommon Case

Introduction:: Gangliocytic paraganglioma is an extremely rare tumor that is composed of epithelioid, ganglion, and spindle cells. It has a predilection site in the duodenum, especially the periampullary region. The clinical course is usually benign, but a few cases of metastasis to lymph nodes or distant sites have been noted. Several case reports or small series reviews of gangliocytic paraganglioma have been published, but so far, cecal gangliocytic paraganglioma has not been described. Case description: A 61-year-old man underwent an abdominal Computed Tomography (CT) scan for known GB stones, which revealed an incidental cecal mass. The patient underwent wedge resection of the cecum for diagnostic and therapeutic purposes. Histopathological examination of the cecal mass identified a gangliocytic paraganglioma. There was no evidence of metastasis in the dissected regional lymph nodes. No additional treatment, such as adjuvant chemotherapy or radiotherapy, was administered, and the patient underwent regular follow-up without any complications. Conclusion: The most common radiologic finding in gangliocytic paraganglioma is a circumscribed, enhancing subepithelial mass. Herein, we report an uncommon case of cecal-origin gangliocytic paraganglioma. With knowledge of the radiologic and histologic characteristics of gangliocytic paraganglioma, appropriate management can be provided without unnecessary radical resection.

Lymph Nodal Merkel Cell Carcinoma; Primary or Metastatic Disease? A Clinical Case

2002 ◽  
Vol 88 (5) ◽  
pp. 424-426 ◽  
Author(s):  
Giuseppe Fotia ◽  
Roberto Barni ◽  
Cristiana Bellan ◽  
Alessandro Neri
Keyword(s):  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Pulmonary Metastases ◽  
Histopathological Examination ◽  
Palliative Radiotherapy ◽  
Merkel Cell ◽  
Neoplastic Tissue ◽  
Regional Lymph Nodes

We report a case of Merkel cell carcinoma (MCC) presenting in the lymph nodes in the absence of a primary cutaneous site. The MCC was treated by palliative radiotherapy, which controlled the disease locally. Eight months after diagnosis a mass appeared on the ipsilateral knee; histopathological examination of this lesion confirmed the diagnosis of MCC. The patient died two months later due to the development of pulmonary metastases. Interestingly, the neoplastic tissue was confined to the regional lymph nodes for several months before the primary site appeared. Primary lymph nodal MCC is rare and the diagnosis is difficult. In our opinion the only way to make a diagnosis of primary lymph nodal MCC is by appropriate clinical follow-up.

scholarly journals Inflammatory Cells in Gastric Cancer: Promoting the Tumour or Protecting the Host?

2020 ◽  
Vol 74 (2) ◽  
pp. 111-117
Author(s):  
Tatjana Tone ◽  
Elīna Tauvēna ◽  
Ilze Štrumfa ◽  
Jānis Gardovskis
Keyword(s):  
Gastric Carcinoma ◽  
Lymph Nodes ◽  
Inflammatory Cells ◽  
World Health Organisation ◽  
World Health ◽  
Histological Structure ◽  
Regional Lymph Nodes ◽  
Tumour Spread ◽  
Local Tumour ◽  
And Gender

AbstractThe study represents a comprehensive retrospective morphological profiling of gastric carcinoma in order to reveal associations between certain tumour-infiltrating inflammatory cells and clinical and/or pathological parameters. Patients’ age and gender, the extent of local tumour spread (pT), presence of metastases in regional lymph nodes (pN), tumour grade (G) as well as type according to World Health Organisation (WHO) and Lauren classifications were assessed in 211 consecutive surgically resected gastric carcinomas. Tumour-infiltrating inflammatory cells including eosinophils, neutrophils and lymphocytes were counted within the cancer stroma in five randomly selected high-power fields representative of the tumour. Descriptive statistics, Mann–Whitney and Kruskal–Wallis tests were applied; p < 0.05 was considered significant. Higher number of stromal eosinophils was associated with absence of metastases in regional lymph nodes (pN0) and histological structure of adenocarcinoma by WHO classification (p = 0.005 and p = 0.002, respectively). Higher count of stromal neutrophils showed significant associations with younger age (less than 65 years), and intestinal type by Lauren classification (p = 0.029 and p = 0.007, respectively). The density of stromal lymphocytes lacked any statistically significant association with the evaluated clinical or morphological parameters. In conclusion, the current study highlights the links between certain innate immune system cells and morphological features of gastric carcinoma.

scholarly journals Гістологічні зміни в собак за коронавірусної інфекції

2017 ◽  
Vol 19 (78) ◽  
pp. 154-157 ◽  
Author(s):  
V. Lisova ◽  
O. Dubinenko
Keyword(s):  
Small Intestine ◽  
Lymph Nodes ◽  
Histological Study ◽  
Polymerase Chain Reaction Analysis ◽  
Histological Structure ◽  
Mesenteric Lymph Nodes ◽  
Regional Lymph Nodes ◽  
Liver And Kidney ◽  
Coronavirus Infection ◽  
Pathological Material

The article presents the results of the study of histological changes in organs and tissues of dogs for coronavirus infection. The histological study of the pathological material of cadavers (n =5) dogs of different breeds and sex between the ages of 2 to 6 months, who died with diarrheal syndrome. The study of presence of coronavirus, without other assiociants, in these cases had previously been confirmed in the polymerase chain reaction analysis of fecal samples. The made histological sections were stained with hematoxylin and eosin according to standard prescriptions. The general histological structure and microstructural changes in histological preparations were studied under a light microscope. Histological studies have been confirmed and supplemented with pathoanatomical diagnoses, established after autopsies of dead bodies of dead animals. The most pronounced lesions and typical change in all dead dogs fixed contact in the small intestine (jejunum and to the ileum) and the regional lymph nodes to it, as well as in the spleen. It is shown that the morphological manifestations of coronavirus infection in dogs following features are on the microscopic level: the presence of exudative inflammation in the small intestine in the form serous-fibrinous jejuno-ileitis; hyperplasia of single and congested lymphoid nodes of the mucous membrane of the small intestine; hyperplasia and serous-hemorrhagic lymphadenitis mesenteric lymph nodes; foci of hemorrhage and hemorrhagic heart attacks in the spleen parenchyma; hyperplasia lymphoid nodes of the spleen; foci of hemorrhage in the serous membrane of the small intestine. Also, non-specific, but constant morphological features, which arose as a result of circulatory disorders and heart failure were: passive venous congestion of the liver and kidney; degenerative processes in the liver and kidney parenchyma. Consequently, local and general immunological processes develop during the coronaviral infection. Therefore, additional diagnostic markers appear hyperplastic and inflammatory changes of regional seats to the reproduction of the virus lymphoid organs.

Distribution of Tattoo Pigment in Lymph Nodes Dissected for Gynecological Malignancy

2019 ◽  
Vol 27 (7) ◽  
pp. 773-777 ◽  
Author(s):  
Daisuke Tamura ◽  
Daichi Maeda ◽  
Yukihiro Terada ◽  
Akiteru Goto
Keyword(s):  
Lymph Nodes ◽  
Histopathological Examination ◽  
Clinical Stage ◽  
Clinical Information ◽  
Left Thigh ◽  
Cervical Adenocarcinoma ◽  
Regional Lymph Nodes ◽  
Gynecological Malignancy ◽  
Systemic Distribution ◽  
Tattoo Pigment

Tattoo pigment migrates to regional lymph nodes, often causing acute or chronic lymphadenopathy. Past reports on tattoo lymphadenopathy are almost exclusively from Western countries. However, systemic distribution of tattoo pigment in lymph nodes has not been assessed in detail. In this article, we report a Japanese case of cervical adenocarcinoma, in which we successfully assessed the distribution of tattoo pigment deposition in pelvic and para-aortic lymph nodes. A 61-year-old woman with Japanese-style tattoos on both arms and her left thigh visited another clinic with postcoital bleeding. She was diagnosed with clinical stage 1B1 (cervical adenocarcinoma) and underwent radical hysterectomy and pelvic/para-aortic lymph node dissection. Histopathological examination revealed deposition of a black pigment in multiple lymph nodes. The pigment was more abundant in the left pelvic lymph nodes than in the para-aortic lymph nodes, a finding suggestive of pigment drainage from the tattoo on the left thigh. She remains free of disease more than 1 year after surgery. The diagnosis of tattoo lymphadenopathy is not easy when clinical information is lacking. The differential diagnoses include metastatic melanoma. Clinicians and pathologists should better recognize this phenomenon.

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